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Volumn 99, Issue 1, 2016, Pages 69-71

Emerging innovative therapeutic approaches targeting PCSK9 to lower lipids

Author keywords

[No Author keywords available]

Indexed keywords

ALIROCUMAB; ANTISENSE OLIGONUCLEOTIDE; BOCOCIZUMAB; EVOLOCUMAB; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCLONAL ANTIBODY; PEGDINETANIB; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

EID: 84955286686     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.281     Document Type: Article
Times cited : (7)

References (100)
  • 1
    • 84923684106 scopus 로고    scopus 로고
    • Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease
    • Navar-Boggan, A.M., et al,. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation 131, 451-458 (2015).
    • (2015) Circulation , vol.131 , pp. 451-458
    • Navar-Boggan, A.M.1
  • 2
    • 84893113465 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics-2014 update: A report from the American Heart Association
    • Go, A.S., et al,. Executive summary: heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 129, 399-410 (2014).
    • (2014) Circulation , vol.129 , pp. 399-410
    • Go, A.S.1
  • 4
    • 84942223275 scopus 로고
    • Uber den gehalt normaler and atheromatoser aorten an cholesterin und cholesterinester
    • Windhaus, A., Uber den gehalt normaler and atheromatoser aorten an cholesterin und cholesterinester. Z. Physiol. Chem. 67, 174-176 (1910).
    • (1910) Z. Physiol. Chem. , vol.67 , pp. 174-176
    • Windhaus, A.1
  • 5
    • 0029060065 scopus 로고
    • Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the Seven Countries Study
    • Verschuren, W.M., et al,. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the Seven Countries Study. JAMA 274, 131-136 (1995).
    • (1995) JAMA , vol.274 , pp. 131-136
    • Verschuren, W.M.1
  • 6
    • 84928889604 scopus 로고    scopus 로고
    • Lipoprotein(a)-an independent causal risk factor for cardiovascular disease and current therapeutic options
    • Kassner, U., Schlabs, T., Rosada, A., &, Steinhagen-Thiessen, E., Lipoprotein(a)-an independent causal risk factor for cardiovascular disease and current therapeutic options. Atheroscler. Suppl. 18, 263-267 (2015).
    • (2015) Atheroscler. Suppl. , vol.18 , pp. 263-267
    • Kassner, U.1    Schlabs, T.2    Rosada, A.3    Steinhagen-Thiessen, E.4
  • 7
    • 84923684106 scopus 로고    scopus 로고
    • Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease
    • Navar-Boggan, A.M., et al,. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation 3, 131, 451-458 (2015).
    • (2015) Circulation , vol.3 , Issue.131 , pp. 451-458
    • Navar-Boggan, A.M.1
  • 8
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
    • Jonathan, A.T., Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug. Dis. 2, 517-526 (2003).
    • (2003) Nat. Rev. Drug. Dis. , vol.2 , pp. 517-526
    • Jonathan, A.T.1
  • 9
    • 84866495097 scopus 로고    scopus 로고
    • Effect of statins on total cholesterol concentrations and cardiovascular outcomes in patients with diabetes mellitus: A population-based cohort study
    • Sheng, X., Murphy, M.J., MacDonald, T.M., &, Wei, L., Effect of statins on total cholesterol concentrations and cardiovascular outcomes in patients with diabetes mellitus: a population-based cohort study. Eur. J. Clin. Pharmacol. 68, 1201-1208 (2012).
    • (2012) Eur. J. Clin. Pharmacol. , vol.68 , pp. 1201-1208
    • Sheng, X.1    Murphy, M.J.2    MacDonald, T.M.3    Wei, L.4
  • 10
    • 84872296782 scopus 로고    scopus 로고
    • Effect of previous statin therapy on severity and outcome in ischemic stroke patients: A population-based study
    • Aboa-Eboulé, C., et al,. Effect of previous statin therapy on severity and outcome in ischemic stroke patients: a population-based study. J. Neurol. 260, 30-37 (2013).
    • (2013) J. Neurol. , vol.260 , pp. 30-37
    • Aboa-Eboulé, C.1
  • 11
    • 26244432388 scopus 로고    scopus 로고
    • Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent, C., et al,. Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1
  • 12
    • 38049033935 scopus 로고    scopus 로고
    • Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: A meta-analysis
    • Cholesterol Treatment Trialists' (CTT) Collaborators.
    • Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371, 117-125 (2008).
    • (2008) Lancet , vol.371 , pp. 117-125
  • 13
    • 79959746706 scopus 로고    scopus 로고
    • SHARP Investigators. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial
    • Baigent, C., et al,. SHARP Investigators. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181-2192 (2011).
    • (2011) Lancet , vol.377 , pp. 2181-2192
    • Baigent, C.1
  • 14
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaborators
    • Cholesterol Treatment Trialists' (CTT) Collaborators, Mihaylova, B., et al,. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 380, 581-590 (2011).
    • (2011) Lancet , vol.380 , pp. 581-590
    • Mihaylova, B.1
  • 15
    • 84933673677 scopus 로고    scopus 로고
    • Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174,000 participants in 27 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Fulcher, J., et al,. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet 385, 1397-1405 (2015).
    • (2015) Lancet , vol.385 , pp. 1397-1405
    • Fulcher, J.1
  • 16
    • 84875727583 scopus 로고    scopus 로고
    • Discontinuation of statins in routine care settings: A cohort study
    • Zhang, H., et al,. Discontinuation of statins in routine care settings: a cohort study. Ann. Intern. Med. 158, 526-534 (2013).
    • (2013) Ann. Intern. Med. , vol.158 , pp. 526-534
    • Zhang, H.1
  • 17
    • 0034723758 scopus 로고    scopus 로고
    • The lipid treatment assessment project (L-TAP): A multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals
    • Pearson, T.A., Laurora, I., Chu, H., &, Kafonek, S., The lipid treatment assessment project (L-TAP): a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein cholesterol goals. Arch. Intern. Med. 160, 459-467 (2000).
    • (2000) Arch. Intern. Med. , vol.160 , pp. 459-467
    • Pearson, T.A.1    Laurora, I.2    Chu, H.3    Kafonek, S.4
  • 18
    • 0033135086 scopus 로고    scopus 로고
    • Analysis of the degree of undertreatment of hyperlipidemia and congestive heart failure secondary to coronary artery disease
    • Sueta, C.A., et al,. Analysis of the degree of undertreatment of hyperlipidemia and congestive heart failure secondary to coronary artery disease. Am. J. Cardiol. 83, 1303-1307 (1997).
    • (1997) Am. J. Cardiol. , vol.83 , pp. 1303-1307
    • Sueta, C.A.1
  • 19
    • 84861849012 scopus 로고    scopus 로고
    • Persistent lipid abnormalities in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada
    • DYSIS Investigators
    • Gitt, A.K., et al,. DYSIS Investigators. Persistent lipid abnormalities in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada. Eur. J. Prev. Cardiol. 19, 221-230 (2012).
    • (2012) Eur. J. Prev. Cardiol. , vol.19 , pp. 221-230
    • Gitt, A.K.1
  • 20
    • 77749310839 scopus 로고    scopus 로고
    • Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia
    • Avis, H.J., et al,. Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. J. Am. Coll. Cardiol. 55, 1121-1126 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 1121-1126
    • Avis, H.J.1
  • 21
    • 79956288028 scopus 로고    scopus 로고
    • Treatment of adults with familial hypercholesterolemia and evidence for treatment: Recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia
    • Robinson, J.G., &, Goldberg, A.C., Treatment of adults with familial hypercholesterolemia and evidence for treatment: recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J. Clin. Lipidol. 5, S18-S29 (2011).
    • (2011) J. Clin. Lipidol. , vol.5 , pp. S18-S29
    • Robinson, J.G.1    Goldberg, A.C.2
  • 22
    • 84902576469 scopus 로고    scopus 로고
    • American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone, N.J., et al,. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Am. Coll. Cardiol. 63, 2889-2934 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2889-2934
    • Stone, N.J.1
  • 23
    • 84925623172 scopus 로고    scopus 로고
    • Atherosclerotic cardiovascular disease prevention: A comparison between the third adult treatment panel and the new 2013 Treatment of Blood Cholesterol Guidelines
    • Paixao, A.R., Ayers, C.R., Berry, J.D., de Lemos, J.A., &, Khera, A., Atherosclerotic cardiovascular disease prevention: a comparison between the third adult treatment panel and the new 2013 Treatment of Blood Cholesterol Guidelines. Circ. Cardiovasc. Qual. Outcomes. 7, 778-779 (2014).
