Diverse microRNAs with convergent functions regulate tumorigenesis (Review)

Oncology Letters

Volumn 11, Issue 2, 2016, Pages 915-920

  Zhu, Min Yan ^a   Zhang, Wei ^b   Yang, Tao ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HEBEI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Cancer stem cell; Microarray; MicroRNA; Signal transduction; Tumorigenesis

Indexed keywords

BETA CATENIN; LET 7 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR 1; MICRORNA; MICRORNA 130A; MICRORNA 133A; MICRORNA 15; MICRORNA 183; MICRORNA 21; MICRORNA 335; MICRORNA 34A; PROTEIN P53; PROTEIN TYROSINE KINASE; SMAD4 PROTEIN; TRANSCRIPTION FACTOR RUNX; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT1 PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CANCER SURVIVAL; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HYPOPHYSIS ADENOMA; LYMPHATIC LEUKEMIA; OSTEOSARCOMA; OVERLAPPING GENE; PANCREAS CANCER; PROSTATE CANCER; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84954307826     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.4020     Document Type: Article

References (54)

1. Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
2. Gangaraju VK and Lin H: MicroRNAs: Key regulators of stem cells. Nat Rev Mol Cell Biol 10: 116-125, 2009.
3. Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, et al: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 17: 211-215, 2011.
4. Samaraweera L, Grandinetti KB, Huang R, Spengler BA and Ross RA: MicroRNAs define distinct human neuroblastoma cell phenotypes and regulate their differentiation and tumorigenicity. BMC Cancer 14: 309, 2014.
5. Bao B, Ali S, Ahmad A, Li Y, Banerjee S, Kong D, Aboukameel A, Mohammad R, Van Buren E, Azmi AS and Sarkar FH: Differentially expressed miRNAs in cancer-stem-like cells: Markers for tumor cell aggressiveness of pancreatic cancer. Stem Cells Dev 23: 1947-1958, 2014.
6. Zhu X, Lin Z, Du J, Zhou X, Yang L and Liu G: Studies on microRNAs that are correlated with the cancer stem cells in chronic myeloid leukemia. Mol Cell Biochem 390: 75-84, 2014.
7. Feng Z, Takahashi R, Nakamura T, Sato D, Shirasawa N, Nakayama A, Kurashige S, Kosawada T, Kitajima T and Umezu M: Expression of microRNA-1, microRNA-133a and Hand2 protein in cultured embryonic rat cardiomyocytes. In Vitro Cell Dev Biol Anim 50: 700-706, 2014.
8. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906, 2000.
9. Thornton JE and Gregory RI: How does Lin28 let-7 control development and disease? Trends Cell Biol 22: 474-482, 2012.
10. Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H and Bartel DP: Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 127: 1193-1207, 2006.
11. Ambros V: MicroRNAs and developmental timing. Curr Opin Genet Dev 21: 511-517, 2011.
12. Abrahante JE, Daul AL, Li M, Volk ML, Tennessen JM, Miller EA and Rougvie AE: The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell 4: 625-637, 2003.
13. Lin SY, Johnson SM, Abraham M, Vella MC, Pasquinelli A, Gamberi C, Gottlieb E and Slack FJ: The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell 4: 639-650, 2003.
14. Zhao C, Sun G, Li S, Lang MF, Yang S, Li W and Shi Y: MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling. Proc Natl Acad Sci USA 107: 1876-1881, 2010.
15. Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang CF and Chang C: Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science 340: 372-376, 2013.
16. Boyerinas B, Park SM, Hau A, Murmann AE and Peter ME: The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer 17: F19-F36, 2010.
17. Liu C, Kelnar K, Vlassov AV, Brown D, Wang J and Tang DG: Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7. Cancer Res 72: 3393-3404, 2012.
18. Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE, Cha SY, Ryu JK, Yoon D, Fearon ER, et al: A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 195: 417-433, 2011.
19. Cha YH, Kim NH, Park C, Lee I, Kim HS and Yook JI: MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling. Cell Cycle 11: 1273-1281, 2012.
20. Rokavec M, Öner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, et al: IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest 124: 1853-1867, 2014.
21. Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S and Plasterk RH: MicroRNA expression in zebrafish embryonic development. Science 309: 310-311, 2005.
22. Shao P, Zhou H, Xiao ZD, He JH, Huang MB, Chen YQ and Qu LH: Identification of novel chicken microRNAs and analysis of their genomic organization. Gene 418: 34-40, 2008.
23. Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S and Plasterk RH: In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods 3: 27-29, 2006.
24. Weston MD, Pierce ML, Rocha-Sanchez S, Beisel KW and Soukup GA: MicroRNA gene expression in the mouse inner ear. Brain Res 1111: 95-104, 2006.
