메뉴 건너뛰기




Volumn 18, Issue 1, 2016, Pages 72-81

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

Author keywords

18F FDG PET CT; Energy expenditure; Glucagon; Human brown adipose tissue; Thermal imaging

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCAGON; NORADRENALIN;

EID: 84955210967     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12585     Document Type: Article
Times cited : (127)

References (39)
  • 2
    • 84922570654 scopus 로고    scopus 로고
    • Pharmacological management of obesity: an endocrine Society clinical practice guideline
    • Apovian CM, Aronne LJ, Bessesen DH et al. Pharmacological management of obesity: an endocrine Society clinical practice guideline. J Clin Endocrinol Metabol 2015; 100: 342-362.
    • (2015) J Clin Endocrinol Metabol , vol.100 , pp. 342-362
    • Apovian, C.M.1    Aronne, L.J.2    Bessesen, D.H.3
  • 3
    • 84862582505 scopus 로고    scopus 로고
    • Anti-obesity drugs: a review about their effects and safety
    • Kang JG, Park CY. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J 2012; 36: 13-25.
    • (2012) Diabetes Metab J , vol.36 , pp. 13-25
    • Kang, J.G.1    Park, C.Y.2
  • 4
    • 84857425784 scopus 로고    scopus 로고
    • Pharmacotherapies for obesity: past, current, and future therapies
    • Ioannides-Demos LL, Piccenna L, McNeil JJ. Pharmacotherapies for obesity: past, current, and future therapies. J Obesity 2011; 2011: 179674.
    • (2011) J Obesity , vol.2011 , pp. 179674
    • Ioannides-Demos, L.L.1    Piccenna, L.2    McNeil, J.J.3
  • 5
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • Pocai A, Carrington PE, Adams JR et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009; 58: 2258-2266.
    • (2009) Diabetes , vol.58 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3
  • 6
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
    • Day JW, Ottaway N, Patterson JT et al. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 2009; 5: 749-757.
    • (2009) Nat Chem Biol , vol.5 , pp. 749-757
    • Day, J.W.1    Ottaway, N.2    Patterson, J.T.3
  • 7
    • 84875409178 scopus 로고    scopus 로고
    • Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    • Tan TM, Field BC, McCullough KA et al. Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia. Diabetes 2013; 62: 1131-1138.
    • (2013) Diabetes , vol.62 , pp. 1131-1138
    • Tan, T.M.1    Field, B.C.2    McCullough, K.A.3
  • 8
    • 84908632199 scopus 로고    scopus 로고
    • Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake
    • Cegla J, Troke RC, Jones B et al. Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake. Diabetes 2014; 63: 3711-3720.
    • (2014) Diabetes , vol.63 , pp. 3711-3720
    • Cegla, J.1    Troke, R.C.2    Jones, B.3
  • 9
    • 0031264289 scopus 로고    scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Obesity Res 1997; 5: 650-656.
    • (1997) Obesity Res , vol.5 , pp. 650-656
    • Rothwell, N.J.1    Stock, M.J.2
  • 10
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360: 1509-1517.
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 11
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009; 360: 1518-1525.
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 12
    • 84881260642 scopus 로고    scopus 로고
    • Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
    • van der Lans AA, Hoeks J, Brans B et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 2013; 123: 3395-3403.
    • (2013) J Clin Invest , vol.123 , pp. 3395-3403
    • van der Lans, A.A.1    Hoeks, J.2    Brans, B.3
  • 13
    • 0023657981 scopus 로고
    • Modulation by insulin and glucagon of noradrenaline-induced activation of isolated brown adipocytes from the rat
    • Howland RJ, Bond KD. Modulation by insulin and glucagon of noradrenaline-induced activation of isolated brown adipocytes from the rat. Eur J Biochem 1987; 169: 155-166.
