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Volumn 39, Issue 1, 2016, Pages 23-33

miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway

Author keywords

Gastric cancer; microRNAs; miR 101 2; miR 125b 2; miR 451a; PI3K AKT mTOR pathway

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 101; MICRORNA 101 2; MICRORNA 125B; MICRORNA 125B 2; MICRORNA 451A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; TSC1 PROTEIN; UNCLASSIFIED DRUG; MIRN101 MICRORNA, HUMAN; MIRN125 MICRORNA, HUMAN; MIRN451 MICRORNA, HUMAN; PIK3CB PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84955353129     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-015-0247-3     Document Type: Article
Times cited : (118)

References (53)
  • 6
    • 11044225555 scopus 로고    scopus 로고
    • Gastric adenocarcinoma: review and considerations for future directions
    • PID: 15621988
    • B.J. Dicken, D.L. Bigam, C. Cass, J.R. Mackey, A.A. Joy, S.M. Hamilton, Gastric adenocarcinoma: review and considerations for future directions. Ann. Surg. 241, 27–39 (2005)
    • (2005) Ann. Surg. , vol.241 , pp. 27-39
    • Dicken, B.J.1    Bigam, D.L.2    Cass, C.3    Mackey, J.R.4    Joy, A.A.5    Hamilton, S.M.6
  • 7
    • 82255194078 scopus 로고    scopus 로고
    • mTOR as a therapeutic target in patients with gastric cancer
    • COI: 1:CAS:528:DC%2BC3MXhsFaru7vK, PID: 21898386
    • S.-E. Al-Batran, M. Ducreux, A. Ohtsu, mTOR as a therapeutic target in patients with gastric cancer. Int. J. Cancer 130, 491–6 (2012)
    • (2012) Int. J. Cancer , vol.130 , pp. 491-496
    • Al-Batran, S.-E.1    Ducreux, M.2    Ohtsu, A.3
  • 9
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive Molecular Characterization of Gastric Adenocarcinoma
    • The Cancer Genome Atlas Research Network, Comprehensive Molecular Characterization of Gastric Adenocarcinoma. Nature. 513, 202–9 (2014)
    • (2014) Nature , vol.513 , pp. 202-209
  • 11
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • COI: 1:CAS:528:DC%2BD2MXntlSkt78%3D, PID: 16096426
    • D. Morgensztern, H.L. McLeod, PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 16, 797–803 (2005)
    • (2005) Anticancer Drugs , vol.16 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 12
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • COI: 1:CAS:528:DC%2BD2cXhtVals7o%3D, PID: 14744438
    • D.P. Bartel, MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–97 (2004)
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 13
    • 84892698663 scopus 로고    scopus 로고
    • MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal carcinoma
    • COI: 1:CAS:528:DC%2BC3sXhsFSktb3J
    • Y. Wang, M. Li, W. Zang, Y. Ma, N. Wang, P. Li, T. Wang, G. Zhao, MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal carcinoma. Cell. Oncol. 36, 385–94 (2013)
    • (2013) Cell. Oncol. , vol.36 , pp. 385-394
    • Wang, Y.1    Li, M.2    Zang, W.3    Ma, Y.4    Wang, N.5    Li, P.6    Wang, T.7    Zhao, G.8
  • 15
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • COI: 1:CAS:528:DC%2BD28XivVyqtrs%3D, PID: 16557279
    • A. Esquela-Kerscher, F.J. Slack, Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 6, 259–69 (2006)
