Inflammation, adiposity, and mortality in the oldest old

Rejuvenation Research

Volumn 15, Issue 5, 2012, Pages 445-452

  Lisko, Inna ^a,b   Tiainen, Kristina ^a   Stenholm, Sari ^c   Luukkaala, Tiina ^a,d   Hurme, Mikko ^d,e   Lehtimäki, Terho ^d,e   Hervonen, Antti ^a   Jylhä, Marja ^a  

^a Jyvaskyla University   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d PIRKANMAA HOSPITAL DISTRICT   (Finland)

^e TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BLOOD SAMPLING; BODY MASS; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBESITY; PRIORITY JOURNAL; SMOKING; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ABDOMINAL FAT; ADIPOSITY; AGE FACTORS; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; FEMALE; FINLAND; HUMANS; INFLAMMATION; LINEAR MODELS; MALE; MORTALITY; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SEX FACTORS; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84868019547     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1310     Document Type: Article

References (39)

1. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C. Innate immunity and inflam-mation in ageing: A key for understanding age-related dis-eases. Immun Ageing 2005:8.
2. Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005;1:29-35.
3. Tsai HJ, Tsai AC The association of plasma C-reactive protein levels with anthropometric and lipid parameters in elderly Taiwanese. Asia Pac J Clin Nutr 2008;4:651-656.
4. Meier CA, Bobbioni E, Gabay C, Assimacopoulos-Jeannet F, Golay A, Dayer JM. IL-1 receptor antagonist serum levels are increased in human obesity: A possible link to the resistance to leptin? J Clin Endocrinol Metab 2002;3:1184-1188.
5. Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Tracy RP, Rubin SM, Harris TB, Pahor M. Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am J Cardiol 2003;5:522-528.
6. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;6917:860-867.
7. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegenera-tion. Cell 2010;6:918-934.
8. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007;1:83-91.
9. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Et-tinger WH,Jr, Heimovitz H, Cohen HJ, Wallace R Associa-tions of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 1999;5:506-512.
10. Janssen I, Mark AE. Elevated body mass index and mortality risk in the elderly. Obes Rev 2007;1:41-59.
11. Beddhu S. The body mass index paradox and an obesity, inflammation, and atherosclerosis syndrome in chronic kidney disease. Semin Dial 2004;3:229-232.
12. Lakoski SG, Le AH, Muntner P, Judd SE, Safford MM, Le-vine DA, Howard G, Cushman M. Adiposity, inflammation, and risk for death in black and white men and women in the United States: The Reasons for Geographic and Racial Dif-ferences in Stroke (REGARDS) study. J Clin Endocrinol Metab 2011;6:1805-1814.
13. Jylhä M, Paavilainen P, Lehtimäki T, Goebeler S, Karhunen PJ, Hervonen A, Hurme M. Interleukin-1 receptor antago-nist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: The vitality 90+ study. J Ger-ontol A Biol Sci Med Sci 2007;9:1016-1021.
14. Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hervonen A, Jylhä M. Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: The Vitality 90+ Study. J Gerontol A Biol Sci Med Sci 2011;11: 1244-1250.
15. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 1995:1-452.
16. Juge-Aubry CE, Somm E, Giusti V, Pernin A, Chicheportiche R, Verdumo C, Rohner-Jeanrenaud F, Burger D, Dayer JM, Meier CA. Adipose tissue is a major source of interleukin-1 receptor antagonist: Upregulation in obesity and inflam-mation. Diabetes 2003;5:1104-1110.
17. Seidell JC, Perusse L, Despres JP, Bouchard C. Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: The Quebec Family Study. Am J Clin Nutr 2001;3:315-321.