    • (1987) Eur J Biochem , vol.169 , pp. 155-166
    • Howland, R.J.1    Bond, K.D.2
  • 16
    • 0031765348 scopus 로고    scopus 로고
    • Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells
    • Dicker A, Zhao J, Cannon B, Nedergaard J. Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. Am J Physiol 1998; 275(5 Pt 2): R1674-R1682.
    • (1998) Am J Physiol , vol.275 , Issue.5 , pp. R1674-R1682
    • Dicker, A.1    Zhao, J.2    Cannon, B.3    Nedergaard, J.4
  • 17
    • 85003698520 scopus 로고    scopus 로고
    • Infrared thermography in the detection of brown adipose tissue in humans
    • Jang C, Jalapu S, Thuzar M et al. Infrared thermography in the detection of brown adipose tissue in humans. Physiol Rep 2014; 2: e12167.
    • (2014) Physiol Rep , vol.2 , pp. e12167
    • Jang, C.1    Jalapu, S.2    Thuzar, M.3
  • 18
    • 84867877438 scopus 로고    scopus 로고
    • Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children
    • Symonds ME, Henderson K, Elvidge L et al. Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children. J Pediatr 2012; 161: 892-898.
    • (2012) J Pediatr , vol.161 , pp. 892-898
    • Symonds, M.E.1    Henderson, K.2    Elvidge, L.3
  • 19
    • 84862515329 scopus 로고    scopus 로고
    • Cold but not sympathomimetics activates human brown adipose tissue in vivo
    • Cypess AM, Chen YC, Sze C et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A 2012; 109: 10001-10005.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 10001-10005
    • Cypess, A.M.1    Chen, Y.C.2    Sze, C.3
  • 20
    • 79960945989 scopus 로고    scopus 로고
    • Different metabolic responses of human brown adipose tissue to activation by cold and insulin
    • Orava J, Nuutila P, Lidell ME et al. Different metabolic responses of human brown adipose tissue to activation by cold and insulin. Cell Metab 2011; 14: 272-279.
    • (2011) Cell Metab , vol.14 , pp. 272-279
    • Orava, J.1    Nuutila, P.2    Lidell, M.E.3
  • 21
    • 78650676545 scopus 로고    scopus 로고
    • Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men
    • Yoneshiro T, Aita S, Matsushita M et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity (Silver Spring) 2011; 19: 13-16.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 13-16
    • Yoneshiro, T.1    Aita, S.2    Matsushita, M.3
  • 23
    • 0035672507 scopus 로고    scopus 로고
    • Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis
    • Virtanen KA, Peltoniemi P, Marjamaki P et al. Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis. Diabetologia 2001; 44: 2171-2179.
    • (2001) Diabetologia , vol.44 , pp. 2171-2179
    • Virtanen, K.A.1    Peltoniemi, P.2    Marjamaki, P.3
  • 24
    • 84868206600 scopus 로고    scopus 로고
    • Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans
    • Vosselman MJ, van der Lans AA, Brans B et al. Systemic beta-adrenergic stimulation of thermogenesis is not accompanied by brown adipose tissue activity in humans. Diabetes 2012; 61: 3106-3113.
    • (2012) Diabetes , vol.61 , pp. 3106-3113
    • Vosselman, M.J.1    van der Lans, A.A.2    Brans, B.3
  • 26
    • 84876542381 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 mediates specific glucagon actions
    • Habegger KM, Stemmer K, Cheng C et al. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes 2013; 62: 1453-1463.
    • (2013) Diabetes , vol.62 , pp. 1453-1463
    • Habegger, K.M.1    Stemmer, K.2    Cheng, C.3
  • 27
    • 84903388798 scopus 로고    scopus 로고
    • Supraclavicular skin temperature as a measure of 18 F-FDG uptake by BAT in human subjects
    • Boon MR, Bakker LE, van der Linden RA et al. Supraclavicular skin temperature as a measure of 18 F-FDG uptake by BAT in human subjects. PLoS One 2014; 9: e98822.
    • (2014) PLoS One , vol.9 , pp. e98822
    • Boon, M.R.1    Bakker, L.E.2    van der Linden, R.A.3
  • 28
