Dry powder inhalers of gentamicin and leucine: Formulation parameters, aerosol performance and in vitro toxicity on CuFi1 cells

International Journal of Pharmaceutics

Volumn 426, Issue 1-2, 2012, Pages 100-107

  Aquino, R P ^a   Prota, L ^a   Auriemma, G ^a   Santoro, A ^a   Mencherini, T ^a   Colombo, G ^b   Russo, P ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

CF airway epithelial cells; Cystic fibrosis; Dry powder inhaler; Gentamicin sulfate; l leucine; Spray drying

Indexed keywords

2 PROPANOL; GENTAMICIN; LEUCINE; WATER;

AEROSOL; ARTICLE; BRONCHUS MUCOSA; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOTOXICITY; DRUG FORMULATION; DRUG STORAGE; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MORPHOLOGY; MUTANT; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL; SPRAY DRYING; WATER TRANSPORT;

2-PROPANOL; ADMINISTRATION, INHALATION; AEROSOLS; ANTI-BACTERIAL AGENTS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; DRUG STABILITY; DRY POWDER INHALERS; EXCIPIENTS; GENTAMICINS; HUMANS; LEUCINE; MUTATION; PARTICLE SIZE; POWDERS; RESPIRATORY MUCOSA; RISK ASSESSMENT; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; WATER;

EID: 84857784969     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.01.026     Document Type: Article

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