메뉴 건너뛰기




Volumn 68, Issue 5, 2016, Pages 630-640

Obesity and metabolic syndrome: Pathological effects on the gastrointestinal tract

Author keywords

Abdominal obesity; Carcinogenesis; Inflammation; Metabolic syndrome; Obesity

Indexed keywords

ADIPOCYTOKINE; CARCINOGEN; SOMATOMEDIN; VASCULOTROPIN; TRIACYLGLYCEROL;

EID: 84955303840     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12907     Document Type: Review
Times cited : (45)

References (91)
  • 1
    • 84961706553 scopus 로고    scopus 로고
    • Cancer Research UK. The 20 most common causes of cancer deaths, UK.
    • Cancer Research UK. The 20 most common causes of cancer deaths, UK. 2015. Available at: http://www.cancerresearchuk.org/health-professional/cancer-statistics/mortality/common-cancers-compared#heading-Zero
    • (2015)
  • 2
    • 84961714036 scopus 로고    scopus 로고
    • Cancer Research UK. The 10 most common causes of cancer death, world.
    • Cancer Research UK. The 10 most common causes of cancer death, world. 2015. Available at: http://www.cancerresearchuk.org/health-professional/cancer-statistics/worldwide-cancer/mortality#heading-One
    • (2015)
  • 4
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
    • Ng M, Fleming T, Robinson M et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384; 766-781.
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3
  • 5
    • 84961706612 scopus 로고    scopus 로고
    • Obesity and overweight. Fact sheet No. 311. World Health Organization Media Centre
    • World Health Organization. Obesity and overweight. Fact sheet No. 311. World Health Organization Media Centre, 2015. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/
    • (2015)
  • 6
    • 84961756737 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. Overweight and obesity.
    • Centers for Disease Control and Prevention. Overweight and obesity. 2012. Available at: http://www.cdc.gov/obesity/adult/causes/index.html
    • (2012)
  • 7
    • 25144459980 scopus 로고    scopus 로고
    • IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition
    • Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition. Lancet 2005; 366; 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 8
    • 84887491918 scopus 로고    scopus 로고
    • Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium
    • Kubo A, Cook MB, Shaheen NJ et al. Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium. Gut 2013; 62; 1684-1691.
    • (2013) Gut , vol.62 , pp. 1684-1691
    • Kubo, A.1    Cook, M.B.2    Shaheen, N.J.3
  • 9
    • 77958091749 scopus 로고    scopus 로고
    • Gastrointestinal system and obesity
    • Ashburn DD, Reed MJ. Gastrointestinal system and obesity. Crit. Care Clin. 2010; 26; 625-627.
    • (2010) Crit. Care Clin. , vol.26 , pp. 625-627
    • Ashburn, D.D.1    Reed, M.J.2
  • 11
    • 23044493202 scopus 로고    scopus 로고
    • Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications
    • Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann. Intern. Med. 2005; 143; 199-211.
    • (2005) Ann. Intern. Med. , vol.143 , pp. 199-211
    • Hampel, H.1    Abraham, N.S.2    El-Serag, H.B.3
  • 12
    • 84885751662 scopus 로고    scopus 로고
    • Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis
    • Singh S, Sharma AN, Murad MH et al. Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: a systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 2013; 11; 1399-1412.
    • (2013) Clin. Gastroenterol. Hepatol. , vol.11 , pp. 1399-1412
    • Singh, S.1    Sharma, A.N.2    Murad, M.H.3
  • 13
    • 79960616415 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets
    • Ryan AM, Duong M, Healy L et al. Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets. Cancer Epidemiol. 2011; 35; 309-319.
    • (2011) Cancer Epidemiol. , vol.35 , pp. 309-319
    • Ryan, A.M.1    Duong, M.2    Healy, L.3
  • 14
    • 0036320042 scopus 로고    scopus 로고
    • Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations
    • Barak N, Ehrenpreis ED, Harrison JR, Sitrin MD. Gastro-oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations. Obes. Rev. 2002; 3; 9-15.
