메뉴 건너뛰기




Volumn 14, Issue 1, 2016, Pages

Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome

Author keywords

Association; Chronic fatigue syndrome (CFS); Haplogroup; Heteroplasmy; Mitochondrial DNA; MtDNA; Myalgic encephalomyelitis (ME); Next generation sequencing; SNPs; Variants

Indexed keywords

MITOCHONDRIAL DNA; GENETIC MARKER;

EID: 84955243580     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-0771-6     Document Type: Article
Times cited : (46)

References (45)
  • 1
    • 84890555533 scopus 로고    scopus 로고
    • Vision-related symptoms as a clinical feature of chronic fatigue syndrome/myalgic encephalomyelitis? Evidence from the DePaul Symptom Questionnaire
    • Hutchinson CV, Maltby J, Badham SP, Jason LA. Vision-related symptoms as a clinical feature of chronic fatigue syndrome/myalgic encephalomyelitis? Evidence from the DePaul Symptom Questionnaire. Br J Ophthalmol. 2014;98(1):144-5. doi: 10.1136/bjophthalmol-2013-304439.
    • (2014) Br J Ophthalmol , vol.98 , Issue.1 , pp. 144-145
    • Hutchinson, C.V.1    Maltby, J.2    Badham, S.P.3    Jason, L.A.4
  • 2
    • 79951678895 scopus 로고    scopus 로고
    • The development of a revised Canadian myalgic encephalomyelitis-chronic fatigue syndrome case definition
    • Jason LA, Evans M, Porter N, Brown M, Brown A, Hunnell J, et al. The development of a revised Canadian myalgic encephalomyelitis-chronic fatigue syndrome case definition. Am J Biochem Biotechnol. 2010;6:120-35.
    • (2010) Am J Biochem Biotechnol , vol.6 , pp. 120-135
    • Jason, L.A.1    Evans, M.2    Porter, N.3    Brown, M.4    Brown, A.5    Hunnell, J.6
  • 3
    • 0034707662 scopus 로고    scopus 로고
    • Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder
    • Aaron LA, Burke MM, Buchwald D. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch Int Med. 2000;160:221-7.
    • (2000) Arch Int Med , vol.160 , pp. 221-227
    • Aaron, L.A.1    Burke, M.M.2    Buchwald, D.3
  • 4
    • 0025770311 scopus 로고
    • Symptoms and signs of chronic fatigue syndrome
    • Komaroff AL, Buchwald D. Symptoms and signs of chronic fatigue syndrome. Rev Infect Dis. 1991;13(Suppl 1):S8-11.
    • (1991) Rev Infect Dis , vol.13 , pp. S8-S11
    • Komaroff, A.L.1    Buchwald, D.2
  • 5
    • 84870330099 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-a clinical audit
    • Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-a clinical audit. Int J Clin Exp Med. 2013;6(1):1-15.
    • (2013) Int J Clin Exp Med , vol.6 , Issue.1 , pp. 1-15
    • Myhill, S.1    Booth, N.E.2    McLaren-Howard, J.3
  • 6
    • 77957679024 scopus 로고    scopus 로고
    • Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
    • Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010;8:93. doi: 10.1186/1479-5876-8-93.
    • (2010) J Transl Med , vol.8 , pp. 93
    • Vermeulen, R.C.1    Kurk, R.M.2    Visser, F.C.3    Sluiter, W.4    Scholte, H.R.5
  • 7
    • 79961207300 scopus 로고    scopus 로고
    • Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome
    • Smits B, van den Heuvel L, Knoop H, Kusters B, Janssen A, Borm G, et al. Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Mitochondrion. 2011;11(5):735-8. doi: 10.1016/j.mito.2011.05.005.
    • (2011) Mitochondrion , vol.11 , Issue.5 , pp. 735-738
    • Smits, B.1    Heuvel, L.2    Knoop, H.3    Kusters, B.4    Janssen, A.5    Borm, G.6
  • 8
    • 0028803859 scopus 로고
    • Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome
    • Plioplys AV, Plioplys S. Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome. Neuropsychobiology. 1995;32(4):175-81.
