메뉴 건너뛰기




Volumn 18, Issue 3, 2015, Pages 201-204

Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function

Author keywords

Aging; hypogonadism; late onset hypogonadism; testosterone

Indexed keywords

TESTOSTERONE;

EID: 84942511748     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2015.1052392     Document Type: Review
Times cited : (58)

References (37)
  • 1
    • 47549107694 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: The European Male Aging Study
    • Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab 2008; 93: 2737-45.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2737-2745
    • Wu, F.C.1    Tajar, A.2    Pye, S.R.3
  • 2
    • 0036170745 scopus 로고    scopus 로고
    • Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study
    • Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002; 87: 589-98.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 589-598
    • Feldman, H.A.1    Longcope, C.2    Derby, C.A.3
  • 3
    • 0031001347 scopus 로고    scopus 로고
    • Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
    • Morley JE, Kaiser FE, Perry HM, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997; 46: 410-13.
    • (1997) Metabolism , vol.46 , pp. 410-413
    • Morley, J.E.1    Kaiser, F.E.2    Perry, H.M.3
  • 4
    • 0035097033 scopus 로고    scopus 로고
    • Baltimore longitudinal study of aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men
    • Harman SM, Metter EJ, Tobin JD, et al. Baltimore longitudinal study of aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001; 86: 724-31.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3
  • 5
    • 84923047921 scopus 로고    scopus 로고
    • The effect of hypogonadism and testosterone-enhancing therapy on alkaline phosphatase and bone mineral density
    • Dabaja AA, Bryson CF, Schlegel PN, Paduch DA. The effect of hypogonadism and testosterone-enhancing therapy on alkaline phosphatase and bone mineral density. BJU Int 2015; 115: 480-5.
    • (2015) BJU Int , vol.115 , pp. 480-485
    • Dabaja, A.A.1    Bryson, C.F.2    Schlegel, P.N.3    Paduch, D.A.4
  • 6
    • 84922399430 scopus 로고    scopus 로고
    • Hypogonadal symptoms are associated with different serum testosterone thresholds in middle-aged and elderly men
    • Ramasamy R, Wilken N, Scovell JM, et al. Hypogonadal symptoms are associated with different serum testosterone thresholds in middle-aged and elderly men. Urology 2014; 84: 1378-82.
    • (2014) Urology , vol.84 , pp. 1378-1382
    • Ramasamy, R.1    Wilken, N.2    Scovell, J.M.3
  • 7
    • 77954414397 scopus 로고    scopus 로고
    • Identification of late-onset hypogonadism in middle-aged and elderly men
    • Wu FC, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010; 363: 123-35.
    • (2010) N Engl J Med , vol.363 , pp. 123-135
    • Wu, F.C.1    Tajar, A.2    Beynon, J.M.3
  • 8
    • 80053412843 scopus 로고    scopus 로고
    • Are there symptom-specific testosterone thresholds in aging men?
    • Lackner JE, Rucklinger E, Schatzl G, et al. Are there symptom-specific testosterone thresholds in aging men? BJU Int 2011; 108: 1310-15.
    • (2011) BJU Int , vol.108 , pp. 1310-1315
    • Lackner, J.E.1    Rucklinger, E.2    Schatzl, G.3
  • 9
    • 33751533215 scopus 로고    scopus 로고
    • Association of specific symptoms and metabolic risks with serum testosterone in older men
    • Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men. J Clin Endocrinol Metab 2006; 91: 4335-43.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4335-4343
    • Zitzmann, M.1    Faber, S.2    Nieschlag, E.3
  • 10
    • 84933673789 scopus 로고    scopus 로고
    • Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng/dL
    • Epub ahead of print
    • Scovell JM, Ramasamy R, Wilken N, et al. Hypogonadal symptoms in young men are associated with a serum total testosterone threshold of 400 ng/dL. BJU Int 2015. [Epub ahead of print]. doi: 10.1111/bju.12970.
    • (2015) BJU Int
    • Scovell, J.M.1    Ramasamy, R.2    Wilken, N.3
  • 11