    • (2002) Obes. Rev. , vol.3 , pp. 9-15
    • Barak, N.1    Ehrenpreis, E.D.2    Harrison, J.R.3    Sitrin, M.D.4
  • 15
    • 0037827736 scopus 로고    scopus 로고
    • Obesity and estrogen as risk factors for gastroesophageal reflux symptoms
    • Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. JAMA 2003; 290; 66-72.
    • (2003) JAMA , vol.290 , pp. 66-72
    • Nilsson, M.1    Johnsen, R.2    Ye, W.3    Hveem, K.4    Lagergren, J.5
  • 18
    • 84862691710 scopus 로고    scopus 로고
    • Distribution of body fat and its influence on esophageal inflammation and dysplasia in patients with Barrett's esophagus
    • Nelsen EM, Kirihara Y, Takahashi N et al. Distribution of body fat and its influence on esophageal inflammation and dysplasia in patients with Barrett's esophagus. Clin. Gastroenterol. Hepatol. 2012; 10; 728-734.
    • (2012) Clin. Gastroenterol. Hepatol. , vol.10 , pp. 728-734
    • Nelsen, E.M.1    Kirihara, Y.2    Takahashi, N.3
  • 19
    • 44449139615 scopus 로고    scopus 로고
    • Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state
    • Ryan AM, Healy LA, Power DG et al. Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state. Ann. Surg. 2008; 247; 909-915.
    • (2008) Ann. Surg. , vol.247 , pp. 909-915
    • Ryan, A.M.1    Healy, L.A.2    Power, D.G.3
  • 20
    • 84872141801 scopus 로고    scopus 로고
    • Metabolic syndrome, obesity, and gastrointestinal cancer
    • Fujihara S, Mori H, Kobara H et al. Metabolic syndrome, obesity, and gastrointestinal cancer. Gastroenterol. Res. Pract. 2012; 2012; 483623.
    • (2012) Gastroenterol. Res. Pract. , vol.2012 , pp. 483623
    • Fujihara, S.1    Mori, H.2    Kobara, H.3
  • 21
    • 84871851757 scopus 로고    scopus 로고
    • The role of tobacco, alcohol, and obesity in neoplastic progression to esophageal adenocarcinoma: a prospective study of Barrett's esophagus
    • Hardikar S, Onstad L, Blount PL, Odze RD, Reid BJ, Vaughan TL. The role of tobacco, alcohol, and obesity in neoplastic progression to esophageal adenocarcinoma: a prospective study of Barrett's esophagus. PLoS ONE 2013; 8; e52192.
    • (2013) PLoS ONE , vol.8 , pp. e52192
    • Hardikar, S.1    Onstad, L.2    Blount, P.L.3    Odze, R.D.4    Reid, B.J.5    Vaughan, T.L.6
  • 22
    • 84894259981 scopus 로고    scopus 로고
    • Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580,000 subjects within the Me-Can project
    • Lindkvist B, Johansen D, Stocks T et al. Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580, 000 subjects within the Me-Can project. BMC Cancer 2014; 14; 103.
    • (2014) BMC Cancer , vol.14 , pp. 103
    • Lindkvist, B.1    Johansen, D.2    Stocks, T.3
  • 23
    • 84898546756 scopus 로고    scopus 로고
    • Leptin and adiponectin receptor expression in oesophageal cancer
    • Howard JM, Cathcart MC, Healy L et al. Leptin and adiponectin receptor expression in oesophageal cancer. Br. J. Surg. 2014; 101; 643-652.
    • (2014) Br. J. Surg. , vol.101 , pp. 643-652
    • Howard, J.M.1    Cathcart, M.C.2    Healy, L.3
  • 24
    • 77953882601 scopus 로고    scopus 로고
    • A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence
    • McElholm AR, McKnight AJ, Patterson CC et al. A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. Gastroenterology 2010; 139; 204-212.
    • (2010) Gastroenterology , vol.139 , pp. 204-212
    • McElholm, A.R.1    McKnight, A.J.2    Patterson, C.C.3
  • 25
    • 84897552607 scopus 로고    scopus 로고
    • Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer
    • Ong J, Salomon J, te Morsche RH et al. Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer. PLoS ONE 2014; 9; e90916.
