Identification of DGAT2 Inhibitors Using Mass Spectrometry

Journal of Biomolecular Screening

Volumn 21, Issue 2, 2016, Pages 117-126

  Song, Xuelei S ^a   Zhang, Jiaping ^a   Chen, Xun U N ^a   Palyha, Oksana ^a   Chung, Christine ^a   Sonatore, Lisa M ^a   Wilsie, Larissa ^a   Stout, Steven ^a   McLaren, David G ^a   Taggart, Andrew ^a   Imbriglio, Jason E ^a   Pinto, Shirly ^a   Garcia Calvo, Margarita ^a   Addona, George H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

DGAT2; LC MS; triglycerides

Indexed keywords

ACYLTRANSFERASE INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE 2; DIACYLGLYCEROL O ACYLTRANSFERASE 2 INHIBITOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; DGAT2 PROTEIN, HUMAN; DIACYLGLYCEROL ACYLTRANSFERASE; ENZYME INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG IDENTIFICATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLUOROGENIC ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; IC50; LIQUID CHROMATOGRAPHY; LIVER CELL; MOUSE; NONHUMAN; PARALLEL DESIGN; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; ENZYME ASSAY; MASS SPECTROMETRY; PROCEDURES; SF9 CELL LINE;

ANIMALS; CELL LINE; CHROMATOGRAPHY, LIQUID; DIACYLGLYCEROL O-ACYLTRANSFERASE; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; MASS SPECTROMETRY; SF9 CELLS; TRIGLYCERIDES;

EID: 84954559961     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115607463     Document Type: Article

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