18. Kalantar-Zadeh K. Recent advances in understanding the malnutrition-inflammation-cachexia syndrome in chronic kid-ney disease patients: What is next? Semin Dial 2005;5:365-369.
19. Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang BL. As-sembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One 2007;10:e1035.
20. Hurme M, Kivimäki M, Pertovaara M, Lehtimäki T, Kar-hunen PJ, Jylhä M, Hervonen A, Eklund C. CRP gene is involved in the regulation of human longevity: A follow-up study in Finnish nonagenarians. Mech Ageing Dev 2007; 10:574-576.
21. Jenny NS, Yanez ND, Psaty BM, Kuller LH, Hirsch CH, Tracy RP. Inflammation biomarkers and near-term death in older men. Am J Epidemiol 2007;6:684-695.
22. Candore G, Balistreri CR, Colonna-Romano G, Lio D, Listi F, Vasto S, Caruso C. Gender-related immune-inflammatory factors, age-related diseases, and longevity. Rejuvenation Res 2010;2-3:292-297.
23. Giugliano D, Ceriello A, Esposito K. The effects of diet on inflammation: Emphasis on the metabolic syndrome. J Am Coll Cardiol 2006;4:677-685.
24. Guigoz Y, Dore J, Schiffrin EJ. The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care 2008;1:13-20.
25. Ibrahim MM. Subcutaneous and visceral adipose tissue: Structural and functional differences. Obes Rev 2010;1: 11-18.
26. Davey Smith G, Timpson N, Lawlor DA. C-reactive protein and cardiovascular disease risk: Still an unknown quantity? Ann Intern Med 2006;1:70-72.
27. Paffen E, DeMaat MP. C-reactive protein in atherosclerosis: A causal factor? Cardiovasc Res 2006;1:30-39.
28. Flegal KM, Shepherd JA, Looker AC, Graubard BI, Borrud LG, Ogden CL, Harris TB, Everhart JE, Schenker N. Com-parisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr 2009;2:500-508.
29. Lecour S, James RW. When are pro-inflammatory cytokines SAFE in heart failure? Eur Heart J 2011;6:680-685.
30. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovas-cular disease: Risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009;21:1925-1932.
31. Ades PA, Savage PD. The obesity paradox: Perception vs knowledge. Mayo Clin Proc 2010;2:112-114.
32. Artham SM, Lavie CJ, Patel DA, Ventura HO. Obesity par-adox in the elderly: Is fatter really fitter? Aging Health 2009: 177-184.
33. Goel K, Thomas RJ, Squires RW, Coutinho T, Trejo-Gutierrez JF, Somers VK, Miles JM, Lopez-Jimenez F. Combined effect of cardiorespiratory fitness and adiposity on mortality in patients with coronary artery disease. Am Heart J 2011;3:590-597.
34. McAuley PA, Kokkinos PF, Oliveira RB, Emerson BT, Myers JN. Obesity paradox and cardiorespiratory fitness in 12,417 male veterans aged 40 to 70 years. Mayo Clin Proc 2010;2: 115-121.
35. Bays HE. Adiposopathy is "sick fat" a cardiovascular dis-ease? J Am Coll Cardiol 2011;25:2461-2473.
36. Hong NS, Kim KS, Lee IK, Lind PM, Lind L, Jacobs DR Lee DH. The association between obesity and mortality in the elderly differs by serum concentrations of persis-tent organic pollutants: A possible explanation for the obesity paradox. Int J Obes (Lond) 2011; doi:10.1038/ijo .2011.187.
37. Clark AL, Fonarow GC, Horwich TB. Waist circumference, body mass index, and survival in systolic heart failure: the obesity paradox revisited. J Card Fail 2011;5:374-380.
38. Coutinho T, Goel K, Correa de Sa D, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, Torp-Pedersen C, Cottin Y, Lorgis L, Lee SH, Kim YJ, Thomas R, Roger VL, Somers VK, Lopez-Jimenez F. Central obesity and survival in subjects with coronary artery disease: A systematic review of the literature and collaborative analysis with individual subject data. J Am Coll Cardiol 2011;19:1877-1886.
39. Wijsman CA, Maier AB, de Craen AJ, van den Biggelaar AH, Westendorp RG. An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus Study. J Gerontol A Biol Sci Med Sci 2011;4:393-399.