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011; 17: 200-205.
    • (2011) Nat Med , vol.17 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 29
    • 84879993961 scopus 로고    scopus 로고
    • Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature
    • Chen KY, Brychta RJ, Linderman JD et al. Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature. J Clin Endocrinol Metab 2013; 98: E1218-E1223.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1218-E1223
    • Chen, K.Y.1    Brychta, R.J.2    Linderman, J.D.3
  • 30
    • 84859650824 scopus 로고    scopus 로고
    • Intense FDG activity in the brown adipose tissue in omental and mesenteric regions in a patient with malignant pheochromocytoma
    • Cheng W, Zhu Z, Jin X, Chen L, Zhuang H, Li F. Intense FDG activity in the brown adipose tissue in omental and mesenteric regions in a patient with malignant pheochromocytoma. Clin Nucl Med 2012; 37: 514-515.
    • (2012) Clin Nucl Med , vol.37 , pp. 514-515
    • Cheng, W.1    Zhu, Z.2    Jin, X.3    Chen, L.4    Zhuang, H.5    Li, F.6
  • 31
    • 79960044076 scopus 로고    scopus 로고
    • Challenges in beta(3)-adrenoceptor agonist drug development
    • Arch JR. Challenges in beta(3)-adrenoceptor agonist drug development. Ther Adv Endocrinol Metab 2011; 2: 59-64.
    • (2011) Ther Adv Endocrinol Metab , vol.2 , pp. 59-64
    • Arch, J.R.1
  • 32
    • 84920627180 scopus 로고    scopus 로고
    • Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist
    • Cypess AM, Weiner LS, Roberts-Toler C et al. Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab 2015; 21: 33-38.
    • (2015) Cell Metab , vol.21 , pp. 33-38
    • Cypess, A.M.1    Weiner, L.S.2    Roberts-Toler, C.3
  • 33
    • 84940719531 scopus 로고    scopus 로고
    • The bile acid chenodeoxycholic acid increases human brown adipose tissue Activity
    • Broeders EP, Nascimento EB, Havekes B et al. The bile acid chenodeoxycholic acid increases human brown adipose tissue Activity. Cell Metab 2015; 22: 418-426.
    • (2015) Cell Metab , vol.22 , pp. 418-426
    • Broeders, E.P.1    Nascimento, E.B.2    Havekes, B.3
  • 34
    • 84902345191 scopus 로고    scopus 로고
    • A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo
    • Crane JD, Mottillo EP, Farncombe TH, Morrison KM, Steinberg GR. A standardized infrared imaging technique that specifically detects UCP1-mediated thermogenesis in vivo. Mol Metab 2014; 3: 490-494.
    • (2014) Mol Metab , vol.3 , pp. 490-494
    • Crane, J.D.1    Mottillo, E.P.2    Farncombe, T.H.3    Morrison, K.M.4    Steinberg, G.R.5
  • 35
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbe SM, Blondin DP et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 2012; 122: 545-552.
    • (2012) J Clin Invest , vol.122 , pp. 545-552
    • Ouellet, V.1    Labbe, S.M.2    Blondin, D.P.3
  • 37
    • 0028147026 scopus 로고
    • Insulin dissociates hepatic glucose cycling and glucagon-induced thermogenesis in man
    • Calles-Escandon J. Insulin dissociates hepatic glucose cycling and glucagon-induced thermogenesis in man. Metabolism 1994; 43: 1000-1005.
    • (1994) Metabolism , vol.43 , pp. 1000-1005
    • Calles-Escandon, J.1
  • 38
    • 50349088761 scopus 로고    scopus 로고
    • Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP
    • Harney JA, Rodgers RL. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab 2008; 295: E155-E161.
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. E155-E161
    • Harney, J.A.1    Rodgers, R.L.2
  • 39
    • 77953724748 scopus 로고    scopus 로고
    • Glucagon regulation of energy metabolism
    • Heppner KM, Habegger KM, Day J et al. Glucagon regulation of energy metabolism. Physiol Behav 2010; 100: 545-548.
    • (2010) Physiol Behav , vol.100 , pp. 545-548
    • Heppner, K.M.1    Habegger, K.M.2    Day, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.