메뉴 건너뛰기




Volumn 19, Issue 2, 2016, Pages 134-142

Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study

Author keywords

Ageing male syndrome; androgens; sexual function; testofen; testosterone; Trigonella foenum graecum

Indexed keywords

FENUGREEK EXTRACT; PLACEBO; TESTOFEN; TESTOSTERONE; UNCLASSIFIED DRUG; PLANT EXTRACT;

EID: 84955135837     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2015.1135323     Document Type: Article
Times cited : (60)

References (54)
  • 1
    • 0031001347 scopus 로고    scopus 로고
    • Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
    • J.E.Morley, F.E.Kaiser, H.M.PerryIII,. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metab Clin Exp 1997;46:410–13.
    • (1997) Metab Clin Exp , vol.46 , pp. 410-413
    • Morley, J.E.1    Kaiser, F.E.2    Perry, H.M.3
  • 2
    • 0036176556 scopus 로고    scopus 로고
    • Andropause: Clinical implications of the decline in serum testosterone level with aging in men
    • A.M.Matsumoto Andropause: Clinical implications of the decline in serum testosterone level with aging in men. J Gerontol a Biol Sci Med Sci 2002;57:76–99.
    • (2002) J Gerontol a Biol Sci Med Sci , vol.57 , pp. 76-99
    • Matsumoto, A.M.1
  • 3
    • 0036170745 scopus 로고    scopus 로고
    • Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
    • H.A.Feldman, C.Longcope, C.A.Derby,. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002;87:589–98.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 589-598
    • Feldman, H.A.1    Longcope, C.2    Derby, C.A.3
  • 4
    • 84867249434 scopus 로고    scopus 로고
    • Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study
    • G.Sartorius, S.Spasevska, A.Idan,. Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study. Clin Endocrinol (Oxf). 2012;77:755–63.
    • (2012) Clin Endocrinol (Oxf) , vol.77 , pp. 755-763
    • Sartorius, G.1    Spasevska, S.2    Idan, A.3
  • 5
    • 84875863886 scopus 로고    scopus 로고
    • Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study
    • E.M.1.Camacho, I.T.Huhtaniemi, T.W.O'Neill,. EMAS Group. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. Eur J Endocrinol. 2013 Feb 20;168:445–55.
    • (2013) Eur J Endocrinol , vol.168 , pp. 445-455
    • Camacho, E.M.1.1    Huhtaniemi, I.T.2    O'Neill, T.W.3
  • 6
    • 84881522951 scopus 로고    scopus 로고
    • Longitudinal changes in testosterone over five years in community-dwelling men
    • Z.Shi, A.B.Araujo, S.Martin,. Longitudinal changes in testosterone over five years in community-dwelling men. J Clin Endocrinol Metab. 2013 Aug;98:3289–97.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3289-3297
    • Shi, Z.1    Araujo, A.B.2    Martin, S.3
  • 7
    • 33646813958 scopus 로고    scopus 로고
    • An ensemble model of the male gonadal axis: illustrative application in aging men
    • D.M.Keenan, P.Y.Takahashi, P.Y.Liu,. An ensemble model of the male gonadal axis: illustrative application in aging men. Endocrinology 2006;147:2817–28.
    • (2006) Endocrinology , vol.147 , pp. 2817-2828
    • Keenan, D.M.1    Takahashi, P.Y.2    Liu, P.Y.3
  • 8
    • 84942511748 scopus 로고    scopus 로고
    • Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function
    • R.Golan, J.M.Scovell, R.Ramasamy Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function. Aging Male. 2015;18:201–4.
    • (2015) Aging Male , vol.18 , pp. 201-204
    • Golan, R.1    Scovell, J.M.2    Ramasamy, R.3
  • 9
    • 84890074062 scopus 로고    scopus 로고
    • Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome
    • J.Rodriguez-Tolrà, J.Torremadé Barreda, L.del Rio,. Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome. Aging Male 2013;16:184–90.