    • (2014) Circ. Cardiovasc. Qual. Outcomes. , vol.7 , pp. 778-779
    • Paixao, A.R.1    Ayers, C.R.2    Berry, J.D.3    De Lemos, J.A.4    Khera, A.5
  • 24
    • 84926152401 scopus 로고    scopus 로고
    • Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA)
    • Yeboah, J., et al,. Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Am. Heart J. 169, 387-395 (2015).
    • (2015) Am. Heart J. , vol.169 , pp. 387-395
    • Yeboah, J.1
  • 25
    • 84898721405 scopus 로고    scopus 로고
    • Application of new cholesterol guidelines to a population-based sample
    • Pencina, M.J., et al,. Application of new cholesterol guidelines to a population-based sample. N. Engl. J. Med. 370, 1422-1431 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1422-1431
    • Pencina, M.J.1
  • 26
    • 84908058596 scopus 로고    scopus 로고
    • Starting primary prevention earlier with statins
    • Robinson, J.G., Starting primary prevention earlier with statins. Am. J. Cardiol. 114, 1437-1442 (2014).
    • (2014) Am. J. Cardiol. , vol.114 , pp. 1437-1442
    • Robinson, J.G.1
  • 27
    • 84936750939 scopus 로고    scopus 로고
    • Cardiovascular disease and risk management
    • American Diabetes Association.
    • American Diabetes Association. Cardiovascular disease and risk management. Diabetes Care 38, S49-S57 (2014).
    • (2014) Diabetes Care , vol.38 , pp. S49-S57
  • 28
    • 84857881695 scopus 로고    scopus 로고
    • Lipid modification: Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease
    • National Institute for Health and Care Excellence
    • National Institute for Health and Care Excellence. Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease (Clinical guideline 181). < www.nice.org.uk/guidance/CG181 > (2014).
    • (2014) Clinical Guideline , vol.181
  • 29
    • 78449267756 scopus 로고    scopus 로고
    • Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: A double-blind randomised trial
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group
    • Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage, J., et al,. Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet 376, 1658-1669 (2010).
    • (2010) Lancet , vol.376 , pp. 1658-1669
    • Armitage, J.1
  • 30
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent, C., et al,. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376, 1670-1681 (2010).
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1
  • 31
    • 84955244904 scopus 로고    scopus 로고
    • Effects of extended-release niacin with laropriprant in high-risk patients
    • The HPS2-THRIVE Collaborative Group
    • The HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropriprant in high-risk patients. N. Engl. J. Med. 371, 2003-2012 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2003-2012
  • 32
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with Low HDL cholesterol levels receiving intensive statin therapy
    • The AIM-HIGH Investigators
    • The AIM-HIGH Investigators. Niacin in patients with Low HDL cholesterol levels receiving intensive statin therapy. N. Engl. J. Med. 365, 2255-2267 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2255-2267
  • 33
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • The Accord Study Group
    • The Accord Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1563-1574 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1563-1574
  • 34
    • 84915734906 scopus 로고    scopus 로고
    • On behalf of the IMPROVE-IT study group. Presented at the American Heart Association Scientific Sessions, November 17, (serial on the Internet)
    • Cannon, C., On behalf of the IMPROVE-IT study group. IMProved Reduction of OUtcomes: Vytorin Efficacy International Trial. Presented at the American Heart Association Scientific Sessions, November 17, 2014 (serial on the Internet).
    • (2014) IMProved Reduction of OUtcomes: Vytorin Efficacy International Trial
    • Cannon, C.1
  • 35
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
    • Seidah, N.G., et al,. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc. Natl. Acad. Sci. U. S. A. 100, 928-933 (2003).
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 928-933
    • Seidah, N.G.1
  • 36
    • 84860383419 scopus 로고    scopus 로고
    • The biology and therapeutic targeting of the proprotein convertases
    • Seidah, N.G., &, Prat, A., The biology and therapeutic targeting of the proprotein convertases. Nat. Rev. Drug Discov. 11, 367-383 (2012).
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 367-383
    • Seidah, N.G.1    Prat, A.2
  • 37
    • 34247605063 scopus 로고    scopus 로고
    • Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
    • Cunningham, D., et al,. Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat. Struct. Mol. Biol. 14, 413-419 (2007).
