MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 12, 2015, Pages 2793-2805

  Li, Jiefang ^a   Wang, Qinrong ^a   Wen, Ruiling ^a   Liang, Jieman ^a   Zhong, Xiaoling ^a   Yang, Wei ^a   Su, Dongxiang ^a   Tang, Jun ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

EMT; GIT1; MiRNA; Non small cell lung cancer; Proliferation; SEMA4C

Indexed keywords

MICRORNA; MICRORNA 138; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CELL CYCLE PROTEIN; GIT1 PROTEIN, HUMAN; MIRN138 MICRORNA, HUMAN; SEMA4C PROTEIN, HUMAN; SEMAPHORIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ARTICLE; CELL CYCLE ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LUCIFERASE ASSAY; MTT ASSAY; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURVIVAL RATE; WOUND HEALING; 3' UNTRANSLATED REGION; BINDING SITE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; MICROSCOPY, FLUORESCENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEMAPHORINS;

EID: 84955206061     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12666     Document Type: Article

References (33)

1. van Zandwijk N, Fong KM. Update in lung cancer: prologue to a modern review series. Respirology. 2015; 20: 183-4.
2. Stinchcombe TE. Recent advances in the treatment of non-small cell and small cell lung cancer. F1000Prime Rep. 2014; 6: 117.
3. O'Dowd EL, Baldwin DR. Early diagnosis pivotal to survival in lung cancer. Practitioner. 2014; 258: 21-4.
4. Zhao Q, Ping LI, Junrong MA, et al. MicroRNAs in lung cancer and lung cancer bone metastases: biomarkers for early diagnosis and targets for treatment. Recent Pat Anticancer Drug Discov. 2015; 10: 182-200.
5. Wang H, Wu S, Zhao L, et al. Clinical use of microRNAs as potential non-invasive biomarkers for detecting non-small cell lung cancer: a meta-analysis. Respirology. 2015; 20: 56-65.
6. Sharma SP. New therapeutic target for non-small-cell lung cancer. Lancet Oncol. 2014; 15: e533.
7. Yuan X, Wu H, Han N, et al. Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application. J Hematol Oncol. 2014; 7: 87.
8. Liu X, Wang C, Chen Z, et al. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J. 2011; 440: 23-31.
9. Yang Q, Wang Y, Lu X, et al. MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells. Oncotarget. 2014; 6: 3268-79.
10. Yuan H, Kajiyama H, Ito S, et al. ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells. Cancer Res. 2013; 73: 1581-90.
11. Zeng R, Han M, Luo Y, et al. Role of Sema4C in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. Nephrol Dial Transplant. 2011; 26: 1149-56.
12. Xu C, Zheng Y, Lian D, et al. Analysis of MicroRNA expression profile identifies novel biomarkers for non-small cell lung cancer. Tumori. 2015; 101:104-10.
13. Vrijens K, Bollati V, Nawrot TS. MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect. 2015; 123: 399-411.
14. Qin X, Xu H, Gong W, et al. The tumor cytosol miRNAs, fluid miRNAs, and exosome miRNAs in lung cancer. Front Oncol. 2014; 4: 357.
15. Fortunato O, Boeri M, Verri C, et al. Therapeutic use of microRNAs in lung cancer. Biomed Res Int. 2014; 2014: 756975.
16. Zhang H, Zhang H, Zhao M, et al. MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer. Cell Physiol Biochem. 2013; 31: 56-65.
17. Yeh YM, Chuang CM, Chao KC, et al. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1alpha. Int J Cancer. 2013; 133: 867-78.
18. Wang W, Zhao LJ, Tan YX, et al. MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. Carcinogenesis. 2012; 33: 1113-20.
19. Ye XW, Yu H, Jin YK, et al. miR-138 inhibits proliferation by targeting 3-phosphoinositide-dependent protein kinase-1 in non-small cell lung cancer cells. Clin Respir J. 2015; 9: 27-33.
20. Liu X, Lv XB, Wang XP, et al. MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle. 2012; 11: 2495-506.
21. Chan SH, Wang LH. Regulation of cancer metastasis by microRNAs. J Biomed Sci. 2015; 22: 9.
22. Tafsiri E, Darbouy M, Shadmehr MB, et al. Expression of miRNAs in non-small-cell lung carcinomas and their association with clinicopathological features. Tumour Biol. 2014; 36: 1603-12.
23. Yingjie L, Jian T, Changhai Y, et al. Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell. Tumour Biol. 2013; 34: 2773-80.
24. Tan M, Song X, Zhang G, et al. Overexpression of adenylate cyclase-associated protein 1 is associated with metastasis of lung cancer. Oncol Rep. 2013; 30: 1639-44.
25. Jin Y, Chen D, Cabay RJ, et al. Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma. Int Rev Cell Mol Biol. 2013; 303: 357-85.
26. Peng H, Dara L, Li TW, et al. MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. Hepatology. 2013; 57: 2299-313.
27. Chan SH, Huang WC, Chang JW, et al. MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis. Oncogene. 2014; 33: 4496-507.
28. Zhang N, Cai W, Yin G, et al. GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions. Cell Biol Int. 2010; 34: 41-7.
29. Schmalzigaug R, Garron ML, Roseman JT, et al. GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Cell Signal. 2007; 19: 1733-44.
30. Manabe R, Kovalenko M, Webb DJ, et al. GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. J Cell Sci. 2002; 115: 1497-510.
31. Huang WC, Chan SH, Jang TH, et al. miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. Cancer Res. 2014; 74: 751-64.
32. Zhou QD, Ning Y, Zeng R, et al. Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells. J Huazhong Univ Sci Technolog Med Sci. 2013; 33: 672-9.
33. Wu H, Wang X, Liu S, et al. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. Eur J Cell Biol. 2007; 86: 331-44.