    • (2013) Aging Male , vol.16 , pp. 184-190
    • Rodriguez-Tolrà, J.1    Torremadé Barreda, J.2    del Rio, L.3
  • 10
    • 84871229564 scopus 로고    scopus 로고
    • Do low testosterone levels contribute to ill-health during male ageing?
    • B.B.1.Yeap, A.B.Araujo, G.A.Wittert Do low testosterone levels contribute to ill-health during male ageing? Crit Rev Clin Lab Sci. 2012;49:168–82.
    • (2012) Crit Rev Clin Lab Sci , vol.49 , pp. 168-182
    • Yeap, B.B.1.1    Araujo, A.B.2    Wittert, G.A.3
  • 11
    • 84927590992 scopus 로고    scopus 로고
    • The longitudinal relationship of sexual function and androgen status in older men: the concord health and ageing in men project
    • B.Hsu, R.G.Cumming, F.M.Blyth,. The longitudinal relationship of sexual function and androgen status in older men: the concord health and ageing in men project. J Clin Endocrinol Metab 2015;100:1350–8.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1350-1358
    • Hsu, B.1    Cumming, R.G.2    Blyth, F.M.3
  • 12
    • 84927648769 scopus 로고    scopus 로고
    • Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men
    • L.Antonio, F.C.Wu, T.W.O'Neill,. EMAS Study Group. Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men. J Clin Endocrinol Metab 2015;100:1396–404.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1396-1404
    • Antonio, L.1    Wu, F.C.2    O'Neill, T.W.3
  • 13
    • 84930811539 scopus 로고    scopus 로고
    • Longitudinal relationships between reproductive hormones and cognitive decline in older men: the concord health and ageing in men project
    • B.Hsu, R.G.Cumming, L.M.Waite,. Longitudinal relationships between reproductive hormones and cognitive decline in older men: the concord health and ageing in men project. J Clin Endocrinol Metab 2015;100:2223–30.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2223-2230
    • Hsu, B.1    Cumming, R.G.2    Waite, L.M.3
  • 14
    • 70849117428 scopus 로고    scopus 로고
    • Testosterone deficiency, insulin resistance and the metabolic syndrome
    • M.Zitzmann Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol 2009;5:673–81.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 673-681
    • Zitzmann, M.1
  • 15
    • 84869792056 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of testosterone gel on body composition and health-related quality-of-life in men with hypogonadal to low-normal levels of serum testosterone and symptoms of androgen deficiency over 6 months with 12 months open-label follow-up
    • M.Behre, T.Tammela, S.Arver,. A randomized, double-blind, placebo-controlled trial of testosterone gel on body composition and health-related quality-of-life in men with hypogonadal to low-normal levels of serum testosterone and symptoms of androgen deficiency over 6 months with 12 months open-label follow-up. Aging Male 2012;15:198–207.
    • (2012) Aging Male , vol.15 , pp. 198-207
    • Behre, M.1    Tammela, T.2    Arver, S.3
  • 16
    • 37349118353 scopus 로고    scopus 로고
    • Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study
    • K.T.Khaw, M.Dowsett, E.Folkerd,. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 2007;116:2694–701.
    • (2007) Circulation , vol.116 , pp. 2694-2701
    • Khaw, K.T.1    Dowsett, M.2    Folkerd, E.3
  • 17
    • 2342644814 scopus 로고    scopus 로고
    • Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    • D.E.Laaksonen, L.Niskanen, K.Punnonen,. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004;27:1036–41.
    • (2004) Diabetes Care , vol.27 , pp. 1036-1041
    • Laaksonen, D.E.1    Niskanen, L.2    Punnonen, K.3
  • 18
    • 0018900123 scopus 로고
    • Effects of exogenous and endogenous opiates on the hypothalamic-pituitary-gonadal axis in the male
    • T.J.Cicero Effects of exogenous and endogenous opiates on the hypothalamic-pituitary-gonadal axis in the male. Fed Proc 1980;39:2551–4.
