메뉴 건너뛰기




Volumn 13, Issue 1, 2016, Pages 7-22

Inhaled antibiotics in the treatment of non-cystic fibrosis bronchiectasis: Clinical and drug delivery perspectives

Author keywords

combination antibiotics; inhaled antibiotics; non cystic fibrosis bronchhiectasis; Pseudomonas aeruginosa; respiratory tract infections; sustained release antibiotics

Indexed keywords

ANTIINFECTIVE AGENT;

EID: 84955208340     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2015.1078309     Document Type: Review
Times cited : (18)

References (98)
  • 2
    • 84925023856 scopus 로고    scopus 로고
    • Inhalation of macrolides: A novel approach to treatment of pulmonary infections
    • Siekmeier R, Hofmann T, Scheuch G. Inhalation of macrolides: a novel approach to treatment of pulmonary infections. Adv Exp Med Biol 2015; 839: 13-24
    • (2015) Adv Exp Med Biol , vol.839 , pp. 13-24
    • Siekmeier, R.1    Hofmann, T.2    Scheuch, G.3
  • 3
    • 84875625613 scopus 로고    scopus 로고
    • Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis
    • Chalmers JD, Hill AT. Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis. Mol Immunol 2013; 55 (1): 27-34
    • (2013) Mol Immunol , vol.55 , Issue.1 , pp. 27-34
    • Chalmers, J.D.1    Hill, A.T.2
  • 4
    • 23244450093 scopus 로고    scopus 로고
    • Prevalence and economic burden of bronchiectasis
    • Weycker D, Edelsberg J, Oster G, et al. Prevalence and economic burden of bronchiectasis. Clin Pulm Med 2005; 12 (4): 205-9
    • (2005) Clin Pulm Med , vol.12 , Issue.4 , pp. 205-209
    • Weycker, D.1    Edelsberg, J.2    Oster, G.3
  • 5
    • 84906643002 scopus 로고    scopus 로고
    • Aerosolized antibiotics for non-cystic fibrosis bronchiectasis
    • Rubin BK, Williams RW. Aerosolized antibiotics for non-cystic fibrosis bronchiectasis. Respiration 2014; 88: 177-84
    • (2014) Respiration , vol.88 , pp. 177-184
    • Rubin, B.K.1    Williams, R.W.2
  • 6
    • 84885374207 scopus 로고    scopus 로고
    • Non-Tuberculous mycobacterial disease is common in patients with non-cystic fibrosis bronchiectasis
    • Mirsaeidi M, Hadid W, Ericsoussi B, et al. Non-Tuberculous mycobacterial disease is common in patients with non-cystic fibrosis bronchiectasis. Int J Infect Dis 2013; 17 (11): e1000-e04
    • (2013) Int J Infect Dis , vol.17 , Issue.11 , pp. e1000-e10004
    • Mirsaeidi, M.1    Hadid, W.2    Ericsoussi, B.3
  • 7
    • 84867114791 scopus 로고    scopus 로고
    • Short-And long-Term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis
    • Chalmers JD, Smith MP, McHugh BJ, et al. Short-And long-Term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2012; 186 (7): 657-65
    • (2012) Am J Respir Crit Care Med , vol.186 , Issue.7 , pp. 657-665
    • Chalmers, J.D.1    Smith, M.P.2    McHugh, B.J.3
  • 8
    • 84921310705 scopus 로고    scopus 로고
    • Developing drug therapies in bronchiectasis
    • Sidhu MK, Mandal P, Hill AT. Developing drug therapies in bronchiectasis. Exp Opin Drug Deliv 2014; 24 (2): 169-81
    • (2014) Exp Opin Drug Deliv , vol.24 , Issue.2 , pp. 169-181
    • Sidhu, M.K.1    Mandal, P.2    Hill, A.T.3
  • 9
    • 84919660351 scopus 로고    scopus 로고
    • Delivery of antibiotics with polymeric particles
    • Xiong MH, Bao Y, Yang XZ, et al. Delivery of antibiotics with polymeric particles. Adv Drug Deliv Rev 2014; 78: 63-76
    • (2014) Adv Drug Deliv Rev , vol.78 , pp. 63-76
    • Xiong, M.H.1    Bao, Y.2    Yang, X.Z.3
  • 10
    • 84930088821 scopus 로고    scopus 로고
    • Inhaled antimicrobial therapy-Barriers to effective treatment
    • Weers J. Inhaled antimicrobial therapy-Barriers to effective treatment. Adv Drug Deliv Rev 2015; 85: 24-43
    • (2015) Adv Drug Deliv Rev , vol.85 , pp. 24-43
    • Weers, J.1
  • 11
    • 77955283910 scopus 로고    scopus 로고
    • British Thoracic Society guideline for non-cystic fibrosis bronchiectasis
    • Pasteur MC, Bilton D, Hill AT. British Thoracic Society guideline for non-cystic fibrosis bronchiectasis. Thorax 2010; 65 (Suppl 1): i1-i58
    • (2010) Thorax , vol.65 , pp. i1-i58
    • Pasteur, M.C.1    Bilton, D.2    Hill, A.T.3
  • 12
    • 84903949034 scopus 로고    scopus 로고
    • Treatment adherence and health outcomes in patients with bronchiectasis
    • McCullough AR, Tunney MM, Quittner AL, et al. Treatment adherence and health outcomes in patients with bronchiectasis. BMC Pulm Med 2014; 14: 107
    • (2014) BMC Pulm Med , vol.14 , pp. 107
    • McCullough, A.R.1    Tunney, M.M.2    Quittner, A.L.3
  • 13
    • 84955195842 scopus 로고    scopus 로고
    • Respiratory Expert Group. 5th edition. Therapeutic Guidelines Limited, Melbourne
    • Respiratory Expert Group. Therapeutic Guidelines: Respiratory. 5th edition. Therapeutic Guidelines Limited, Melbourne; 2015
