A heritable missense polymorphism in CDKN2A confers strong risk of childhood acute lymphoblastic leukemia and is preferentially selected during clonal evolution

Cancer Research

Volumn 75, Issue 22, 2015, Pages 4884-4894

  Walsh, Kyle M ^a,g   De Smith, Adam J ^a   Hansen, Helen M ^a   Smirnov, Ivan V ^a   Gonseth, Semira ^a   Endicott, Alyson A ^a   Xiao, Jianqiao ^a   Rice, Terri ^a   Fu, Cecilia H ^b   McCoy, Lucie S ^a   Lachance, Daniel H ^c   Eckel Passow, Jeanette E ^c   Wiencke, John K ^a,d   Jenkins, Robert B ^c   Wrensch, Margaret R ^a,d   Ma, Xiaomei ^e   Metayer, Catherine ^f   Wiemels, Joseph L ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c Mayo Clinic College of Medicine   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e YALE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CANCER RISK; CASE CONTROL STUDY; CDKN2A GENE; CHILD; CHILDHOOD LEUKEMIA; CLONAL EVOLUTION; CONTROLLED STUDY; ETHNICITY; EUROPEAN; GENE DELETION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME ANALYSIS; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR GROWTH; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; MALE; MOLECULAR EVOLUTION; TUMOR SUPPRESSOR GENE;

CASE-CONTROL STUDIES; CHILD; EVOLUTION, MOLECULAR; FEMALE; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84955275619     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1105     Document Type: Article

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