Increased chitinase expression and fungal-specific antibodies in the bronchoalveolar lavage fluid of asthmatic children

Clinical and Experimental Allergy

Volumn 42, Issue 4, 2012, Pages 523-530

  Goldman, D L ^a   Li, X ^b   Tsirilakis, K ^a,c   Andrade, C ^a   Casadevall, A ^b   Vicencio, A G ^a,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Children's Medical Center   (United States)

^c Northwell Health   (United States)

Author keywords

Asthma; Bronchoalveolar lavage fluid; Chitinase; Fungal infection; YKL 40

Indexed keywords

CHITINASE; CORTICOSTEROID; FUNGUS ANTIBODY; FUNGUS ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LEUKOTRIENE RECEPTOR BLOCKING AGENT; OMALIZUMAB;

ADOLESCENT; ADULT; ALTERNARIA ALTERNATA; ANTIBODY SPECIFICITY; ARTICLE; ASPERGILLUS FUMIGATUS; ASTHMA; BRONCHOSCOPY; CANDIDA ALBICANS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOBLOTTING; LUNG FUNCTION TEST; LUNG LAVAGE; MALE; MYCOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ANTIBODIES, FUNGAL; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHITINASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MYCOSES;

EID: 84863337574     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03886.x     Document Type: Article

References (48)

