Lung clearance index in adults with non-cystic fibrosis bronchiectasis

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Gonem, Sherif ^a,e   Scadding, Alys ^a   Soares, Marcia ^a   Singapuri, Amisha ^a   Gustafsson, Per ^b   Ohri, Chandra ^a   Range, Simon ^a   Brightling, Christopher E ^a   Pavord, Ian ^a   Horsley, Alex ^c,d   Siddiqui, Salman ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b CENTRAL HOSPITAL   (Sweden)

^c Pulmonary Research and Treatment Center   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

Bronchiectasis; Lung clearance index; Ventilation heterogeneity

Indexed keywords

INERT GAS; SULFUR HEXAFLUORIDE;

ADULT; AGED; AIRWAY OBSTRUCTION; ARTICLE; BRONCHIECTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYSTIC FIBROSIS; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG CLEARANCE; LUNG CLEARANCE INDEX; LUNG DEAD SPACE; LUNG MODEL; LUNG VENTILATION DISTRIBUTION; MALE; NON CYSTIC FIBROSIS BRONCHIECTASIS; SPIROMETRY; CELL CULTURE; LUNG; LUNG VENTILATION; METABOLISM; MIDDLE AGED; MUCOCILIARY CLEARANCE; PATHOLOGY; PHYSIOLOGY; YOUNG ADULT;

ADULT; AGED; BRONCHIECTASIS; CELLS, CULTURED; CYSTIC FIBROSIS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MUCOCILIARY CLEARANCE; PULMONARY VENTILATION; YOUNG ADULT;

EID: 84901585708     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-15-59     Document Type: Article

References (27)

