Adverse effects after the use of JWH-210 – a case series from the EU Spice II plus project

Drug Testing and Analysis

Volumn 8, Issue 10, 2016, Pages 1030-1038

  Hermanns Clausen, Maren ^a   Kithinji, Josephine ^a   Spehl, Marco ^a   Angerer, Verena ^a,b   Franz, Florian ^a,b   Eyer, Florian ^c   Auwärter, Volker ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

cannabimimetics; CB1 receptor agonist; JWH 210; poisoning; synthetic cannabinoids; synthetic marijuana

Indexed keywords

BLOOD PRESSURE; BODY FLUIDS; COPYRIGHTS; TOXICITY;

'SPICE'; ADVERSE EFFECT; CANNABIMIMETIC; CB1 RECEPTOR AGONIST; HERBAL MIXTURES; JWH-210; POISONING; SERUM SAMPLES; SYNTHETIC CANNABINOID; SYNTHETIC MARIJUANA;

ELECTROCARDIOGRAMS;

ANTIEMETIC AGENT; BENZODIAZEPINE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; DESIGNER DRUG; DRUG METABOLITE; HERBACEOUS AGENT; JWH 210; METOPROLOL; POTASSIUM; RECREATIONAL DRUG; SYNTHETIC CANNABINOID; UNCLASSIFIED DRUG; 4-ETHYLNAPHTHALEN-1-YL-(1-PENTYLINDOL-3-YL)METHANONE; INDOLE DERIVATIVE; NAPHTHALENE DERIVATIVE; STREET DRUG;

ACUTE TOXICITY; ADOLESCENT; ADULT; AGITATION; ARTICLE; BRADYCARDIA; CASE STUDY; CENTRAL NERVOUS SYSTEM DEPRESSION; CHILD; CLINICAL ARTICLE; DATA BASE; DIPLOPIA; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG INTOXICATION; DRUG USE; EMERGENCY WARD; EUROPEAN UNION; FAINTNESS; FEMALE; HUMAN; HYPERTENSION; HYPOKALEMIA; MALE; NAUSEA; OBSERVATIONAL STUDY; POISON CENTER; PRIORITY JOURNAL; RESTLESSNESS; RETROSPECTIVE STUDY; SEIZURE; SOMNOLENCE; T WAVE INVERSION; TACHYCARDIA; AGONISTS; CHEMISTRY; ELECTROCARDIOGRAPHY; INHALATION; METABOLISM; PROCEDURES; SPICE; SUBSTANCE ABUSE; SYNTHESIS;

CANNABINOIDS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INDOLES; INHALATION; MALE; NAPHTHALENES; RECEPTOR, CANNABINOID, CB1; RETROSPECTIVE STUDIES; SPICES; STREET DRUGS; SUBSTANCE ABUSE DETECTION;

EID: 84954287582     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1936     Document Type: Article

References (35)