1. Tariq SM, Matthews SM, Stevens M, Hakim EA. Sensitization to Alternaria and Cladosporium by the age of 4 years. Clin Exp Allergy 1996; 26:794-8.
2. Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J, Neukirch F. Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ 2002; 325:411-4.
3. Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F. Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol 1999; 103:709-11.
4. Call RS, Ward G, Jackson S, Platts-Mills TA. Investigating severe and fatal asthma. J Allergy Clin Immunol 1994; 94:1065-72.
5. Hinson Kf, Moon Aj, Plummer Ns. Broncho-pulmonary aspergillosis; a review and a report of eight new cases. Thorax 1952; 7:317-33.
6. Stevens DA, Moss RB, Kurup VP et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis-state of the art: Cystic Fibrosis Foundation Consensus Conference. Clin Infect Dis 2003; 37(Suppl. 3):S225-64.
7. Sandhu RS, Mehta SK, Khan ZU, Singh MM. Role of Aspergillus and Candida species in allergic bronchopulmonary mycoses. A comparative study. Scand J Respir Dis 1979; 60:235-42.
8. Lake FR, Tribe AE, McAleer R, Froudist J, Thompson PJ. Mixed allergic bronchopulmonary fungal disease due to Pseudallescheria boydii and Aspergillus. Thorax 1990; 45:489-91.
9. Ward GW, Jr., Woodfolk JA, Hayden ML, Jackson S, Platts-Mills TA. Treatment of late-onset asthma with fluconazole. J Allergy Clin Immunol 1999; 104:541-6.
10. Schubert MS. Allergic fungal sinusitis: pathogenesis and management strategies. Drugs 2004; 64:363-74.
11. Denning DW, O'Driscoll BR, Powell G et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med 2009; 179:11-8.
12. Littman ML, Schneierson SS. Cryptococcus neoformans in pigeon excreta in New York City. Am J Hyg 1959; 69:49-59.
13. Campbell GD. Primary pulmonary cryptococcosis. Am Rev Respir Dis 1966; 94:236-43.
14. Warr W, Bates JH, Stone A. The spectrum of pulmonary cryptococcosis. Ann Intern Med 1968; 69:1109-16.
15. DeShaw M, Pirofski LA. Antibodies to the Cryptococcus neoformans capsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV- individuals. Clin Exp Immunol 1995; 99:425-32.
16. Goldman DL, Khine H, Abadi J et al. Serologic evidence for Cryptococcus neoformans infection in early childhood. Pediatrics 2001; 107:E66.
17. Davis J, Zheng WY, Glatman-Freedman A et al. Serologic evidence for regional differences in pediatric cryptococcal infection. Pediatr Infect Dis J 2007; 26:549-51.
18. Hernandez Y, Arora S, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB. Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J Immunol 2005; 174:1027-36.
19. Abe K, Kadota J, Ishimatsu Y et al. Th1-Th2 cytokine kinetics in the bronchoalveolar lavage fluid of mice infected with Cryptococcus neoformans of different virulences. Microbiol Immunol 2000; 44:849-55.
20. Muller U, Stenzel W, Kohler G et al. A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J Infect Dis 2008; 198:1714-21.
21. Goldman DL, Davis J, Bommarito F, Shao X, Casadevall A. Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma. J Infect Dis 2006; 193:1178-86.
22. Goldman DL, Huffnagle GB. Potential contribution of fungal infection and colonization to the development of allergy. Med Mycol 2009; 47:445-56.
23. Lamhamedi-Cherradi SE, Martin RE, Ito T et al. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol 2008; 180:6000-9.
24. Noverr MC, Erb-Downward JR, Huffnagle GB. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin Microbiol Rev 2003; 16:517-33.
25. Gordon-Thomson C, Kumari A, Tomkins L et al. Chitotriosidase and gene therapy for fungal infections. Cell Mol Life Sci 2009; 66:1116-25.
26. Zhu Z, Zheng T, Homer RJ et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004; 304:1678-82.
27. Chupp GL, Lee CG, Jarjour N et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 2007; 357:2016-27.
28. Tang H, Fang Z, Sun Y et al. YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E. Eur Respir J 2010; 35:757-60.
29. Vicencio AG, Narain S, Du Z et al. Pulmonary cryptococcosis induces chitinase in the rat. Respir Res 2008; 9:40.
30. Overdijk B, Van Steijn GJ, Odds FC. Chitinase levels in guinea pig blood are increased after systemic infection with Aspergillus fumigatus. Glycobiology 1996; 6:627-34.
31. Saha DC, Xess I, Zeng WY, Goldman DL. Antibody responses to Cryptococcus neoformans in Indian patients with cryptococcosis. Med Mycol 2008; 46:457-63.
32. Hill TW, Loprete DM, Momany M et al. Isolation of cell wall mutants in Aspergillus nidulans by screening for hypersensitivity to Calcofluor White. Mycologia 2006; 98:399-409.
33. Saha DC, Goldman DL, Shao X et al. Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients. Clin Vaccine Immunol 2007; 14:1550-4.
34. Payne D, Bush A. Phenotype-specific treatment of difficult asthma in children. Paediatr Respir Rev 2004; 5:116-23.
35. Payne DN, Wilson NM, James A, Hablas H, Agrafioti C, Bush A. Evidence for different subgroups of difficult asthma in children. Thorax 2001; 56:345-50.
36. Webb DC, McKenzie AN, Foster PS. Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. J Biol Chem 2001; 276:41969-76.
37. Kuepper M, Bratke K, Virchow JC. Chitinase-like protein and asthma. N Engl J Med 2008; 358:1073-5.
38. Vicencio AG, Chupp GL, Tsirilakis K et al. CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization? Pediatrics 2010; 126:e982-5.
39. Fairs A, Agbetile J, Hargadon B et al. IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J Respir Crit Care Med 2010; 182:1362-8.
40. Greenberger PA, Smith LJ, Hsu CC, Roberts M, Liotta JL. Analysis of bronchoalveolar lavage in allergic bronchopulmonary aspergillosis: divergent responses of antigen-specific antibodies and total IgE. J Allergy Clin Immunol 1988; 82:164-70.
41. Guo L, Johnson RS, Schuh JC. Biochemical characterization of endogenously formed eosinophilic crystals in the lungs of mice. J Biol Chem 2000; 275:8032-7.
42. Feldmesser M, Kress Y, Casadevall A. Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection. Infect Immun 2001; 69:2723-7.
43. van Eijk M, van Roomen CP, Renkema GH et al. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. Int Immunol 2005; 17:1505-12.
44. Bierbaum S, Superti-Furga A, Heinzmann A. Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma. Int J Immunogenet 2006; 33:201-4.
45. Bierbaum S, Nickel R, Koch A et al. Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma. Am J Respir Crit Care Med 2005; 172:1505-9.
46. Chatterjee R, Batra J, Das S, Sharma SK, Ghosh B. Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels. J Allergy Clin Immunol 2008; 122:202-8.
47. Ober C, Tan Z, Sun Y et al. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 2008; 358:1682-91.
48. Wu AC, Lasky-Su J, Rogers CA, Klanderman BJ, Litonjua AA. Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations. Am J Respir Crit Care Med 2010; 182:884-9.