Characterization of Induced Pluripotent Stem Cell Microvesicle Genesis, Morphology and Pluripotent Content

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Zhou, Jing ^a,b   Ghoroghi, Shima ^a   Benito Martin, Alberto ^c   Wu, Hao ^a,b   Unachukwu, Uchenna John ^a,d   Einbond, Linda Saxe ^a   Guariglia, Sara ^d   Peinado, Hector ^c,e   Redenti, Stephen ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e Structural Biology and Biocomputing Programme   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN;

ANIMAL; CELL FUSION; CELL MEMBRANE; CELL SIZE; CYTOLOGY; GENETICS; INDUCED PLURIPOTENT STEM CELL; MEMBRANE MICROPARTICLE; METABOLISM; MOUSE; REAL TIME POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

ANIMALS; CELL FUSION; CELL MEMBRANE; CELL SIZE; CELL-DERIVED MICROPARTICLES; INDUCED PLURIPOTENT STEM CELLS; MICE; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84955489586     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19743     Document Type: Article

References (42)

1. Record, M., Subra, C., Silvente-Poirot, S. & Poirot, M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol 81, 1171-1182 (2011).
2. Deregibus, M. C., Tetta, C. & Camussi, G. The dynamic stem cell microenvironment is orchestrated by microvesicle-mediated transfer of genetic information. Histol Histopathol 25, 397-404 (2010).
3. Baj-Krzyworzeka, M. et al. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol Immunother 55, 808-818 (2006).
4. Schorey, J. S. & Bhatnagar, S. Exosome function: from tumor immunology to pathogen biology. Traffic 9, 871-881 (2008).
5. Deregibus, M. C. et al. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 110, 2440-2448 (2007).
6. Goon, P. K., Lip, G. Y., Boos, C. J., Stonelake, P. S. & Blann, A. D. Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer. Neoplasia 8, 79-88 (2006).
7. Smalley, D. M., Sheman, N. E., Nelson, K. & Theodorescu, D. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J Proteome Res 7, 2088-2096 (2008).
8. Yuan, A. et al. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One 4, e4722 (2009).
9. Pap, E., Pallinger, E. & Falus, A. The role of membrane vesicles in tumorigenesis. Crit Rev Oncol Hematol 79, 213-223 (2011).
10. Muralidharan-Chari, V., Clancy, J. W., Sedgwick, A. & D'Souza-Schorey, C. Microvesicles: mediators of extracellular communication during cancer progression. J Cell Sci 123, 1603-1611 (2010).
11. Pap, E., Pallinger, E., Pasztoi, M. & Falus, A. Highlights of a new type of intercellular communication: microvesicle-based information transfer. Inflamm Res 58, 1-8 (2009).
12. Thery, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2, 569-579 (2002).
13. Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. The Journal of cell biology 172, 923-935 (2006).
14. Cocucci, E., Racchetti, G. & Meldolesi, J. Shedding microvesicles: artefacts no more. Trends Cell Biol 19, 43-51 (2009).
15. Muller, G., Schneider, M., Biemer-Daub, G. & Wied, S. Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis. Cell Signal 23, 1207-1223 (2011).
16. Grimm, D. Small silencing RNAs: state-of-the-art. Adv Drug Deliv Rev 61, 672-703 (2009).
17. Collino, F. et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One 5, e11803 (2010).
18. Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell research 24, 766-769 (2014).
19. Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature medicine 18, 883-891 (2012).
20. Ludwig, A. K. & Giebel, B. Exosomes: small vesicles participating in intercellular communication. Int J Biochem Cell Biol 44, 11-15 (2012).
21. Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A. & Ratajczak, M. Z. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20, 1487-1495 (2006).
22. Quesenberry, P. J. & Aliotta, J. M. Cellular phenotype switching and microvesicles. Adv Drug Deliv Rev 62, 1141-1148 (2010).
23. Ratajczak, J. et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20, 847-856 (2006).
24. Bruno, S. et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 20, 1053-1067 (2009).
25. Herrera, M. B. et al. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med 14, 1605-1618 (2010).
26. Klassen, H. J. et al. Multipotent Retinal Progenitors Express Developmental Markers, Differentiate into Retinal Neurons, and Preserve Light-Mediated Behavior. Investigative Ophthalmology & Visual Science 45, 4167-4173 (2004).
27. Raposo, G. & Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. The Journal of cell biology 200, 373-383 (2013).
28. Schneider, A. & Simons, M. Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders. Cell and tissue research 352, 33-47 (2013).
29. S, E. L. A., Mager, I., Breakefield, X. O. & Wood, M. J. Extracellular vesicles: biology and emerging therapeutic opportunities. Nature reviews. Drug discovery 12, 347-357 (2013).
30. Stadtfeld, M. & Hochedlinger, K. Induced pluripotency: history, mechanisms, and applications. Genes & development 24, 2239-2263 (2010).
31. Takahashi, K. & Yamanaka, S. Induced pluripotent stem cells in medicine and biology. Development 140, 2457-2461 (2013).
32. Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
33. Mathivanan, S., Ji, H. & Simpson, R. J. Exosomes: extracellular organelles important in intercellular communication. J Proteomics 73, 1907-1920 (2010).
34. Mrvar-Brecko, A. et al. Isolated microvesicles from peripheral blood and body fluids as observed by scanning electron microscope. Blood Cells Mol Dis 44, 307-312 (2010).
35. Hunter, M. P. et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 3, e3694 (2008).
36. Liang, Y. et al. Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. The Journal of biological chemistry 289, 32526-32537 (2014).
37. Tian, T. et al. Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery. The Journal of biological chemistry 289, 22258-22267 (2014).
38. Smalheiser, N. R. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol Direct 2, 35 (2007).
39. Aliotta, J. M. et al. Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription. Exp Hematol 38, 233-245 (2010).
40. Katsman, D., Stackpole, E. J., Domin, D. R. & Farber, D. B. Embryonic stem cell-derived microvesicles induce gene expression changes in Muller cells of the retina. PloS one 7, e50417 (2012).
41. Sreekumar, P. G. et al. alphaB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PloS one 5, e12578 (2010).
42. Tuo, J., Grob, S., Zhang, K. & Chan, C. C. Genetics of immunological and inflammatory components in age-related macular degeneration. Ocular immunology and inflammation 20, 27-36 (2012).