    • (1995) Neuropsychobiology , vol.32 , Issue.4 , pp. 175-181
    • Plioplys, A.V.1    Plioplys, S.2
  • 10
    • 76049126501 scopus 로고    scopus 로고
    • Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro endocrinol Lett. 2009;30(4):470-6.
    • (2009) Neuro endocrinol Lett , vol.30 , Issue.4 , pp. 470-476
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 11
    • 77953510759 scopus 로고    scopus 로고
    • Impaired cardiovascular response to standing in chronic fatigue syndrome
    • Hollingsworth KG, Jones DE, Taylor R, Blamire AM, Newton JL. Impaired cardiovascular response to standing in chronic fatigue syndrome. Eur J Clin Invest. 2010;40(7):608-15. doi: 10.1111/j.1365-2362.2010.02310.x.
    • (2010) Eur J Clin Invest , vol.40 , Issue.7 , pp. 608-615
    • Hollingsworth, K.G.1    Jones, D.E.2    Taylor, R.3    Blamire, A.M.4    Newton, J.L.5
  • 12
    • 0032077922 scopus 로고    scopus 로고
    • Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle
    • Lane RJ, Barrett MC, Taylor DJ, Kemp GJ, Lodi R. Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle. Neuromuscul Dis. 1998;8(3-4):204-9.
    • (1998) Neuromuscul Dis , vol.8 , Issue.3-4 , pp. 204-209
    • Lane, R.J.1    Barrett, M.C.2    Taylor, D.J.3    Kemp, G.J.4    Lodi, R.5
  • 13
    • 0026685872 scopus 로고
    • Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy
    • Wong R, Lopaschuk G, Zhu G, Walker D, Catellier D, Burton D, et al. Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy. Chest. 1992;102(6):1716-22.
    • (1992) Chest , vol.102 , Issue.6 , pp. 1716-1722
    • Wong, R.1    Lopaschuk, G.2    Zhu, G.3    Walker, D.4    Catellier, D.5    Burton, D.6
  • 14
    • 0037777751 scopus 로고    scopus 로고
    • Blood flow and muscle metabolism in chronic fatigue syndrome
    • McCully KK, Smith S, Rajaei S, Leigh JS Jr, Natelson BH. Blood flow and muscle metabolism in chronic fatigue syndrome. Clin Sci. 2003;104(6):641-7. doi: 10.1042/CS20020279.
    • (2003) Clin Sci , vol.104 , Issue.6 , pp. 641-647
    • McCully, K.K.1    Smith, S.2    Rajaei, S.3    Leigh, J.S.4    Natelson, B.H.5
  • 15
    • 1342325485 scopus 로고    scopus 로고
    • Muscle metabolism with blood flow restriction in chronic fatigue syndrome
    • McCully KK, Smith S, Rajaei S, Leigh JS Jr, Natelson BH. Muscle metabolism with blood flow restriction in chronic fatigue syndrome. J Appl Phys. 2004;96(3):871-8. doi: 10.1152/japplphysiol.00141.2003.
    • (2004) J Appl Phys , vol.96 , Issue.3 , pp. 871-878
    • McCully, K.K.1    Smith, S.2    Rajaei, S.3    Leigh, J.S.4    Natelson, B.H.5
  • 16
    • 77953507107 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in disease and aging
    • Wallace DC. Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen. 2010;51(5):440-50. doi: 10.1002/em.20586.
    • (2010) Environ Mol Mutagen , vol.51 , Issue.5 , pp. 440-450
    • Wallace, D.C.1
  • 17
    • 33847191391 scopus 로고    scopus 로고
    • Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
    • Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, et al. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet. 2007;80(3):407-15. doi: 10.1086/512202.
    • (2007) Am J Hum Genet , vol.80 , Issue.3 , pp. 407-415
    • Fuku, N.1    Park, K.S.2    Yamada, Y.3    Nishigaki, Y.4    Cho, Y.M.5    Matsuo, H.6
  • 18
    • 84936804373 scopus 로고    scopus 로고
    • Hurt, tired and queasy: specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic "functional" symptomatology including pain, fatigue and gastrointestinal dysmotility
    • Boles RG, Hornung HA, Moody AE, Ortiz TB, Wong SA, Eggington JM, et al. Hurt, tired and queasy: specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic "functional" symptomatology including pain, fatigue and gastrointestinal dysmotility. Mitochondrion. 2015;23:64-70. doi: 10.1016/j.mito.2015.05.002.
