Chances and shortcomings of adenovirus-mediated ATP7B gene transfer in Wilson disease: Proof of principle demonstrated in a pilot study with LEC rats

Zeitschrift fur Gastroenterologie

Volumn 40, Issue 4, 2002, Pages 209-216

  Ha Hao, Duc ^a   Hofmann, Christian ^b   Wesch, Horst ^c   Doll, Josef ^c   Auburger, Georg ^d   Tuma, Sabine ^a   Merle, Uta ^a   Strauss, Michael ^e   Stremmel, Wolfgang ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b HepaVec AG for Genetherap   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e HepaVec AG   (Germany)

Author keywords

Adenoviral Vector; Gene Therapy; LEC Rat; PET; Wilson Disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CATION TRANSPORT PROTEIN; COPPER; WILSON DISEASE PROTEIN; ADENOVIRUS VECTOR; CERULOPLASMIN; COMPLEMENTARY DNA; GENE PRODUCT; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL; ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; FLUORESCENCE MICROSCOPY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; GENETICS; HUMAN; LIVER; LONG EVANS CINNAMON RAT; LONG EVANS RAT; METABOLISM; PATHOLOGY; PILOT STUDY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILSON DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOSOMAL RECESSIVE DISORDER; BILIARY EXCRETION; BIOACCUMULATION; CONTROLLED STUDY; GENE MUTATION; IMMUNOFLUORESCENCE; LIVER CIRRHOSIS; LIVER INJURY; LIVER TRANSPLANTATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; ADENOVIRIDAE; ANIMALS; CATION TRANSPORT PROTEINS; COPPER; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEPATOLENTICULAR DEGENERATION; HUMANS; LIVER; MICROSCOPY, FLUORESCENCE; PILOT PROJECTS; RATS; RATS, INBRED LEC; RATS, LONG-EVANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOMOGRAPHY, EMISSION-COMPUTED; TRANSDUCTION, GENETIC;

EID: 0035999550     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-25151     Document Type: Article

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