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 17
    • 22144461002 scopus 로고    scopus 로고
    • miRNAs, cancer, and stem cell division
    • COI: 1:CAS:528:DC%2BD2MXmsFeitb8%3D, PID: 16009126
    • C.M. Croce, G.A. Calin, miRNAs, cancer, and stem cell division. Cell 122, 6–7 (2005)
    • (2005) Cell , vol.122 , pp. 6-7
    • Croce, C.M.1    Calin, G.A.2
  • 18
    • 77957664647 scopus 로고    scopus 로고
    • MicroRNAs as regulators of differentiation and cell fate decisions
    • COI: 1:CAS:528:DC%2BC3cXps12ktrs%3D, PID: 20621048
    • K.N. Ivey, D. Srivastava, MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell 7, 36–41 (2010)
    • (2010) Cell Stem Cell , vol.7 , pp. 36-41
    • Ivey, K.N.1    Srivastava, D.2
  • 19
  • 20
    • 36649025655 scopus 로고    scopus 로고
    • OncomiRs: the discovery and progress of microRNAs in cancers
    • PID: 17894887
    • W.C.S. Cho, OncomiRs: the discovery and progress of microRNAs in cancers. Mol. Cancer 6, 60 (2007)
    • (2007) Mol. Cancer , vol.6 , pp. 60
    • Cho, W.C.S.1
  • 21
    • 77952522153 scopus 로고    scopus 로고
    • miRNAs as molecular biomarkers of cancer
    • COI: 1:CAS:528:DC%2BC3cXmtVSnsr8%3D, PID: 20465498
    • M. Fabbri, miRNAs as molecular biomarkers of cancer. Expert Rev. Mol. Diagn. 10, 435–44 (2010)
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , pp. 435-444
    • Fabbri, M.1
  • 22
    • 79955649353 scopus 로고    scopus 로고
    • Cancer microRNAs: from subtype profiling to predictors of response to therapy
    • COI: 1:CAS:528:DC%2BC3MXmtFans7w%3D, PID: 21354374
    • E. Chan, D.E. Prado, J.B. Weidhaas, Cancer microRNAs: from subtype profiling to predictors of response to therapy. Trends Mol. Med. 17, 235–43 (2011)
    • (2011) Trends Mol. Med. , vol.17 , pp. 235-243
    • Chan, E.1    Prado, D.E.2    Weidhaas, J.B.3
  • 24
    • 84890369345 scopus 로고    scopus 로고
    • MicroRNA-101 (miR-101) enhances chemosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells by inhibition of MTOR signaling Via PRAS40
    • R.B. Batchu, O. Gruzdyn, A.M. Qazi, D. Bouwman, S.A. Gruber, D.W. Weaver, MicroRNA-101 (miR-101) enhances chemosensitivity of pancreatic ductal adenocarcinoma (PDAC) cells by inhibition of MTOR signaling Via PRAS40. J. Surg. Res. 172, 233 (2012)
    • (2012) J. Surg. Res. , vol.172 , pp. 233
    • Batchu, R.B.1    Gruzdyn, O.2    Qazi, A.M.3    Bouwman, D.4    Gruber, S.A.5    Weaver, D.W.6
  • 25
    • 79960211493 scopus 로고    scopus 로고
    • Tumour-suppressor microRNAs Let-7 and Mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma
    • COI: 1:CAS:528:DC%2BC3MXoslyiu74%3D, PID: 21654684
    • J. Buechner, E. Tømte, B.H. Haug, J.R. Henriksen, C. Løkke, T. Flægstad, C. Einvik, Tumour-suppressor microRNAs Let-7 and Mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma. Br. J. Cancer 105, 296–303 (2011)
    • (2011) Br. J. Cancer , vol.105 , pp. 296-303
    • Buechner, J.1    Tømte, E.2    Haug, B.H.3    Henriksen, J.R.4    Løkke, C.5    Flægstad, T.6    Einvik, C.7
  • 27
    • 78049521995 scopus 로고    scopus 로고
    • MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2
    • COI: 1:CAS:528:DC%2BC3cXhsFOnsrvO, PID: 20827722
