Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria

Journal of Molecular Medicine

Volumn 94, Issue 6, 2016, Pages 667-679

  Hwang, John H ^a,b   Lyes, Matthew ^a,f   Sladewski, Katherine ^a   Enany, Shymaa ^a,c   McEachern, Elisa ^a,e   Mathew, Denzil P ^a   Das, Soumita ^b   Moshensky, Alexander ^a   Bapat, Sagar ^d   Pride, David T ^b   Ongkeko, Weg M ^b   Crotty Alexander, Laura E ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Suez Canal University   (Egypt)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimicrobial peptide LL 37; Cytotoxicity; E cigarette vapor; Inflammatory lung disease; MRSA pneumonia; Staphylococcal virulence

Indexed keywords

ACUTE PHASE PROTEIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYTOKINE; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM COLONY; BIOFILM; CELL DEATH; CONTROLLED STUDY; ELECTRONIC CIGARETTE; EPITHELIUM CELL; FEMALE; HOST CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; INHALATION; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN BLOOD LEVEL; STAPHYLOCOCCUS AUREUS; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BACTERIAL PNEUMONIA; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; DRUG MIXTURE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; SMOKE; TOBACCO; TOXICITY;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOFILMS; CELL DEATH; COMPLEX MIXTURES; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRONIC NICOTINE DELIVERY SYSTEMS; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNITY, INNATE; MACROPHAGES, ALVEOLAR; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; NEUTROPHILS; PNEUMONIA, BACTERIAL; SMOKE; TOBACCO;

EID: 84955239575     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1378-3     Document Type: Article

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