25. Xu S, Witmer PD, Lumayag S, Kovacs B and Valle D: MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem 282: 25053-25066, 2007.
26. Weston MD, Pierce ML, Jensen-Smith HC, Fritzsch B, Rocha-Sanchez S, Beisel KW and Soukup GA: MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival. Dev Dyn 240: 808-819, 2011.
27. Ueno K, Hirata H, Shahryari V, Deng G, Tanaka Y, Tabatabai ZL, Hinoda Y and Dahiya R: MicroRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer. Br J Cancer 108: 1659-1667, 2013.
28. Zhu J, Feng Y, Ke Z, Yang Z, Zhou J, Huang X and Wang L: Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. Am J Pathol 180: 2440-2451, 2012.
29. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, et al: Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99: 15524-15529, 2002.
30. Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC and degli Uberti EC: miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol 204: 280-285, 2005.
31. Aqeilan RI, Calin GA and Croce CM: miR-15a and miR-16-1 in cancer: Discovery, function and future perspectives. Cell Death Differ 17: 215-220, 2010.
32. Xue G, Yan HL, Zhang Y, Hao LQ, Zhu XT, Mei Q and Sun SH: c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2. Oncogene 34: 1393-1406, 2015.
33. Yang F, Miao L, Mei Y and Wu M: Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a. Cell Signal 25: 1476-1485, 2013.
34. Xu N, Shen C, Luo Y, Xia L, Xue F, Xia Q and Zhang J: Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell. Biochem Biophys Res Commun 425: 468-472, 2012.
35. Larsen MT, Häger M, Glenthøj A, Asmar F, Clemmensen SN, Mora-Jensen H, Borregaard N and Cowland JB: miRNA-130a regulates C/EBP-ε expression during granulopoiesis. Blood 123: 1079-1089, 2014.
36. Wang XC, Tian LL, Wu HL, Jiang XY, Du LQ, Zhang H, Wang YY, Wu HY, Li DG, She Y, et al: Expression of miRNA-130a in nonsmall cell lung cancer. Am J Med Sci 340: 385-388, 2010.
37. Qiu S, Lin S, Hu D, Feng Y, Tan Y and Peng Y: Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients. J Transl Med 11: 10, 2013.
38. Haghikia A and Hilfiker-Kleiner D: MiRNA-21: A key to controlling the cardiac fibroblast compartment? Cardiovasc Res 82: 1-3, 2009.
39. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST and Patel T: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658, 2007.
40. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S and Allgayer H: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27: 2128-2136, 2008.
41. Li L, Zhou L, Li Y, Lin S and Tomuleasa C: MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog. J BUON 19: 228-236, 2014.
42. Lynch J, Fay J, Meehan M, Bryan K, Watters KM, Murphy DM and Stallings RL: MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway. Carcinogenesis 33: 976-985, 2012.
43. Martin NT, Nakamura K, Davies R, Nahas SA, Brown C, Tunuguntla R, Gatti RA and Hu H: ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response. PLoS Genet 9: e1003505, 2013.
44. Schoeftner S, Scarola M, Comisso E, Schneider C and Benetti R: An Oct4-pRb axis, controlled by MiR-335, integrates stem cell self-renewal and cell cycle control. Stem Cells 31: 717-728, 2013.
45. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL and Massagué J: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152, 2008.
46. Nohata N, Hanazawa T, Enokida H and Seki N: MicroRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers. Oncotarget 3: 9-21, 2012.
47. Muraoka N, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Isomi M, Nakashima H, Akiyama M, Wada R, Inagawa K, et al: MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures. EMBO J 33: 1565-1581, 2014.
48. Atlasi Y, Looijenga L and Fodde R: Cancer stem cells, pluripotency, and cellular heterogeneity: A WNTer perspective. Curr Top Dev Biol 107: 373-404, 2014.
49. Zhao JJ and Carrasco RD: Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: Implications for multiple myeloma therapy. Cancer Res 74: 5351-5358, 2014.
50. Fagotto F: Looking beyond the Wnt pathway for the deep nature of β -catenin. EMBO Rep 14: 422-433, 2013.
51. Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A and Behnam B: Crosstalk between breast cancer stem cells and metastatic niche: Emerging molecular metastasis pathway? Tumour Biol 34: 2019-2030, 2013.
52. Miyazono K: Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins. Bone 25: 91-93, 1999.
53. Shibuya M: VEGFR and type-V RTK activation and signaling. Cold Spring Harb Perspect Biol 5: a009092, 2013.
54. Wang D, Du L, Liu Q, Liu X and Wang Z: Receptor tyrosine kinase alterations and therapeutic opportunities in squamous cell carcinoma of the lung. Cancer Chemother Pharmacol 72: 725-731, 2013.