Central infusion of ketone bodies modulates body weight and hepatic insulin sensitivity by modifying hypothalamic leptin and insulin signaling pathways in type 2 diabetic rats

Brain Research

Volumn 1401, Issue , 2011, Pages 95-103

  Park, Sunmin ^a   Kim, Da Sol ^a   Daily, James W ^b  

^a Hoseo University   (South Korea)

^b Daily Manufacturing Inc   (United States)

Author keywords

hydroxybutyrate; Euglycemic hyperinsulinemic clamp; Gluconeogenesis; Hyperglycemic clamp; Hypothalamus; Insulin signaling

Indexed keywords

3 HYDROXYBUTYRIC ACID; INSULIN; KETONE BODY; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CEREBROSPINAL FLUID; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; ENERGY METABOLISM; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPERINSULINEMIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS RESECTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RANDOMIZED CONTROLLED TRIAL; RAT;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; INFUSIONS, INTRAVENTRICULAR; INSULIN; INSULIN RESISTANCE; KETONE BODIES; LEPTIN; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 79959763844     PISSN: 00068993     EISSN: 00068993     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.05.040     Document Type: Article

References (28)

1. American Institute of Nutrition AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet J. Nutr. 123 1993 1939 1951
2. C. Bjorbaek, and B.B. Kahn Leptin signaling in the central nervous system and the periphery Recent Prog. Horm. Res. 59 2004 305 331
3. C. Buettner, and R.C. Camacho Hypothalamic control of hepatic glucose production and its potential role in insulin resistance Endocrinol. Metab. Clin. North Am. 37 2008 825 840
4. M. Claret, M.A. Smith, R.L. Batterham, C. Selman, A.I. Choudhury, L.G. Fryer, M. Clements, H. Al-Qassab, H. Heffron, A.W. Xu, J.R. Speakman, G.S. Barsh, B. Viollet, S. Vaulont, M.L. Ashford, D. Carling, and D.J. Withers AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons J. Clin. Invest. 117 2007 2325 2336 (Pubitemid 47219577)
5. K.A. Clark, M.S. MohanKumar, B.S. Kasturi, and P.S. MohanKumar Effects of central and systemic administration of leptin on neurotransmitter concentrations in specific areas of the hypothalamus Am. J. Physiol. - Reg. I. 290 2006 R306 R312
6. D. Cota, K. Proulx, and R.J. Seeley The role of CNS fuel sensing in energy and glucose regulation Gastroenterology 132 2007 2158 2168 (Pubitemid 46693748)
7. H.M. Dashti, T.C. Mathew, M. Khadada, M. Al-Mousawi, H. Talib, S.K. Asfar, A.I. Behbahani, and N.S. Al-Zaid Beneficial effects of ketogenic diet in obese diabetic subjects Mol. Cell. Biochem. 302 2007 249 256 (Pubitemid 47202341)
8. R.A. DeFronzo Pathogenesis of type 2 diabetes mellitus Med. Clin. North Am. 88 2004 787 835
9. K. Gerozissis Brain insulin and feeding: a bi-directional communication Eur. J. Pharmacol. 490 2004 59 70 (Pubitemid 38488858)
10. Y.A. Hosokawa, H. Hosokawa, C. Chen, and J.L. Leahy Mechanism of impaired glucose-potentiated insulin-secretion in diabetic 90 percent pancreatectomy rats-study using glucagon-like peptide-1 (7-37) J. Clin. Invest. 97 1996 180 186 (Pubitemid 26022593)
11. C.S. Johnston, S.L. Tjonn, P.D. Swan, A. White, H. Hutchins, and B. Sears Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets Am. J. Clin. Nutr. 83 2006 1055 1061 (Pubitemid 44713104)
12. J.K. Kim, Y.J. Kim, J.J. Fillmore, Y. Chen, I. Moore, J. Lee, M. Yuan, Z.W. Li, M. Karin, P. Perret, S.E. Shoelson, and G.I. Shulman Prevention of fat-induced insulin resistance by salicylate J. Clin. Invest. 108 2001 437 446 (Pubitemid 32730790)
