Serotonin improves high fat diet induced obesity in mice

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Watanabe, Hitoshi ^a   Nakano, Tatsuya ^a   Saito, Ryo ^a   Akasaka, Daisuke ^a   Saito, Kazuki ^a   Ogasawara, Hideki ^a   Minashima, Takeshi ^a   Miyazawa, Kohtaro ^a   Kanaya, Takashi ^a   Takakura, Ikuro ^a   Inoue, Nao ^a   Ikeda, Ikuo ^a   Chen, Xiangning ^a   Miyake, Masato ^a   Kitazawa, Haruki ^a   Shirakawa, Hitoshi ^a   Sato, Kan ^b   Tahara, Kohji ^c   Nagasawa, Yuya ^a   Rose, Michael T ^d   Ohwada, Shyuichi ^a   Watanabe, Kouichi ^a   Aso, Hisashi ^a   more..

^a TOHOKU UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c Kawagoe shi   (Japan)

^d ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; CARBON DIOXIDE; KETANSERIN; MESSENGER RNA; METHYSERGIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SB 204741; SEROTONIN; SEROTONIN 2A ANTAGONIST; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY EXPENDITURE; FAST MUSCLE FIBER; FOOD INTAKE; GENE EXPRESSION; GLYCOLYSIS; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID DIET; MALE; METABOLIC DISORDER; METABOLISM; MOUSE; NONHUMAN; OBESITY; OXIDATION; OXYGEN CONSUMPTION; SLOW MUSCLE FIBER; SOLEUS MUSCLE; WEIGHT GAIN; ADIPOSE TISSUE; ADVERSE EFFECTS; ANIMAL; BODY WEIGHT; DISEASE MODEL; ENERGY METABOLISM; GENETICS; SKELETAL MUSCLE;

ADIPOSE TISSUE; ADIPOSITY; ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GENE EXPRESSION; MALE; MICE; MUSCLE, SKELETAL; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; RNA, MESSENGER; SEROTONIN; TRANSCRIPTION FACTORS;

EID: 84955265533     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147143     Document Type: Article

References (38)

1. Walther DJ, Bader M. (2003) A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66: 1673-1680. PMID: 14563478
2. Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, et al. (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299: 76. PMID: 12511643
3. Woolley DW, Shaw E. (1954) A biological and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci USA 40: 228-231. PMID: 16589461
4. Merritt JH, Chamness AF, Allen SJ (1978) Studies on Blood-Brain Barrier Permeability After Microwave-Radiation. Radiat Environ Biophys 15: 367-377. PMID: 756056
5. Blundell JE. (1986) Serotonin manipulations and the structure of feeding behavior. Appetite 7: 39-56. PMID: 3527061
6. Leibowitz SF, Weiss GF, Shor-Posner G. (1988) Hypothalamic serotonin: Pharmacological, biochemical, and behavioral analyses of its feeding- suppressive action. Clin Neuropharmacol 11: S51-71.
7. Curzon G. (1990) Serotonin and appetite. Ann NY Acad Sci 600: 521-530. PMID: 2252331
8. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, et al. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374: 542-546. PMID: 7700379
9. Simansky KJ. (1996) Serotonergic control of the organization of feeding and satiety. Behav Brain Res 73: 37-42. PMID: 8788474
10. Leibowitz SF, Alexander JT. (1998) Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biol Psychiatry 44: 851-864. PMID: 9807640
11. Kim HJ, Kim JH, Noh S, Hur HJ, Sung MJ, Hwang JT, et al. (2011) Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice. J Proteome Res 10: 722-731. doi: 10.1021/pr100892r PMID: 21047143
12. Bertrand RL, Senadheera S, Markus I, Liu L, Howitt L, Chen H, et al. (2011) A Western diet increases serotonin availability in rat small intestine. Endocrinology 152: 36-47. doi: 10.1210/en.2010-0377 PMID: 21068163
13. Watanabe H, Akasaka D, Ogasawara H, Sato K, Miyake M, Saito K, et al. (2010) Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover. Endocrinology 151: 4776-4786. doi: 10.1210/en.2009-1349 PMID: 20685881
14. Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. (2008) Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab 7: 533-544. doi: 10.1016/j.cmet.2008.04.012 PMID: 18522834
15. Paulmann N, Grohmann M, Voigt JP, Bert B, Vowinckel J, Bader M, et al. (2009) Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation. PLoS Biol 7: e1000229 doi: 10.1371/journal.pbio.1000229 PMID: 19859528
16. Sumara G, Sumara O, Kim JK, Karsenty G. (2012) Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab 16: 588-600. doi: 10.1016/j.cmet.2012.09.014 PMID: 23085101
17. Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, et al. (2015) Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 21: 166-172. doi: 10.1038/nm.3766 PMID: 25485911
18. Berchtold MW, Brinkmeier H, Müntener M. (2000) Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. Physiol Rev 80: 1215-1265. PMID: 10893434
19. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, et al. (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418: 797-801. PMID: 12181572
20. Puigserver P, Spiegelman BM. (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 24: 78-90. PMID: 12588810
21. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124. PMID: 10412986
22. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, et al. (2007) Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest 117: 3463-3474. PMID: 17932564
23. Hickey MS, Carey JO, Azevedo JL, Houmard JA, Pories WJ, Israel RG, et al. (1995) Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am J Physiol 268: E453-457. PMID: 7900793
24. Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG. (2010) 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther 332: 632-639. doi: 10.1124/jpet.109.159947 PMID: 19875674
25. Uchida-Kitajima S, Yamauchi T, Takashina Y, Okada-Iwabu M, Iwabu M, Ueki K, et al. (2008) 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue. FEBS Lett 582:3037-3044. doi: 10.1016/j.febslet.2008.07.044 PMID: 18675814
26. Miura S, Kai Y, Kamei Y, Ezaki O. (2008) Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise. Endocrinology 149: 4527-4533. doi: 10.1210/en.2008-0466 PMID: 18511502
27. Pompeiano M, Palacios JM, Mengod G. (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res 23: 163-178.
28. Heisler LK, Chu HM, Tecott LH. (1998) Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice. Ann NY Acad Sci 861: 74-78. PMID: 9928241
29. Katagiri H, Yamada T, Oka Y. (2007) Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. Circ Res 101: 27-39. PMID: 17615379
30. Imai J, Katagiri H, Yamada T, Ishigaki Y, Suzuki T, Kudo H, et al. (2008) Regulation of pancreatic beta cell mass by neuronal signals from the liver. Science 322: 1250-1254. doi: 10.1126/science.1163971 PMID: 19023081
31. Tadaishi M, Miura S, Kai Y, Kano Y, Oishi Y, Ezaki O. (2011) Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. PLoS One 6: e28290 doi: 10.1371/journal.pone.0028290 PMID: 22174785
32. Hampson LJ, Mackin P, Agius L. (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 2007 50: 1743-1751. PMID: 17579833
33. Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD. (2004) Portal serotonin infusion and glucose disposal in conscious dogs.Diabetes 53:14-20. PMID: 14693692
34. Hoyer D, Hannon JP, Martin GR. (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71: 533-554. PMID: 11888546
35. Akimoto T, Sorg BS, Yan Z. (2004) Real-time imaging of peroxisome proliferator-activated receptor-α coactivator-1α promoter activity in skeletal muscles of living mice. Am J Physiol Cell Physiol 287: C790-C796.
36. Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci USA 103: 14379-14384. PMID: 16980408
37. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119: 61-74. PMID: 15454081
38. Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz, Arrang JM, et al. (1993) Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. Proc Natl Acad Sci USA 90: 8547-8551. PMID: 8397408