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Bhasin S, Cunningham GR, Hayes FJ, et al. Endocrine Society Task Force. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010; 95: 2536-59.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Endocrine Society Task Force1    Bhasin, S.2    Cunningham, G.R.3    Hayes, F.J.4
  • 12
    • 77951642063 scopus 로고    scopus 로고
    • Characteristics of secondary, primary, and compensated hypogonadism in aging men: Evidence from the European Male Ageing Study
    • Tajar A, Forti G, O'Neill TW, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab 2010; 95: 1810-18.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1810-1818
    • Tajar, A.1    Forti, G.2    O'Neill, T.W.3
  • 13
    • 73249139551 scopus 로고    scopus 로고
    • Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds
    • Scott HM, Mason JI, Sharpe RM. Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev 2009; 30: 883-925.
    • (2009) Endocr Rev , vol.30 , pp. 883-925
    • Scott, H.M.1    Mason, J.I.2    Sharpe, R.M.3
  • 15
    • 0028558510 scopus 로고
    • Age-related decreased Leydig cell testosterone production in the brown Norway rat
    • Chen H, Hardy MP, Huhtaniemi I, Zirkin BR. Age-related decreased Leydig cell testosterone production in the brown Norway rat. J Androl 1994; 15: 551-7.
    • (1994) J Androl , vol.15 , pp. 551-557
    • Chen, H.1    Hardy, M.P.2    Huhtaniemi, I.3    Zirkin, B.R.4
  • 16
    • 0021123879 scopus 로고
    • Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men
    • Neaves WB, Johnson L, Porter JC, et al. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984; 59: 756-63.
    • (1984) J Clin Endocrinol Metab , vol.59 , pp. 756-763
    • Neaves, W.B.1    Johnson, L.2    Porter, J.C.3
  • 17
    • 0014603925 scopus 로고
    • Vascular patterns of the human testis with special reference to its senile changes
    • Sasano N, Ichijo S. Vascular patterns of the human testis with special reference to its senile changes. Tohoku J Exp Med 1969; 99: 269-80.
    • (1969) Tohoku J Exp Med , vol.99 , pp. 269-280
    • Sasano, N.1    Ichijo, S.2
  • 18
    • 0018077577 scopus 로고
    • Age-associated changes in microvasculature of human adult testis
    • Takizawa T, Hatakeyama S. Age-associated changes in microvasculature of human adult testis. Acta Pathol Jpn 1978; 28: 541-54.
    • (1978) Acta Pathol Jpn , vol.28 , pp. 541-554
    • Takizawa, T.1    Hatakeyama, S.2
  • 19
    • 0021930333 scopus 로고
    • Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis
    • Regadera J, Nistal M, Paniagua R. Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis. Arch Pathol Lab Med 1985; 109: 663-7.
    • (1985) Arch Pathol Lab Med , vol.109 , pp. 663-667
    • Regadera, J.1    Nistal, M.2    Paniagua, R.3
  • 20
    • 84937617513 scopus 로고    scopus 로고
    • Leydig cell aging and hypogonadism
    • Epub ahead of print
    • Beattie MC, Adekola L, Papadopoulos V, et al. Leydig cell aging and hypogonadism. Exp Gerontol 2015. [Epub ahead of print]. doi: 10.1016/j.exger.2015.02.014.
    • (2015) Exp Gerontol
    • Beattie, M.C.1    Adekola, L.2    Papadopoulos, V.3
  • 22
    • 18844415053 scopus 로고    scopus 로고
    • Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: Evidence that age attenuates hypothalamic GnRH outflow
    • Takahashi PY, Liu PY, Roebuck PD, et al. Graded inhibition of pulsatile luteinizing hormone secretion by a selective gonadotropin-releasing hormone (GnRH)-receptor antagonist in healthy men: evidence that age attenuates hypothalamic GnRH outflow. J Clin Endocrinol Metab 2005; 90: 2768-74.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2768-2774
    • Takahashi, P.Y.1    Liu, P.Y.2    Roebuck, P.D.3
  • 23
    • 0033979380 scopus 로고    scopus 로고
    • Age-related decrease in hypothalmic gonadotropin-releasing hormone (GnRH) gene expression, but not pituitary responsiveness to GnRH, in the male brown Norway rat
    • Gruenewald DA, Naai MA, Marck BT, Matsumoto AM. Age-related decrease in hypothalmic gonadotropin-releasing hormone (GnRH) gene expression, but not pituitary responsiveness to GnRH, in the male brown Norway rat. J Andrology 2000; 21: 72-84.
    • (2000) J Andrology , vol.21 , pp. 72-84
    • Gruenewald, D.A.1    Naai, M.A.2    Marck, B.T.3    Matsumoto, A.M.4
  • 24
    • 0023935385 scopus 로고