    • (2014) PLoS ONE , vol.9 , pp. e90916
    • Ong, J.1    Salomon, J.2    te Morsche, R.H.3
  • 26
    • 85027951435 scopus 로고    scopus 로고
    • Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults
    • Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014; 384; 755-765.
    • (2014) Lancet , vol.384 , pp. 755-765
    • Bhaskaran, K.1    Douglas, I.2    Forbes, H.3    dos-Santos-Silva, I.4    Leon, D.A.5    Smeeth, L.6
  • 27
    • 84898047786 scopus 로고    scopus 로고
    • Gastric histopathology in laparoscopic sleeve gastrectomy: pre- and post-operative comparison
    • Onzi TR, d'Acampora AJ, de Araujo FM et al. Gastric histopathology in laparoscopic sleeve gastrectomy: pre- and post-operative comparison. Obes. Surg. 2014; 24; 371-376.
    • (2014) Obes. Surg. , vol.24 , pp. 371-376
    • Onzi, T.R.1    d'Acampora, A.J.2    de Araujo, F.M.3
  • 28
    • 84888023933 scopus 로고    scopus 로고
    • Host genetic variants in obesity-related nonalcoholic fatty liver disease
    • Mehta R, Birerdinc A, Younossi ZM. Host genetic variants in obesity-related nonalcoholic fatty liver disease. Clin. Liver Dis. 2014; 18; 249-267.
    • (2014) Clin. Liver Dis. , vol.18 , pp. 249-267
    • Mehta, R.1    Birerdinc, A.2    Younossi, Z.M.3
  • 29
    • 84924354883 scopus 로고    scopus 로고
    • Gastric bypass surgery in NASH: a major modulator of hepatic mitochondrial dysfunction
    • Baraille F, Guilmeau S, Postic C. Gastric bypass surgery in NASH: a major modulator of hepatic mitochondrial dysfunction. Gut 2015; 64; 524-526.
    • (2015) Gut , vol.64 , pp. 524-526
    • Baraille, F.1    Guilmeau, S.2    Postic, C.3
  • 30
    • 84898885516 scopus 로고    scopus 로고
    • Gastric xanthelasma may be a warning sign for the presence of early gastric cancer
    • Sekikawa A, Fukui H, Maruo T et al. Gastric xanthelasma may be a warning sign for the presence of early gastric cancer. J. Gastroenterol. Hepatol. 2014; 29; 951-956.
    • (2014) J. Gastroenterol. Hepatol. , vol.29 , pp. 951-956
    • Sekikawa, A.1    Fukui, H.2    Maruo, T.3
  • 34
    • 70350010461 scopus 로고    scopus 로고
    • Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies
    • Yang P, Zhou Y, Chen B et al. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur. J. Cancer 2009; 45; 2867-2873.
    • (2009) Eur. J. Cancer , vol.45 , pp. 2867-2873
    • Yang, P.1    Zhou, Y.2    Chen, B.3
  • 35
    • 84906885509 scopus 로고    scopus 로고
    • Body mass index and risk of gastric cancer: a meta-analysis
    • Lin XJ, Wang CP, Liu XD et al. Body mass index and risk of gastric cancer: a meta-analysis. Jpn. J. Clin. Oncol. 2014; 44; 783-791.
    • (2014) Jpn. J. Clin. Oncol. , vol.44 , pp. 783-791
    • Lin, X.J.1    Wang, C.P.2    Liu, X.D.3
  • 37
    • 84964300545 scopus 로고    scopus 로고
    • Visceral abdominal obesity is associated with an increased risk of irritable bowel syndrome
    • Lee CG, Lee JK, Kang YS et al. Visceral abdominal obesity is associated with an increased risk of irritable bowel syndrome. Am. J. Gastroenterol. 2015; 110; 310-319.
