Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture

Circulation Research

Volumn 116, Issue 4, 2015, Pages 612-623

  Anzai, Atsushi ^a   Shimoda, Masayuki ^a   Endo, Jin ^a   Kohno, Takashi ^a   Katsumata, Yoshinori ^a   Matsuhashi, Tomohiro ^a   Yamamoto, Tsunehisa ^a   Ito, Kentaro ^a   Yan, Xiaoxiang ^a   Shirakawa, Kosuke ^a   Shimizu Hirota, Ryoko ^a   Yamada, Yoshitake ^a   Ueha, Satoshi ^b   Shinmura, Ken ^a   Okada, Yasunori ^a   Fukuda, Keiichi ^a   Sano, Motoaki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Angiotensin II; Aortic dissection; Chemokines; Inflammation; Interleukin 6; Neutrophils

Indexed keywords

ANGIOTENSIN II; CHEMOATTRACTANT; CONTRAST MEDIUM; CXCL1 CHEMOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; 3 AMINOPROPIONITRILE; AUTACOID; BETA-AMINOPROPIONITRILE FUMARATE; CHEMOKINE RECEPTOR CXCR2; CXCL1 PROTEIN, MOUSE; CXCL12 PROTEIN, MOUSE; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; INTERLEUKIN 8; INTERLEUKIN-6, MOUSE; MONOCLONAL ANTIBODY; STROMAL CELL DERIVED FACTOR 1;

ACUTE AORTIC DISSECTION; ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISSECTION; AORTA RUPTURE; ARTICLE; BONE MARROW; CD3+ T LYMPHOCYTE; CELL INFILTRATION; CELL MIGRATION; CELL SUSPENSION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOTHORAX; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE; LEUKOCYTE ACTIVATION; LIMIT OF DETECTION; MOUSE; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; VASCULITIS; ACUTE DISEASE; AGED; ANALOGS AND DERIVATIVES; ANEURYSM, DISSECTING; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTIC ANEURYSM, THORACIC; AORTIC RUPTURE; AORTOGRAPHY; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; KNOCKOUT MOUSE; LESIONS AND DEFECTS; MALE; METABOLISM; MIDDLE AGED; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; RADIOGRAPHY; SIGNAL TRANSDUCTION; THORACIC AORTA; TIME; TRANSPLANTATION;

ACUTE DISEASE; ADVENTITIA; AGED; AMINOPROPIONITRILE; ANEURYSM, DISSECTING; ANGIOTENSIN II; ANIMALS; ANTIBODIES, MONOCLONAL; AORTA, THORACIC; AORTIC ANEURYSM, THORACIC; AORTIC RUPTURE; AORTOGRAPHY; CHEMOKINE CXCL1; CHEMOKINE CXCL12; CHEMOTAXIS, LEUKOCYTE; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHIL INFILTRATION; NEUTROPHILS; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84924234012     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304918     Document Type: Article

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