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 413-419
    • Cunningham, D.1
  • 38
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel, M., et al,. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34, 154-156 (2003).
    • (2003) Nat. Genet. , vol.34 , pp. 154-156
    • Abifadel, M.1
  • 39
    • 17144363236 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin 9: The third locus implicated in autosomal dominant hypercholesterolemia
    • Maxwell, K.N., &, Breslow, J.L., Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia. Curr. Opin. Lipidol. 16, 167-172 (2005).
    • (2005) Curr. Opin. Lipidol. , vol.16 , pp. 167-172
    • Maxwell, K.N.1    Breslow, J.L.2
  • 40
    • 33344474328 scopus 로고    scopus 로고
    • Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: Relationship with plasma lipid traits, heart disease risk and utility in relative tracing
    • Humphries, S.E., et al,. Mutational analysis in UK patients with a clinical diagnosis of familial hypercholesterolaemia: relationship with plasma lipid traits, heart disease risk and utility in relative tracing. J. Mol. Med. (Berl) 84, 203-214 (2006).
    • (2006) J. Mol. Med. (Berl) , vol.84 , pp. 203-214
    • Humphries, S.E.1
  • 41
    • 29944443017 scopus 로고    scopus 로고
    • Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
    • Allard, D., et al,. Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum. Mutat. 26, 497-498 (2005).
    • (2005) Hum. Mutat. , vol.26 , pp. 497-498
    • Allard, D.1
  • 42
    • 33847075832 scopus 로고    scopus 로고
    • A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol
    • Fasano, T., et al,. A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol. Arterioscler. Thromb. Vasc. Biol. 27, 677-681 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 677-681
    • Fasano, T.1
  • 43
    • 33748661502 scopus 로고    scopus 로고
    • Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
    • Zhao, Z., et al,. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am. J. Hum. Genet. 79, 514-523 (2006).
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 514-523
    • Zhao, Z.1
  • 44
    • 34447299120 scopus 로고    scopus 로고
    • The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
    • Hooper, A.J., Marais, A.D., Tanyanyiwa, D.M., &, Burnett, J.R., The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis 193, 445-448 (2007).
    • (2007) Atherosclerosis , vol.193 , pp. 445-448
    • Hooper, A.J.1    Marais, A.D.2    Tanyanyiwa, D.M.3    Burnett, J.R.4
  • 45
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen, J., et al,. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 37, 161-165 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 161-165
    • Cohen, J.1
  • 46
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen, J.C., Boerwinkle, E., Mosley, T.H. Jr., &, Hobbs, H.H., Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264-1272 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 47
    • 77953309816 scopus 로고    scopus 로고
    • PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    • Benn, M., Nordestgaard, B.G., Grande, P., Schnohr, P., &, Tybjaerg-Hansen, A., PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. J. Am. Coll. Cardiol. 55, 2833-2842 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 2833-2842
    • Benn, M.1    Nordestgaard, B.G.2    Grande, P.3    Schnohr, P.4    Tybjaerg-Hansen, A.5
  • 48
    • 34447299120 scopus 로고    scopus 로고
    • The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
    • Hooper, A.J., Marais, A.D., Tanyanyiwa, D.M., &, Burnett, J.R., The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis 193, 445-448 (2007).
    • (2007) Atherosclerosis , vol.193 , pp. 445-448
    • Hooper, A.J.1    Marais, A.D.2    Tanyanyiwa, D.M.3    Burnett, J.R.4
  • 49
    • 33748661502 scopus 로고    scopus 로고
    • Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
    • Zhao, Z., et al,. Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am. J. Hum. Genet. 79, 514-523 (2006).
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 514-523
    • Zhao, Z.1
  • 50
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
    • Zhang, D.W., et al,. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 282, 18602-18612 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 18602-18612
    • Zhang, D.W.1
  • 51
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
    • Poirier, S., et al,. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J. Biol. Chem. 283, 2363-2372 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 2363-2372
    • Poirier, S.1
  • 52
    • 46349103159 scopus 로고    scopus 로고
    • Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo
    • Schmidt, R.J., et al,. Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo. Biochem. Biophys. Res. Commun. 370, 634-640 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.370 , pp. 634-640
    • Schmidt, R.J.1
  • 53
    • 65549116032 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia
    • Le May, C., et al,. Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia. Arterioscler. Thromb. Vasc. Biol. 29, 684-690 (2009).