    • (2015) Am. J. Gastroenterol. , vol.110 , pp. 310-319
    • Lee, C.G.1    Lee, J.K.2    Kang, Y.S.3
  • 38
    • 82955251603 scopus 로고    scopus 로고
    • Inflammatory bowel disease in the obese patient
    • Boutros M, Maron D. Inflammatory bowel disease in the obese patient. Clin. Colon Rectal Surg. 2011; 24; 244-252.
    • (2011) Clin. Colon Rectal Surg. , vol.24 , pp. 244-252
    • Boutros, M.1    Maron, D.2
  • 39
    • 84881352959 scopus 로고    scopus 로고
    • High-fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a-/- male mice
    • Paik J, Fierce Y, Treuting PM, Brabb T, Maggio-Price L. High-fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a-/- male mice. J. Nutr. 2013; 143; 1240-1247.
    • (2013) J. Nutr. , vol.143 , pp. 1240-1247
    • Paik, J.1    Fierce, Y.2    Treuting, P.M.3    Brabb, T.4    Maggio-Price, L.5
  • 40
    • 84925819779 scopus 로고    scopus 로고
    • Impact of abdominal visceral adipose tissue on disease outcome in pediatric Crohn's disease
    • Uko V, Vortia E, Achkar JP et al. Impact of abdominal visceral adipose tissue on disease outcome in pediatric Crohn's disease. Inflamm. Bowel Dis. 2014; 20; 2286-2291.
    • (2014) Inflamm. Bowel Dis. , vol.20 , pp. 2286-2291
    • Uko, V.1    Vortia, E.2    Achkar, J.P.3
  • 41
    • 84941599447 scopus 로고    scopus 로고
    • Morphometric measurement of submucosal thickness in areas of fat deposition in the terminal ileum and colonic sections, with correlation with body mass index, weight and age: a male autopsy study
    • Mesa H, Drawz S, Dykoski R, Manivel JC. Morphometric measurement of submucosal thickness in areas of fat deposition in the terminal ileum and colonic sections, with correlation with body mass index, weight and age: a male autopsy study. Histopathology 2015; 67; 457-463.
    • (2015) Histopathology , vol.67 , pp. 457-463
    • Mesa, H.1    Drawz, S.2    Dykoski, R.3    Manivel, J.C.4
  • 42
    • 84929008235 scopus 로고    scopus 로고
    • Metabolic syndrome and colorectal neoplasms: an ominous association
    • Trabulo D, Ribeiro S, Martins C et al. Metabolic syndrome and colorectal neoplasms: an ominous association. World J. Gastroenterol. 2015; 21; 5320-5327.
    • (2015) World J. Gastroenterol. , vol.21 , pp. 5320-5327
    • Trabulo, D.1    Ribeiro, S.2    Martins, C.3
  • 43
    • 77749306533 scopus 로고    scopus 로고
    • Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer
    • Guiu B, Petit JM, Bonnetain F et al. Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer. Gut 2010; 59; 341-347.
    • (2010) Gut , vol.59 , pp. 341-347
    • Guiu, B.1    Petit, J.M.2    Bonnetain, F.3
  • 44
    • 78149416859 scopus 로고    scopus 로고
    • Impact of obesity on surgical and oncological outcomes in the management of colorectal cancer
    • Healy LA, Ryan AM, Sutton E et al. Impact of obesity on surgical and oncological outcomes in the management of colorectal cancer. Int. J. Colorectal Dis. 2010; 25; 1293-1299.
    • (2010) Int. J. Colorectal Dis. , vol.25 , pp. 1293-1299
    • Healy, L.A.1    Ryan, A.M.2    Sutton, E.3
  • 46
    • 33846890892 scopus 로고    scopus 로고
    • Association of metabolic syndrome with proximal and synchronous colorectal neoplasm
    • quiz 141.
    • Chiu HM, Lin JT, Shun CT et al. Association of metabolic syndrome with proximal and synchronous colorectal neoplasm. Clin. Gastroenterol. Hepatol. 2007; 5; 221-229; quiz 141.