    • L. Liang, C.-M. Wong, Q. Ying, D.N.-Y. Fan, S. Huang, J. Ding, J. Yao, M. Yan, J. Li, M. Yao, I.O.-L. Ng, X. He, MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology 52, 1731–40 (2010)
    • (2010) Hepatology , vol.52 , pp. 1731-1740
    • Liang, L.1    Wong, C.-M.2    Ying, Q.3    Fan, D.N.-Y.4    Huang, S.5    Ding, J.6    Yao, J.7    Yan, M.8    Li, J.9    Yao, M.10    Ng, I.O.-L.11    He, X.12
  • 28
    • 83055163471 scopus 로고    scopus 로고
    • miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3
    • COI: 1:CAS:528:DC%2BC3MXhs1Sgsr%2FK, PID: 22093834
    • L. Liu, H. Li, J. Li, H. Zhong, H. Zhang, J. Chen, T. Xiao, miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. Biochem. Biophys. Res. Commun. 416, 31–8 (2011)
    • (2011) Biochem. Biophys. Res. Commun. , vol.416 , pp. 31-38
    • Liu, L.1    Li, H.2    Li, J.3    Zhong, H.4    Zhang, H.5    Chen, J.6    Xiao, T.7
  • 29
    • 33847738628 scopus 로고    scopus 로고
    • Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
    • COI: 1:CAS:528:DC%2BD2sXit1KqtQ%3D%3D, PID: 17110380
    • G.K. Scott, A. Goga, D. Bhaumik, C.E. Berger, C.S. Sullivan, C.C. Benz, Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J. Biol. Chem. 282, 1479–86 (2007)
    • (2007) J. Biol. Chem. , vol.282 , pp. 1479-1486
    • Scott, G.K.1    Goga, A.2    Bhaumik, D.3    Berger, C.E.4    Sullivan, C.S.5    Benz, C.C.6
  • 31
    • 77957981791 scopus 로고    scopus 로고
    • MiRNA-451 plays a role as tumor suppressor in human glioma cells
    • COI: 1:CAS:528:DC%2BC3cXhtlSgt7%2FF, PID: 20816946
    • Y. Nan, L. Han, A. Zhang, G. Wang, Z. Jia, Y. Yang, X. Yue, P. Pu, Y. Zhong, C. Kang, MiRNA-451 plays a role as tumor suppressor in human glioma cells. Brain Res. 1359, 14–21 (2010)
    • (2010) Brain Res. , vol.1359 , pp. 14-21
    • Nan, Y.1    Han, L.2    Zhang, A.3    Wang, G.4    Jia, Z.5    Yang, Y.6    Yue, X.7    Pu, P.8    Zhong, Y.9    Kang, C.10
  • 33
    • 77954541671 scopus 로고    scopus 로고
    • Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker
    • COI: 1:CAS:528:DC%2BC3cXmsFOqsLc%3D
    • H. Zhou, J.-M. Guo, Y.-R. Lou, X.-J. Zhang, F.-D. Zhong, Z. Jiang, J. Cheng, B.-X. Xiao, Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker. J. Mol. Med. (Berl.) 88, 709–17 (2010)
    • (2010) J. Mol. Med. (Berl.) , vol.88 , pp. 709-717
    • Zhou, H.1    Guo, J.-M.2    Lou, Y.-R.3    Zhang, X.-J.4    Zhong, F.-D.5    Jiang, Z.6    Cheng, J.7    Xiao, B.-X.8
  • 34
    • 77955717754 scopus 로고    scopus 로고
    • MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion
    • COI: 1:CAS:528:DC%2BC3cXpsFyisrk%3D, PID: 20712078
    • H.-J. Wang, H.-J. Ruan, X.-J. He, Y.-Y. Ma, X.-T. Jiang, Y.-J. Xia, Z.-Y. Ye, H.-Q. Tao, MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. Eur. J. Cancer 46, 2295–2303 (2010)
    • (2010) Eur. J. Cancer , vol.46 , pp. 2295-2303
    • Wang, H.-J.1    Ruan, H.-J.2    He, X.-J.3    Ma, Y.-Y.4    Jiang, X.-T.5    Xia, Y.-J.6    Ye, Z.-Y.7    Tao, H.-Q.8
  • 35
    • 84873801809 scopus 로고    scopus 로고
    • MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells
    • COI: 1:CAS:528:DC%2BC38XhvVGnurjM, PID: 23128435
