Long-term metabolic correction of Wilson's disease in a murine model by gene therapy

Journal of Hepatology

Volumn 64, Issue 2, 2016, Pages 419-426

  Murillo, Oihana ^a,b   Luqui, Daniel Moreno ^a,b   Gazquez, Cristina ^a,b   Martinez Espartosa, Debora ^b,c   Navarro Blasco, Iñigo ^a,b   Monreal, Jose Ignacio ^b,c   Guembe, Laura ^a,b   Moreno Cermeño, Armando ^a,b   Corrales, Fernando J ^a,b   Prieto, Jesus ^a,b   Hernandez Alcoceba, Ruben ^a,b   Gonzalez Aseguinolaza, Gloria ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Recinto de Complejo Hospitalario de Navarra   (Spain)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Adenoassociated virus (AAV); ATPase copper transporting beta polypeptide (ATP7B); Copper metabolism; Gene transfer

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA 1 ANTITRYPSIN; ASPARTATE AMINOTRANSFERASE; CD45 ANTIGEN; CERULOPLASMIN; COMPLEMENTARY DNA; PARVOVIRUS VECTOR; WILSON DISEASE PROTEIN; ADENOSINE TRIPHOSPHATASE; ATP7A PROTEIN, MOUSE; C105Y PEPTIDE; CATION TRANSPORT PROTEIN; COPPER; PEPTIDE FRAGMENT;

ADENO ASSOCIATED VIRUS 8; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CERULOPLASMIN BLOOD LEVEL; CONTROLLED STUDY; COPPER METABOLISM; DISEASE COURSE; DOSE RESPONSE; GENE EXPRESSION; LIVER HISTOLOGY; LONG TERM CARE; MALE; MOUSE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WILSON DISEASE; ADMINISTRATION AND DOSAGE; ANIMAL; DISEASE MODEL; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HEPATOLENTICULAR DEGENERATION; HUMAN; LIVER; METABOLISM; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME;

ADENOSINE TRIPHOSPHATASES; ALPHA 1-ANTITRYPSIN; ANIMALS; CATION TRANSPORT PROTEINS; COPPER; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; HEPATOLENTICULAR DEGENERATION; HUMANS; LIVER; MICE; PEPTIDE FRAGMENTS; TREATMENT OUTCOME;

EID: 84954376464     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.09.014     Document Type: Article

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