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 684-690
    • Le May, C.1
  • 54
    • 84857600072 scopus 로고    scopus 로고
    • Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice
    • Denis, M., et al,. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation 125: 894-901 (2012).
    • (2012) Circulation , vol.125 , pp. 894-901
    • Denis, M.1
  • 55
    • 84866499818 scopus 로고    scopus 로고
    • PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages
    • Tang, Z., et al,. PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-κB activation in THP-1-derived macrophages. Int. J. Mol. Med. 30, 931-938 (2012).
    • (2012) Int. J. Mol. Med. , vol.30 , pp. 931-938
    • Tang, Z.1
  • 57
    • 84861728908 scopus 로고    scopus 로고
    • Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)
    • Sharotri, V., Collier, D.M., Olson, D.R., Zhou, R., &, Snyder, P.M., Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J. Biol. Chem. 287, 19266-19274 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 19266-19274
    • Sharotri, V.1    Collier, D.M.2    Olson, D.R.3    Zhou, R.4    Snyder, P.M.5
  • 58
    • 77649274263 scopus 로고    scopus 로고
    • PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
    • Mbikay, M., et al,. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Lett. 584, 701-706 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 701-706
    • Mbikay, M.1
  • 59
    • 79953760698 scopus 로고    scopus 로고
    • Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue
    • Roubtsova, A., et al,. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arterioscler. Thromb. Vasc. Biol. 31, 785-791 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol. , vol.31 , pp. 785-791
    • Roubtsova, A.1
  • 60
    • 84921262461 scopus 로고    scopus 로고
    • On the function and homeostasis of PCSK9: Teciprocal interaction with LDLR and additional lipid effects
    • Tavori, H., Rashid, S., &, Fazio, S., On the function and homeostasis of PCSK9: teciprocal interaction with LDLR and additional lipid effects. Atherosclerosis 238, 264-270 (2014).
    • (2014) Atherosclerosis , vol.238 , pp. 264-270
    • Tavori, H.1    Rashid, S.2    Fazio, S.3
  • 61
    • 84856077137 scopus 로고    scopus 로고
    • Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: The JUPITER trial
    • Awan, Z., et al,. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clin. Chem. 58, 183-189 (2012).
    • (2012) Clin. Chem. , vol.58 , pp. 183-189
    • Awan, Z.1
  • 62
    • 84885447918 scopus 로고    scopus 로고
    • Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis
    • Urban, D., Pöss, J., Böhm, M., &, Laufs, U., Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis. J. Am. Coll. Cardiol. 62, 1401-1408 (2013).
    • (2013) J. Am. Coll. Cardiol. , vol.62 , pp. 1401-1408
    • Urban, D.1    Pöss, J.2    Böhm, M.3    Laufs, U.4
  • 63
    • 34147136507 scopus 로고    scopus 로고
    • Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    • Graham, M.J., et al,. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J. Lipid Res. 48, 763-767 (2007).
    • (2007) J. Lipid Res. , vol.48 , pp. 763-767
    • Graham, M.J.1
  • 64
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky, M., et al,. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl. Acad. Sci. U. S.A. 105, 11915-11920 (2008).
    • (2008) Proc. Natl. Acad. Sci. U. S.A. , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1
  • 65
    • 84905001697 scopus 로고    scopus 로고
    • Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering
    • Mitchell, T., et al,. Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering. J. Pharmacol. Exp. Ther. 350, 412-424 (2014).
    • (2014) J. Pharmacol. Exp. Ther. , vol.350 , pp. 412-424
    • Mitchell, T.1
  • 66
    • 84891904473 scopus 로고    scopus 로고
    • Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor
    • Zhang, Y., et al,. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J. Biol. Chem. 289, 942-955 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 942-955
    • Zhang, Y.1
  • 67
    • 84942104125 scopus 로고    scopus 로고
    • PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: Past, present, and the future
    • Shimada, Y.J., &, Cannon, C.P., PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future. Eur. Heart J. 36, 2415-1424 (2015).
    • (2015) Eur. Heart J. , vol.36 , pp. 2415-1424
    • Shimada, Y.J.1    Cannon, C.P.2
  • 68
    • 67649834056 scopus 로고    scopus 로고
    • A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    • Chan, J.C., et al,. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc. Natl. Acad. Sci. U. S. A. 106, 9820-9825 (2009).