    • (1980) Fed Proc , vol.39 , pp. 2551-2554
    • Cicero, T.J.1
  • 19
    • 84873527513 scopus 로고    scopus 로고
    • Non-analgesic effects of opioids: opioids and the endocrine system
    • J.A.Elliott, S.E.Opper, S.Agarwal, E.E.Fibuch Non-analgesic effects of opioids: opioids and the endocrine system. Curr Pharm Des 2012;18:6070–8.
    • (2012) Curr Pharm Des , vol.18 , pp. 6070-6078
    • Elliott, J.A.1    Opper, S.E.2    Agarwal, S.3    Fibuch, E.E.4
  • 20
    • 0033804254 scopus 로고    scopus 로고
    • Acute effects of interferon-alpha administration on testosterone concentrations in healthy men
    • E.P.Corssmit, E.Endert, H.P.Sauerwein, J.A.Romijn Acute effects of interferon-alpha administration on testosterone concentrations in healthy men. Eur J Endocrinol 2000;143:371–4.
    • (2000) Eur J Endocrinol , vol.143 , pp. 371-374
    • Corssmit, E.P.1    Endert, E.2    Sauerwein, H.P.3    Romijn, J.A.4
  • 21
    • 84918773337 scopus 로고    scopus 로고
    • Andropause: current concepts
    • P.Singh Andropause: current concepts. Indian J Endocrinol Metab 2013;17:621–9.
    • (2013) Indian J Endocrinol Metab , vol.17 , pp. 621-629
    • Singh, P.1
  • 22
  • 23
    • 34548722899 scopus 로고    scopus 로고
    • Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    • P.Y.Liu, J.Beilin, C.Meier,. Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts. J Clin Endocrinol Metab 2007;92:3599–603.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3599-3603
    • Liu, P.Y.1    Beilin, J.2    Meier, C.3
  • 24
    • 77954414397 scopus 로고    scopus 로고
    • Identification of late-onset hypogonadism in middle-aged and elderly men
    • F.C.Wu, A.Tajar, J.M.Beynon,. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363:123–35.
    • (2010) N Engl J Med , vol.363 , pp. 123-135
    • Wu, F.C.1    Tajar, A.2    Beynon, J.M.3
  • 25
    • 33745108447 scopus 로고    scopus 로고
    • Prevalence of hypogonadism in males aged at least 45 years: the HIM study
    • T.Mulligan, M.F.Frick, Q.C.Zuraw,. Prevalence of hypogonadism in males aged at least 45 years: the HIM study. Int J Clin Pract 2006;60:762–9.
    • (2006) Int J Clin Pract , vol.60 , pp. 762-769
    • Mulligan, T.1    Frick, M.F.2    Zuraw, Q.C.3
  • 26
    • 56149086229 scopus 로고    scopus 로고
    • Testosterone replacement therapy in hypogonadal men: assessing benefits, risks, and best practices
    • M.Miner, D.J.Canty, R.Shabsigh Testosterone replacement therapy in hypogonadal men: assessing benefits, risks, and best practices. Postgrad Med 2008;120:130–53.
    • (2008) Postgrad Med , vol.120 , pp. 130-153
    • Miner, M.1    Canty, D.J.2    Shabsigh, R.3
  • 27
    • 83155187283 scopus 로고    scopus 로고
    • Higher testosterone levels are associated with less loss of lean body mass in older men
    • E.S.LeBlanc, P.Y.Wang, C.G.Lee,. Higher testosterone levels are associated with less loss of lean body mass in older men. J Clin Endocrinol Metab 2011;96:3855–63.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3855-3863
    • LeBlanc, E.S.1    Wang, P.Y.2    Lee, C.G.3
  • 28
    • 79955536922 scopus 로고    scopus 로고
    • Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men
    • T.W.Auyeung, J.S.Lee, T.Kwok,. Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men. Eur J Endocrinol 2011;164:811–17.
