Plasma urate and coronary heart disease: Fingerprint match, but no smoking gun

The Lancet Diabetes and Endocrinology

Volumn 4, Issue 4, 2016, Pages 292-294

  Burgess, Stephen ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; URATE; URIC ACID;

BLOOD PRESSURE; CAUSAL ATTRIBUTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; ISCHEMIC HEART DISEASE; MENDELIAN RANDOMIZATION ANALYSIS; NOTE; PLEIOTROPY; PRIORITY JOURNAL; URIC ACID BLOOD LEVEL; CORONARY ARTERY DISEASE; RISK FACTOR; SMOKING;

CORONARY DISEASE; HUMANS; RISK FACTORS; SMOKING; URIC ACID;

EID: 84954357285     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(15)00425-8     Document Type: Note

References (9)

1. White J, Sofat R, Hemani G, et al. Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol 2016, published online Jan 15. http://dx.doi.org/10.1016/S2213-8587(15)00386-1.
2. Davey Smith G, Ebrahim S 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?. Int J Epidemiol 2003, 32:1-22.
3. Burgess S, Thompson SG Mendelian randomization: methods for using genetic variants in causal estimation 2015, Chapman & Hall, London.
4. Davey Smith G, Lawlor D, Harbord R, Timpson N, Day I, Ebrahim S Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med 2007, 4:e352.
5. Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data. BMJ 2011, 342:d548. CRP CHD Genetics Collaboration.
6. Hingorani A, Humphries S Nature's randomised trials. Lancet 2005, 366:1906-1908.
7. Ference BA, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol 2012, 60:2631-2639.
8. Burgess S, Thompson S Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol 2015, 181:251-260.
9. Bowden J, Davey Smith G, Burgess S Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 2015, 44:512-525.