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9820-9825
    • Chan, J.C.1
  • 69
    • 84868206496 scopus 로고    scopus 로고
    • Effects of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
    • Dias, C.S., et al,. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J. Am. Coll. Cardiol. 60, 1888-1898 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.60 , pp. 1888-1898
    • Dias, C.S.1
  • 70
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
    • Sullivan, D., et al,. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 308, 2497-2506 (2012).
    • (2012) JAMA , vol.308 , pp. 2497-2506
    • Sullivan, D.1
  • 71
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial
    • Raal, F., et al,. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial. Circulation 126, 2408-2417 (2012).
    • (2012) Circulation , vol.126 , pp. 2408-2417
    • Raal, F.1
  • 72
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
    • Koren, M.J., et al,. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 380, 1995-2006 (2012).
    • (2012) Lancet , vol.380 , pp. 1995-2006
    • Koren, M.J.1
  • 73
    • 84906323762 scopus 로고    scopus 로고
    • Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24 week, double-blind, randomized phase 3 trial
    • Roth, E.M., et al,. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized phase 3 trial. Int. J. Cardiol. 176, 55-61 (2014).
    • (2014) Int. J. Cardiol. , vol.176 , pp. 55-61
    • Roth, E.M.1
  • 74
    • 84937635895 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and the future of lipid lowering therapy
    • Joseph, L., &, Robinson, J.G., Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and the future of lipid lowering therapy. Prog. Cardiovasc. Dis. 58, 19-31 (2015).
    • (2015) Prog. Cardiovasc. Dis. , vol.58 , pp. 19-31
    • Joseph, L.1    Robinson, J.G.2
  • 75
    • 84902142901 scopus 로고    scopus 로고
    • MENDEL-2 Investigators. Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab
    • Koren, M.J., et al,. MENDEL-2 Investigators. Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J. Am. Coll. Cardiol. 63, 2531-2540 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2531-2540
    • Koren, M.J.1
  • 76
    • 84899846576 scopus 로고    scopus 로고
    • A 52-week placebo-controlled trial of evolocumab in hyperlipidemia
    • DESCARTES Investigators.
    • Blom, D.J., et al,. DESCARTES Investigators. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N. Engl. J. Med. 370, 1809-1819 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1809-1819
    • Blom, D.J.1
  • 77
    • 84922938167 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in high cardiovascular risk patients with suboptimally controlled hypercholesterolemia on maximally tolerated doses of statins: The ODYSSEY COMBO i study under late-breaking clinical trial abstracts
    • Kereiakes, J.G.R., et al,. Efficacy and safety of alirocumab in high cardiovascular risk patients with suboptimally controlled hypercholesterolemia on maximally tolerated doses of statins: the ODYSSEY COMBO I study under late-breaking clinical trial abstracts. Circulation 130, 2105-2126 (2014).
    • (2014) Circulation , vol.130 , pp. 2105-2126
    • Kereiakes, J.G.R.1
  • 79
    • 84937643240 scopus 로고    scopus 로고
    • Efficacy and safety of combining alirocumab with atorvastatin or rosuvastatin versus statin intensification or adding ezetimibe in high cardiovascular risk patients: ODYSSEY OPTIONS i and II under late-breaking clinical trial abstracts
    • Harold Bays, M.F., et al,. Efficacy and safety of combining alirocumab with atorvastatin or rosuvastatin versus statin intensification or adding ezetimibe in high cardiovascular risk patients: ODYSSEY OPTIONS I and II under late-breaking clinical trial abstracts. Circulation 130 (2014).
    • (2014) Circulation , vol.130
    • Harold Bays, M.F.1
  • 80
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
    • ODYSSEY LONG TERM Investigators.
    • Robinson, J.G., et al,. ODYSSEY LONG TERM Investigators. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N. Engl. J. Med. 372, 1489-1499 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 1489-1499
    • Robinson, J.G.1
  • 81
    • 84900303213 scopus 로고    scopus 로고
    • Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: The LAPLACE-2 randomized clinical trial
    • Robinson, J.G., et al,. Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 311, 1870-1882 (2014).
