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Volumn 14, Issue 1, 2016, Pages 103-113

Tumor cell-derived periostin regulates cytokines that maintain breast cancer stem cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; STAT3 PROTEIN; TRANSCRIPTION FACTOR RUNX2; VITRONECTIN RECEPTOR; CELL ADHESION MOLECULE; POSTN PROTEIN, HUMAN;

EID: 84954473105     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-15-0079     Document Type: Article
Times cited : (50)

References (54)
  • 1
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009;138:822-9.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 2
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 4
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007;1:555-67.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 5
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253-70.
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3    Jackson, K.W.4    Clarke, M.F.5    Kawamura, M.J.6
  • 6
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    • Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65:5506-11.
    • (2005) Cancer Res , vol.65 , pp. 5506-5511
    • Ponti, D.1    Costa, A.2    Zaffaroni, N.3    Pratesi, G.4    Petrangolini, G.5    Coradini, D.6
  • 7
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-15.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 9
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007;356:217-26.
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3    Dalerba, P.4    Gurney, A.5    Hoey, T.6
  • 11
    • 77953696850 scopus 로고    scopus 로고
    • Controversies in cancer stem cells: Targeting embryonic signaling pathways
    • Takebe N, Ivy SP. Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res 2010;16:3106-12.
    • (2010) Clin Cancer Res , vol.16 , pp. 3106-3112
    • Takebe, N.1    Ivy, S.P.2
  • 13
    • 80053401068 scopus 로고    scopus 로고
    • Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    • Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 2011;121:3804-9.
    • (2011) J Clin Invest , vol.121 , pp. 3804-3809
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 14
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A 2011;108:1397-402.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 15
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44 (+)CD24(-) stem cell-like breast cancer cells in human tumors
    • Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44 (+)CD24(-) stem cell-like breast cancer cells in human tumors. J Clin Invest 2011;121:2723-35.
    • (2011) J Clin Invest , vol.121 , pp. 2723-2735
    • Marotta, L.L.1    Almendro, V.2    Marusyk, A.3    Shipitsin, M.4    Schemme, J.5    Walker, S.R.6
  • 16
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest 2010;120:485-97.
    • (2010) J Clin Invest , vol.120 , pp. 485-497
    • Ginestier, C.1    Liu, S.2    Diebel, M.E.3    Korkaya, H.4    Luo, M.5    Brown, M.6
  • 20
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 2009;106:13820-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 21
    • 76249084838 scopus 로고    scopus 로고
    • Smad signaling is required to maintain epigenetic silencing during breast cancer progression
    • Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, et al. Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res 2010;70:968-78.
    • (2010) Cancer Res , vol.70 , pp. 968-978
    • Papageorgis, P.1    Lambert, A.W.2    Ozturk, S.3    Gao, F.4    Pan, H.5    Manne, U.6
  • 22
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006;10:515-27.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3    Yeh, J.4    Baehner, F.L.5    Fevr, T.6
  • 24
    • 0034534734 scopus 로고    scopus 로고
    • Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers
    • Strickland LB, Dawson PJ, Santner SJ, Miller FR. Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers. Breast Cancer Res Treat 2000;64:235-40.
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 235-240
    • Strickland, L.B.1    Dawson, P.J.2    Santner, S.J.3    Miller, F.R.4
  • 25
    • 0036022145 scopus 로고    scopus 로고
    • A novel mechanism for the regulation of osteoblast differentiation: Transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, twist
    • Oshima A, Tanabe H, Yan T, Lowe GN, Glackin CA, Kudo A. A novel mechanism for the regulation of osteoblast differentiation: transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, twist. J Cell Biochem 2002;86:792-804.
    • (2002) J Cell Biochem , vol.86 , pp. 792-804
    • Oshima, A.1    Tanabe, H.2    Yan, T.3    Lowe, G.N.4    Glackin, C.A.5    Kudo, A.6
  • 26
    • 0032973197 scopus 로고    scopus 로고
    • Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    • Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, et al. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res 1999;14:1239-49.
    • (1999) J Bone Miner Res , vol.14 , pp. 1239-1249
    • Horiuchi, K.1    Amizuka, N.2    Takeshita, S.3    Takamatsu, H.4    Katsuura, M.5    Ozawa, H.6
  • 27
    • 67650451085 scopus 로고    scopus 로고
    • The multifaceted role of periostin in tumorigenesis
    • Ruan K, Bao S, Ouyang G. The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci 2009;66:2219-30.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2219-2230
    • Ruan, K.1    Bao, S.2    Ouyang, G.3
  • 28
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009;69:1302-13.
    • (2009) Cancer Res , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3    Wicinski, J.4    Cervera, N.5    Finetti, P.6
  • 29
    • 0030839766 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
    • King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol 1997;17:4406-18.
    • (1997) Mol Cell Biol , vol.17 , pp. 4406-4418
    • King, W.G.1    Mattaliano, M.D.2    Chan, T.O.3    Tsichlis, P.N.4    Brugge, J.S.5
  • 30
    • 84863539707 scopus 로고    scopus 로고
    • Periostin promotes chronic allergic inflammation in response to Th2 cytokines
    • Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, et al. Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest 2012;122:2590-600.
    • (2012) J Clin Invest , vol.122 , pp. 2590-2600
    • Masuoka, M.1    Shiraishi, H.2    Ohta, S.3    Suzuki, S.4    Arima, K.5    Aoki, S.6
  • 31
    • 68349150810 scopus 로고    scopus 로고
    • Mammary development meets cancer genomics
    • Prat A, Perou CM. Mammary development meets cancer genomics. Nat Med 2009;15:842-4.
    • (2009) Nat Med , vol.15 , pp. 842-844
    • Prat, A.1    Perou, C.M.2
  • 32
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res Treat 2010;123:725-31.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6
  • 33
    • 1942422179 scopus 로고    scopus 로고
    • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression
    • Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, et al. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol 2004;24:3992-4003.
    • (2004) Mol Cell Biol , vol.24 , pp. 3992-4003
    • Shao, R.1    Bao, S.2    Bai, X.3    Blanchette, C.4    Anderson, R.M.5    Dang, T.6
  • 34
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 35
    • 84867312244 scopus 로고    scopus 로고
    • Cancer stem cell-related gene periostin: A novel prognostic marker for breast cancer
    • Xu D, Xu H, Ren Y, Liu C, Wang X, Zhang H, et al. Cancer stem cell-related gene periostin: a novel prognostic marker for breast cancer. PLoS ONE 2012;7:e46670.
    • (2012) PLoS ONE , vol.7
    • Xu, D.1    Xu, H.2    Ren, Y.3    Liu, C.4    Wang, X.5    Zhang, H.6
  • 37
    • 84878552107 scopus 로고    scopus 로고
    • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8
    • Hartman ZC, Poage GM, den Hollander P, Tsimelzon A, Hill J, Panupinthu N, et al. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res 2013;73:3470-80.
    • (2013) Cancer Res , vol.73 , pp. 3470-3480
    • Hartman, Z.C.1    Poage, G.M.2    Den Hollander, P.3    Tsimelzon, A.4    Hill, J.5    Panupinthu, N.6
  • 38
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009;138:645-59.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 39
    • 0036775425 scopus 로고    scopus 로고
    • Matricellular proteins: Extracellular modulators of cell function
    • Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002;14:608-16.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 608-616
    • Bornstein, P.1    Sage, E.H.2
  • 40
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009;15:907-13.
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4    Pal, B.5    Hart, A.H.6
  • 41
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 2010;7:403-17.
    • (2010) Cell Stem Cell , vol.7 , pp. 403-417
    • Molyneux, G.1    Geyer, F.C.2    Magnay, F.A.3    McCarthy, A.4    Kendrick, H.5    Natrajan, R.6
  • 42
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M, et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 2011;8:149-63.
    • (2011) Cell Stem Cell , vol.8 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3    Klebba, I.4    Jones, A.D.5    Sedic, M.6
  • 44
    • 84863116087 scopus 로고    scopus 로고
    • Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
    • Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, et al. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A 2012;109:2778-83.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2778-2783
    • Herschkowitz, J.I.1    Zhao, W.2    Zhang, M.3    Usary, J.4    Murrow, G.5    Edwards, D.6
  • 45
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 2010;12:R68.
    • (2010) Breast Cancer Res , vol.12 , pp. R68
    • Prat, A.1    Parker, J.S.2    Karginova, O.3    Fan, C.4    Livasy, C.5    Herschkowitz, J.I.6
  • 46
    • 84883231603 scopus 로고    scopus 로고
    • Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells
    • Wang X, Liu J, Wang Z, Huang Y, Liu W, Zhu X, et al. Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS ONE 2013;8:e72962.
    • (2013) PLoS ONE , vol.8
    • Wang, X.1    Liu, J.2    Wang, Z.3    Huang, Y.4    Liu, W.5    Zhu, X.6
  • 47
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu F, Deng H, Yao H, Liu Q, Su F, Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010;29:4194-204.
    • (2010) Oncogene , vol.29 , pp. 4194-4204
    • Yu, F.1    Deng, H.2    Yao, H.3    Liu, Q.4    Su, F.5    Song, E.6
  • 49
    • 84886046699 scopus 로고    scopus 로고
    • Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer
    • Balko JM, Schwarz LJ, Bhola NE, Kurupi R, Owens P, Miller TW, et al. Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer. Cancer Res 2013;73:6346-58.
    • (2013) Cancer Res , vol.73 , pp. 6346-6358
    • Balko, J.M.1    Schwarz, L.J.2    Bhola, N.E.3    Kurupi, R.4    Owens, P.5    Miller, T.W.6
  • 50
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009;139:693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 51
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011;146:633-44.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6
  • 53
    • 84923068676 scopus 로고    scopus 로고
    • Periostin secreted by glioblastoma stem cells recruits M2 tumor-associated macrophages and promotes malignant grwoth
    • Zhou W, Ke SQ, Huang Z, Flavahan W, Fang X, Paul J, et al. Periostin secreted by glioblastoma stem cells recruits M2 tumor-associated macrophages and promotes malignant grwoth. Nat Cell Biol 2015;17:170-82.
    • (2015) Nat Cell Biol , vol.17 , pp. 170-182
    • Zhou, W.1    Ke, S.Q.2    Huang, Z.3    Flavahan, W.4    Fang, X.5    Paul, J.6
  • 54
    • 84899860489 scopus 로고    scopus 로고
    • An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
    • Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, et al. An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol 2014;16:457-68.
    • (2014) Nat Cell Biol , vol.16 , pp. 457-468
    • Seguin, L.1    Kato, S.2    Franovic, A.3    Camargo, M.F.4    Lesperance, J.5    Elliott, K.C.6


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