메뉴 건너뛰기




Volumn 310, Issue 2, 2016, Pages E103-E115

Evidence for hypothalamic ketone body sensing: Impact on food intake and peripheral metabolic responses in mice

Author keywords

Glucose homeostasis; Monocarboxylate transporters; Obesity; hydroxybutyrate

Indexed keywords

ADENYLATE KINASE; AGOUTI RELATED PROTEIN; GLUCOSE BLOOD LEVEL; KETONE BODY; NEUROPEPTIDE Y;

EID: 84955116869     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00282.2015     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 0037107408 scopus 로고    scopus 로고
    • Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: Evidence for ATP-independent control of ATP- sensitive K() channels
    • Ainscow EK, Mirshamsi S, Tang T, Ashford ML, Rutter GA. Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP- sensitive K() channels. J Physiol 544: 429-445, 2002.
    • (2002) J Physiol , vol.544 , pp. 429-445
    • Ainscow, E.K.1    Mirshamsi, S.2    Tang, T.3    Ashford, M.L.4    Rutter, G.A.5
  • 2
    • 77249131674 scopus 로고    scopus 로고
    • Hypothalamic nutrient sensing in the control of energy homeostasis
    • Blouet C, Schwartz GJ. Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res 209: 1-12, 2010.
    • (2010) Behav Brain Res , vol.209 , pp. 1-12
    • Blouet, C.1    Schwartz, G.J.2
  • 3
    • 0345700729 scopus 로고    scopus 로고
    • Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation
    • Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes 52: 663-666, 2003.
    • (2003) Diabetes , vol.52 , pp. 663-666
    • Borg, M.A.1    Tamborlane, W.V.2    Shulman, G.I.3    Sherwin, R.S.4
  • 4
    • 84921449824 scopus 로고    scopus 로고
    • Monocarboxylate transporters: New players in body weight regulation. Obes Rev 16
    • Carneiro L, Pellerin L. Monocarboxylate transporters: new players in body weight regulation. Obes Rev 16, Suppl 1: 55-66, 2015.
    • (2015) Suppl , vol.1 , pp. 55-66
    • Carneiro, L.1    Pellerin, L.2
  • 6
    • 0037707488 scopus 로고    scopus 로고
    • Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy
    • Ebert D, Haller RG, Walton ME. Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci 23: 5928-5935, 2003.
    • (2003) J Neurosci , vol.23 , pp. 5928-5935
    • Ebert, D.1    Haller, R.G.2    Walton, M.E.3
  • 7
    • 34248204584 scopus 로고    scopus 로고
    • Characterization of glucosensing neuron subpopulations in the arcuate nucleus: Integration in neuropeptide Y and pro-opio melanocortin net- works?
    • Fioramonti X, Contie S, Song Z, Routh VH, Lorsignol A, Penicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin net- works? Diabetes 56: 1219-1227, 2007.
    • (2007) Diabetes , vol.56 , pp. 1219-1227
    • Fioramonti, X.1    Contie, S.2    Song, Z.3    Routh, V.H.4    Lorsignol, A.5    Penicaud, L.6
  • 8
    • 78650887915 scopus 로고    scopus 로고
    • Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: A two-edged sword
    • Fioramonti X, Song Z, Vazirani RP, Beuve A, Routh VH. Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword. Antiox Redox Signal 14: 505-517, 2011.
    • (2011) Antiox Redox Signal , vol.14 , pp. 505-517
    • Fioramonti, X.1    Song, Z.2    Vazirani, R.P.3    Beuve, A.4    Routh, V.H.5
  • 9
    • 0029075183 scopus 로고
    • Peripheral 3-hydroxybutyrate and food intake in a model of dietary-fat induced obesity: Effect of vagotomy
    • Fisler JS, Egawa M, Bray GA. Peripheral 3-hydroxybutyrate and food intake in a model of dietary-fat induced obesity: effect of vagotomy. Physiol Behav 58: 1-7, 1995.
    • (1995) Physiol Behav , vol.58 , pp. 1-7
    • Fisler, J.S.1    Egawa, M.2    Bray, G.A.3
  • 11
    • 84858029073 scopus 로고    scopus 로고