    • (2015) Therapeutic Guidelines: Respiratory
  • 14
    • 84914816367 scopus 로고    scopus 로고
    • Antibiotic Expert Group. 5th edition. Therapeutic Guidelines Limited, Melbourne
    • Antibiotic Expert Group. Therapeutic guidelines: Antibiotics. 5th edition. Therapeutic Guidelines Limited, Melbourne; 2014
    • (2014) Therapeutic Guidelines: Antibiotics
  • 15
    • 84890469602 scopus 로고    scopus 로고
    • Inhaled antibiotics to treat lung infection
    • Cipolla D, Chan HK. Inhaled antibiotics to treat lung infection. Pharm Pat Anal 2013; 2 (5): 647-63
    • (2013) Pharm Pat Anal , vol.2 , Issue.5 , pp. 647-663
    • Cipolla, D.1    Chan, H.K.2
  • 16
    • 84881556337 scopus 로고    scopus 로고
    • Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): A randomised, double-blind, placebo-controlled trial
    • Serisier DJ, Bilton D, De Soyza A, et al. Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): A randomised, double-blind, placebo-controlled trial. Thorax 2013; 68 (9): 812-17
    • (2013) Thorax , vol.68 , Issue.9 , pp. 812-817
    • Serisier, D.J.1    Bilton, D.2    De Soyza, A.3
  • 17
    • 84896795789 scopus 로고    scopus 로고
    • The PulmoSphere platform for pulmonary drug delivery
    • Weers J, Tarara T. The PulmoSphere platform for pulmonary drug delivery. Ther Deliv 2014; 5 (3): 277-95
    • (2014) Ther Deliv , vol.5 , Issue.3 , pp. 277-295
    • Weers, J.1    Tarara, T.2
  • 19
    • 84873343392 scopus 로고    scopus 로고
    • Dose emission characteristics of placebo PulmoSphere particles are unaffected by a subjects inhalation maneuver
    • Weers J, Ung K, Le J, et al. Dose emission characteristics of placebo PulmoSphere particles are unaffected by a subjects inhalation maneuver. J Aerosol Med Pulm Drug Deliv 2013; 26 (1): 56-68
    • (2013) J Aerosol Med Pulm Drug Deliv , vol.26 , Issue.1 , pp. 56-68
    • Weers, J.1    Ung, K.2    Le, J.3
  • 20
    • 84878695314 scopus 로고    scopus 로고
    • Inhalation of a dry powder ciprofloxacin formulation in healthy subjects: A phase i study
    • Stass H, Nagelschmitz J, Willmann S, et al. Inhalation of a dry powder ciprofloxacin formulation in healthy subjects: a phase I study. Clin Drug Investig 2013; 33 (6): 419-27
    • (2013) Clin Drug Investig , vol.33 , Issue.6 , pp. 419-427
    • Stass, H.1    Nagelschmitz, J.2    Willmann, S.3
  • 21
    • 84885841052 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetic properties of ciprofloxacin dry powder for inhalation in patients with cystic fibrosis: A phase I, randomized, dose-escalation study
    • Stass H, Weimann B, Nagelschmitz J, et al. Tolerability and pharmacokinetic properties of ciprofloxacin dry powder for inhalation in patients with cystic fibrosis: a phase I, randomized, dose-escalation study. Clin Ther 2013; 35 (10): 1571-81
    • (2013) Clin Ther , vol.35 , Issue.10 , pp. 1571-1581
    • Stass, H.1    Weimann, B.2    Nagelschmitz, J.3
  • 22
    • 84877093743 scopus 로고    scopus 로고
    • Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: A phase II randomised study
    • Wilson R, Welte T, Polverino E, et al. Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study. Eur Respir J 2013; 41 (5): 1107-15
    • (2013) Eur Respir J , vol.41 , Issue.5 , pp. 1107-1115
    • Wilson, R.1    Welte, T.2    Polverino, E.3
  • 23
    • 0033841109 scopus 로고    scopus 로고
    • Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis
    • Barker AF, Couch L, Fiel SB, et al. Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis. Am J Respir Crit Care Med 2000; 162 (2): 481-5
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.2 , pp. 481-485
    • Barker, A.F.1    Couch, L.2    Fiel, S.B.3
  • 24
    • 11144228397 scopus 로고    scopus 로고
    • Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa
    • Drobnic ME, Sune P, Montoro JB, et al. Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa. Ann Pharmacother 2005; 39 (1): 39-44
    • (2005) Ann Pharmacother , vol.39 , Issue.1 , pp. 39-44
    • Drobnic, M.E.1    Sune, P.2    Montoro, J.B.3
  • 25
    • 84898994995 scopus 로고    scopus 로고
    • Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection
    • Haworth CS, Foweraker JE, Wilkinson P, et al. Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 2014; 189 (8): 975-82
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.8 , pp. 975-982
    • Haworth, C.S.1    Foweraker, J.E.2    Wilkinson, P.3
  • 26
    • 79951824943 scopus 로고    scopus 로고
    • A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis
    • Murray MP, Govan JRW, Doherty CJ, et al. A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2011; 183 (4): 491-9