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , pp. 221-229
    • Chiu, H.M.1    Lin, J.T.2    Shun, C.T.3
  • 47
    • 77956543005 scopus 로고    scopus 로고
    • Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project
    • Johansen D, Stocks T, Jonsson H et al. Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580, 000 men and women in the Metabolic Syndrome and Cancer Project. Cancer Epidemiol. Biomarkers Prev. 2010; 19; 2307-2317.
    • (2010) Cancer Epidemiol. Biomarkers Prev. , vol.19 , pp. 2307-2317
    • Johansen, D.1    Stocks, T.2    Jonsson, H.3
  • 48
    • 84917740140 scopus 로고    scopus 로고
    • Obesity is a risk factor for multifocal disease and recurrence after colorectal cancer surgery: a case-control study
    • Scarpa M, Ruffolo C, Erroi F et al. Obesity is a risk factor for multifocal disease and recurrence after colorectal cancer surgery: a case-control study. Anticancer Res. 2014; 34; 5735-5741.
    • (2014) Anticancer Res. , vol.34 , pp. 5735-5741
    • Scarpa, M.1    Ruffolo, C.2    Erroi, F.3
  • 49
    • 84862783903 scopus 로고    scopus 로고
    • Association of colorectal adenoma with components of metabolic syndrome
    • Kim BC, Shin A, Hong CW et al. Association of colorectal adenoma with components of metabolic syndrome. Cancer Causes Control 2012; 23; 727-735.
    • (2012) Cancer Causes Control , vol.23 , pp. 727-735
    • Kim, B.C.1    Shin, A.2    Hong, C.W.3
  • 50
    • 21044459814 scopus 로고    scopus 로고
    • Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance
    • Otake S, Takeda H, Suzuki Y et al. Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. Clin. Cancer Res. 2005; 11; 3642-3646.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3642-3646
    • Otake, S.1    Takeda, H.2    Suzuki, Y.3
  • 51
    • 77957915915 scopus 로고    scopus 로고
    • Body mass index as a predictor of colorectal neoplasia in ethnically diverse screening population
    • Stein B, Anderson JC, Rajapakse R, Alpern ZA, Messina CR, Walker G. Body mass index as a predictor of colorectal neoplasia in ethnically diverse screening population. Dig. Dis. Sci. 2010; 55; 2945-2952.
    • (2010) Dig. Dis. Sci. , vol.55 , pp. 2945-2952
    • Stein, B.1    Anderson, J.C.2    Rajapakse, R.3    Alpern, Z.A.4    Messina, C.R.5    Walker, G.6
  • 52
    • 84934993404 scopus 로고    scopus 로고
    • Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance
    • East JE, Vieth M, Rex DK. Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance. Gut 2015; 64; 991-1000.
    • (2015) Gut , vol.64 , pp. 991-1000
    • East, J.E.1    Vieth, M.2    Rex, D.K.3
  • 53
    • 84932621321 scopus 로고    scopus 로고
    • Long-term risk of colorectal cancer in individuals with serrated polyps
    • Holme O, Bretthauer M, Eide TJ et al. Long-term risk of colorectal cancer in individuals with serrated polyps. Gut 2015; 64; 929-936.
    • (2015) Gut , vol.64 , pp. 929-936
    • Holme, O.1    Bretthauer, M.2    Eide, T.J.3
  • 54
    • 84875988320 scopus 로고    scopus 로고
    • Differences in epidemiologic risk factors for colorectal adenomas and serrated polyps by lesion severity and anatomical site
    • Burnett-Hartman AN, Passarelli MN, Adams SV et al. Differences in epidemiologic risk factors for colorectal adenomas and serrated polyps by lesion severity and anatomical site. Am. J. Epidemiol. 2013; 177; 625-637.
    • (2013) Am. J. Epidemiol. , vol.177 , pp. 625-637
    • Burnett-Hartman, A.N.1    Passarelli, M.N.2    Adams, S.V.3
  • 58
    • 40049112404 scopus 로고    scopus 로고
    • Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort
    • Stolzenberg-Solomon RZ, Adams K, Leitzmann M et al. Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am. J. Epidemiol. 2008; 167; 586-597.