    • Z.-X. Yang, C.-Y. Lu, Y.-L. Yang, K.-F. Dou, K.-S. Tao, MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells. Mol. Med. Rep. 7, 229–232 (2013)
    • (2013) Mol. Med. Rep. , vol.7 , pp. 229-232
    • Yang, Z.-X.1    Lu, C.-Y.2    Yang, Y.-L.3    Dou, K.-F.4    Tao, K.-S.5
  • 36
    • 84902080966 scopus 로고    scopus 로고
    • Expression profiling and functional analysis of hsa-miR-125b and its target genes in drug-resistant cell line of human gastric cancer
    • COI: 1:CAS:528:DC%2BC2cXosVKlurc%3D, PID: 24846940
    • Y. Cheng, L. Chen, X. Cao, S. Ha, X. Xia, Expression profiling and functional analysis of hsa-miR-125b and its target genes in drug-resistant cell line of human gastric cancer. Hereditas 36, 119–128 (2014)
    • (2014) Hereditas , vol.36 , pp. 119-128
    • Cheng, Y.1    Chen, L.2    Cao, X.3    Ha, S.4    Xia, X.5
  • 37
    • 84865702767 scopus 로고    scopus 로고
    • Found in translation of mTOR signaling
    • COI: 1:CAS:528:DC%2BC38XhtlWhs7bO, PID: 22641373
    • J.G. Clohessy, M. Reschke, P.P. Pandolfi, Found in translation of mTOR signaling. Cell Res. 22, 1315–8 (2012)
    • (2012) Cell Res. , vol.22 , pp. 1315-1318
    • Clohessy, J.G.1    Reschke, M.2    Pandolfi, P.P.3
  • 38
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • COI: 1:CAS:528:DC%2BD2MXjtVOqt7Y%3D, PID: 15797377
    • I. Beuvink, A. Boulay, S. Fumagalli, F. Zilbermann, S. Ruetz, T. O’Reilly, F. Natt, J. Hall, H.A. Lane, G. Thomas, The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120, 747–59 (2005)
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3    Zilbermann, F.4    Ruetz, S.5    O’Reilly, T.6    Natt, F.7    Hall, J.8    Lane, H.A.9    Thomas, G.10
  • 39
    • 79954516239 scopus 로고    scopus 로고
    • Role of mTOR signaling in tumor cell motility, invasion and metastasis
    • PID: 21190521
    • H. Zhou, S. Huang, Role of mTOR signaling in tumor cell motility, invasion and metastasis. Curr. Protein Pept. Sci. 12, 30–42 (2011)
    • (2011) Curr. Protein Pept. Sci. , vol.12 , pp. 30-42
    • Zhou, H.1    Huang, S.2
  • 40
    • 0031557653 scopus 로고    scopus 로고
    • Regulation of thrombin-induced stress fibre formation in swiss 3T3 cells by the 70-kDa S6 kinase
    • COI: 1:CAS:528:DyaK2sXislCrtr4%3D, PID: 9144421
    • M.F. Crouch, Regulation of thrombin-induced stress fibre formation in swiss 3T3 cells by the 70-kDa S6 kinase. Biochem. Biophys. Res. Commun. 233, 193–9 (1997)
    • (1997) Biochem. Biophys. Res. Commun. , vol.233 , pp. 193-199
    • Crouch, M.F.1
  • 41
    • 2442459672 scopus 로고    scopus 로고
    • Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration
    • COI: 1:CAS:528:DC%2BD2cXktVKgsLg%3D, PID: 15149849
    • L.A. Berven, F.S. Willard, M.F. Crouch, Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp. Cell Res. 296, 183–95 (2004)
    • (2004) Exp. Cell Res. , vol.296 , pp. 183-195
    • Berven, L.A.1    Willard, F.S.2    Crouch, M.F.3
  • 42
    • 19344367393 scopus 로고    scopus 로고
    • Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
    • COI: 1:CAS:528:DC%2BD2MXlsVyntLg%3D, PID: 15708965
    • K. Sakakibara, B. Liu, S. Hollenbeck, K.C. Kent, Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am. J. Physiol. Heart Circ. Physiol. 288, H2861–H2868 (2005)