    • (2011) Eur J Endocrinol , vol.164 , pp. 811-817
    • Auyeung, T.W.1    Lee, J.S.2    Kwok, T.3
  • 29
    • 77749283792 scopus 로고    scopus 로고
    • Androgens and male aging: current evidence of safety and efficacy
    • L.J.Gooren Androgens and male aging: current evidence of safety and efficacy. Asian J Androl 2010;12:136–51.
    • (2010) Asian J Androl , vol.12 , pp. 136-151
    • Gooren, L.J.1
  • 30
    • 76149135996 scopus 로고    scopus 로고
    • Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    • U.Srinivas-Shankar, S.A.Roberts, M.J.Connolly,. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 2010;95:639–50.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 639-650
    • Srinivas-Shankar, U.1    Roberts, S.A.2    Connolly, M.J.3
  • 31
    • 80052290613 scopus 로고    scopus 로고
    • Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation
    • E.Steels, A.Rao, L.Vitetta Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytotherapy Res 2011;25:1294–300.
    • (2011) Phytotherapy Res , vol.25 , pp. 1294-1300
    • Steels, E.1    Rao, A.2    Vitetta, L.3
  • 32
    • 84975476138 scopus 로고    scopus 로고
    • Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: a randomized controlled pilot study
    • S.Wankhede, V.Mohan, P.Thakurdesai Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: a randomized controlled pilot study. J Sport and Health Sci 2015; ‘in press.’
    • (2015) J Sport and Health Sci
    • Wankhede, S.1    Mohan, V.2    Thakurdesai, P.3
  • 33
    • 0023064090 scopus 로고
    • The chemistry and biological significance of saponins in foods and feedingstuffs
    • K.R.Price, I.T.Johnson, G.R.Fenwick The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr 1987;26:27–135.
    • (1987) Crit Rev Food Sci Nutr , vol.26 , pp. 27-135
    • Price, K.R.1    Johnson, I.T.2    Fenwick, G.R.3
  • 34
    • 78649433884 scopus 로고    scopus 로고
    • Effect of furostanol glycosides from Trigonella foenum-graecum on the reproductive system of male albino rats
    • U.Aswar, S.L.Bodhankar, V.Mohan, P.A.Thakurdesai Effect of furostanol glycosides from Trigonella foenum-graecum on the reproductive system of male albino rats. Phytother Res 2010;24:1482–8.
    • (2010) Phytother Res , vol.24 , pp. 1482-1488
    • Aswar, U.1    Bodhankar, S.L.2    Mohan, V.3    Thakurdesai, P.A.4
  • 35
    • 78649369813 scopus 로고    scopus 로고
    • Effects of a purported aromatase and 5 a-reductase inhibitor on hormone profiles in college-age man
    • C.Wilborn, L.Taylor, C.Poole,. Effects of a purported aromatase and 5 a-reductase inhibitor on hormone profiles in college-age man. Int J Sport Nutr Exe 2010;20:457–65.
    • (2010) Int J Sport Nutr Exe , vol.20 , pp. 457-465
    • Wilborn, C.1    Taylor, L.2    Poole, C.3
  • 36
    • 2942591614 scopus 로고    scopus 로고
    • The Aging Males Symptoms (AMS) scale: review of its methodological characteristics
    • I.Daig, L.A.J.Heinemann, S.Kim,. The Aging Males Symptoms (AMS) scale: review of its methodological characteristics. Health Quality Life Outcomes 2003;1:77.
    • (2003) Health Quality Life Outcomes , vol.1 , pp. 77
    • Daig, I.1    Heinemann, L.A.J.2    Kim, S.3
  • 37
    • 0018567015 scopus 로고
    • The DSFI: a multidimensional measure of sexual functioning
    • L.R.Derogatis, N.Mellisaratos The DSFI: a multidimensional measure of sexual functioning. J Sex Marital Ther 1979;5:244–81.