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.4 , pp. 491-499
    • Murray, M.P.1    Govan, J.R.W.2    Doherty, C.J.3
  • 27
    • 0032875068 scopus 로고    scopus 로고
    • Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa
    • Orriols R, Roig J, Ferrer J, et al. Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa. Respir Med 1999; 93 (7): 476-80
    • (1999) Respir Med , vol.93 , Issue.7 , pp. 476-480
    • Orriols, R.1    Roig, J.2    Ferrer, J.3
  • 28
    • 84905653266 scopus 로고    scopus 로고
    • Inhaled colistin in elderly patients with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa bronchial infection
    • Tabernero E, Gil P, Alkiza R, et al. Inhaled colistin in elderly patients with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa bronchial infection. Chest 2014; 145 (Suppl 3): 431A
    • (2014) Chest , vol.145 , pp. 431A
    • Tabernero, E.1    Gil, P.2    Alkiza, R.3
  • 29
    • 84908070796 scopus 로고    scopus 로고
    • Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): Two randomised double-blind, placebo-controlled phase 3 trials
    • Barker AF, ODonnell AE, Flume P, et al. Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): Two randomised double-blind, placebo-controlled phase 3 trials. Lancet Respir Med 2014; 2 (9): 738-49
    • (2014) Lancet Respir Med , vol.2 , Issue.9 , pp. 738-749
    • Barker, A.F.1    O'Donnell, A.E.2    Flume, P.3
  • 30
    • 33751243366 scopus 로고    scopus 로고
    • Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis
    • Bilton D, Henig N, Morrissey B, et al. Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis. Chest 2006; 130 (5): 1503-10
    • (2006) Chest , vol.130 , Issue.5 , pp. 1503-1510
    • Bilton, D.1    Henig, N.2    Morrissey, B.3
  • 31
    • 84905644717 scopus 로고    scopus 로고
    • Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: A systematic review
    • Brodt AM, Stovold E, Zhang L. Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: A systematic review. Eur Respir J 2014; 44 (2): 382-93
    • (2014) Eur Respir J , vol.44 , Issue.2 , pp. 382-393
    • Brodt, A.M.1    Stovold, E.2    Zhang, L.3
  • 32
    • 84922237712 scopus 로고    scopus 로고
    • Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
    • Langton Hewer SC, Smyth AR. Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev 2014; 11: CD004197
    • (2014) Cochrane Database Syst Rev , vol.11 , pp. CD004197
    • Langton Hewer, S.C.1    Smyth, A.R.2
  • 33
    • 84855887761 scopus 로고    scopus 로고
    • Outcomes of Pseudomonas eradication therapy in patients with non-cystic fibrosis bronchiectasis
    • White L, Mirrani G, Grover M, et al. Outcomes of Pseudomonas eradication therapy in patients with non-cystic fibrosis bronchiectasis. Respir Med 2012; 106 (3): 356-60
    • (2012) Respir Med , vol.106 , Issue.3 , pp. 356-360
    • White, L.1    Mirrani, G.2    Grover, M.3
  • 34
    • 79957942626 scopus 로고    scopus 로고
    • Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa
    • Geller DE, Flume PA, Staab D, et al. Levofloxacin inhalation solution (MP-376) in patients with cystic fibrosis with Pseudomonas aeruginosa. Am J Respir Crit Care Med 2011; 183 (11): 1510-16
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.11 , pp. 1510-1516
    • Geller, D.E.1    Flume, P.A.2    Staab, D.3
  • 35
    • 84875215401 scopus 로고    scopus 로고
    • Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: A randomised study
    • Schuster A, Haliburn C, Döring G, et al. Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study. Thorax 2013; 68 (4): 344-50
    • (2013) Thorax , vol.68 , Issue.4 , pp. 344-350
    • Schuster, A.1    Haliburn, C.2    Döring, G.3
  • 36
    • 84856010859 scopus 로고    scopus 로고
    • Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with Pseudomonas airway infection
    • Trapnell BC, McColley SA, Kissner DG, et al. Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with Pseudomonas airway infection. Am J Respir Crit Care Med 2012; 185 (2): 171-8
    • (2012) Am J Respir Crit Care Med , vol.185 , Issue.2 , pp. 171-178
    • Trapnell, B.C.1    McColley, S.A.2    Kissner, D.G.3
  • 37
    • 84860626732 scopus 로고    scopus 로고
    • Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions
    • McCaughey G, McKevitt M, Elborn JS, et al. Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions. J Cyst Fibros 2012; 11 (3): 163-72
    • (2012) J Cyst Fibros , vol.11 , Issue.3 , pp. 163-172
    • McCaughey, G.1    McKevitt, M.2    Elborn, J.S.3
  • 38
    • 70349444999 scopus 로고    scopus 로고
    • Antibacterial activities of a fosfomycin/tobramycin combination: A novel inhaled antibiotic for bronchiectasis
