Hurt, tired and queasy: Specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic "functional" symptomatology including pain, fatigue and gastrointestinal dysmotility

Mitochondrion

Volumn 23, Issue , 2015, Pages 64-70

  Boles, Richard G ^a   Hornung, Holly A ^a   Moody, Alastair E ^a   Ortiz, Thomas B ^a   Wong, Stacey A ^a   Eggington, Julie M ^a   Stanley, Christine M ^a   Gao, Mu ^b   Zhou, Hongyi ^b   McLaughlin, Stephen ^a   Zare, Amir S ^a   Sheldon, Katherine M ^a   Skolnick, Jeffrey ^b   McKernan, Kevin J ^a  

^a Courtagen Life Sciences ^*  (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Autistic spectrum disorder; Computational protein analysis; Functional disease; Functional medicine; NextGen sequencing; Protein chaperones

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CHAPERONE; HEAT SHOCK PROTEIN 90; TRAP1 PROTEIN, HUMAN;

ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; ENZYME BINDING; EXON; FATIGUE; GASTROINTESTINAL MOTILITY DISORDER; GENE; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; NEXT GENERATION SEQUENCING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; RETROSPECTIVE STUDY; SEQUENCE ANALYSIS; TRAP1 GENE; AMINO ACID SUBSTITUTION; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETICS; METABOLISM; NAUSEA; PAIN;

AMINO ACID SUBSTITUTION; FATIGUE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NAUSEA; PAIN; RETROSPECTIVE STUDIES;

EID: 84936804373     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2015.05.002     Document Type: Article

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