Central adiposity is associated with increased risk of esophageal inflammation, metaplasia, and adenocarcinoma: A systematic review and meta-analysis

Clinical Gastroenterology and Hepatology

Volumn 11, Issue 11, 2013, Pages

  Singh, Siddharth ^a   Sharma, Anamay N ^a   Murad, Mohammad Hassan ^a   Buttar, Navtej S ^a   El Serag, Hashem B ^b   Katzka, David A ^a   Iyer, Prasad G ^a  

^a MAYO CLINIC   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Barrett's Esophagus; Body Habitus; Esophageal Cancer; Visceral Fat

Indexed keywords

ABDOMINAL OBESITY; ARTICLE; BARRETT ESOPHAGUS; BODY FAT DISTRIBUTION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGITIS; GASTROESOPHAGEAL REFLUX; HUMAN; INTESTINE ENDOSCOPY; INTESTINE METAPLASIA; META ANALYSIS (TOPIC); OUTCOME ASSESSMENT; PUBLISHING; REFLUX ESOPHAGITIS; RISK ASSESSMENT; SYSTEMATIC REVIEW; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADJUSTED ODDS RATIO; AOR; BARRETT'S ESOPHAGUS; BE; BMI; BODY HABITUS; BODY MASS INDEX; CI; COMPUTED TOMOGRAPHY; CONFIDENCE INTERVAL; CT; EAC; EE; EROSIVE ESOPHAGITIS; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL CANCER; GASTROESOPHAGEAL REFLUX DISEASE; GERD; ODDS RATIO; OR; RELATIVE RISK; RR; VISCERAL FAT; WAIST CIRCUMFERENCE; WAIST-HIP RATIO; WC; WHR;

ADENOCARCINOMA; BODY MASS INDEX; ESOPHAGITIS; HUMANS; METAPLASIA; OBESITY, ABDOMINAL; RISK ASSESSMENT;

EID: 84885751662     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.05.009     Document Type: Article

References (76)