    • MacLeod DL, Barker LM, Sutherland JL, et al. Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis. J Antimicrob Chemother 2009; 64 (4): 829-36
    • (2009) J Antimicrob Chemother , vol.64 , Issue.4 , pp. 829-836
    • MacLeod, D.L.1    Barker, L.M.2    Sutherland, J.L.3
  • 39
    • 78651397850 scopus 로고    scopus 로고
    • Available from [Last accessed 27 July 2015]
    • Clinical trial registry and database. Available from: https://clinicaltrials.gov. [Last accessed 27 July 2015]
    • Clinical Trial Registry and Database
  • 40
    • 33845364453 scopus 로고    scopus 로고
    • Nontuberculous mycobacteria in bronchiectasis: Prevalence and patient characteristics
    • Fowler SJ, French J, Screaton NJ, et al. Nontuberculous mycobacteria in bronchiectasis: prevalence and patient characteristics. Eur Respir J 2006; 28 (6): 1204-10
    • (2006) Eur Respir J , vol.28 , Issue.6 , pp. 1204-1210
    • Fowler, S.J.1    French, J.2    Screaton, N.J.3
  • 41
    • 77954595517 scopus 로고    scopus 로고
    • Mechanisms of action and clinical application of macrolides as immunomodulatory medications
    • Kanoh S, Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev 2010; 23 (3): 590-615
    • (2010) Clin Microbiol Rev , vol.23 , Issue.3 , pp. 590-615
    • Kanoh, S.1    Rubin, B.K.2
  • 42
    • 84896317661 scopus 로고    scopus 로고
    • Long-Term macrolides for non-cystic fibrosis bronchiectasis: A systematic review and meta-Analysis
    • Wu Q, Shen W, Cheng H, et al. Long-Term macrolides for non-cystic fibrosis bronchiectasis: A systematic review and meta-Analysis. Respirology 2014; 19 (3): 321-9
    • (2014) Respirology , vol.19 , Issue.3 , pp. 321-329
    • Wu, Q.1    Shen, W.2    Cheng, H.3
  • 43
    • 84859398578 scopus 로고    scopus 로고
    • Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections
    • Togami K, Chono S, Morimoto K. Aerosol-based efficient delivery of clarithromycin, a macrolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. J Aerosol Med Pulm Drug Deliv 2012; 25 (2): 110-15
    • (2012) J Aerosol Med Pulm Drug Deliv , vol.25 , Issue.2 , pp. 110-115
    • Togami, K.1    Chono, S.2    Morimoto, K.3
  • 44
    • 84875523410 scopus 로고    scopus 로고
    • Development of a nano-micro carrier system for sustained pulmonary delivery of clarithromycin
    • Moghaddam PH, Ramezani V, Esfandi E, et al. Development of a nano-micro carrier system for sustained pulmonary delivery of clarithromycin. Powder Technol 2013; 239: 478-83
    • (2013) Powder Technol , vol.239 , pp. 478-483
    • Moghaddam, P.H.1    Ramezani, V.2    Esfandi, E.3
  • 45
    • 77953195425 scopus 로고    scopus 로고
    • Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections
    • Togami K, Chono S, Seki T, et al. Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. Drug Dev Ind Pharm 2010; 36 (7): 861-6
    • (2010) Drug Dev Ind Pharm , vol.36 , Issue.7 , pp. 861-866
    • Togami, K.1    Chono, S.2    Seki, T.3
  • 46
    • 33645469145 scopus 로고    scopus 로고
    • Inhaled azithromycin therapy
    • Hickey AJ, Lu D, Ashley ED, et al. Inhaled azithromycin therapy. J Aerosol Med 2006; 19 (1): 54-60
    • (2006) J Aerosol Med , vol.19 , Issue.1 , pp. 54-60
    • Hickey, A.J.1    Lu, D.2    Ashley, E.D.3
  • 48
    • 0030795298 scopus 로고    scopus 로고
    • Liposomes in drug delivery: Progress and limitations
    • Sharma A, Sharma US. Liposomes in drug delivery: progress and limitations. Int J Pharm 1997; 154 (2): 123-40
    • (1997) Int J Pharm , vol.154 , Issue.2 , pp. 123-140
    • Sharma, A.1    Sharma, U.S.2
  • 49
    • 84863479128 scopus 로고    scopus 로고
    • Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery
    • Willis L, Hayes D Jr, Mansour HM. Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery. Lung 2012; 190 (3): 251-62
    • (2012) Lung , vol.190 , Issue.3 , pp. 251-262
    • Willis, L.1    Hayes, D.2    Mansour, H.M.3
  • 50
    • 77957749362 scopus 로고    scopus 로고
    • Enhancing encapsulation efficiency of highly water-soluble antibiotic in poly (lactic-co-glycolic acid) nanoparticles: Modifications of standard nanoparticle preparation methods
    • Cheow WS, Hadinoto K. Enhancing encapsulation efficiency of highly water-soluble antibiotic in poly (lactic-co-glycolic acid) nanoparticles: Modifications of standard nanoparticle preparation methods. Colloids Surf A 2010; 370 (1): 79-86
    • (2010) Colloids Surf A , vol.370 , Issue.1 , pp. 79-86
    • Cheow, W.S.1    Hadinoto, K.2
  • 51
    • 64749110689 scopus 로고    scopus 로고
    • Recent advances in liposomal dry powder formulations: Preparation and evaluation
    • Misra A, Jinturkar K, Patel D, et al. Recent advances in liposomal dry powder formulations: preparation and evaluation. Exp Opin Drug Deliv 2009; 6 (1): 71-89