    • (2015) Mitochondrion , vol.23 , pp. 64-70
    • Boles, R.G.1    Hornung, H.A.2    Moody, A.E.3    Ortiz, T.B.4    Wong, S.A.5    Eggington, J.M.6
  • 19
    • 84929659386 scopus 로고    scopus 로고
    • Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: are we describing different parts of an energy-depleted elephant?
    • Boles RG, Zaki EA, Kerr JR, Das K, Biswas S, Gardner A. Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: are we describing different parts of an energy-depleted elephant? Mitochondrion. 2015;23:1-6.
    • (2015) Mitochondrion , vol.23 , pp. 1-6
    • Boles, R.G.1    Zaki, E.A.2    Kerr, J.R.3    Das, K.4    Biswas, S.5    Gardner, A.6
  • 20
    • 84904650179 scopus 로고    scopus 로고
    • Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals
    • Ye K, Lu J, Ma F, Keinan A, Gu Z. Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals. Proc Natl Acad Sci USA. 2014;111(29):10654-9. doi: 10.1073/pnas.1403521111.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.29 , pp. 10654-10659
    • Ye, K.1    Lu, J.2    Ma, F.3    Keinan, A.4    Gu, Z.5
  • 21
    • 84867847316 scopus 로고    scopus 로고
    • Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A>G mutation
    • de Laat P, Koene S, van den Heuvel LP, Rodenburg RJ, Janssen MC, Smeitink JA. Clinical features and heteroplasmy in blood, urine and saliva in 34 Dutch families carrying the m.3243A>G mutation. J Inherit Metab Dis. 2012;35(6):1059-69. doi: 10.1007/s10545-012-9465-2.
    • (2012) J Inherit Metab Dis , vol.35 , Issue.6 , pp. 1059-1069
    • Laat, P.1    Koene, S.2    Heuvel, L.P.3    Rodenburg, R.J.4    Janssen, M.C.5    Smeitink, J.A.6
  • 22
    • 85006304443 scopus 로고    scopus 로고
    • Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome
    • Klimas NG, Ironson G, Carter A, Balbin E, Bateman L, Felsenstein D, et al. Findings from a clinical and laboratory database developed for discovery of pathogenic mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue. 2015;3:75-96. doi: 10.1080/21641846.2015.1023652.
    • (2015) Fatigue , vol.3 , pp. 75-96
    • Klimas, N.G.1    Ironson, G.2    Carter, A.3    Balbin, E.4    Bateman, L.5    Felsenstein, D.6
  • 23
    • 0029282302 scopus 로고
    • Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the medical outcomes study
    • Ware JE Jr, Kosinski M, Bayliss MS, McHorney CA, Rogers WH, Raczek A. Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the medical outcomes study. Med Care. 1995;33(4 Suppl):AS264-79.
    • (1995) Med Care , vol.33 , Issue.4 , pp. AS264-AS279
    • Ware, J.E.1    Kosinski, M.2    Bayliss, M.S.3    McHorney, C.A.4    Rogers, W.H.5    Raczek, A.6
  • 24
    • 0027973857 scopus 로고
    • The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group
    • Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121(12):953-9.
    • (1994) Ann Intern Med , vol.121 , Issue.12 , pp. 953-959
    • Fukuda, K.1    Straus, S.E.2    Hickie, I.3    Sharpe, M.C.4    Dobbins, J.G.5    Komaroff, A.6
  • 25
    • 0037282328 scopus 로고    scopus 로고
    • Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatments protocols
    • Carruthers BM, Jain AK, DeMeirleir KL, Peterson DL, Klimas NG, Lerner AM, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical working case definition, diagnostic and treatments protocols. J Chronic Fatigue Synd. 2003;11:7-115.
    • (2003) J Chronic Fatigue Synd , vol.11 , pp. 7-115
    • Carruthers, B.M.1    Jain, A.K.2    DeMeirleir, K.L.3    Peterson, D.L.4    Klimas, N.G.5    Lerner, A.M.6
  • 27
    • 84931575560 scopus 로고    scopus 로고
    • Test-retest reliability of the DePaul symptom questionnaire
    • Jason LA, So S, Brown AA, Sunnquist M, Evans ME. Test-retest reliability of the DePaul symptom questionnaire. Fatigue. 2015;3:16-32. doi: 10.1080/21641846.2014.978110.