    • (2008) Am. J. Epidemiol. , vol.167 , pp. 586-597
    • Stolzenberg-Solomon, R.Z.1    Adams, K.2    Leitzmann, M.3
  • 59
    • 84929339047 scopus 로고    scopus 로고
    • Association between gastroenterological malignancy and diabetes mellitus and anti-diabetic therapy: a nationwide, population-based cohort study
    • Lin CM, Huang HL, Chu FY et al. Association between gastroenterological malignancy and diabetes mellitus and anti-diabetic therapy: a nationwide, population-based cohort study. PLoS ONE 2015; 10; e0125421.
    • (2015) PLoS ONE , vol.10 , pp. e0125421
    • Lin, C.M.1    Huang, H.L.2    Chu, F.Y.3
  • 60
    • 84942899732 scopus 로고    scopus 로고
    • Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN)
    • Rebours V, Gaujoux S, d'Assignies G et al. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN). Clin. Cancer Res. 2015; 21; 3522-3528.
    • (2015) Clin. Cancer Res. , vol.21 , pp. 3522-3528
    • Rebours, V.1    Gaujoux, S.2    d'Assignies, G.3
  • 62
    • 84899005488 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and cholesterol gallstones: which comes first?
    • Ahmed MH, Ali A. Nonalcoholic fatty liver disease and cholesterol gallstones: which comes first? Scand. J. Gastroenterol. 2014; 49; 521-527.
    • (2014) Scand. J. Gastroenterol. , vol.49 , pp. 521-527
    • Ahmed, M.H.1    Ali, A.2
  • 63
    • 84899551868 scopus 로고    scopus 로고
    • Not only type 2 diabetes but also prediabetes is associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver disease
    • Yilmaz Y, Senates E, Yesil A, Ergelen R, Colak Y. Not only type 2 diabetes but also prediabetes is associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver disease. J. Diabetes Complications 2014; 28; 328-331.
    • (2014) J. Diabetes Complications , vol.28 , pp. 328-331
    • Yilmaz, Y.1    Senates, E.2    Yesil, A.3    Ergelen, R.4    Colak, Y.5
  • 64
    • 79951725594 scopus 로고    scopus 로고
    • Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study
    • Borena W, Stocks T, Jonsson H et al. Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study. Cancer Causes Control 2011; 22; 291-299.
    • (2011) Cancer Causes Control , vol.22 , pp. 291-299
    • Borena, W.1    Stocks, T.2    Jonsson, H.3
  • 65
    • 82555172378 scopus 로고    scopus 로고
    • Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis
    • Jing W, Jin G, Zhou X et al. Diabetes mellitus and increased risk of cholangiocarcinoma: a meta-analysis. Eur. J. Cancer Prev. 2012; 21; 24-31.
    • (2012) Eur. J. Cancer Prev. , vol.21 , pp. 24-31
    • Jing, W.1    Jin, G.2    Zhou, X.3
  • 66
    • 84899438034 scopus 로고    scopus 로고
    • Obesity-associated gastrointestinal tract cancer: from beginning to end
    • Berger NA. Obesity-associated gastrointestinal tract cancer: from beginning to end. Cancer 2014; 120; 935-939.
    • (2014) Cancer , vol.120 , pp. 935-939
    • Berger, N.A.1
  • 67
    • 84899416864 scopus 로고    scopus 로고
    • Impact of obesity on the survival of patients with early-stage squamous cell carcinoma of the oral tongue
    • Iyengar NM, Kochhar A, Morris PG et al. Impact of obesity on the survival of patients with early-stage squamous cell carcinoma of the oral tongue. Cancer 2014; 120; 983-991.
    • (2014) Cancer , vol.120 , pp. 983-991
    • Iyengar, N.M.1    Kochhar, A.2    Morris, P.G.3
  • 68
    • 84905403644 scopus 로고    scopus 로고
    • Role of liver biopsy in nonalcoholic fatty liver disease
    • Nalbantoglu IL, Brunt EM. Role of liver biopsy in nonalcoholic fatty liver disease. World J. Gastroenterol. 2014; 20; 9026-9037.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 9026-9037
    • Nalbantoglu, I.L.1    Brunt, E.M.2
  • 69
    • 84892793168 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification
    • Dyson JK, McPherson S, Anstee QM. Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification. J. Clin. Pathol. 2013; 66; 1033-1045.