1. Cook M.B., Greenwood D.C., Hardie L.J., et al. Asystematic review and meta-analysis of the risk of increasing adiposity on Barrett's esophagus. Am J Gastroenterol 2008, 103:292-300.
2. Corley D.A., Kubo A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am J Gastroenterol 2006, 101:2619-2628.
3. Hampel H., Abraham N.S., El-Serag H.B. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005, 143:199-211.
4. Lagergren J. Influence of obesity on the risk of esophageal disorders. Nat Rev Gastroenterol Hepatol 2011, 8:340-347.
5. Turati F., Tramacere I., La Vecchia C., et al. Ameta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma. Ann Oncol 2013, 24:609-617.
6. Pandolfino J.E., El-Serag H.B., Zhang Q., et al. Obesity: a challenge toesophagogastric junction integrity. Gastroenterology 2006, 130:639-649.
7. Friedenberg F.K., Xanthopoulos M., Foster G.D., et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol 2008, 103:2111-2122.
8. Moayyedi P. Barrett's esophagus and obesity: the missing part of the puzzle. Am J Gastroenterol 2008, 103:301-303.
9. Corley D.A., Kubo A., Levin T.R., et al. Abdominal obesity and body mass index as risk factors for Barrett's esophagus. Gastroenterology 2007, 133:34-41. quiz 311.
10. Edelstein Z.R., Farrow D.C., Bronner M.P., et al. Central adiposity and risk of Barrett's esophagus. Gastroenterology 2007, 133:403-411.
11. Rubenstein J.H., Kao J.Y., Madanick R.D., et al. Association of adiponectin multimers with Barrett's oesophagus. Gut 2009, 58:1583-1589.
12. Nam S.Y., Choi I.J., Ryu K.H., et al. Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women. Gastroenterology 2010, 139:1902-1911.
13. Anderson L.A., Watson R.G., Murphy S.J., et al. Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. World J Gastroenterol 2007, 13:1585-1594.
14. Sogabe M., Okahisa T., Kimura Y., et al. Visceral fat predominance is associated with erosive esophagitis in Japanese men with metabolic syndrome. Eur J Gastroenterol Hepatol 2012, 24:910-916.
15. Tilg H., Moschen A.R. Visceral adipose tissue attacks beyond the liver: esophagogastric junction as a new target. Gastroenterology 2010, 139:1823-1826.
16. Nelsen E.M., Kirihara Y., Takahashi N., et al. Distribution of body fat and its influence on esophageal inflammation and dysplasia in patients with Barrett's esophagus. Clin Gastroenterol Hepatol 2012, 10:728-734. quiz e61-e62.
17. Higgins J.P.T. Cochrane handbook for systematic reviews of interventions 2011, [updated March 2011], The Cochrane Collaboration, Oxford, UK.
18. Moher D., Liberati A., Tetzlaff J., et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009, 151:264-269. W64.
19. Chinn S. Asimple method for converting an odds ratio to effect size for use in meta-analysis. Stat Med 2000, 19:3127-3131.
20. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188.
21. Kanwal F., White D. Systematic reviews and meta-analyses in Clinical Gastroenterology and Hepatology. Clin Gastroenterol Hepatol 2012, 10:1184-1186.
22. Higgins J.P., Thompson S.G., Deeks J.J., et al. Measuring inconsistency in meta-analyses. BMJ 2003, 327:557-560.
23. Thompson S.G., Pocock S.J. Can meta-analyses be trusted?. Lancet 1991, 338:1127-1130.
24. Guyatt G.H., Oxman A.D., Kunz R., et al. GRADE guidelines: 7-rating the quality of evidence: inconsistency. JClin Epidemiol 2011, 64:1294-1302.
25. Egger M., Davey Smith G., Schneider M., et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
26. Easterbrook P.J., Berlin J.A., Gopalan R., et al. Publication bias in clinical research. Lancet 1991, 337:867-872.
27. Chua C.S., Lin Y.M., Yu F.C., et al. Metabolic risk factors associated with erosive esophagitis. JGastroenterol Hepatol 2009, 24:1375-1379.
28. Chung S.J., Kim D., Park M.J., et al. Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups. Gut 2008, 57:1360-1365.
29. Gunji T., Sato H., Iijima K., et al. Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males. JGastroenterol 2011, 46:448-455.
30. Ha N.R., Lee H.L., Lee O.Y., et al. Differences in clinical characteristics between patients with non-erosive reflux disease and erosive esophagitis in Korea. JKorean Med Sci 2010, 25:1318-1322.
31. Hsu C.S., Wang P.C., Chen J.H., et al. Increasing insulin resistance is associated with increased severity and prevalence of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011, 34:994-1004.
32. Koo J.S., Lee S.W., Park S.M., et al. Abdominal obesity as a risk factor for the development of erosive esophagitis in subjects with a normal esophago-gastric junction. Gut Liver 2009, 3:276-284.
33. Lee H.L., Eun C.S., Lee O.Y., et al. Association between GERD-related erosive esophagitis and obesity. JClin Gastroenterol 2008, 42:672-675.
34. Lee H.L., Eun C.S., Lee O.Y., et al. Association between erosive esophagitis and visceral fat accumulation quantified by abdominal CT scan. JClin Gastroenterol 2009, 43:240-243.
35. Mokrowiecka A., Daniel P., Jasinska A., et al. Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barrett's esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD. Hepatogastroenterology 2012, 59:2395-2399.
36. Mulholland H.G., Cantwell M.M., Anderson L.A., et al. Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Causes Control 2009, 20:279-288.
37. Nam S.Y., Choi I.J., Nam B.H., et al. Obesity and weight gain as risk factors for erosive oesophagitis in men. Aliment Pharmacol Ther 2009, 29:1042-1052.
38. Park J.H., Park D.I., Kim H.J., et al. Metabolic syndrome is associated with erosive esophagitis. World J Gastroenterol 2008, 14:5442-5447.
39. Tai C.M., Lee Y.C., Tu H.P., et al. The relationship between visceral adiposity and the risk of erosive esophagitis in severely obese Chinese patients. Obesity (Silver Spring) 2010, 18:2165-2169.
40. Wu P., Ma L., Dai G.X., et al. The association of metabolic syndrome with reflux esophagitis: a case-control study. Neurogastroenterol Motil 2011, 23:989-994.