    • (2015) Fatigue , vol.3 , pp. 16-32
    • Jason, L.A.1    So, S.2    Brown, A.A.3    Sunnquist, M.4    Evans, M.E.5
  • 28
    • 84921367485 scopus 로고    scopus 로고
    • Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology
    • Brown AA, Jason LA. Validating a measure of myalgic encephalomyelitis/chronic fatigue syndrome symptomatology. Fatigue. 2014;2:132-52.
    • (2014) Fatigue , vol.2 , pp. 132-152
    • Brown, A.A.1    Jason, L.A.2
  • 29
    • 84890286468 scopus 로고    scopus 로고
    • A high-throughput Sanger strategy for human mitochondrial genome sequencing
    • Lyons EA, Scheible MK, Sturk-Andreaggi K, Irwin JA, Just RS. A high-throughput Sanger strategy for human mitochondrial genome sequencing. BMC Genomics. 2013;14:881. doi: 10.1186/1471-2164-14-881.
    • (2013) BMC Genomics , vol.14 , pp. 881
    • Lyons, E.A.1    Scheible, M.K.2    Sturk-Andreaggi, K.3    Irwin, J.A.4    Just, R.S.5
  • 30
    • 79960914105 scopus 로고    scopus 로고
    • Inference of human population history from individual whole-genome sequences
    • Li H, Durbin R. Inference of human population history from individual whole-genome sequences. Nature. 2011;475(7357):493-6. doi: 10.1038/nature10231.
    • (2011) Nature , vol.475 , Issue.7357 , pp. 493-496
    • Li, H.1    Durbin, R.2
  • 31
    • 84896691255 scopus 로고    scopus 로고
    • The case for the continuing use of the revised cambridge reference sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies
    • Bandelt HJ, Kloss-Brandstatter A, Richards MB, Yao YG, Logan I. The case for the continuing use of the revised cambridge reference sequence (rCRS) and the standardization of notation in human mitochondrial DNA studies. J Hum Genet. 2014;59:66-77.
    • (2014) J Hum Genet , vol.59 , pp. 66-77
    • Bandelt, H.J.1    Kloss-Brandstatter, A.2    Richards, M.B.3    Yao, Y.G.4    Logan, I.5
  • 32
    • 84923828628 scopus 로고    scopus 로고
    • The genomic landscape of polymorphic human nuclear mitochondrial insertions
    • Dayama G, Emery SB, Kidd JM, Mills RE. The genomic landscape of polymorphic human nuclear mitochondrial insertions. Nuc Acids Res. 2014;42(20):12640-9. doi: 10.1093/nar/gku1038.
    • (2014) Nuc Acids Res , vol.42 , Issue.20 , pp. 12640-12649
    • Dayama, G.1    Emery, S.B.2    Kidd, J.M.3    Mills, R.E.4
  • 33
    • 68549104404 scopus 로고    scopus 로고
    • The sequence alignment/map format and SAMtools
    • Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The sequence alignment/map format and SAMtools. Bioinformatics. 2009;25(16):2078-9. doi: 10.1093/bioinformatics/btp352.
    • (2009) Bioinformatics , vol.25 , Issue.16 , pp. 2078-2079
    • Li, H.1    Handsaker, B.2    Wysoker, A.3    Fennell, T.4    Ruan, J.5    Homer, N.6
  • 34
    • 78650459836 scopus 로고    scopus 로고
    • HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups
    • Kloss-Brandstatter A, Pacher D, Schonherr S, Weissensteiner H, Binna R, Specht G, et al. HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups. Hum Mutat. 2011;32:25-32. doi: 10.1002/humu.21382.
    • (2011) Hum Mutat , vol.32 , pp. 25-32
    • Kloss-Brandstatter, A.1    Pacher, D.2    Schonherr, S.3    Weissensteiner, H.4    Binna, R.5    Specht, G.6
  • 35
    • 64049089255 scopus 로고    scopus 로고
    • Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation
    • van Oven M, Kayser M. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat. 2009;30(2):E386-94.
