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Volumn 22, Issue 1, 2016, Pages 16-19

Molecular pathways: IDH2 mutations-co-opting cellular metabolism for malignant transformation

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN;

EID: 84954316943     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0362     Document Type: Article
Times cited : (33)

References (24)
  • 3
    • 79958226901 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in othermesenchymal tumours
    • Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in othermesenchymal tumours. J Pathol 2011;224:334-43.
    • (2011) J Pathol , vol.224 , pp. 334-343
    • Amary, M.F.1    Bacsi, K.2    Maggiani, F.3    Damato, S.4    Halai, D.5    Berisha, F.6
  • 5
    • 84856298658 scopus 로고    scopus 로고
    • Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
    • Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist 2012;17:72-9.
    • (2012) Oncologist , vol.17 , pp. 72-79
    • Borger, D.R.1    Tanabe, K.K.2    Fan, K.C.3    Lopez, H.U.4    Fantin, V.R.5    Straley, K.S.6
  • 6
    • 77149134353 scopus 로고    scopus 로고
    • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    • Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 2010;207:339-44.
    • (2010) J Exp Med , vol.207 , pp. 339-344
    • Gross, S.1    Cairns, R.A.2    Minden, M.D.3    Driggers, E.M.4    Bittinger, M.A.5    Jang, H.G.6
  • 7
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010;17:225-34.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6
  • 8
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18:553-67.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 9
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013;340:622-6.
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3    Penard-Lacronique, V.4    Schalm, S.5    Hansen, E.6
  • 10
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012;483:474-8.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5    Abdel-Wahab, O.6
  • 12
    • 84920971376 scopus 로고    scopus 로고
    • IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition
    • Kernytsky A, Wang F, Hansen E, Schalm S, Straley K, Gliser C, et al. IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition. Blood 2015;125: 296-303.
    • (2015) Blood , vol.125 , pp. 296-303
    • Kernytsky, A.1    Wang, F.2    Hansen, E.3    Schalm, S.4    Straley, K.5    Gliser, C.6
  • 13
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • Tefferi A, Lasho TL, Abdel-Wahab O, Guglielmelli P, Patel J, Caramazza D, et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 2010;24:1302-9.
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3    Guglielmelli, P.4    Patel, J.5    Caramazza, D.6
  • 14
    • 77952426827 scopus 로고    scopus 로고
    • Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
    • Kosmider O, Gelsi-Boyer V, Slama L, Dreyfus F, Beyne-Rauzy O, Quesnel B, et al. Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia 2010;24:1094-6.
    • (2010) Leukemia , vol.24 , pp. 1094-1096
    • Kosmider, O.1    Gelsi-Boyer, V.2    Slama, L.3    Dreyfus, F.4    Beyne-Rauzy, O.5    Quesnel, B.6
  • 15
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Kronke J, Bullinger L, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010;28:3636-43.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 16
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Boissel N, Nibourel O, Renneville A, Gardin C, Reman O, Contentin N, et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2010;28:3717-23.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3    Gardin, C.4    Reman, O.5    Contentin, N.6
  • 17
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010;28:2348-55.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3    Radmacher, M.D.4    Mrozek, K.5    Margeson, D.6
  • 18
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations inAMLdepends on the location of the mutation
    • Green CL, Evans CM, Zhao L, Hills RK, Burnett AK, Linch DC, et al. The prognostic significance of IDH2 mutations inAMLdepends on the location of the mutation. Blood 2011;118:409-12.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3    Hills, R.K.4    Burnett, A.K.5    Linch, D.C.6
  • 19
    • 84895821588 scopus 로고    scopus 로고
    • Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Janin M, Mylonas E, Saada V, Micol JB, Renneville A, Quivoron C, et al. Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2014;32:297-305.
    • (2014) J Clin Oncol , vol.32 , pp. 297-305
    • Janin, M.1    Mylonas, E.2    Saada, V.3    Micol, J.B.4    Renneville, A.5    Quivoron, C.6
  • 21
    • 84879374380 scopus 로고    scopus 로고
    • Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
    • DiNardo CD, Propert KJ, Loren AW, Paietta E, Sun Z, Levine RL, et al. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood 2013;121:4917-24.
    • (2013) Blood , vol.121 , pp. 4917-4924
    • DiNardo, C.D.1    Propert, K.J.2    Loren, A.W.3    Paietta, E.4    Sun, Z.5    Levine, R.L.6
  • 22
    • 84870557152 scopus 로고    scopus 로고
    • Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
    • Fathi AT, Sadrzadeh H, Borger DR, Ballen KK, Amrein PC, Attar EC, et al. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response. Blood 2012;120:4649-52.
    • (2012) Blood , vol.120 , pp. 4649-4652
    • Fathi, A.T.1    Sadrzadeh, H.2    Borger, D.R.3    Ballen, K.K.4    Amrein, P.C.5    Attar, E.C.6
  • 23
    • 84896617557 scopus 로고    scopus 로고
    • A targeted mutational landscape of angioimmunoblastic T-cell lymphoma
    • Odejide O, Weigert O, Lane AA, Toscano D, Lunning MA, Kopp N, et al. A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. Blood 2014;123:1293-6.
    • (2014) Blood , vol.123 , pp. 1293-1296
    • Odejide, O.1    Weigert, O.2    Lane, A.A.3    Toscano, D.4    Lunning, M.A.5    Kopp, N.6
  • 24
    • 84954332860 scopus 로고    scopus 로고
    • AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase 1 study of IDH2 mutation-positive advanced hematologic malignancies [abstract]
    • Jun 11-15; Vienna, Austria. The Hague (The Netherlands): European Hematology Association. Abstract nr P569
    • DiNardo CS, Stein EM, Altman JK, Collins R, DeAngelo D, Fathi AT, et. al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase 1 study of IDH2 mutation-positive advanced hematologic malignancies [abstract]. In: Proceedings of the EHA 20th Congress; 2015 Jun 11-15; Vienna, Austria. The Hague (The Netherlands): European Hematology Association. Abstract nr P569.
    • (2015) Proceedings of the EHA 20th Congress
    • DiNardo, C.S.1    Stein, E.M.2    Altman, J.K.3    Collins, R.4    DeAngelo, D.5    Fathi, A.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.