    • (1979) J Sex Marital Ther , vol.5 , pp. 244-281
    • Derogatis, L.R.1    Mellisaratos, N.2
  • 38
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature
    • R.Sodergad, T.Backstrom, V.Shanbhag, H.Carstensen Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982;16:801–10.
    • (1982) J Steroid Biochem , vol.16 , pp. 801-810
    • Sodergad, R.1    Backstrom, T.2    Shanbhag, V.3    Carstensen, H.4
  • 39
    • 0024389366 scopus 로고
    • The Pittsburgh Sleep Quality Index (PSQI): a new instrument for psychiatric research and practice
    • D.J.Buysse, C.F.Reynolds, T.H.Monk,. The Pittsburgh Sleep Quality Index (PSQI): a new instrument for psychiatric research and practice. Psychiatry Res 1989;28:193–213.
    • (1989) Psychiatry Res , vol.28 , pp. 193-213
    • Buysse, D.J.1    Reynolds, C.F.2    Monk, T.H.3
  • 40
    • 0031956999 scopus 로고    scopus 로고
    • A multidimensional measure of fatigue for use with cancer patients
    • K.D.Stein, S.C.Martin, D.M.Hann, P.B.Jacobsen A multidimensional measure of fatigue for use with cancer patients. Cancer Pract 1998;6:143–52.
    • (1998) Cancer Pract , vol.6 , pp. 143-152
    • Stein, K.D.1    Martin, S.C.2    Hann, D.M.3    Jacobsen, P.B.4
  • 41
    • 0042855872 scopus 로고    scopus 로고
    • International Physical Activity Questionnaire: 12-country reliability and validity
    • C.L.Craig, A.L.Marshall, A.Sjostrom,. International Physical Activity Questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381–95.
    • (2003) Med Sci Sports Exerc , vol.35 , pp. 1381-1395
    • Craig, C.L.1    Marshall, A.L.2    Sjostrom, A.3
  • 43
    • 33745782301 scopus 로고    scopus 로고
    • The relationship between libido and testosterone levels in aging men
    • T.G.Travison, J.E.Morley, A.B.Araujo,. The relationship between libido and testosterone levels in aging men. J Clin Endocrinol Metab 2006;91:2509–13.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2509-2513
    • Travison, T.G.1    Morley, J.E.2    Araujo, A.B.3
  • 44
    • 33644615112 scopus 로고    scopus 로고
    • Comparison of screening questionnaires for the diagnosis of hypogonadism
    • J.E.Morley, H.M.Perry, IIIR.T.Kevorkian, P.Patrick Comparison of screening questionnaires for the diagnosis of hypogonadism. Maturitas 2006;53:424–9.
    • (2006) Maturitas , vol.53 , pp. 424-429
    • Morley, J.E.1    Perry, H.M.2    Kevorkian, R.T.3    Patrick, P.4
  • 45
    • 60149096172 scopus 로고    scopus 로고
    • Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires
    • R.Clapauch, D.J.Braga, L.P.Marinheiro,. Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires. Arq Bras Endocrinol Metabol 2008;52:1439–47.
    • (2008) Arq Bras Endocrinol Metabol , vol.52 , pp. 1439-1447
    • Clapauch, R.1    Braga, D.J.2    Marinheiro, L.P.3
  • 46
    • 33745283957 scopus 로고    scopus 로고
    • Correlation between the Aging Males’ Symptoms Scale and sex steroids, gonadotropins, dehydroepiandrosterone sulfate, and growth hormone levels in ambulatory men
    • Y.Miwa, T.Kaneda, O.Yokoyama Correlation between the Aging Males’ Symptoms Scale and sex steroids, gonadotropins, dehydroepiandrosterone sulfate, and growth hormone levels in ambulatory men. J Sex Med 2006;3:723–6.