    • Clinical review: Regulation of food intake, energy balance, and body fat mass: Implications for the pathogenesis and treatment of obesity
    • Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 97: 745-755, 2012.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 745-755
    • Guyenet, S.J.1    Schwartz, M.W.2
  • 12
    • 0018751594 scopus 로고
    • Ketone bodies are selectively used by individual brain regions
    • Hawkins RA, Biebuyck JF. Ketone bodies are selectively used by individual brain regions. Science 205: 325-327, 1979.
    • (1979) Science , vol.205 , pp. 325-327
    • Hawkins, R.A.1    Biebuyck, J.F.2
  • 13
    • 0022552442 scopus 로고
    • Regional ketone body utilization by rat brain in starvation and diabetes
    • Hawkins RA, Mans AM, Davis DW. Regional ketone body utilization by rat brain in starvation and diabetes. Am J Physiol Endocrinol Metab 250:E169-E178, 1986.
    • (1986) Am J Physiol Endocrinol Metab , vol.250
    • Hawkins, R.A.1    Mans, A.M.2    Davis, D.W.3
  • 15
    • 67650257653 scopus 로고    scopus 로고
    • Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: An NADPH oxidase-dependent mechanism
    • Jaillard T, Roger M, Galinier A, Guillou P, Benani A, Leloup C, Casteilla L, Penicaud L, Lorsignol A. Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism. Diabetes 58: 1544-1549, 2009.
    • (2009) Diabetes , vol.58 , pp. 1544-1549
    • Jaillard, T.1    Roger, M.2    Galinier, A.3    Guillou, P.4    Benani, A.5    Leloup, C.6    Casteilla, L.7    Penicaud, L.8    Lorsignol, A.9
  • 16
    • 33745119830 scopus 로고    scopus 로고
    • Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets
    • Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears B. Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Am J Clin Nutr 83: 1055-1061, 2006.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1055-1061
    • Johnston, C.S.1    Tjonn, S.L.2    Swan, P.D.3    White, A.4    Hutchins, H.5    Sears, B.6
  • 17
    • 38149134457 scopus 로고    scopus 로고
    • Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum
    • Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. Am J Clin Nutr 87: 44-55, 2008.
    • (2008) Am J Clin Nutr , vol.87 , pp. 44-55
    • Johnstone, A.M.1    Horgan, G.W.2    Murison, S.D.3    Bremner, D.M.4    Lobley, G.E.5
  • 19
    • 0021356212 scopus 로고
    • Hormonal regulation of hepatic gluconeogenesis. Lamic leptin and insulin signaling pathways in type 2 diabetic rats
    • Kraus-Friedmann N. Hormonal regulation of hepatic gluconeogenesis. lamic leptin and insulin signaling pathways in type 2 diabetic rats. Physiol Rev 64: 170-259, 1984
    • (1984) Physiol Rev , vol.64 , pp. 170-259
    • Kraus-Friedmann, N.1
  • 20
    • 84862084744 scopus 로고    scopus 로고
    • The ketone body betahydroxybutyricacid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells
    • Laeger T, Pohland R, Metges CC, Kuhla B. The ketone body betahydroxybutyricacid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells. J Endocrinol 213: 193–203, 2012.
    • (2012) J Endocrinol , vol.213 , pp. 193-203
    • Laeger, T.1    Pohland, R.2    Metges, C.C.3    Kuhla, B.4
  • 21
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 15: 412-426, 1999.
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 426
    • Laffel, L.1
  • 22
    • 84891710015 scopus 로고    scopus 로고
    • FAT/CD36: A major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice
    • Le Foll C, Dunn-Meynell A, Musatov S, Magnan C, Levin BE. FAT/CD36: a major regulator of neuronal fatty acid sensing and energy homeostasis in rats and mice. Diabetes 62: 2709–2716, 2013.
    • (2013) Diabetes , vol.62 , pp. 2709-2716
