Inducible knock-down of the mineralocorticoid receptor in mice disturbs regulation of the renin-angiotensin-aldosterone system and attenuates heart failure induced by pressure overload

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Montes Cobos, Elena ^a   Li, Xiao ^a   Fischer, Henrike J ^a   Sasse, André ^a   Kügler, Sebastian ^a   Didié, Michael ^a,c   Toischer, Karl ^a,c   Fassnacht, Martin ^b   Dressel, Ralf ^a,c   Reichardt, Holger M ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; COLLAGEN; DOXYCYCLINE; ENHANCED GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; RENIN; ELECTROLYTE; SMALL INTERFERING RNA;

ADULTHOOD; ALDOSTERONE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE TARGETING; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; HEART VENTRICLE PRESSURE; HORMONAL REGULATION; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PLASMA RENIN ACTIVITY; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA INTERFERENCE; SODIUM EXCRETION; TRANSGENIC MOUSE; ANIMAL; BLOOD; COMPLICATION; DEFICIENCY; DISEASE MODEL; ECHOCARDIOGRAPHY; FIBROSIS; GENE SILENCING; GENETICS; HYPERTENSION; KNOCKOUT MOUSE; METABOLISM; URINE;

ALDOSTERONE; ANIMALS; COLLAGEN; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ELECTROLYTES; FIBROSIS; GENE EXPRESSION; GENE SILENCING; HEART FAILURE; HYPERTENSION; MICE; MICE, KNOCKOUT; RECEPTORS, MINERALOCORTICOID; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, SMALL INTERFERING;

EID: 84955453375     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143954     Document Type: Article

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