    • (2009) Exp Opin Drug Deliv , vol.6 , Issue.1 , pp. 71-89
    • Misra, A.1    Jinturkar, K.2    Patel, D.3
  • 52
    • 58149177361 scopus 로고    scopus 로고
    • Inhaled liposomes-Current strategies and future challenges
    • Gaspar MM, Bakowsky U, Ehrhardt C. Inhaled liposomes-current strategies and future challenges. J Biomed Nanotechnol 2008; 4 (3): 245-57
    • (2008) J Biomed Nanotechnol , vol.4 , Issue.3 , pp. 245-257
    • Gaspar, M.M.1    Bakowsky, U.2    Ehrhardt, C.3
  • 53
    • 29244461477 scopus 로고    scopus 로고
    • Preparation and characterization of dehydration-rehydration vesicles loaded with aminoglycoside and macrolide antibiotics
    • Mugabe C, Azghani AO, Omri A. Preparation and characterization of dehydration-rehydration vesicles loaded with aminoglycoside and macrolide antibiotics. Int J Pharm 2006; 307 (2): 244-50
    • (2006) Int J Pharm , vol.307 , Issue.2 , pp. 244-250
    • Mugabe, C.1    Azghani, A.O.2    Omri, A.3
  • 54
    • 41349084816 scopus 로고    scopus 로고
    • Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains
    • Alipour M, Halwani M, Omri A, et al. Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains. Int J Pharm 2008; 355 (1-2): 293-8
    • (2008) Int J Pharm , vol.355 , Issue.12 , pp. 293-298
    • Alipour, M.1    Halwani, M.2    Omri, A.3
  • 55
    • 84876325172 scopus 로고    scopus 로고
    • Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies
    • Wallace SJ, Nation RL, Li J, et al. Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies. J Pharm Sci 2013; 102 (5): 1578-87
    • (2013) J Pharm Sci , vol.102 , Issue.5 , pp. 1578-1587
    • Wallace, S.J.1    Nation, R.L.2    Li, J.3
  • 56
    • 84881539706 scopus 로고    scopus 로고
    • Liposomal formulations for inhalation
    • Cipolla D, Gonda I, Chan HK. Liposomal formulations for inhalation. Ther Deliv 2013; 4 (8): 1047-72
    • (2013) Ther Deliv , vol.4 , Issue.8 , pp. 1047-1072
    • Cipolla, D.1    Gonda, I.2    Chan, H.K.3
  • 57
    • 84864719781 scopus 로고    scopus 로고
    • Engineered PLGA nano-And micro-carriers for pulmonary delivery: Challenges and promises
    • Ungaro F, dAngelo I, Miro A, et al. Engineered PLGA nano-And micro-carriers for pulmonary delivery: challenges and promises. J Pharm Pharmacol 2012; 64 (9): 1217-35
    • (2012) J Pharm Pharmacol , vol.64 , Issue.9 , pp. 1217-1235
    • Ungaro, F.1    D'Angelo, I.2    Miro, A.3
  • 58
    • 84893738574 scopus 로고    scopus 로고
    • The bronchiectasis severity index. An international derivation and validation study
    • Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med 2014; 189 (5): 576-85
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.5 , pp. 576-585
    • Chalmers, J.D.1    Goeminne, P.2    Aliberti, S.3
  • 59
    • 84896758582 scopus 로고    scopus 로고
    • Defining severity in non-cystic fibrosis bronchiectasis
    • Poppelwell L, Chalmers JD. Defining severity in non-cystic fibrosis bronchiectasis. Exp Rev Respir Med 2014; 8 (2): 249-62
    • (2014) Exp Rev Respir Med , vol.8 , Issue.2 , pp. 249-262
    • Poppelwell, L.1    Chalmers, J.D.2
  • 60
    • 84901045169 scopus 로고    scopus 로고
    • Nebulized colistin for non-cystic fibrosis bronchiectasis: Deja vu all over again?
    • Metersky ML, ODonnell AE. Nebulized colistin for non-cystic fibrosis bronchiectasis: deja vu all over again? Am J Respir Crit Care Med 2014; 189 (10): 1151-2
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.10 , pp. 1151-1152
    • Metersky, M.L.1    O'Donnell, A.E.2
  • 61
    • 84879417221 scopus 로고    scopus 로고
    • Research priorities in bronchiectasis
    • De Soyza A, Brown JS, Loebinger MR. Research priorities in bronchiectasis. Thorax 2013; 68 (7): 695-6
    • (2013) Thorax , vol.68 , Issue.7 , pp. 695-696
    • De Soyza, A.1    Brown, J.S.2    Loebinger, M.R.3
  • 62
    • 1642329318 scopus 로고    scopus 로고
    • Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care
    • Fried LP, Ferrucci L, Darer J, et al. Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care. J Gerontol A Biol Sci Med Sci 2004; 59 (3): M255-M63
    • (2004) J Gerontol A Biol Sci Med Sci , vol.59 , Issue.3 , pp. M255-M263
    • Fried, L.P.1    Ferrucci, L.2    Darer, J.3
  • 63
    • 84862523978 scopus 로고    scopus 로고
    • Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis
    • Greally P, Whitaker P, Peckham D. Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis. Curr Med Res Opin 2012; 28 (6): 1059-67
    • (2012) Curr Med Res Opin , vol.28 , Issue.6 , pp. 1059-1067
    • Greally, P.1    Whitaker, P.2    Peckham, D.3
  • 64
    • 84898730884 scopus 로고    scopus 로고
    • Inhaled antibiotics for lower airway infections