    • Le Foll, C.1    Dunn-Meynell, A.2    Musatov, S.3    Magnan, C.4    Levin, B.E.5
  • 23
    • 84897885703 scopus 로고    scopus 로고
    • Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids
    • Le Foll C, Dunn-Meynell AA, Miziorko HM, Levin BE. Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids. Diabetes 63: 1259–1269, 2014.
    • (2014) Diabetes , vol.63 , pp. 1259-1269
    • Le Foll, C.1    Dunn-Meynell, A.A.2    Miziorko, H.M.3    Levin, B.E.4
  • 24
    • 0035106634 scopus 로고    scopus 로고
    • Dietinduced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain
    • Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR. Dietinduced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 38: 519–527, 2001.
    • (2001) Neurochem Int , vol.38 , pp. 519-527
    • Leino, R.L.1    Gerhart, D.Z.2    Duelli, R.3    Enerson, B.E.4    Drewes, L.R.5
  • 27
    • 84890978770 scopus 로고    scopus 로고
    • Ketone bodies as signaling metabolites
    • Newman JC, Verdin E. Ketone bodies as signaling metabolites. Trends Endocrinol Metab 25: 42–52, 2014.
    • (2014) Trends Endocrinol Metab , vol.25 , pp. 42-52
    • Newman, J.C.1    Verdin, E.2
  • 28
    • 24044518735 scopus 로고    scopus 로고
    • Perceived hunger is lower and weight loss is greater in overweight premenopausal women consuming a low-carbohydrate/high-protein vs high-carbohydrate/low-fat diet
    • Nickols-Richardson SM, Coleman MD, Volpe JJ, Hosig KW. Perceived hunger is lower and weight loss is greater in overweight premenopausal women consuming a low-carbohydrate/high-protein vs high-carbohydrate/low-fat diet. J Am Diet Assoc 105: 1433–1437, 2005.
    • (2005) J am Diet Assoc , vol.105 , pp. 1433-1437
    • Nickols-Richardson, S.M.1    Coleman, M.D.2    Volpe, J.J.3    Hosig, K.W.4
  • 29
    • 84890531149 scopus 로고    scopus 로고
    • Long term successful weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol
    • Paoli A, Bianco A, Grimaldi KA, Lodi A, Bosco G. Long term successful weight loss with a combination biphasic ketogenic Mediterranean diet and Mediterranean diet maintenance protocol. Nutrients 5:5205–5217, 2013.
    • (2013) Nutrients , vol.5 , pp. 5205-5217
    • Paoli, A.1    Bianco, A.2    Grimaldi, K.A.3    Lodi, A.4    Bosco, G.5
  • 30
    • 84926434504 scopus 로고    scopus 로고
    • Ketosis, ketogenic diet and food intake control: A complex relationship
    • Paoli A, Bosco G, Camporesi EM, Mangar D. Ketosis, ketogenic diet and food intake control: a complex relationship. Front Psychol 6: 27,2015.
    • (2015) Front Psychol , vol.6 , pp. 27
    • Paoli, A.1    Bosco, G.2    Camporesi, E.M.3    Mangar, D.4
  • 31
    • 80053910028 scopus 로고    scopus 로고
    • Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees
    • Paoli A, Cenci L, Grimaldi KA. Effect of ketogenic Mediterranean diet with phytoextracts and low carbohydrates/high-protein meals on weight, cardiovascular risk factors, body composition and diet compliance in Italian council employees. Nutr J 10: 112, 2011.
    • (2011) Nutr J , vol.10 , pp. 112
    • Paoli, A.1    Cenci, L.2    Grimaldi, K.A.3
  • 32
    • 79959763844 scopus 로고    scopus 로고
    • Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic rats
    • Park S, Kim da S, Daily JW. Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic rats. Brain Res 1401: 95–103, 2011.
    • (2011) Brain Res , vol.1401 , pp. 95-103
    • Park, S.1    Kim Da, S.2    Daily, J.W.3
  • 33
    • 78650764923 scopus 로고    scopus 로고
    • Food for thought: The importance of glucose and other energy substrates for sustaining brain function under varying levels of activity
    • Pellerin L. Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity. Diabetes Metab 36, Suppl 3: S59–S63, 2010.