41. Kang M.S., Park D.I., Oh S.Y., et al. Abdominal obesity is an independent risk factor for erosive esophagitis in a Korean population. JGastroenterol Hepatol 2007, 22:1656-1661.
42. Kato M., Watabe K., Hamasaki T., et al. Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups. JGastroenterol 2011, 46:1361-1367.
43. Lee S.J., Jung M.K., Kim S.K., et al. [Clinical characteristics of gastroesophageal reflux disease with esophageal injury in Korean: focusing on risk factors]. Korean J Gastroenterol 2011, 57:281-287.
44. Akiyama T., Yoneda M., Inamori M., et al. Visceral obesity and the risk of Barrett's esophagus in Japanese patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2009, 9:56.
45. Edelstein Z.R., Bronner M.P., Rosen S.N., et al. Risk factors for Barrett's esophagus among patients with gastroesophageal reflux disease: a community clinic-based case-control study. Am J Gastroenterol 2009, 104:834-842.
46. El-Serag H.B., Kvapil P., Hacken-Bitar J., et al. Abdominal obesity and the risk of Barrett's esophagus. Am J Gastroenterol 2005, 100:2151-2156.
47. Healy L.A., Ryan A.M., Pidgeon G., et al. Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease. Dis Esophagus 2010, 23:386-391.
48. Jacobson B.C., Chan A.T., Giovannucci E.L., et al. Body mass index and Barrett's oesophagus in women. Gut 2009, 58:1460-1466.
49. Kendall B.J., Macdonald G.A., Hayward N.K., et al. The risk of Barrett's esophagus associated with abdominal obesity in males and females. Int J Cancer 2013, 132:2192-2199.
50. Rubenstein J.H., Dahlkemper A., Kao J.Y., et al. Apilot study of the association of low plasma adiponectin and Barrett's esophagus. Am J Gastroenterol 2008, 103:1358-1364.
51. Greer K.B., Thompson C.L., Brenner L., et al. Association of insulin and insulin-like growth factors with Barrett's oesophagus. Gut 2012, 61:665-672.
52. Rubenstein J.H., Morgenstern H., Appelman H., et al. Prediction of Barrett's esophagus among men. Am J Gastroenterol 2013, 108:353-362.
53. El-Serag H.B., Hashmi A., Garcia J., et al. Visceral abdominal obesity measured by CT scan is associated with an increased risk of Barrett's oesophagus: a case-control study. Gut 2013, Feb 13. Epub ahead of print.
54. Kramer J.R., Fischbach L.A., Richardson P., et al. Waist-to-hip ratio, butnot body mass index, is associated with an increased risk ofBarrett's esophagus in white men. Clin Gastroenterol Hepatol 2013, 11:373-381.
55. Beddy P., Howard J., McMahon C., et al. Association of visceral adiposity with oesophageal and junctional adenocarcinomas. Br J Surg 2010, 97:1028-1034.
56. Corley D.A., Kubo A., Zhao W. Abdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol Biomarkers Prev 2008, 17:352-358.
57. MacInnis R.J., English D.R., Hopper J.L., et al. Body size and composition and the risk of gastric and oesophageal adenocarcinoma. Int J Cancer 2006, 118:2628-2631.
58. O'Doherty M.G., Freedman N.D., Hollenbeck A.R., et al. Aprospective cohort study of obesity and risk of oesophageal and gastric adenocarcinoma in the NIH-AARP Diet and Health Study. Gut 2012, 61:1261-1268.
59. Steffen A., Schulze M.B., Pischon T., et al. Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2009, 18:2079-2089.
60. Thompson O.M., Beresford S.A., Kirk E.A., et al. Serum leptin and adiponectin levels and risk of Barrett's esophagus and intestinal metaplasia of the gastroesophageal junction. Obesity (Silver Spring) 2010, 18:2204-2211.
61. Kubo A., Levin T.R., Block G., et al. Cigarette smoking and the risk of Barrett's esophagus. Cancer Causes Control 2009, 20:303-311.
62. Leggett C., Dunagan K.T., Katzka D.A., et al. Influence of central obesity on esophageal injury: a population based study. Gastroenterology 2012, 142. S-759.
63. Rubenstein J.H., Chey W.D., Murray J.A., et al. Acid reflux, erosive esophagitis, and Barrett's esophagus are associated with different measures of abdominal obesity in men. Gastroenterology 2012, 142. S-754.
64. Cooper S.C., Podmore L.K., Nightingale P., et al. The effect of smoking, body mass index, and waist circumference on the development of oesophageal adenocarcinoma: results from MOSES (Midlands Oesophageal Adenocarcinoma Epidemiology Study). Gastroenterology 2009, 136:A456.
65. Duval S., Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000, 56:455-463.
66. El-Serag H.B., Ergun G.A., Pandolfino J., et al. Obesity increases oesophageal acid exposure. Gut 2007, 56:749-755.
67. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
68. Ryan A.M., Duong M., Healy L., et al. Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets. Cancer Epidemiol 2011, 35:309-319.
69. Kendall B.J., Macdonald G.A., Hayward N.K., et al. Leptin and the risk of Barrett's oesophagus. Gut 2008, 57:448-454.
70. Francois F., Roper J., Goodman A.J., et al. The association of gastric leptin with oesophageal inflammation and metaplasia. Gut 2008, 57:16-24.
71. Larsson S.C., Wolk A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 2007, 86:556-565.
72. Aune D., Greenwood D.C., Chan D.S., et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol 2012, 23:843-852.
73. Doyle S.L., Donohoe C.L., Finn S.P., et al. IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity. Am J Gastroenterol 2012, 107:196-204.
74. McElholm A.R., McKnight A.J., Patterson C.C., et al. Apopulation-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. Gastroenterology 2010, 139:204-212.
75. Hardikar S., Onstad L., Blount P.L., et al. The role of tobacco, alcohol, and obesity in neoplastic progression to esophageal adenocarcinoma: a prospective study of Barrett's esophagus. PLoS One 2013, 8:e52192.
76. Kubo A., Cook M.B., Shaheen N.J., et al. Sex-specific associations between body mass index, waist circumference and the risk of Barrett's oesophagus: a pooled analysis from the international BEACON consortium. Gut 2013, Jan 26. Epub ahead of print.