    • (2014) JAMA , vol.311 , pp. 1870-1882
    • Robinson, J.G.1
  • 82
    • 84902157271 scopus 로고    scopus 로고
    • Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
    • Stroes, E., et al,. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J. Am. Coll. Cardiol. 63, 2541-2548 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2541-2548
    • Stroes, E.1
  • 83
    • 84922938167 scopus 로고    scopus 로고
    • ODYSSEY ALTERNATIVE: Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody, alirocumab, versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm under late-breaking clinical trial abstracts
    • Patrick, M., et al,. ODYSSEY ALTERNATIVE: efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody, alirocumab, versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm under late-breaking clinical trial abstracts. Circulation 130, 2108 (2014).
    • (2014) Circulation , vol.130 , pp. 2108
    • Patrick, M.1
  • 85
    • 84937637206 scopus 로고    scopus 로고
    • ODYSSEY HIGH FH: Efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia under late-breaking clinical trial abstracts
    • Ginsberg, D.J.R., et al,. ODYSSEY HIGH FH: efficacy and safety of alirocumab in patients with severe heterozygous familial hypercholesterolemia under late-breaking clinical trial abstracts. Circulation 130, 2119 (2014).
    • (2014) Circulation , vol.130 , pp. 2119
    • Ginsberg, D.J.R.1
  • 86
    • 84921483643 scopus 로고    scopus 로고
    • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebo-controlled trial
    • Raal, F.J., et al,. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 385, 331-340 (2014).
    • (2014) Lancet , vol.385 , pp. 331-340
    • Raal, F.J.1
  • 87
    • 84921459685 scopus 로고    scopus 로고
    • TESLA Investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): A randomised, double-blind, placebo-controlled trial
    • Raal, F.J., et al,. TESLA Investigators. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet. 385, 341-350 (2014).
    • (2014) Lancet. , vol.385 , pp. 341-350
    • Raal, F.J.1
  • 88
    • 84926206074 scopus 로고    scopus 로고
    • Open-label study of long-term evaluation against LDL cholesterol (OSLER) investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine, M.S., et al,. Open-label study of long-term evaluation against LDL cholesterol (OSLER) investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N. Engl. J. Med. 372, 1500-1509.
    • N. Engl. J. Med. , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1
  • 89
    • 84931849550 scopus 로고    scopus 로고
    • Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: A systematic review and meta-analysis
    • Navarese, E.P., et al,. Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis. Ann. Intern. Med. 163, 40-51 (2015).
    • (2015) Ann. Intern. Med. , vol.163 , pp. 40-51
    • Navarese, E.P.1
  • 97
    • 84908318230 scopus 로고    scopus 로고
    • Impact of baseline lipoprotein and c-reactive protein levels on coronary atheroma regression following high-intensity statin therapy
    • Puri, R., et al,. Impact of baseline lipoprotein and c-reactive protein levels on coronary atheroma regression following high-intensity statin therapy. Am. J. Cardiol 114, 1465-1472 (2014).
    • (2014) Am. J. Cardiol , vol.114 , pp. 1465-1472
    • Puri, R.1
  • 98
    • 83255193890 scopus 로고    scopus 로고
    • Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: A randomised controlled trial
    • Heart Protection Study Collaborative G.
    • Heart Protection Study Collaborative G. Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet 378, 2013-2020 (2011).
    • (2011) Lancet , vol.378 , pp. 2013-2020
  • 99
    • 84903177781 scopus 로고    scopus 로고
    • Curing atherosclerosis should be the next major cardiovascular prevention goal
    • Robinson, J.G., &, Gidding, S.S., Curing atherosclerosis should be the next major cardiovascular prevention goal. J. Am. Coll. Cardiol. 63, 2779-2785 (2014).
    • (2014) J. Am. Coll. Cardiol. , vol.63 , pp. 2779-2785
    • Robinson, J.G.1    Gidding, S.S.2
  • 100
    • 84931033888 scopus 로고    scopus 로고
    • Are PCSK9 inhibitors the next breakthrough in the cardiovascular field
    • Giugliano, R.P., &, Sabatine, M.S., Are PCSK9 inhibitors the next breakthrough in the cardiovascular field? J. Am. Coll. Cardiol. 65, 2638-2651 (2015).
    • (2015) J. Am. Coll. Cardiol. , vol.65 , pp. 2638-2651
    • Giugliano, R.P.1    Sabatine, M.S.2


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