Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 4, 2016, Pages 822-829

  Berndt, Andre ^a   Lee, Soo Yeun ^a   Wietek, Jonas ^b   Ramakrishnan, Charu ^a   Steinberg, Elizabeth E ^c,d   Rashid, Asim J ^e   Kim, Hoseok ^f   Park, Sungmo ^e   Santoro, Adam ^e   Frankland, Paul W ^e   Iyer, Shrivats M ^a   Pak, Sally ^a   Ährlund Richter, Sofie ^f   Delp, Scott L ^a   Malenka, Robert C ^c,d   Josselyn, Sheena A ^e   Carlén, Marie ^f   Hegemann, Peter ^b   Deisseroth, Karl ^a,c  

^a Stanford University   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c STANFORD UNIVERSITY   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Channelrhodopsin; Chloride; Neuronal inhibition; Optogenetics; Structure

Indexed keywords

ARGININE; BROMIDE; CHANNELRHODOPSIN; CHLORIDE; CHLORIDE CHANNEL; GLUTAMINE; HISTIDINE; IODIDE; MEMBRANE PROTEIN; OPSIN; SERINE; UNCLASSIFIED DRUG; RHODOPSIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHLORIDE CONDUCTANCE; CHLORIDE TRANSPORT; CRYSTAL STRUCTURE; DOPAMINERGIC NERVE CELL; EVOKED RESPONSE; HEK293 CELL LINE; HIPPOCAMPAL NEURONAL CULTURE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IN VITRO STUDY; INTERNEURON; MEDIAL PREFRONTAL CORTEX; MOUSE; NERVE CELL MEMBRANE; NONHUMAN; OPTOGENETICS; PH; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTON TRANSPORT; REVERSAL POTENTIAL; SUBSTANTIA NIGRA PARS COMPACTA; VENTRAL TEGMENTUM; ADMINISTRATION AND DOSAGE; AMINO ACID SEQUENCE; ANIMAL; AVOIDANCE BEHAVIOR; BASOLATERAL AMYGDALA; C57BL MOUSE; CELL CULTURE; CHANNEL GATING; CHEMISTRY; CYTOLOGY; DEPENDOPARVOVIRUS; ELECTRIC SHOCK; FEAR; FIBER OPTICS; GENE VECTOR; GENETICS; HIPPOCAMPUS; MALE; MEMORY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; NERVE CELL; PHYSIOLOGY; PROTEIN CONFORMATION; RADIATION RESPONSE; RAT; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; ARGININE; AVOIDANCE LEARNING; BASOLATERAL NUCLEAR COMPLEX; CELLS, CULTURED; CHLORIDES; DEPENDOVIRUS; ELECTROSHOCK; FEAR; FIBER OPTIC TECHNOLOGY; GENETIC VECTORS; HEK293 CELLS; HIPPOCAMPUS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MALE; MEMORY; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; OPTOGENETICS; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RHODOPSIN; SEQUENCE ALIGNMENT; VENTRAL TEGMENTAL AREA;

EID: 84955461716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523341113     Document Type: Article

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