    • Attenuated release of biologically active luteinizing hormone in healthy aging men
    • Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML. Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest 1988; 81: 1020-9.
    • (1988) J Clin Invest , vol.81 , pp. 1020-1029
    • Urban, R.J.1    Veldhuis, J.D.2    Blizzard, R.M.3    Dufau, M.L.4
  • 25
    • 0026762786 scopus 로고
    • Attenuation of luteinizing-hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men
    • Veldhuis JD, Urban RJ, Lizarralde G, et al. Attenuation of luteinizing-hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men. J Clin Endocrinol Metab 1992; 75: 52-8.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 52-58
    • Veldhuis, J.D.1    Urban, R.J.2    Lizarralde, G.3
  • 26
    • 0021235279 scopus 로고
    • Anterior-pituitary luteinizing-hormone secretion during continuous perifusion in aging male-rats
    • Kaler LW, Critchlow V. Anterior-pituitary luteinizing-hormone secretion during continuous perifusion in aging male-rats. Mech Ageing Dev 1984; 25: 103-15.
    • (1984) Mech Ageing Dev , vol.25 , pp. 103-115
    • Kaler, L.W.1    Critchlow, V.2
  • 27
    • 0021713004 scopus 로고
    • The gonadotropin-suppressive activity of androgen is increased in elderly men
    • Winters SJ, Sherins RJ, Troen P. The gonadotropin-suppressive activity of androgen is increased in elderly men. Metab Clin Exp 1984; 33: 1052-9.
    • (1984) Metab Clin Exp , vol.33 , pp. 1052-1059
    • Winters, S.J.1    Sherins, R.J.2    Troen, P.3
  • 28
    • 84867760925 scopus 로고    scopus 로고
    • Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man
    • Molnar CS, Vida B, Sipos MT, et al. Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. Endocrinology 2012; 153: 5428-39.
    • (2012) Endocrinology , vol.153 , pp. 5428-5439
    • Molnar, C.S.1    Vida, B.2    Sipos, M.T.3
  • 29
    • 31144445179 scopus 로고    scopus 로고
    • Male hypogonadism: An update on diagnosis and treatment
    • Darby E, Anawalt BD. Male hypogonadism: an update on diagnosis and treatment. Treat Endocrinol 2005; 4: 293-309.
    • (2005) Treat Endocrinol , vol.4 , pp. 293-309
    • Darby, E.1    Anawalt, B.D.2
  • 30
    • 84867249434 scopus 로고    scopus 로고
    • Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study
    • Sartorius G, Spasevska S, Idan A, et al. Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study. Clin Endocrinol (Oxf) 2012; 77: 755-63.
    • (2012) Clin Endocrinol (Oxf) , vol.77 , pp. 755-763
    • Sartorius, G.1    Spasevska, S.2    Idan, A.3
  • 31
    • 84875863886 scopus 로고    scopus 로고
    • Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: Longitudinal results from the European Male Ageing Study
    • Camacho EM, Huhtaniemi IT, O'Neill TW, et al. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. Eur J Endocrinol 2013; 168: 445-55.
    • (2013) Eur J Endocrinol , vol.168 , pp. 445-455
    • Camacho, E.M.1    Huhtaniemi, I.T.2    O'Neill, T.W.3
  • 33
    • 84924424068 scopus 로고    scopus 로고
    • Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men
    • Lunenfeld B, Mskhalaya G, Zitzmann M, et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male 2015; 18: 5-15.
    • (2015) Aging Male , vol.18 , pp. 5-15
    • Lunenfeld, B.1    Mskhalaya, G.2    Zitzmann, M.3
  • 36
    • 84928399408 scopus 로고    scopus 로고
    • Disease mongering of age-associated declines in testosterone and growth hormone levels
    • Perls T, Handelsman DJ. Disease mongering of age-associated declines in testosterone and growth hormone levels. J Am Geriatr Soc 2015; 63: 809 - 11.
    • (2015) J Am Geriatr Soc , vol.63 , pp. 809-811
    • Perls, T.1    Handelsman, D.J.2
  • 37
    • 84901262898 scopus 로고    scopus 로고
    • The testosterone trials: Seven coordinated trials of testosterone treatment in elderly men
    • Snyder PJ, Ellenberg SS, Cunningham GR, et al. The testosterone trials: seven coordinated trials of testosterone treatment in elderly men. Clin Trials 2014; 11: 362-75
    • (2014) Clin Trials , vol.11 , pp. 362-375
    • Snyder, P.J.1    Ellenberg, S.S.2    Cunningham, G.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.