1. Seitz AE, Olivier KN, Adjemian J, Holland SM, Prevots R. Trends in bronchiectasis among medicare beneficiaries in the United States, 2000 to 2007. Chest 2012, 142(2):432-439. 3425339, 22302301.
2. Weycker D, Edelsberg J, Oster G, Tino G. Prevalence and economic burden of bronchiectasis. Clin Pulm Med 2005, 12(4):205-209.
3. McShane PJ, Naureckas ET, Tino G, Strek ME. Non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2013, 188(6):647-656. 10.1164/rccm.201303-0411CI, 23898922.
4. De Soyza A, Brown JS, Loebinger MR, . Bronchiectasis Research & Academic Network Research priorities in bronchiectasis. Thorax 2013, 68(7):695-696. 10.1136/thoraxjnl-2012-202893, 23242949, Bronchiectasis Research & Academic Network.
5. Robinson PD, Goldman MD, Gustafsson PM. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 2009, 78(3):339-355. 10.1159/000225373, 19521061.
6. Verbanck S, Schuermans D, Noppen M, Van Muylem A, Paiva M, Vincken W. Evidence of acinar airway involvement in asthma. Am J Respir Crit Care Med 1999, 159(5 Pt 1):1545-1550.
7. Horsley AR, Gustafsson PM, Macleod KA, Saunders C, Greening AP, Porteous DJ, Davies JC, Cunningham S, Alton EW, Innes JA. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax 2008, 63(2):135-140.
8. Robinson P, Latzin P, Verbanck S, Hall GL, Horsley A, Gappa M, Thamrin C, Arets HG, Aurora P, Fuchs S, King GG, Lum S, Macleod K, Paiva M, Pillow J, Ranganathan S, Ratjen F, Singer F, Sonnappa S, Stocks J, Subbarao P, Thompson B, Gustafsson PM. Consensus statement for inert gas washout measurement using multiple and single breath tests. Eur Respir J 2013, 41(3):507-522. 10.1183/09031936.00069712, 23397305.
9. Bouhuys A, Lichtneckert S, Lundgren C, Lundin G. Voluntary changes in breathing pattern and N2 clearance from lungs. J Appl Physiol 1961, 16(6):1039-1042.
10. Horsley A. Lung clearance index in the assessment of airways disease. Resp Med 2009, 103(6):793-799.
11. Amin R, Subbarao P, Jabar A, Balkovec S, Jensen R, Kerrigan S, Gustafsson P, Ratjen F. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax 2010, 65(5):379-383. 10.1136/thx.2009.125831, 20435858.
12. Amin R, Subbarao P, Lou W, Jabar A, Balkovec S, Jensen R, Kerrigan S, Gustafsson P, Ratjen F. The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis. Eur Respir J 2011, 37(4):806-812. 10.1183/09031936.00072510, 20693248.
13. Horsley AR, Davies JC, Gray RD, Macleod KA, Donovan J, Aziz ZA, Bell NJ, Rainer M, Mt-Isa S, Voase N, Dewar MH, Saunders C, Gibson JS, Parra-Leiton J, Larsen MD, Jeswiet S, Soussi S, Bakar Y, Meister MG, Tyler P, Doherty A, Hansell DM, Ashby D, Hyde SC, Gill DR, Greening AP, Porteous DJ, Innes JA, Boyd AC, Griesenbach U, et al. Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax 2013, 68(6):532-539. 10.1136/thoraxjnl-2012-202538, 23396354.
14. Rowan SA, Bradley JM, Bradbury I, Lawson J, Lynch T, Gustafsson P, Horsley A, O'Neill K, Ennis M, Elborn JS. Lung clearance index is a repeatable and sensitive indicator of radiological changes in bronchiectasis. Am J Respir Crit Care Med 2014, 189(5):586-592. 10.1164/rccm.201310-1747OC, 24428575.
15. Verbanck S, Paiva M, Schuermans D, Hanon S, Vincken W, Van Muylem A. Relationships between the lung clearance index and conductive and acinar ventilation heterogeneity. J Appl Physiol 2012, 112(5):782-790. 10.1152/japplphysiol.01221.2011, 22162528.
16. Verbanck S, Schuermans D, van Muylem A, Noppen M, Paiva M, Vincken W. Ventilation distribution during histamine provocation. J Appl Physiol 1997, 83(6):1907-1916.
17. Crawford AB, Makowska M, Paiva M, Engel LA. Convection- and diffusion-dependent ventilation maldistribution in normal subjects. J Appl Physiol 1985, 59(3):838-846.
18. Horsley AR, Macleod KA, Robson AG, Lenney J, Bell NJ, Cunningham S, Greening AP, Gustafsson PM, Innes JA. Effects of cystic fibrosis lung disease on gas mixing indices derived from alveolar slope analysis. Respir Physiol Neurobiol 2008, 162(3):197-203. 10.1016/j.resp.2008.06.014, 18625345.
19. Verbanck S, Paiva M, Schuermans D, Malfroot A, Vincken W, Vanderhelst E. Acinar and conductive ventilation heterogeneity in severe CF lung disease: back to the model. Respir Physiol Neurobiol 2013, 188(2):124-132. 10.1016/j.resp.2013.05.011, 23692927.
20. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, . ATS/ERS Task Force Standardisation of spirometry. Eur Respir J 2005, 26(2):319-338. 10.1183/09031936.05.00034805, 16055882, ATS/ERS Task Force.
21. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G. Standardisation of the measurement of lung volumes. Eur Respir J 2005, 26(3):511-522. 10.1183/09031936.05.00035005, 16135736.
22. Darling RC, Cournand A, Richards DW. Studies on the intrapulmonary mixture of gases III. An open circuit method for measuring residual air. J Clin Invest 1940, 19(4):609-618. 10.1172/JCI101163, 434995, 16694777.
23. Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros 2003, 2(1):29-34. 10.1016/S1569-1993(02)00141-8, 15463843.
24. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 2005, 434(7034):777-782. 10.1038/nature03490, 15772676.
25. Belessis Y, Dixon B, Hawkins G, Pereira J, Peat J, MacDonald R, Field P, Numa A, Morton J, Lui K, Jaffe A. Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index. Am J Respir Crit Care Med 2012, 185(8):862-873. 10.1164/rccm.201109-1631OC, 22323305.
26. Martínez-García MA, Soler-Cataluña JJ, Perpiñá-Tordera M, Román-Sánchez P, Soriano J. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest 2007, 132(5):1565-1572. 10.1378/chest.07-0490, 17998359.
27. Verbanck S, Thompson BR, Schuermans D, Kalsi H, Biddiscombe M, Stuart-Andrews C, Hanon S, Van Muylem A, Paiva M, Vincken W, Usmani O. Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung. Thorax 2012, 67(9):789-795. 10.1136/thoraxjnl-2011-201484, 22544894.