The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice

European Journal of Immunology

Volumn 46, Issue 4, 2016, Pages 897-911

  Charmoy, Melanie ^a   Hurrell, Benjamin P ^b   Romano, Audrey ^a   Lee, Sang Hun ^a   Ribeiro Gomes, Flavia ^a   Riteau, Nicolas ^a   Mayer Barber, Katrin ^a   Tacchini Cottier, Fabienne ^b   Sacks, David L ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

IL 1 ; Leishmaniasis; Neutrophils; Nlrp3 inflammasome; Skin

Indexed keywords

CASPASE 11; CD11B ANTIGEN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; CARRIER PROTEIN; CASP11 PROTEIN, MOUSE; CASPASE; CYTOKINE RECEPTOR; IL17A PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; IL1R1 PROTEIN, MOUSE; IL27RA PROTEIN, MOUSE; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 17; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DISEASE PREDISPOSITION; EAR; ENZYME ACTIVATION; EX VIVO STUDY; HEALING; IMMUNE RESPONSE; IMMUNITY; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY CELL; LEISHMANIA MAJOR; MACROPHAGE; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PARASITE CLEARANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKIN CELL; SKIN GRANULOMA; SKIN INFECTION; SKIN LEISHMANIASIS; TH1 CELL; TISSUE INJURY; TISSUE SECTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; NEUTROPHIL CHEMOTAXIS; PARASITOLOGY;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CASPASES; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-17; INTERLEUKIN-1BETA; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN-1 TYPE I; RNA, MESSENGER; TH1 CELLS;

EID: 84954472942     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546015     Document Type: Article

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