Effects of the immobilization of heparin and rhPDGF-BB to titanium surfaces for the enhancement of osteoblastic functions and anti-inflammation

Journal of Advanced Prosthodontics

Volumn 3, Issue 3, 2011, Pages 152-160

  Huh, Jung Bo ^a   Lee, Jeong Yol ^b   Lee, Kyung Lae ^b   Kim, Sung Eun ^b   Yun, Mi Jung ^a   Shim, Ji Suk ^b   Shim, June Sung ^c   Shin, Sang Wan ^b  

^a Pusan National University   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Yonsei University College of Dentistry   (South Korea)

Author keywords

Anti inflammation; Heparin; Osteoblastic function; RhPDGF BB; Titanium

Indexed keywords

EID: 84883165789     PISSN: 20057806     EISSN: 20057814     Source Type: Journal    
DOI: 10.4047/jap.2011.3.3.152     Document Type: Article

References (30)

1. Rezania A, Healy KE. The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells. J Biomed Mater Res 2000;52:595-600.
2. Bab I, Chorev M. Osteogenic growth peptide: from concept to drug design. Biopolymers 2002;66:33-48.
3. Giannobile WV. Periodontal tissue engineering by growth factors. Bone 1996;19:23S-37S.
4. Park YJ, Ku Y, Chung CP, Lee SJ. Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration. J Control Release 1998;51:201-11.
5. Camelo M, Nevins ML, Schenk RK, Lynch SE, Nevins M. Periodontal regeneration in human Class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft. Int J Periodontics Restorative Dent 2003;23:213-25.
6. Nevins ML, Camelo M, Lynch SE, Schenk RK, Nevins M. Evaluation of periodontal regeneration following grafting intrabony defects with bio-oss collagen: a human histologic report. Int J Periodontics Restorative Dent 2003;23:9-17.
7. Nevins M, Camelo M, Nevins ML, Schenk RK, Lynch SE. Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. J Periodontol 2003;74:1282-92.
8. Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, McAllister BS, Murphy KS, McClain PK, Nevins ML, Paquette DW, Han TJ, Reddy MS, Lavin PT, Genco RJ, Lynch SE. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol 2005;76:2205-15.
9. Lynch SE, de Castilla GR, Williams RC, Kiritsy CP, Howell TH, Reddy MS, Antoniades HN. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. J Periodontol 1991;62:458-67.
10. Lynch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, Antoniades HN. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 1989;16:545-8.
11. Bolander ME. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med 1992;200:165-70.
12. Andrew JG, Hoyland JA, Freemont AJ, Marsh DR. Platelet-derived growth factor expression in normally healing human fractures. Bone 1995;16:455-60.
13. Fujii H, Kitazawa R, Maeda S, Mizuno K, Kitazawa S. Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse. Histochem Cell Biol 1999;112:131-8.
14. Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15:203-8.
15. Mitlak BH, Finkelman RD, Hill EL, Li J, Martin B, Smith T, D'Andrea M, Antoniades HN, Lynch SE. The effect of systemically administered PDGF-BB on the rodent skeleton. J Bone Miner Res 1996;11:238-47.
16. Sasisekharan R, Ernst S, Venkataraman G. On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis 1997;1:45-54.
17. Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A 2003;65:489-97.
18. Ishibe T, Goto T, Kodama T, Miyazaki T, Kobayashi S, Takahashi T. Bone formation on apatite-coated titanium with incorporated BMP-2/heparin in vivo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:867-75.
19. Young E. The anti-inflammatory effects of heparin and related compounds. Thromb Res 2008;122:743-52.
20. von Walter M, Herren C, Gensior TJ, Steffens GC, Hermanns-Sachweh B, Jahnen-Dechent W, Rüger M, Erli HJ. Biomimetic modification of the TiO2/glass composite Ecopore with heparinized collagen and the osteoinductive factor BMP-2. Acta Biomater 2008;4:997-1004.
21. Kodama T, Goto T, Miyazaki T, Takahashi T. Bone formation on apatite-coated titanium incorporated with bone morphogenetic protein and heparin. Int J Oral Maxillofac Implants 2008;23:1013-9.
22. Kim SE, Song SH, Yun YP, Choi BJ, Kwon IK, Bae MS, Moon HJ, Kwon YD. The effect of immobilization of heparin and bone morphogenic protein-2 (BMP-2) to titanium surfaces on inflammation and osteoblast function. Biomaterials 2011;32:366-73.
23. Clark AE, Hench LL, Paschall HA. The influence of surface chemistry on implant interface histology: a theoretical basis for implant materials selection. J Biomed Mater Res 1976;10:161-74.
24. Puleo DA, Nanci A. Understanding and controlling the bone-implant interface. Biomaterials 1999;20:2311-21.
25. De Giglio E, Sabbatini L, Colucci S, Zambonin G. Synthesis, analytical characterization, and osteoblast adhesion properties on RGD-grafted polypyrrole coatings on titanium substrates. J Biomater Sci Polym Ed 2000;11:1073-83.
26. Tosatti S, De Paul SM, Askendal A, Vande Vondele S, Hubbell JA, Tengvall P, Textor M. Peptide functionalized poly(L-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma. Biomaterials 2003; 24:4949-58.
27. Damsky CH. Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling. Bone 1999;25:95-6.
28. Turksen K, Bhargava U, Moe HK, Aubin JE. Isolation of monoclonal antibodies recognizing rat bone-associated molecules in vitro and in vivo. J Histochem Cytochem 1992;40:1339-52.
29. van den Beucken JJ, Walboomers XF, Boerman OC, Vos MR, Sommerdijk NA, Hayakawa T, Fukushima T, Okahata Y, Nolte RJ, Jansen JA. Functionalization of multilayered DNAcoatings with bone morphogenetic protein 2. J Control Release 2006;113:63-72.
30. Hochart H, Jenkins PV, Smith OP, White B. Low molecular weight and unfractionated heparins induce a downregulation of inflammation: decreased levels of proinflammatory cytokines and nuclear factor-kappaB in LPS-stimulated human monocytes. Br J Haematol 2006;133:62-7.