    • (2013) J. Clin. Pathol. , vol.66 , pp. 1033-1045
    • Dyson, J.K.1    McPherson, S.2    Anstee, Q.M.3
  • 70
    • 84871612062 scopus 로고    scopus 로고
    • Non-variceal gastrointestinal bleeding in patients with liver cirrhosis: a review
    • Kalafateli M, Triantos CK, Nikolopoulou V, Burroughs A. Non-variceal gastrointestinal bleeding in patients with liver cirrhosis: a review. Dig. Dis. Sci. 2012; 57; 2743-2754.
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 2743-2754
    • Kalafateli, M.1    Triantos, C.K.2    Nikolopoulou, V.3    Burroughs, A.4
  • 71
    • 77950288866 scopus 로고    scopus 로고
    • CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: an immunohistochemical and digital morphometric study
    • Westerhoff M, Tretiakova M, Hovan L, Miller J, Noffsinger A, Hart J. CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: an immunohistochemical and digital morphometric study. Am. J. Surg. Pathol. 2010; 34; 494-501.
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 494-501
    • Westerhoff, M.1    Tretiakova, M.2    Hovan, L.3    Miller, J.4    Noffsinger, A.5    Hart, J.6
  • 73
    • 84866328666 scopus 로고    scopus 로고
    • Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer
    • Liu Z, Brooks RS, Ciappio ED et al. Diet-induced obesity elevates colonic TNF-alpha in mice and is accompanied by an activation of Wnt signaling: a mechanism for obesity-associated colorectal cancer. J. Nutr. Biochem. 2012; 23; 1207-1213.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1207-1213
    • Liu, Z.1    Brooks, R.S.2    Ciappio, E.D.3
  • 75
    • 53449102961 scopus 로고    scopus 로고
    • IGF-I, IGFBP-3, and IGF-I/IGFBP-3 ratio: no association with incident colorectal cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
    • Max JB, Limburg PJ, Ogunseitan A et al. IGF-I, IGFBP-3, and IGF-I/IGFBP-3 ratio: no association with incident colorectal cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cancer Epidemiol. Biomarkers Prev. 2008; 17; 1832-1834.
    • (2008) Cancer Epidemiol. Biomarkers Prev. , vol.17 , pp. 1832-1834
    • Max, J.B.1    Limburg, P.J.2    Ogunseitan, A.3
  • 76
    • 84856764349 scopus 로고    scopus 로고
    • IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity
    • Doyle SL, Donohoe CL, Finn SP et al. IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity. Am. J. Gastroenterol. 2012; 107; 196-204.
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 196-204
    • Doyle, S.L.1    Donohoe, C.L.2    Finn, S.P.3
  • 78
    • 33747615242 scopus 로고    scopus 로고
    • Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation
    • Ogunwobi O, Mutungi G, Beales IL. Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. Endocrinology 2006; 147; 4505-4516.
    • (2006) Endocrinology , vol.147 , pp. 4505-4516
    • Ogunwobi, O.1    Mutungi, G.2    Beales, I.L.3
  • 79
    • 84864279981 scopus 로고    scopus 로고
    • High-fat diers gene expression in the liver and colon: links to increased development of aberrant crypt foci
    • Padidar S, Farquharson AJ, Williams LM, Kearney R, Arthur JR, Drew JE. High-fat diet alters gene expression in the liver and colon: links to increased development of aberrant crypt foci. Dig. Dis. Sci. 2012; 57; 1866-1874.
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 1866-1874
    • Padidar, S.1    Farquharson, A.J.2    Williams, L.M.3    Kearney, R.4    Arthur, J.R.5    Drew, J.E.6
  • 80
    • 38349146520 scopus 로고    scopus 로고
    • The association of gastric leptin with oesophageal inflammation and metaplasia
    • Francois F, Roper J, Goodman AJ et al. The association of gastric leptin with oesophageal inflammation and metaplasia. Gut 2008; 57; 16-24.
