No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

Biogerontology

Volumn 17, Issue 1, 2016, Pages 189-198

  Goldeck, David ^a   Pawelec, Graham ^a,b   Norman, Kristina ^c   Steinhagen Thiessen, Elisabeth ^c   Oettinger, Lilly ^a   Haehnel, Karin ^a   Demuth, Ilja ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Ageing; CMV; CRP; Cytokines; Hand grip strength; Telomere length

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; CYTOKINE;

ADULT; AGED; AGING; ARTICLE; BODY MASS; COHORT ANALYSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GRIP STRENGTH; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; VERY ELDERLY; YOUNG ADULT; BLOOD; COMPARATIVE STUDY; CYTOMEGALOVIRUS INFECTIONS; GERMANY; HAND STRENGTH; IMMUNOLOGY; IMMUNOSENESCENCE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICS;

AGED; AGING; COHORT STUDIES; CYTOKINES; CYTOMEGALOVIRUS INFECTIONS; FEMALE; GERMANY; HAND STRENGTH; HUMANS; IMMUNOSENESCENCE; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STATISTICS AS TOPIC; YOUNG ADULT;

EID: 84955364608     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-015-9577-9     Document Type: Article

References (47)

1. Auyeung TW, Lee SW, Leung J, Kwok T, Woo J (2014) Age-associated decline of muscle mass, grip strength and gait speed: a 4-year longitudinal study of 3018 community-dwelling older Chinese. Geriatr Gerontol Int 14(1):76–84. doi:10.1111/ggi.12213
2. Baragetti A et al (2014) Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population. J Intern Med. doi:10.1111/joim.12282
3. Bartlett DB et al (2012) The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. Aging Cell 11:912–915. doi:10.1111/j.1474-9726.2012.00849.x
4. Baylis D et al (2014) Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif Tissue Int 95:54–63. doi:10.1007/s00223-014-9862-7
5. Benetos A et al (2013) Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell 12:615–621. doi:10.1111/acel.12086
6. Bennett JM, Glaser R, Malarkey WB, Beversdorf DQ, Peng J, Kiecolt-Glaser JK (2012) Inflammation and reactivation of latent herpesviruses in older adults. Brain Behav Immun 26:739–746. doi:10.1016/j.bbi.2011.11.007
7. Bertram L et al (2013) Cohort profile: the Berlin aging study II (BASE-II). Int J Epidemiol. doi:10.1093/ije/dyt018
8. Callicott RJ, Womack JE (2006) Real-time PCR assay for measurement of mouse telomeres. Comp Med 56:17–22
9. Carmelli D, Reed T (2000) Stability and change in genetic and environmental influences on hand-grip strength in older male twins. J Appl Physiol 89:1879–1883
10. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30:e47
11. Choi J, Joseph L, Pilote L (2013) Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obes Rev 14:232–244. doi:10.1111/obr.12003
12. Collerton J et al (2012) Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the newcastle 85+ Study. Mech Ageing Dev 133:456–466. doi:10.1016/j.mad.2012.05.005
13. Crawford KW et al (2013) Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS body composition substudy. AIDS Res Hum Retrovir 29:1138–1145. doi:10.1089/AID.2013.0020
14. Devaraj S, Jialal I (2011) C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype. Arterioscler Thromb Vasc Biol 31:1397–1402. doi:10.1161/ATVBAHA.111.225508
15. Flood A, Chung A, Parker H, Kearns V, O’Sullivan TA (2014) The use of hand grip strength as a predictor of nutrition status in hospital patients. Clin Nutr 33:106–114. doi:10.1016/j.clnu.2013.03.003
16. Fulop T, Witkowski JM, Pawelec G, Alan C, Larbi A (2014) On the immunological theory of aging. Interdiscip Top Gerontol 39:163–176. doi:10.1159/000358904
17. Gale CR, Martyn CN, Cooper C, Sayer AA (2007) Grip strength, body composition, and mortality. Int J Epidemiol 36:228–235. doi:10.1093/ije/dyl224
18. Gardner M et al (2014) Gender and telomere length: systematic review and meta-analysis. Exp Gerontol 51:15–27. doi:10.1016/j.exger.2013.12.004
19. Haidar SG, Kumar D, Bassi RS, Deshmukh SC (2004) Average versus maximum grip strength: which is more consistent? J Hand Surg Br 29:82–84
20. Jenkins EC et al (2006) Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiol Aging 27:941–945. doi:10.1016/j.neurobiolaging.2005.05.021
21. Kaya MS, Bayiroglu F, Mis L, Kilinc D, Comba B (2014) In case of obesity, longevity-related mechanisms lead to anti-inflammation. Age 36:677–687. doi:10.1007/s11357-013-9598-8