13. N. Kubota, W. Yano, T. Kubota, T. Yamauchi, S. Itoh, H. Kumagai, H. Kozono, I. Takamoto, S. Okamoto, T. Shiuchi, R. Suzuki, H. Satoh, A. Tsuchida, M. Moroi, K. Sugi, T. Noda, H. Ebinuma, Y. Ueta, T. Kondo, E. Araki, O. Ezaki, R. Nagai, K. Tobe, Y. Terauchi, K. Ueki, Y. Minokoshi, and T. Kadowaki Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake Cell Metab. 6 2007 55 68 (Pubitemid 47007437)
14. B.E. Levin Metabolic sensing neurons and the control of energy homeostasis Physiol. Behav. 89 2006 486 489 (Pubitemid 44634575)
15. B.E. Levin, A.A. Dunn-Meynell, and V.H. Routh Brain glucose sensing and body energy homeostasis: role in obesity and diabetes Am. J. Physiol. 276 1999 R1223 R1231
16. Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, B. Xue, J. Mu, F. Foufelle, P. Ferre, M.J. Birnbaum, B.J. Stuck, and B.B. Kahn AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574 (Pubitemid 38480541)
17. S. Obici, B.B. Zhang, G. Karkanias, and L. Rossetti Hypothalamic insulin signaling is required for inhibition of glucose production Nat. Med. 8 2002 1376 1382 (Pubitemid 36019422)
18. H. Ono, A. Pocai, Y. Wang, H. Sakoda, T. Asano, J.M. Backer, G.J. Schwartz, and L. Rossetti Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats J. Clin. Invest. 118 2008 2959 2968
19. S. Park, C.H. Park, and J.S. Jang Antecedent intake of traditional Asian-style diets exacerbates pancreatic β-cell function, growth and survival after Western-style diet feeding in weaning male rats J. Nutr. Biochem. 17 2006 307 318
20. S. Park, S.M. Hong, and I.S. Ahn Long-term intracerebroventricular infusion of insulin, but not glucose, modulates body weight and hepatic insulin sensitivity by modifying the hypothalamic insulin signaling pathway in type 2 diabetic rats Neuroendocrinology 89 2009 387 399
21. S. Park, I.L. Ahn, D.S. Kim, and J.W. Daily A ketogenic diet impairs energy and glucose homeostasis by the attenuation of hypothalamic leptin signaling and hepatic insulin signaling in type 2 diabetic rats Exp. Biol. Med. 236 2011 194 204
22. E. Prodi, and S. Obici The brain as a molecular target for diabetic therapy Endocrinology 147 2006 2664 2669 (Pubitemid 43764601)
23. Y. Qi, N. Takahashi, S.M. Hileman, H.R. Patel, A.H. Berg, U.B. Pajvani, P.E. Scherer, and R.S. Ahima Adiponectin acts in the brain to decrease body weight Nat. Med. 10 2004 524 529 (Pubitemid 38667912)
24. L.C. Ribeiro, A.L. Chittó, A.P. Müller, J.K. Rocha, M. Castro da Silva, A. Quincozes-Santos, P. Nardin, L.N. Rotta, D.R. Ziegler, C.A. Gonçalves, R.S. Da Silva, M.L. Perry, and C. Gottfried Ketogenic diet-fed rats have increased fat mass and phosphoenolpyruvate carboxykinase activity Mol. Nutr. Food Res. 52 2008 1365 1371
25. L. Rossetti, G.I. Shulman, W. Zawalich, and R.A. DeFronzo Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats J. Clin. Invest. 80 1987 1037 1044 (Pubitemid 18075639)
26. M. Sun, R.J. Martin, and G.L. Edwards ICV beta-hydroxybutyrate: effects on food intake, body composition, and body weight in rats Physiol. Behav. 61 1997 433 436 (Pubitemid 27149318)
27. E.C. Westman, W.S. Yancy Jr., J.C. Mavropoulos, M. Marquart, and J.R. McDuffie The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus Nutr. Metab. 5 2008 36 39
28. J. Wylie-Rosett, and N.J. Davis Low-carbohydrate diets: an update on current research Curr. Diab. Rep. 9 2009 396 404