Overexpression of protein kinase C ε improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction

Cell Death and Disease

Volumn 7, Issue , 2016, Pages

  He, H ^a   Zhao, Z H ^b   Han, F S ^a   Liu, X H ^a   Wang, R ^a   Zeng, Y J ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Zhoupu Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BLOOD CLOTTING FACTOR 8; CHEMOKINE RECEPTOR CXCR4; FIBROBLAST GROWTH FACTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; PLERIXAFOR; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; SMOOTH MUSCLE ACTIN; STROMAL CELL DERIVED FACTOR 1; TRANSFORMING GROWTH FACTOR BETA; TROPONIN I; VASCULOTROPIN; VON WILLEBRAND FACTOR; PROTEIN KINASE C;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL SURVIVAL; CLINICAL ASSESSMENT; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE OVEREXPRESSION; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE; HEART PROTECTION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACUTE DISEASE; ANIMAL; CYTOLOGY; DISEASE MODEL; GENETICS; HEART INFARCTION; MESENCHYMAL STROMA CELL; METABOLISM;

ACUTE DISEASE; ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION;

EID: 84955127302     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.417     Document Type: Article

References (46)

1. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB et al. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 2012; 125: e2-e220.
2. Mendis S, Puska P, Norrving B. Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization: Switzerland, 2011.
3. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701-705.
4. Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J et al. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation 2010; 121: 293-305.
5. Sanz-Ruiz R, GIE AA, Fernández Santos ME, Fernández PL, Fernández-Avilés F. Phases i-iii clinical trials using adult stem cells. Stem Cells Int 2010; 2010: 579142.
6. Traverse JH, McKenna DH, Harvey K, Jorgenso BC, Olson RE, Bostrom N et al. Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction. Am Heart J 2010; 160: 428-434.
7. Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, Suncion VY et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA 2012; 308: 2369-2379.
8. He H, Han FS. Clinical studies on stem cells therapy for ischemic heart diseases. Adv Cardiovasc Dis 2012; 33: 181-184.
9. Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Dorn GW 2nd et al. Increased particulate partitioning of PKC epsilon reverses susceptibility of phospholamban knockout hearts to ischemic injury. J Mol Cell Cardiol 2004; 36: 313-318.
10. Shinmura K, Nagai M, Tamaki K, Bolli R. Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C epsilon phosphorylation. Cardiovasc Res 2008; 79: 387-394.
11. Meyer KD, Zhang H, Zhang L. Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts: role of PKCepsilon. Am J Physiol Heart Circ Physiol 2009; 296: H1566-H1576.
12. He H, Zhao ZH, Han FS, Wang XF, Zeng YJ. Activation of protein kinase C epsilon enhanced movement ability and paracrine function of rat bone marrow mesenchymal stem cells partly at least independent of SDF-1/CXCR4 axis and PI3K/AKT pathway. Int J Clin Exp Med 2015; 8: 188-202.
13. Zaruba MM, Franz WM. Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy. Expert Opin Biol Ther 2010; 10: 321-335.
14. Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc Res 2008; 77: 134-142.
15. Frederick JR, Fitzpatrick JR 3rd, McCormick RC, Harris DA, Kim AY, Muenzer JR et al. Stromal cell-derived factor-1alpha activation of tissue-engineered endothelial progenitor cell matrix enhances ventricular function after myocardial infarction by inducing neovasculogenesis. Circulation 2010; 122: S107-S117.
16. Zhang D, Huang W, Dai B, Zhao T, Ashraf A, Millard RW et al. Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol 2010; 299: H1339-H1347.
17. Tang YL, Zhu W, Cheng M, Chen L, Zhang J, Sun T et al. Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res 2009; 104: 1209-1216.
18. Zhang Y, Ou L, Cheng Z, Jia X, Gao N, Kong D. Migration assay in vitro on Cxcr4 genemodified Bone Marrow mesenchymal stem cells. J Biomed Engineer 2009; 26: 595-600.