    • Quon BS, Goss CH, Ramsey BW. Inhaled antibiotics for lower airway infections. Ann Am Thorac Soc 2014; 11 (3): 425-34
    • (2014) Ann Am Thorac Soc , vol.11 , Issue.3 , pp. 425-434
    • Quon, B.S.1    Goss, C.H.2    Ramsey, B.W.3
  • 65
    • 84911956623 scopus 로고    scopus 로고
    • Inhaled versus nebulised tobramycin: A real world comparison in adult cystic fibrosis (CF)
    • Harrison MJ, McCarthy M, Fleming C, et al. Inhaled versus nebulised tobramycin: a real world comparison in adult cystic fibrosis (CF). J Cyst Fibros 2014; 13 (6): 692-8
    • (2014) J Cyst Fibros , vol.13 , Issue.6 , pp. 692-698
    • Harrison, M.J.1    McCarthy, M.2    Fleming, C.3
  • 66
    • 77955492046 scopus 로고    scopus 로고
    • Air and soul: The science and application of aerosol therapy
    • Rubin BK. Air and soul: the science and application of aerosol therapy. Respir Care 2010; 55 (7): 911-21
    • (2010) Respir Care , vol.55 , Issue.7 , pp. 911-921
    • Rubin, B.K.1
  • 67
    • 84901323518 scopus 로고    scopus 로고
    • Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa
    • Alipour M, Suntres ZE. Liposomal antibiotic formulations for targeting the lungs in the treatment of Pseudomonas aeruginosa. Ther Deliv 2014; 5 (4): 409-27
    • (2014) Ther Deliv , vol.5 , Issue.4 , pp. 409-427
    • Alipour, M.1    Suntres, Z.E.2
  • 68
    • 24144466550 scopus 로고    scopus 로고
    • Aminoglycoside antibiotics induce bacterial biofilm formation
    • Hoffman LR, DArgenio DA, MacCoss MJ, et al. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature 2005; 436 (7054): 1171-5
    • (2005) Nature , vol.436 , Issue.7054 , pp. 1171-1175
    • Hoffman, L.R.1    D'Argenio, D.A.2    MacCoss, M.J.3
  • 69
    • 84919754878 scopus 로고    scopus 로고
    • Quality of life questionnaire-bronchiectasis: Final psychometric analyses and determination of minimal important difference scores
    • Quittner AL, ODonnell AE, Salathe MA, et al. Quality of Life Questionnaire-Bronchiectasis: final psychometric analyses and determination of minimal important difference scores. Thorax 2015; 70 (1): 12-20
    • (2015) Thorax , vol.70 , Issue.1 , pp. 12-20
    • Quittner, A.L.1    O'Donnell, A.E.2    Salathe, M.A.3
  • 70
    • 84879963088 scopus 로고    scopus 로고
    • Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition
    • Rogers GB, Van Der Gast CJ, Cuthbertson L, et al. Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition. Thorax 2013; 68 (8): 731-7
    • (2013) Thorax , vol.68 , Issue.8 , pp. 731-737
    • Rogers, G.B.1    Van Der Gast, C.J.2    Cuthbertson, L.3
  • 71
    • 84903478837 scopus 로고    scopus 로고
    • A novel microbiota stratification system predicts future exacerbations in bronchiectasis
    • Rogers GB, Zain NM, Bruce KD, et al. A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Ann Am Thorac Soc 2014; 11 (4): 496-503
    • (2014) Ann Am Thorac Soc , vol.11 , Issue.4 , pp. 496-503
    • Rogers, G.B.1    Zain, N.M.2    Bruce, K.D.3
  • 72
    • 84901585708 scopus 로고    scopus 로고
    • Lung clearance index in adults with non-cystic fibrosis bronchiectasis
    • Gonem S, Scadding A, Soares M, et al. Lung clearance index in adults with non-cystic fibrosis bronchiectasis. Respir Res 2014; 15: 59
    • (2014) Respir Res , vol.15 , pp. 59
    • Gonem, S.1    Scadding, A.2    Soares, M.3
  • 73
    • 77957665989 scopus 로고    scopus 로고
    • Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand
    • Chang AB, Bell SC, Byrnes CA, et al. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. Med J Aust 2010; 193 (6): 356-65
    • (2010) Med J Aust , vol.193 , Issue.6 , pp. 356-365
    • Chang, A.B.1    Bell, S.C.2    Byrnes, C.A.3
  • 74
    • 73149096712 scopus 로고    scopus 로고
    • Qualitative analysis of high-resolution CT scans in severe asthma
    • Gupta S, Siddiqui S, Haldar P, et al. Qualitative analysis of high-resolution CT scans in severe asthma. Chest 2009; 136 (6): 1521-8
    • (2009) Chest , vol.136 , Issue.6 , pp. 1521-1528
    • Gupta, S.1    Siddiqui, S.2    Haldar, P.3
  • 75
    • 84876869179 scopus 로고    scopus 로고
    • Prognostic value of bronchiectasis in patients with moderate-To-severe chronic obstructive pulmonary disease
    • Martínez-García M-A, de la Rosa Carrillo D, Soler-Cataluña J-J, et al. Prognostic value of bronchiectasis in patients with moderate-To-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 187 (8): 823-31
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.8 , pp. 823-831
    • Martínez-García, M.-A.1    De La Rosa Carrillo, D.2    Soler-Cataluña, J.-J.3
  • 76
    • 84856735509 scopus 로고    scopus 로고
    • Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis
