Reactive metabolite trapping screens and potential pitfalls: Bioactivation of a homomorpholine and formation of an unstable thiazolidine adduct

Chemical Research in Toxicology

Volumn 27, Issue 6, 2014, Pages 968-980

  Lenz, Eva M ^a   Martin, Scott ^a   Schmidt, Ralf ^a,b   Morin, Pierre Emmanuel ^a   Smith, Robin ^a   Weston, Daniel J ^a   Bayrakdarian, Malken ^a,c  

^a ASTRAZENECA   (United Kingdom)

^b EMD Serono Research Institute   (United States)

^c IntelliSyn RandD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMIDE; CYSTINE; GLUTATHIONE; GLYCINE; METHOXYAMINE; MORPHOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIAZOLIDINE DERIVATIVE; CYTOCHROME P450;

ARTICLE; CHEMICAL MODIFICATION; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; CYCLIZATION; DECOMPOSITION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; METABOLIC ACTIVATION; MOLECULAR STABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; BACILLUS MEGATERIUM; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM;

BACILLUS MEGATERIUM; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MORPHOLINES; THIAZOLIDINES;

EID: 84902524040     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx5000409     Document Type: Article

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