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288 , pp. H2861-H2868
    • Sakakibara, K.1    Liu, B.2    Hollenbeck, S.3    Kent, K.C.4
  • 43
    • 33645856178 scopus 로고    scopus 로고
    • Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells
    • COI: 1:CAS:528:DC%2BD28XjvFOqs7g%3D, PID: 16469801
    • H.Y. Zhou, A.S.T. Wong, Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. Endocrinology 147, 2557–66 (2006)
    • (2006) Endocrinology , vol.147 , pp. 2557-2566
    • Zhou, H.Y.1    Wong, A.S.T.2
  • 45
    • 84887942578 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics
    • PID: 24261963
    • A. Akinleye, P. Avvaru, M. Furqan, Y. Song, D. Liu, Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J. Hematol. Oncol. 6, 88 (2013)
    • (2013) J. Hematol. Oncol. , vol.6 , pp. 88
    • Akinleye, A.1    Avvaru, P.2    Furqan, M.3    Song, Y.4    Liu, D.5
  • 47
    • 74049160017 scopus 로고    scopus 로고
    • Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells
    • COI: 1:CAS:528:DC%2BD1MXhsFeksr7I, PID: 19951918
    • E.J. Ezratty, C. Bertaux, E.E. Marcantonio, G.G. Gundersen, Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells. J. Cell Biol. 187, 733–47 (2009)
    • (2009) J. Cell Biol. , vol.187 , pp. 733-747
    • Ezratty, E.J.1    Bertaux, C.2    Marcantonio, E.E.3    Gundersen, G.G.4
  • 48
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: biological implications and therapeutic opportunities
    • COI: 1:CAS:528:DC%2BD1MXhsF2hsLzI, PID: 20029421
    • J.S. Desgrosellier, D.A. Cheresh, Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 10, 9–22 (2010)
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 49
    • 79958016002 scopus 로고    scopus 로고
    • A beta version of life: p110β takes center stage
    • PID: 21321382
    • H.A. Dbouk, J.M. Backer, A beta version of life: p110β takes center stage. Oncotarget 1, 729–33 (2010)
    • (2010) Oncotarget , vol.1 , pp. 729-733
    • Dbouk, H.A.1    Backer, J.M.2
  • 50
    • 0034852195 scopus 로고    scopus 로고
    • Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production
    • COI: 1:CAS:528:DC%2BD3MXntlGqt7c%3D, PID: 11532975
    • D. Kim, S. Kim, H. Koh, S.O. Yoon, A.S. Chung, K.S. Cho, J. Chung, Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 15, 1953–62 (2001)
    • (2001) FASEB J. , vol.15 , pp. 1953-1962
    • Kim, D.1    Kim, S.2    Koh, H.3    Yoon, S.O.4    Chung, A.S.5    Cho, K.S.6    Chung, J.7
  • 51
    • 59749095009 scopus 로고    scopus 로고
    • Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer
    • COI: 1:CAS:528:DC%2BD1MXhvF2rtbk%3D, PID: 19110052
    • Y.R. Chin, A. Toker, Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell. Signal. 21, 470–6 (2009)
    • (2009) Cell. Signal. , vol.21 , pp. 470-476
    • Chin, Y.R.1    Toker, A.2
  • 53
    • 84869866890 scopus 로고    scopus 로고
    • MicroRNA and cancer
    • COI: 1:CAS:528:DC%2BC38Xhs12gt7%2FL, PID: 23102669
    • M.D. Jansson, A.H. Lund, MicroRNA and cancer. Mol. Oncol. 6, 590–610 (2012)
    • (2012) Mol. Oncol. , vol.6 , pp. 590-610
    • Jansson, M.D.1    Lund, A.H.2


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