    • (2008) Gut , vol.57 , pp. 16-24
    • Francois, F.1    Roper, J.2    Goodman, A.J.3
  • 81
    • 41149088116 scopus 로고    scopus 로고
    • Leptin and the risk of Barrett's oesophagus
    • Kendall BJ, Macdonald GA, Hayward NK et al. Leptin and the risk of Barrett's oesophagus. Gut 2008; 57; 448-454.
    • (2008) Gut , vol.57 , pp. 448-454
    • Kendall, B.J.1    Macdonald, G.A.2    Hayward, N.K.3
  • 82
    • 44949121499 scopus 로고    scopus 로고
    • A pilot study of the association of low plasma adiponectin and Barrett's esophagus
    • Rubenstein JH, Dahlkemper A, Kao JY et al. A pilot study of the association of low plasma adiponectin and Barrett's esophagus. Am. J. Gastroenterol. 2008; 103; 1358-1364.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1358-1364
    • Rubenstein, J.H.1    Dahlkemper, A.2    Kao, J.Y.3
  • 83
    • 77953643031 scopus 로고    scopus 로고
    • Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma
    • Howard JM, Beddy P, Ennis D, Keogan M, Pidgeon GP, Reynolds JV. Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma. Br. J. Surg. 2010; 97; 1020-1027.
    • (2010) Br. J. Surg. , vol.97 , pp. 1020-1027
    • Howard, J.M.1    Beddy, P.2    Ennis, D.3    Keogan, M.4    Pidgeon, G.P.5    Reynolds, J.V.6
  • 85
    • 84885392560 scopus 로고    scopus 로고
    • Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer
    • Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ. Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin. Cancer Res. 2013; 19; 6074-6083.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 6074-6083
    • Howe, L.R.1    Subbaramaiah, K.2    Hudis, C.A.3    Dannenberg, A.J.4
  • 86
    • 84883552728 scopus 로고    scopus 로고
    • Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer
    • Day SD, Enos RT, McClellan JL, Steiner JL, Velazquez KT, Murphy EA. Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. Cytokine 2013; 64; 454-462.
    • (2013) Cytokine , vol.64 , pp. 454-462
    • Day, S.D.1    Enos, R.T.2    McClellan, J.L.3    Steiner, J.L.4    Velazquez, K.T.5    Murphy, E.A.6
  • 87
    • 0030903037 scopus 로고    scopus 로고
    • Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice
    • Wasan HS, Novelli M, Bee J, Bodmer WF. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc. Natl Acad. Sci. USA 1997; 94; 3308-3313.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3308-3313
    • Wasan, H.S.1    Novelli, M.2    Bee, J.3    Bodmer, W.F.4
  • 88
    • 69249199486 scopus 로고    scopus 로고
    • The interaction of a high-fat diet and regular moderate intensity exercise on intestinal polyp development in Apc Min/+ mice
    • Baltgalvis KA, Berger FG, Pena MM, Davis JM, Carson JA. The interaction of a high-fat diet and regular moderate intensity exercise on intestinal polyp development in Apc Min/+ mice. Cancer Prev. Res. 2009; 2; 641-649.
    • (2009) Cancer Prev. Res. , vol.2 , pp. 641-649
    • Baltgalvis, K.A.1    Berger, F.G.2    Pena, M.M.3    Davis, J.M.4    Carson, J.A.5
  • 89
    • 0025265542 scopus 로고
    • Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet
    • Newmark HL, Lipkin M, Maheshwari N. Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet. J. Natl Cancer Inst. 1990; 82; 491-496.
    • (1990) J. Natl Cancer Inst. , vol.82 , pp. 491-496
    • Newmark, H.L.1    Lipkin, M.2    Maheshwari, N.3
  • 91
    • 84961694206 scopus 로고    scopus 로고
    • Obesity and cancer risk.
    • National Cancer Institute. Obesity and cancer risk. 2012. Available at: http://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/obesity-fact-sheet
    • (2012)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.