19. Yu J, Li M, Qu Z, Yan D, Li D, Ruan Q. SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt. J Cardiovasc Pharmacol 2010; 55: 496-505.
20. Angoulvant D, Ivanes F, Ferrera R, Matthews PG, Nataf S, Ovize M. Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury. J Heart Lung Transplant 2011; 30: 95-102.
21. Ping P, Song C, Zhang J, Guo Y, Cao X, Li RC et al. Formation of protein kinase c(epsilon)- lck signaling modules confers cardioprotection. J Clin Invest 2002; 109: 499-507.
22. Rafiee P, Shi Y, Kong X, Pritchard KA Jr., Tweddell JS, Litwin SB et al. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. Circulation 2002; 106: 239-245.
23. He H, Wang W, Zhang H, Ma L, Wu H, Wang P et al. Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. Cardiovasc Drugs Ther 2006; 20: 259-271.
24. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002; 192: 1-15.
25. Counillon L, Pouyssegur J. The expanding family of eucaryotic Na(+)/H(+) exchangers. J Biol Chem 2000; 275: 1-4.
26. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 1998; 273: 5423-5426.
27. Ren J, Zhang S, Kovacs A, Wang Y, Muslin AJ. Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol 2005; 38: 617-623.
28. Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S et al. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest 2003; 111: 1475-1486.
29. Liang Q, Elson AC, Gerdes AM. p38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in spontaneously hypertensive heart failure rats. J Card Fail 2006; 12: 479-486.
30. Liu YH, Wang D, Rhaleb NE, Yang XP, Xu J, Sankey SS et al. Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction. J Card Fail 2005; 11: 74-81.
31. Cheng TH, Shih NL, Chen CH, Lin H, Liu JC, Chao HH et al. Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced betamyosin heavy chain gene expression and cardiomyocyte hypertrophy. J Biomed Sci 2005; 12: 123-133.
32. Gupta A, Aberle NS 2nd, Kapoor R, Ren J, Sharma AC. Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility in sepsis. Biochim Biophys Acta 2005; 1741: 127-139.
33. Xu L, Kappler CS, Menick DR. The role of p38 in the regulation of Na+-Ca2+ exchanger expression in adult cardiomyocytes. J Mol Cell Cardiol 2005; 38: 735-743.
34. Wang Y, Luther K. Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1alpha/CXCR4 signaling pathway. Prog Mol Biol Transl Sci 2012; 111: 265-284.
35. He H, Han FS. strategies for improving homing and paracrine function of stem cells. Int J Cardiovasc Dis 2013; 40: 3-5.
36. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res 2007; 74: 184-195.
37. Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 2007; 116: 2127-2138.
38. Woodiwiss AJ, Tsotetsi OJ, Sprott S, Lancaster EJ, Mela T, Chung ES et al. Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction. Circulation 2001; 103: 155-160.
39. Li TS, Hayashi M, Ito H, Furutani A, Murata T, Matsuzaki M et al. Regeneration of infarcted myocardium by intramyocardial implantation of ex vivo transforming growth factor-beta-preprogrammed bone marrow stem cells. Circulation 2005; 111: 2438-2445.
40. McCarthy J, McLeod CJ, Minners J, Essop MF, Ping P, Sack MN. PKCepsilon activation augments cardiac mitochondrial respiratory post-anoxic reserve - a putative mechanism in PKCepsilon cardioprotection. J Mol Cell Cardiol 2005; 38: 697-700.
41. Chang Y, Ceacareanu B, Dixit M, Sreejayan N, Hassid A. Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho. Circ Res 2002; 91: 390-397.
42. Deng W, Bivalacqua TJ, Chattergoon NN, Jeter JR Jr., Kadowitz PJ. Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector. Stem Cells 2004; 22: 1279-1291.
43. Pass JM, Gao J, Jones WK, Wead WB, Wu X, Zhang J et al. Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. Am J Physiol Heart Circ Physiol 2001; 281: H2500-H2510.
44. Olivetti G, Capasso JM, Meggs LG, Sonnenblick EH, Anversa P. Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ Res 1991; 68: 856-869.
45. Pogwizd SM, Qi M, Yuan W, Samarel AM, Bers DM. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 1999; 85: 1009-1019.
46. Ichinomiya T, Cho S, Higashijima U, Matsumoto S, Maekawa T, Sumikawa K. High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. Cardiovasc Diabetol 2012; 11: 28.