22. Kilgour AH et al (2013) Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly. Immun Ageing 10:33. doi:10.1186/1742-4933-10-33
23. Legrand D, Adriaensen W, Vaes B, Mathei C, Wallemacq P, Degryse J (2013) The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons. Arch Gerontol Geriatr 57:345–351. doi:10.1016/j.archger.2013.06.003
24. Ling CH, de Craen AJ, Slagboom PE, Westendorp RG, Maier AB (2012) Handgrip strength at midlife and familial longevity. Leiden Longev Study Age 34:1261–1268. doi:10.1007/s11357-011-9295-4
25. Lisko I et al (2012) Inflammation, adiposity, and mortality in the oldest old. Rejuvenation Res 15:445–452. doi:10.1089/rej.2011.1310
26. Luz Correa B et al (2014) The inverted CD4:CD8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults. Neuroimmunomodulation 21:206–212. doi:10.1159/000356827
27. Marzetti E et al (2014) Shorter telomeres in peripheral blood mononuclear cells from older persons with sarcopenia: results from an exploratory study. Front Aging Neurosci 6:233. doi:10.3389/fnagi.2014.00233
28. Mathei C, Adriaensen W, Vaes B, Van Pottelbergh G, Wallemacq P, Degryse J (2014) No relation between CMV infection and mortality in the oldest old: results from the Belfrail study. Age Ageing. doi:10.1093/ageing/afu094
29. Moro-Garcia MA, Alonso-Arias R, Lopez-Vazquez A, Suarez-Garcia FM, Solano-Jaurrieta JJ, Baltar J, Lopez-Larrea C (2012) Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age 34:479–495. doi:10.1007/s11357-011-9240-6
30. Oppewal A, Hilgenkamp TI, van Wijck R, Evenhuis HM (2013) The effect of handedness on grip strength in older adults with intellectual disabilities. Res Dev Disabil 34:1623–1629. doi:10.1016/j.ridd.2013.02.013
31. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
32. Pinke KH, Calzavara B, Faria PF, doNascimento MP, Venturini J, Lara VS (2013) Proinflammatory profile of in vitro monocytes in the ageing is affected by lymphocytes presence. Immun Ageing 10:22. doi:10.1186/1742-4933-10-22
33. Qian L, Flood PM, Hong JS (2010) Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy. J Neural Transm 117:971–979. doi:10.1007/s00702-010-0428-1
34. Rantanen T, Volpato S, Ferrucci L, Heikkinen E, Fried LP, Guralnik JM (2003) Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc 51:636–641
35. Sayer AA, Syddall HE, Martin HJ, Dennison EM, Roberts HC, Cooper C (2006) Is grip strength associated with health-related quality of life? Findings from the Hertfordshire Cohort study. Age Ageing 35:409–415. doi:10.1093/ageing/afl024
36. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA (1990) Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75:40–47
37. Schmaltz HN, Fried LP, Xue QL, Walston J, Leng SX, Semba RD (2005) Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 53:747–754. doi:10.1111/j.1532-5415.2005.53250.x
38. Shin HY, Kim SW, Kim JM, Shin IS, Yoon JS (2012) Association of grip strength with dementia in a Korean older population. Int J Geriatr Psychiatry 27:500–505. doi:10.1002/gps.2742
39. Song Y, Shen H, Schenten D, Shan P, Lee PJ, Goldstein DR (2012) Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 32:103–109. doi:10.1161/ATVBAHA.111.236349
40. Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK (2003) Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 17:884–886. doi:10.1096/fj.02-0670fje
41. Stenholm S, Sallinen J, Koster A, Rantanen T, Sainio P, Heliovaara M, Koskinen S (2011) Association between obesity history and hand grip strength in older adults—exploring the roles of inflammation and insulin resistance as mediating factors. J Gerontol A Biol Sci Med Sci 66:341–348. doi:10.1093/gerona/glq226
42. Terrazzini N, Bajwa M, Thomas D, Smith H, Kern F (2014) Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people. Immunol Lett. doi:10.1016/j.imlet.2014.09.011
43. Turner JE et al (2014) Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Age 36:287–297. doi:10.1007/s11357-013-9557-4
44. Weksler ME, Pawelec G, Franceschi C (2009) Immune therapy for age-related diseases. Trends Immunol 30:344–350. doi:10.1016/j.it.2009.03.011
45. Wikby A et al (2005) An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci 60:556–565
46. Wikby A et al (2006) The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev 127:695–704. doi:10.1016/j.mad.2006.04.003
47. Zhang WG et al (2014) Select aging biomarkers based on telomere length and chronological age to build a biological age equation. Age 36:9639. doi:10.1007/s11357-014-9639-y