Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration

Journal of Tissue Engineering and Regenerative Medicine

Volumn 9, Issue 12, 2015, Pages E219-E228

  Kim, Sung Eun ^a   Yun, Young Pil ^a   Lee, Jae Yong ^a   Shim, June Sung ^b   Park, Kyeongsoon ^c   Huh, Jung Bo ^b,d  

^a Korea University College of Medicine   (South Korea)

^b Yonsei University College of Dentistry   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

BMP 2; Bone regeneration; Osteoblast; Osteointegration; PDGF BB; Titanium implant

Indexed keywords

BONE; METAL IMPLANTS; TITANIUM;

BMP-2; BONE REGENERATION; CO DELIVERIES; GROWTH FACTOR; OSTEOBLAST FUNCTION; OSTEOINTEGRATION; PDGF BB'S; TITANIA; TITANIUM IMPLANTS; TITANIUM SUBSTRATES;

OSTEOBLASTS;

ALKALINE PHOSPHATASE; CALCIUM; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; TITANIUM; BECAPLERMIN; BIOCOMPATIBLE COATED MATERIAL; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; HEPARIN; PLATELET DERIVED GROWTH FACTOR B;

ARTICLE; BONE DEVELOPMENT; CALCIUM METABOLISM; CELL FUNCTION; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; GENE EXPRESSION; HEPARINIZATION; IN VITRO STUDY; OSTEOBLAST; OSTEOCALCIN GENE; OSTEOINTEGRATION; OSTEOPONTIN GENE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; X RAY PHOTOELECTRON SPECTROSCOPY; BONE MINERALIZATION; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HUMAN; METABOLISM;

BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELL LINE; COATED MATERIALS, BIOCOMPATIBLE; HEPARIN; HUMANS; OSTEOBLASTS; PROTO-ONCOGENE PROTEINS C-SIS; TITANIUM;

EID: 84955188328     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.1668     Document Type: Article

References (40)