    • (2006) J Sex Med , vol.3 , pp. 723-726
    • Miwa, Y.1    Kaneda, T.2    Yokoyama, O.3
  • 47
    • 79959826076 scopus 로고    scopus 로고
    • Correlation between serum total testosterone and the AMS and IIEF questionnaires in patients with erectile dysfunction with testosterone deficiency syndrome
    • J.Kang, IIB.K.Ham, M.M.Oh,. Correlation between serum total testosterone and the AMS and IIEF questionnaires in patients with erectile dysfunction with testosterone deficiency syndrome. Korean J Urol 2011;52:416–20.
    • (2011) Korean J Urol , vol.52 , pp. 416-420
    • Kang, J.1    Ham, B.K.2    Oh, M.M.3
  • 48
    • 84869830464 scopus 로고    scopus 로고
    • The Aging Males' Symptoms’ Scale (AMS): predictive value for lowered circulating androgens
    • F.Zengerling, A.Schrader, M.Cronauer,. The Aging Males' Symptoms’ Scale (AMS): predictive value for lowered circulating androgens. Aging Male 2012;15:253–7.
    • (2012) Aging Male , vol.15 , pp. 253-257
    • Zengerling, F.1    Schrader, A.2    Cronauer, M.3
  • 49
    • 84975511638 scopus 로고    scopus 로고
    • Chicago
    • L.F.DeFina, N.B.Radford, D.Leonard,. MON-0012: testosterone level in men is lower with increasing BMI and decreasing cardiorespiratory fitness but is not related to age. Endocrine Society's 96th Annual Meeting and Expo, 21–24 June 2014, Chicago.
    • (2014)
    • DeFina, L.F.1    Radford, N.B.2    Leonard, D.3
  • 50
    • 84896750181 scopus 로고    scopus 로고
    • Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment
    • I.Huhtaniemi Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment. Asian J Androl 2014;16:192–202.
    • (2014) Asian J Androl , vol.16 , pp. 192-202
    • Huhtaniemi, I.1
  • 51
    • 80054896047 scopus 로고    scopus 로고
    • Physical activity and aging male symptoms in a southern Brazilian population
    • L.Correa, A.J.Rombaldi, M.C.da Silva Physical activity and aging male symptoms in a southern Brazilian population. Rev Bras Med Esporte 2011;17:228–31.
    • (2011) Rev Bras Med Esporte , vol.17 , pp. 228-231
    • Correa, L.1    Rombaldi, A.J.2    da Silva, M.C.3
  • 52
    • 19744363523 scopus 로고    scopus 로고
    • Correlations between hormones, physical, and affective parameters in aging urologic outpatients
    • M.E.Beutel, J.Wiltink, E.W.Hauck,. Correlations between hormones, physical, and affective parameters in aging urologic outpatients. Eur Urol 2005;47:749–55.
    • (2005) Eur Urol , vol.47 , pp. 749-755
    • Beutel, M.E.1    Wiltink, J.2    Hauck, E.W.3
  • 53
    • 84896694384 scopus 로고    scopus 로고
    • A 6-month observational study of energy, sexual desire, and body proportions in hypogonadal men treated with a testosterone 1% gel
    • C.Pexman-Fieth, H.M.Behre, A.Morales,. A 6-month observational study of energy, sexual desire, and body proportions in hypogonadal men treated with a testosterone 1% gel. Aging Male 2014;17:1–11.
    • (2014) Aging Male , vol.17 , pp. 1-11
    • Pexman-Fieth, C.1    Behre, H.M.2    Morales, A.3
  • 54
    • 84924424068 scopus 로고    scopus 로고
    • Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men
    • B.Lunenfeld, G.Mskhalaya, M.Zitzmann,. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. The Aging Male 2015;18:5–15.
    • (2015) The Aging Male , vol.18 , pp. 5-15
    • Lunenfeld, B.1    Mskhalaya, G.2    Zitzmann, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.