    • Martinez-Garcia MA, Soler-Cataluna JJ, Catalan-Serra P, et al. Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis. Chest 2012; 141 (2): 461-8
    • (2012) Chest , vol.141 , Issue.2 , pp. 461-468
    • Martinez-Garcia, M.A.1    Soler-Cataluna, J.J.2    Catalan-Serra, P.3
  • 77
    • 84930089002 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy
    • Mukker JK, Singh RSP, Derendorf H. Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy. Adv Drug Deliv Rev 2015; 85: 57-64
    • (2015) Adv Drug Deliv Rev , vol.85 , pp. 57-64
    • Mukker, J.K.1    Singh, R.S.P.2    Derendorf, H.3
  • 78
    • 84930084815 scopus 로고    scopus 로고
    • Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead
    • Velkov T, Abdul Rahim N, Zhou Q, et al. Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. Adv Drug Deliv Rev 2015; 85: 65-82
    • (2015) Adv Drug Deliv Rev , vol.85 , pp. 65-82
    • Velkov, T.1    Abdul Rahim, N.2    Zhou, Q.3
  • 79
    • 84930082170 scopus 로고    scopus 로고
    • Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models
    • Hittinger M, Juntke J, Kletting S, et al. Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models. Adv Drug Deliv Rev 2016; 85: 44-56
    • (2016) Adv Drug Deliv Rev , vol.85 , pp. 44-56
    • Hittinger, M.1    Juntke, J.2    Kletting, S.3
  • 80
    • 77957358644 scopus 로고    scopus 로고
    • Efficacy of the combination of tobramycin and a macrolide in an in vitro Pseudomonas aeruginosa mature biofilm model
    • Tre-Hardy M, Nagant C, El Manssouri N, et al. Efficacy of the combination of tobramycin and a macrolide in an in vitro Pseudomonas aeruginosa mature biofilm model. Antimicrob Agents Chemother 2010; 54 (10): 4409-15
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.10 , pp. 4409-4415
    • Tre-Hardy, M.1    Nagant, C.2    El Manssouri, N.3
  • 81
    • 84915751674 scopus 로고    scopus 로고
    • Efficacy of ciprofloxacin-clarithromycin combination against drug-resistant Pseudomonas aeruginosa mature biofilm using in vitro experimental model
    • Elkhatib W, Noreddin A. Efficacy of ciprofloxacin-clarithromycin combination against drug-resistant Pseudomonas aeruginosa mature biofilm using in vitro experimental model. Microb Drug Resist 2014; 20 (6): 575-82
    • (2014) Microb Drug Resist , vol.20 , Issue.6 , pp. 575-582
    • Elkhatib, W.1    Noreddin, A.2
  • 82
    • 84873722026 scopus 로고    scopus 로고
    • Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation
    • Lee SH, Teo J, Heng D, et al. Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. Eur J Pharm Biopharm 2013; 83 (2): 275-84
    • (2013) Eur J Pharm Biopharm , vol.83 , Issue.2 , pp. 275-284
    • Lee, S.H.1    Teo, J.2    Heng, D.3
  • 83
    • 0028674265 scopus 로고
    • Nebulizer therapy with antibiotics in chronic suppurative lung disease
    • El-Din MA, Palmer LB, el-Tayeb MN, et al. Nebulizer therapy with antibiotics in chronic suppurative lung disease. J Aerosol Med 1994; 7 (4): 345-50
    • (1994) J Aerosol Med , vol.7 , Issue.4 , pp. 345-350
    • El-Din, M.A.1    Palmer, L.B.2    El-Tayeb, M.N.3
  • 84
    • 84857784969 scopus 로고    scopus 로고
    • Dry powder inhalers of gentamicin and leucine: Formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells
    • Aquino RP, Prota L, Auriemma G, et al. Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells. Int J Pharm 2012; 426 (1-2): 100-7
    • (2012) Int J Pharm , vol.426 , Issue.12 , pp. 100-107
    • Aquino, R.P.1    Prota, L.2    Auriemma, G.3
  • 85
    • 81255137213 scopus 로고    scopus 로고
    • Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: Modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers
    • Ungaro F, dAngelo I, Coletta C, et al. Dry powders based on PLGA nanoparticles for pulmonary delivery of antibiotics: modulation of encapsulation efficiency, release rate and lung deposition pattern by hydrophilic polymers. J Control Release 2012; 157 (1): 149-59
    • (2012) J Control Release , vol.157 , Issue.1 , pp. 149-159
    • Ungaro, F.1    D'Angelo, I.2    Coletta, C.3
  • 86
    • 0030048689 scopus 로고    scopus 로고
    • Eradication of mucoid Pseudomonas aeruginosa with fluid liposome-encapsulated tobramycin in an animal model of chronic pulmonary infection
    • Beaulac C, Clément-Major S, Hawari J, et al. Eradication of mucoid Pseudomonas aeruginosa with fluid liposome-encapsulated tobramycin in an animal model of chronic pulmonary infection. Antimicrob Agents Chemother 1996; 40 (3): 665-9
    • (1996) Antimicrob Agents Chemother , vol.40 , Issue.3 , pp. 665-669
    • Beaulac, C.1    Clément-Major, S.2    Hawari, J.3
  • 87
    • 0032821015 scopus 로고    scopus 로고
    • Aerosolization of low phase transition temperature liposomal tobramycin as a dry powder in an animal model of chronic pulmonary infection caused by Pseudomonas aeruginosa
