Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

ACS Medicinal Chemistry Letters

Volumn 7, Issue 1, 2016, Pages 94-99

  Scott, James S ^a   Bailey, Andrew ^a   Davies, Robert D M ^a   Degorce, Sébastien L ^a   Macfaul, Philip A ^a   Gingell, Helen ^a   Moss, Thomas ^a   Norman, Richard A ^a   Pink, Jennifer H ^a   Rabow, Alfred A ^a   Roberts, Bryan ^a   Smith, Peter D ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

antagonist; bioavailable; downregulator; Estrogen receptor; phenol; tetrahydroisoquinoline

Indexed keywords

ESTROGEN RECEPTOR ANTAGONIST; METHYL GROUP; PHENOL DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; ENANTIOMER; HYDROLYSIS; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; VOLUME OF DISTRIBUTION AT STEADY-STATE;

EID: 84955463875     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00413     Document Type: Article

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