    • (2010) Diabetes Metab , vol.36
    • Pellerin, L.1
  • 34
    • 0031238833 scopus 로고    scopus 로고
    • Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line
    • Pellerin L, Stolz M, Sorg O, Martin JL, Deschepper CF, Magistretti PJ. Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line. Glia 21: 74–83, 1997.
    • (1997) Glia , vol.21 , pp. 74-83
    • Pellerin, L.1    Stolz, M.2    Sorg, O.3    Martin, J.L.4    Deschepper, C.F.5    Magistretti, P.J.6
  • 35
    • 34247559154 scopus 로고    scopus 로고
    • Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes
    • Pelletier A, Coderre L. Ketone bodies alter dinitrophenol-induced glucose uptake through AMPK inhibition and oxidative stress generation in adult cardiomyocytes. Am J Physiol Endocrinol Metab 292: E1325-E1332, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Pelletier, A.1    Coderre, L.2
  • 36
    • 34548359349 scopus 로고    scopus 로고
    • Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice
    • Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. J Physiol 583: 469–486, 2007.
    • (2007) J Physiol , vol.583 , pp. 469-486
    • Pierre, K.1    Parent, A.2    Jayet, P.Y.3    Halestrap, A.P.4    Scherrer, U.5    Pellerin, L.6
  • 37
    • 21344444566 scopus 로고    scopus 로고
    • Monocarboxylate transporters in the central nervous system: Distribution, regulation and function
    • Pierre K, Pellerin L. Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94: 1–14, 2005.
    • (2005) J Neurochem , vol.94 , pp. 1-14
    • Pierre, K.1    Pellerin, L.2
  • 38
    • 0034721575 scopus 로고    scopus 로고
    • Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
    • Pierre K, Pellerin L, Debernardi R, Riederer BM, Magistretti PJ. Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy. Neuroscience 100: 617–627, 2000.
    • (2000) Neuroscience , vol.100 , pp. 617-627
    • Pierre, K.1    Pellerin, L.2    Debernardi, R.3    Riederer, B.M.4    Magistretti, P.J.5
  • 42
    • 84872120798 scopus 로고    scopus 로고
    • The defence of body weight: A physiological basis for weight regain after weight loss
    • Sumithran P, Proietto J. The defence of body weight: a physiological basis for weight regain after weight loss. Clin Sci (Lond) 124: 231–241, 2013.
    • (2013) Clin Sci (Lond) , vol.124 , pp. 231-241
    • Sumithran, P.1    Proietto, J.2
  • 43
    • 0020055933 scopus 로고
    • Oxidation and ketogenesis in hepatocytes of lean and obese Zucker rats
    • Triscari J, Greenwood MR, Sullivan AC. Oxidation and ketogenesis in hepatocytes of lean and obese Zucker rats. Metabolism 31: 223–228, 1982.
    • (1982) Metabolism , vol.31 , pp. 223-228
    • Triscari, J.1    Greenwood, M.R.2    Sullivan, A.C.3
  • 44
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: The effects of ketone bodies in pathological conditions: Ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech RL. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids 70: 309–319, 2004.
    • (2004) Prostaglandins Leukot Essent Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 45
    • 60149087568 scopus 로고    scopus 로고
    • The effect of a low-carbohydrate, ketogenic diet versus a lowglycemic index diet on glycemic control in type 2 diabetes mellitus
    • Westman EC, Yancy WS Jr, Mavropoulos JC, Marquart M, McDuffie JR. The effect of a low-carbohydrate, ketogenic diet versus a lowglycemic index diet on glycemic control in type 2 diabetes mellitus. Nutr Metab (Lond) 5: 36, 2008.
    • (2008) Nutr Metab (Lond) , vol.5 , pp. 36
    • Westman, E.C.1    Yancy, W.S.2    Mavropoulos, J.C.3    Marquart, M.4    McDuffie, J.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.