1. Andrew JG, Hoyland JA, Freemont AJ, et al. 1995; Platelet-derived growth factor expression in normally healing human fractures. Bone 16(4): 455-460.
2. Becker W, Becker BE, Handelsman M, et al. 1991; Guided tissue regeneration for implants placed into extraction sockets: a study in dogs. J Periodontol 62(11): 703-709.
3. Bolander ME. 1992; Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med 200(2): 165-170.
4. Centrella M, McCarthy TL, Kusmik WF, et al. 1991; Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet-derived growth factor in osteoblast-enriched cultures from fetal rat bone. J Cell Physiol 147(3): 420-426.
5. Choo T, Marino V, Mark Bartold P. 2011; Effect of PDGF-BB and β-tricalcium phosphate (β-TCP) on bone formation around dental implants: a pilot study in sheep. Clin Oral Implants Res. DOI: 10.1111/j.1600-0501.2011.02345.x
6. Chua PH, Neoh KG, Kang ET, et al. 2008; Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion. Biomaterials 29(10): 1412-1421.
7. Cook SD, Wolfe MW, Salkeld SL, et al. 1995; Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg Am 77(5): 734-750.
8. Fan X, Lin L, Dalsin JL, et al. 2005; Biomimetic anchor for surface-initiated polymerization from metal substrates. J Am Chem Soc 127(45): 15843-15847.
9. Govender S, Csimma C, Genant HK, et al. 2002; Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 84A(12): 2123-2134.
10. Ho YC, Mi FL, Sung HW, et al. 2009; Heparin-functionalized chitosan-alginate scaffolds for controlled release of growth factor. Int J Pharm 376(1-2): 69-75.
11. Hochart H, Jenkins PV, Smith OP, et al. 2006; Low-molecular weight and unfractionated heparins induce a downregulation of inflammation: decreased levels of proinflammatory cytokines and nuclear factor-κB in LPS-stimulated human monocytes. Br J Haematol 133(1): 62-67.
12. Huh JB, Lee JY, Lee KL, et al. 2011; Effects of the immobilization of heparin and rhPDGF-BB to titanium surfaces for the enhancement of osteoblastic functions and anti-inflammation. J Adv Prosthodont 3(3): 152-160.
13. Ishibe T, Goto T, Kodama T, et al. 2009; Bone formation on apatite-coated titanium with incorporated BMP-2/heparin in vivo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(6): 867-875.
14. Karageorgiou V, Meinel L, Hofmann S, et al. 2004; Bone morphogenetic protein-2 decorated silk fibroin films induce osteogenic differentiation of human bone marrow stromal cells. J Biomed Mater Res A 71(3): 528-537.
15. Kim J, Kim IS, Cho TH, et al. 2007; Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 28(10): 1830-1837.
16. Kim SE, Jeon O, Lee JB, et al. 2008; Enhancement of ectopic bone formation by bone morphogenetic protein-2 delivery using heparin-conjugated PLGA nanoparticles with transplantation of bone marrow-derived mesenchymal stem cells. J Biomed Sci 15(6): 771-777.
17. Kim SE, Song SH, Yun YP, et al. 2011; The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function. Biomaterials 32(2): 366-373.
18. King GN, King N, Cruchley AT, et al. 1997; Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 76(8): 1460-1470.
19. Lee H, Dellatore SM, Miller WM, et al. 2007; Mussel-inspired surface chemistry for multifunctional coatings. Science 318(5849): 426-430.
20. Lee H, Scherer NF, Messersmith PB. 2006a; Single-molecule mechanics of mussel adhesion. Proc Natl Acad Sci USA 103(35): 12999-13003.
21. Lee TC, Ho JT, Hung KS, et al. 2006b; Bone morphogenetic protein gene therapy using a fibrin scaffold for a rabbit spinal-fusion experiment. Neurosurgery 58(2): 373-380; discussion, 373-380.
22. Lynch SE, Buser D, Hernandez RA, et al. 1991; Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs. J Periodontol 62(11): 710-716.
23. Merli M, Migani M, Bernardelli F, et al. 2006; Vertical bone augmentation with dental implant placement: efficacy and complications associated with two different techniques. A retrospective cohort study. Int J Oral Maxillofac Implants 21(4): 600-606.
24. Mitlak BH, Finkelman RD, Hill EL, et al. 1996; The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 11(2): 238-247.
25. Nash TJ, Howlett CR, Martin C, et al. 1994; Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 15(2): 203-208.
26. Nociti Jr. FH, Stefani CM, Machado MA, et al. 2000; Histometric evaluation of bone regeneration around immediate implants partially in contact with bone: a pilot study in dogs. Implant Dent 9(4): 321-328.
27. Owen TA, Aronow M, Shalhoub V, et al. 1990; Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143(3): 420-430.
28. Park JS, Park K, Woo DG, et al. 2008a; Triple constructs consisting of nanoparticles and microspheres for bone-marrow-derived stromal cell-delivery microscaffolds. Small 4(11): 1950-1955.
29. Park JS, Park K, Woo DG, et al. 2008b; PLGA microsphere construct coated with TGF-β3 loaded nanoparticles for neocartilage formation. Biomacromolecules 9(8): 2162-2169.
30. Park YJ, Kim KH, Lee JY, et al. 2006; Immobilization of bone morphogenetic protein-2 on a nanofibrous chitosan membrane for enhanced guided bone regeneration. Biotechnol Appl Biochem 43(1): 17-24.
31. Ponader S, von Wilmowsky C, Widenmayer M, et al. 2010; In vivo performance of selective electron beam-melted Ti-6Al-4V structures. J Biomed Mater Res A 92(1): 56-62.
32. Retzepi M, Lewis MP, Donos N. 2010; Effect of diabetes and metabolic control on de novo bone formation following guided bone regeneration. Clin Oral Implants Res 21(1): 71-79.
33. Sasisekharan R, Ernst S, Venkataraman G. 1997; On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis 1(1): 45-54.
34. Shi Z, Neoh KG, Kang ET, et al. 2009; Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions. Tissue Eng Part A 15(2): 417-426.
35. Stefani CM, Machado MA, Sallum EA, et al. 2000; Platelet-derived growth factorinsulin-like growth factor-1 combination and bone regeneration around implants placed into extraction sockets: a histometric study in dogs. Implant Dent 9(2): 126-131.
36. 2 nanotubes: an experimental study in the pig. J Biomed Mater Res B Appl Biomater 89(1): 165-171.
37. Wang EA, Rosen V, D'Alessandro JS, et al. 1990; Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 87(6): 2220-2224.
38. Zellin G, Linde A. 1997; Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes. An experimental study using rhBMP-2 in rat mandibular defects. J Biomed Mater Res 35(2): 181-190.
39. Zhang L, Leeman E, Carnes DC, et al. 1991; Human osteoblasts synthesize and respond to platelet-derived growth factor. Am J Physiol 261(2, pt 1): C348-354.
40. Zhao B, Katagiri T, Toyoda H, et al. 2006; Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenic-2. J Biol Chem 281(32): 23246-23253.