The effect of systemically administered PDGF-BB on the rodent skeleton

Journal of Bone and Mineral Research

Volumn 11, Issue 2, 1996, Pages 238-247

  Mitlak, Bruce H ^a,d   Finkelman, Richard D ^b   Hill, Esther L ^b   Li, Jun ^a   Martin, Bruce ^c   Smith, Tait ^c   D'Andrea, Mark ^b   Antoniades, Harry N ^b   Lynch, Samuel E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Institute of Molecular Biology   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; PLATELET DERIVED GROWTH FACTOR BB; RECOMBINANT PLATELET DERIVED GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE ATROPHY; BONE DENSITY; BONE REMODELING; BONE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; FRACTURE HEALING; IMAGE ANALYSIS; INTRAVENOUS DRUG ADMINISTRATION; MORPHOMETRICS; NONHUMAN; RAT; SKELETON; TIBIA; TRABECULAR BONE; VERTEBRA BODY;

EID: 0030024836     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110213     Document Type: Article

References (31)

1. Piche JE, Graves DT 1989 Study of the growth factor requirements of human bone-derived cells: a comparison with human fibroblasts. Bone 10:131-138.
2. Centrella M. McCarthy TL, Canalis E 1989 Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone. Endocrinology 125:13-19.
3. Canalis E, McCarthy TL, Centrella M 1989 Effects of plateletderived growth factor on bone formation in vitro. J Cell Physiol 140:530-537.
4. Hock JM, Canalis E 1994 Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. Endocrinology 134:1423-1428.
5. Kohler N, Lipton A 1974 Platelets as a source of fibroblast growth promoting activity. Exp Cell Res 87:297-301.
6. Antoniades HN, Scher CD, Stiles CD 1979 Purification of human platelet-derived growth factor. Proc Natl Acad Sci 76: 1809-1813.
7. Ross R, Glomset J, Kariya B, Harker L 1974 A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci 71: 1207-1210.
8. Graves DT, Valentin OA, Delgado R, Valente AJ, Mundy G, Piche J 1989 The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. Connect Tissue Res 23:209-218.
9. Rydziel S, Ladd C, McCarthy TL. Centrella M, Canalis E 1992 Determination and expression of platelet-derived growth factor-AA in bone cell cultures. Endocrinology 130:1916-1922.
10. Cooper JA, Bowen-Pope DF, Raines E, Ross R, Hunter T 1982 Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell 31:263-273.
11. Gilardetti RS, Chaibi MS, Stroumza J, Williams SR, Antoniades HN, Carnes DC, Graves DT 1991 High-affinity binding of PDGF-AA and PDGF-BB to normal human osteoblastic cells and modulation by interleukin-1. Am J Physiol 261:c980-c985.
12. Pfeilschifter J, Krempien R, Naumann A, Gronwald RG, Hoppe J, Ziegler R 1992 Differential effects of platelet-derived growth factor isoforms on plasminogen activator activity in fetal rat osteoblasts due to isoform-specific receptor function. Endocrinology 130:2059-2066.
13. Seifert RA, Hart CE, Phillips PE, Forstrom JW, Ross R, Murray MJ, Bowen-Pope DF 1989 Two different subunits associate to create isoform specific platelet-derived growth factor receptors. J Biol Chem 245:8771-8778.
14. Gruneberg T, Truslove GM 1960 Two closely linked genes in the mouse. Genet Res Camb 1:69-90.
15. Smith EA, Seldin MF, Martinez L. Watson ML, Choudry GG, Lalley PA. Pierce J, Aaronson S, Barker J, Naylor SL. Sakaguchi AY 1991 Mouse platelet-derived growth receptor a gene is deleted in W19H and patch mutations on chromosome 5. Proc Nati Acad Sci 88:4811-4815.
16. Stephenson DA, Mercola M, Anderson E. Wang CY, Stiles CD, Bowen-Pope DF. Chapman VM 1991 Platelet-derived growth factor receptor α-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci 88:6-10.
17. Schatteman GC, Morrison-Graham K. Van Koppen A. Weston JA. Bowen-Pope DF 1992 Regulation and role of PDGF receptor α-subunit expression during embryogenesis. Development 115:123-131.
18. Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ 1994 Effect of platelet-derived growth factor in tibial osteotomies in rabbits. Bone 15:203-208.
19. Lynch SE, Buser D, Hernandez RA, Weber HP, Stich H, Fox CH, Williams RC 1991 Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs. J Periodontol 62:710-716.
20. Lynch SE. Williams RC Poison AM, Howell TH, Reddy MS, Zappa UE, Antoniades HN 1989 A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol 16:545-548.
21. Andrew JG, Hoyland J, Feemont AJ, Marsh DR 1995 Platelet-derived growth factor expression in normally healing human fracture. Bone 16:455-460.
22. Hill EL, Martin RB, Gunther E, Morey-Holton E, Holets VR 1993 Changes in bone in a model of spinal cord injury. J Ortho Res 11:537-547.
23. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott S, Recker RR 1987 Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
24. Kimble RB, Vannice JL, Bloedow DC, Thompson RC, Hopfer W, Kung VT, Brownfield C, Pacifici R 1994 Interleukin-1 receptor agonist decreases bone loss and bone resorption in ovariectomized rats. J Clin Invest 93:1959-1967.
25. Shen V, Birchman R, Xu R, Lindsay R, Dempster DW 1995 Short-term changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen and/or dietary calcium deficient rats. Bone 16:149-156.
26. Mitlak BH, Schoenfeld D, Neer RM 1994 Accuracy, precision, and utility of spine and whole-skeleton mineral measurements by DXA in rats. J Bone Miner Res 9:119-126.
27. Ferretti JL, Gaffuri O. Capozza R, Cointry G, Bozzini C, Olivera M, Zanchetta JR, Bozzi CE 1995 Dexamethasone effects on mechanical, geometric and densitometric properties of rat femur diaphyses as described by peripheral quantitative computerized tomography and bending tests. Bone 16:119-124.
28. Martin RB 1990 Effects of simulated weightlessness on bone properties in rats. J Biomechanics 23:1021-1029.
29. Bikle DD. Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP 1995 Alendronate increase skeletal mass of growing rats during unloading by inhibition resorption of calcified cartilage. J Bone Miner Res 9:1777-1787.
30. Siddhanti SR, Quarles LD 1994 Molecular to pharmacologic control of osteoblast proliferation and differentiation. J Cell Biochem 55:310-320.
31. It H, Ke HZ, Jee WSS, Sakou T 1993 Anabolic responses of an adult cancellous bone site to prostaglandin E2 in the rat. Bone Miner 21:219-236.