    • Beaulac C, Sachetelli S, Lagace J. Aerosolization of low phase transition temperature liposomal tobramycin as a dry powder in an animal model of chronic pulmonary infection caused by Pseudomonas aeruginosa. J Drug Target 1999; 7 (1): 33-41
    • (1999) J Drug Target , vol.7 , Issue.1 , pp. 33-41
    • Beaulac, C.1    Sachetelli, S.2    Lagace, J.3
  • 88
    • 84877855980 scopus 로고    scopus 로고
    • Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors
    • Alhajlan M, Alhariri M, Omri A. Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors. Antimicrob Agents Chemother 2013; 57 (6): 2694-704
    • (2013) Antimicrob Agents Chemother , vol.57 , Issue.6 , pp. 2694-2704
    • Alhajlan, M.1    Alhariri, M.2    Omri, A.3
  • 89
    • 77954309361 scopus 로고    scopus 로고
    • High azithromycin loading powders for inhalation and their in vivo evaluation in rats
    • Zhang Y, Wang X, Lin X, et al. High azithromycin loading powders for inhalation and their in vivo evaluation in rats. Int J Pharm 2010; 395 (1-2): 205-14
    • (2010) Int J Pharm , vol.395 , Issue.12 , pp. 205-214
    • Zhang, Y.1    Wang, X.2    Lin, X.3
  • 90
    • 77953021975 scopus 로고    scopus 로고
    • Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease
    • Adi H, Young PM, Chan H-K, et al. Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. Eur J Pharm Sci 2010; 40 (3): 239-47
    • (2010) Eur J Pharm Sci , vol.40 , Issue.3 , pp. 239-247
    • Adi, H.1    Young, P.M.2    Chan, H.-K.3
  • 91
    • 34547154815 scopus 로고    scopus 로고
    • NanoCipro encapsulation in monodisperse large porous PLGA microparticles
    • Arnold MM, Gorman EM, Schieber LJ, et al. NanoCipro encapsulation in monodisperse large porous PLGA microparticles. J Control Release 2007; 121 (1-2): 100-9
    • (2007) J Control Release , vol.121 , Issue.12 , pp. 100-109
    • Arnold, M.M.1    Gorman, E.M.2    Schieber, L.J.3
  • 92
    • 84872118822 scopus 로고    scopus 로고
    • Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia
    • Ong HX, Traini D, Cipolla D, et al. Liposomal nanoparticles control the uptake of ciprofloxacin across respiratory epithelia. Pharm Res 2012; 29 (12): 3335-46
    • (2012) Pharm Res , vol.29 , Issue.12 , pp. 3335-3346
    • Ong, H.X.1    Traini, D.2    Cipolla, D.3
  • 93
    • 84910068151 scopus 로고    scopus 로고
    • Sodium colistimethate loaded lipid nanocarriers for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis
    • Pastor M, Moreno-Sastre M, Esquisabel A, et al. Sodium colistimethate loaded lipid nanocarriers for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm 2014; 477: 485-94
    • (2014) Int J Pharm , vol.477 , pp. 485-494
    • Pastor, M.1    Moreno-Sastre, M.2    Esquisabel, A.3
  • 94
    • 52449086630 scopus 로고    scopus 로고
    • Cospray dried antibiotics for dry powder lung delivery
    • Adi H, Young PM, Chan HK, et al. Cospray dried antibiotics for dry powder lung delivery. J Pharm Sci 2008; 97 (8): 3356-66
    • (2008) J Pharm Sci , vol.97 , Issue.8 , pp. 3356-3366
    • Adi, H.1    Young, P.M.2    Chan, H.K.3
  • 95
    • 74949121129 scopus 로고    scopus 로고
    • Controlled release antibiotics for dry powder lung delivery
    • Adi H, Young PM, Chan HK, et al. Controlled release antibiotics for dry powder lung delivery. Drug Dev Ind Pharm 2010; 36 (1): 119-26
    • (2010) Drug Dev Ind Pharm , vol.36 , Issue.1 , pp. 119-126
    • Adi, H.1    Young, P.M.2    Chan, H.K.3
  • 96
    • 84922585037 scopus 로고    scopus 로고
    • A novel inhaled multi-pronged attack against respiratory Bacteria
    • Lee SH, Teo J, Heng D, et al. A novel inhaled multi-pronged attack against respiratory Bacteria. Eur J Pharm Sci 2015; 70: 37-44
    • (2015) Eur J Pharm Sci , vol.70 , pp. 37-44
    • Lee, S.H.1    Teo, J.2    Heng, D.3
  • 97
    • 84884124961 scopus 로고    scopus 로고
    • Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols
    • Park CW, Li X, Vogt FG, et al. Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols. Int J Pharm 2013; 455 (1-2): 374-92
    • (2013) Int J Pharm , vol.455 , Issue.12 , pp. 374-392
    • Park, C.W.1    Li, X.2    Vogt, F.G.3
  • 98
    • 84877920804 scopus 로고    scopus 로고
    • New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients
    • Pilcer G, Rosiere R, Traina K, et al. New co-spray-dried tobramycin nanoparticles-clarithromycin inhaled powder systems for lung infection therapy in cystic fibrosis patients. J Pharm Sci 2013; 102 (6): 1836-46
    • (2013) J Pharm Sci , vol.102 , Issue.6 , pp. 1836-1846
    • Pilcer, G.1    Rosiere, R.2    Traina, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.