    • (2009) Hum Mutat , vol.30 , Issue.2 , pp. E386-E394
    • Oven, M.1    Kayser, M.2
  • 36
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Human Genet. 2007;81:559-75. doi: 10.1086/519795.
    • (2007) Am J Human Genet , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 37
    • 0001677717 scopus 로고
    • Controlling the false discovery rate-a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate-a practical and powerful approach to multiple testing. J Roy Stat Soc B Met. 1995;57:289-300.
    • (1995) J Roy Stat Soc B Met , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 38
    • 79959467651 scopus 로고    scopus 로고
    • Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study
    • Goto H, Dickins B, Afgan E, Paul IM, Taylor J, Makova KD, et al. Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study. Genome Biol. 2011;12:R59. doi: 10.1186/gb-2011-12-6-r59.
    • (2011) Genome Biol , vol.12 , pp. R59
    • Goto, H.1    Dickins, B.2    Afgan, E.3    Paul, I.M.4    Taylor, J.5    Makova, K.D.6
  • 39
    • 85026347818 scopus 로고    scopus 로고
    • Distinct plasma immune signatures in ME/CFS are present early in the course of illness
    • Hornig M, Montoya JG, Klimas NG, Levine S, Felsenstein D, Bateman L, et al. Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Sci Adv. 2015;1:e1400121. doi: 10.1126/sciadv.1400121.
    • (2015) Sci Adv , vol.1 , pp. e1400121
    • Hornig, M.1    Montoya, J.G.2    Klimas, N.G.3    Levine, S.4    Felsenstein, D.5    Bateman, L.6
  • 40
    • 0035182136 scopus 로고    scopus 로고
    • The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy
    • Chinnery PF, Brown DT, Andrews RM, Singh-Kler R, Riordan-Eva P, Lindley J, et al. The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy. Brain. 2001;124(Pt 1):209-18.
    • (2001) Brain , vol.124 , pp. 209-218
    • Chinnery, P.F.1    Brown, D.T.2    Andrews, R.M.3    Singh-Kler, R.4    Riordan-Eva, P.5    Lindley, J.6
  • 41
    • 84895858942 scopus 로고    scopus 로고
    • A general framework for estimating the relative pathogenicity of human genetic variants
    • Kircher M, Witten DM, Jain P, O'Roak BJ, Cooper GM, Shendure J. A general framework for estimating the relative pathogenicity of human genetic variants. Nature Genet. 2014;46(3):310-5. doi: 10.1038/ng.2892.
    • (2014) Nature Genet , vol.46 , Issue.3 , pp. 310-315
    • Kircher, M.1    Witten, D.M.2    Jain, P.3    O'Roak, B.J.4    Cooper, G.M.5    Shendure, J.6
  • 43
    • 29144463778 scopus 로고    scopus 로고
    • Mitochondrial DNA and survival after sepsis: a prospective study
    • Baudouin SV, Saunders D, Tiangyou W, Elson JL, Poynter J, Pyle A, et al. Mitochondrial DNA and survival after sepsis: a prospective study. Lancet. 2005;366(9503):2118-21.
    • (2005) Lancet , vol.366 , Issue.9503 , pp. 2118-2121
    • Baudouin, S.V.1    Saunders, D.2    Tiangyou, W.3    Elson, J.L.4    Poynter, J.5    Pyle, A.6
  • 44
    • 84890371679 scopus 로고    scopus 로고
    • The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy
    • Hart AB, Samuels DC, Hulgan T. The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy. AIDS Rev. 2013;15(4):213-20.
    • (2013) AIDS Rev , vol.15 , Issue.4 , pp. 213-220
    • Hart, A.B.1    Samuels, D.C.2    Hulgan, T.3
  • 45
    • 84871554974 scopus 로고    scopus 로고
    • Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells
    • Mueller EE, Brunner SM, Mayr JA, Stanger O, Sperl W, Kofler B. Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells. PLoS One. 2012;7:e52367.
    • (2012) PLoS One , vol.7 , pp. e52367
    • Mueller, E.E.1    Brunner, S.M.2    Mayr, J.A.3    Stanger, O.4    Sperl, W.5    Kofler, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.