1. EMCDDA. European Drug Report 2014 — full package and event information. Available at: http://www.emcdda.europa.eu/edr2014 [1 September 2015].
2. R. G. Pertwee, A. C. Howlett, M. E. Abood, S. P. H. Alexander, V. Di Marzo, M. R. Elphick, P. J. Greasley, H. S. Hansen, G. Kunos, K. Mackie, R. Mechoulam, R. A. Ross. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: Beyond CB1 and CB2. Pharmacol. Rev. 2010, 62, 588.
3. M. S. Castaneto, D. A. Gorelick, N. A. Desrosiers, R. L. Hartman, S. Pirard, M. A. Huestis. Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend. 2014, 144, 12.
4. J. B. Mowry, D. A. Spyker, L. R. Cantilena, J. E. Bailey, M. Ford. 2012 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th Annual Report. Clin. Toxicol., 2013, 51, 949.
5. J. B. Mowry, D. A. Spyker, L. R. Cantilena, N. McMillan, M. Ford. 2013 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 31st Annual Report. Clin. Toxicol. 2014, 52, 1032.
6. M. Forrester, K. Kleinschmidt, E. Schwarz, A. Young. Synthetic cannabinoid and marijuana exposures reported to poison centers. Hum. Exp. Toxicol. 2012, 31, 1006.
7. A. A. Monte, A. C. Bronstein, D. J. Cao, K. J. Heard, J. A. Hoppe, C. O. Hoyte, J. L. Iwanicki, E. J. Lavonas. An outbreak of exposure to a novel synthetic cannabinoid. N. Engl. J. Med. 2014, 370, 389.
8. M. Hermanns-Clausen, S. Kneisel, M. Hutter, B. Szabo, V. Auwärter. Acute intoxication by synthetic cannabinoids--four case reports. Drug Test. Anal. 2013, 5, 790.
9. J. W. Huffman, G. Zengin, M.-J. Wu, J. Lu, G. Hynd, K. Bushell, A. L. S. Thompson, S. Bushell, C. Tartal, D. P. Hurst, P. H. Reggio, D. E. Selley, M. P. Cassidy, J. L. Wiley, B. R. Martin. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorg. Med. Chem. 2005, 13, 89.
10. J. L. Wiley, J. A. Marusich, J. W. Huffman. Moving around the molecule: Relationship between chemical structure and in vivo activity of synthetic cannabinoids. Life Sci. 2014, 97, 55.
11. J. Nakajima, M. Takahashi, R. Nonaka, T. Seto, J. Suzuki, M. Yoshida, C. Kanai, T. Hamano. Identification and quantitation of a benzoylindole (2-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone and a naphthoylindole 1-(5-fluoropentyl-1H-indol-3-yl)-(naphthalene-1-yl)methanone (AM-2201) found in illegal products obtained via the Internet and their cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays. Forensic Toxicol. 2011, 29, 132.
12. H. E. Persson, G. K. Sjöberg, J. A. Haines, J. Pronczuk de Garbino. Poisoning severity score. Grading of acute poisoning. J. Toxicol. Clin. Toxicol. 1998, 36, 205.
13. M. Hermanns-Clausen, S. Kneisel, B. Szabo, V. Auwärter. Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings: Acute intoxications by synthetic cannabinoids. Addiction. 2013, 108, 534.
14. S. Kneisel, V. Auwärter. Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extraction: Analysis of 30 synthetic cannabinoids in serum by LC/ESI-MS/MS. J. Mass Spectrom. 2012, 47, 825.
15. M. Hutter, S. Broecker, S. Kneisel, V. Auwärter. Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in “herbal mixtures” using LC-MS/MS techniques: Major metabolites of seven synthetic cannabinoids. J. Mass Spectrom. 2012, 47, 54.
16. L. D. Paul, F. Mußhoff. Untergruppe “Richtlinienerstellung” des Arbeitskreises Qualitätssicherung. Toxichem. Krimtech. Guidel. Qual. Assur. Forensic-Toxicol. Anal. Append. B - Requir. Valid. Anal. Methods. 2009, 76, 185.
17. H. Schulze, M. Schumacher, R. Urmeew, K. Auerbach. DRUID (Driving under the Influence of Drugs, Alcohol and Medicines) Project. Final Report: Work Performed, Main Results and Recommendations, 2012.
18. A. W. Jones, A. Holmgren, F. C. Kugelberg. Driving under the influence of cannabis: a 10-year study of age and gender differences in the concentrations of tetrahydrocannabinol in blood. Addiction. 2008, 103, 452.
19. H. E. Persson, G. K. Sjöberg, J. A. Haines, J. Pronczuk de Garbino. Poisoning severity score. Grading of acute poisoning. J. Toxicol. Clin. Toxicol. 1998, 36, 205.
20. M. B. Forrester. Adolescent Synthetic Cannabinoid Exposures Reported to Texas Poison Centers. Pediatr. Emerg. Care. 2012, 28, 985.
21. A. Kazory, R. Aiyer. Synthetic marijuana and acute kidney injury: an unforeseen association. Clin. Kidney J. 2013, 6, 330.
22. M. J. Freeman, D. Z. Rose, M. A. Myers, C. L. Gooch, A. C. Bozeman, W. S. Burgin. Ischemic stroke after use of the synthetic marijuana 'spice'. Neurology. 2013, 81, 2090.
23. A. Mir, A. Obafemi, A. Young, C. Kane. Myocardial infarction associated with use of the synthetic cannabinoid K2. Pediatrics. 2011, 128, e1622.
24. C. Stanley, S. E. O'Sullivan. Vascular targets for cannabinoids: animal and human studies. Br. J. Pharmacol. 2014, 171, 1361.
25. H. J. Cha, K.-W. Lee, M.-J. Song, Y.-J. Hyeon, J.-Y. Hwang, C.-G. Jang, J.-I. Ahn, S.-H. Jeon, H.-U. Kim, Y.-H. Kim, W.-K. Seong, H. Kang, H. S. Yoo, H.-S. Jeong. Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches. Biomol. Ther. 2014, 22, 363.
26. + Currents in the Ventricle. Circulation. 2015, 132, 1371.
27. A. M. Dines, D. M. Wood, M. Galicia, C. M. Yates, F. Heyerdahl, K. E. Hovda, I. Giraudon, R. Sedefov, Euro-DEN Research Group, P. I. Dargan. Presentations to the Emergency Department Following Cannabis use-a Multi-Centre Case Series from Ten European Countries. J. Med. Toxicol. Off. J. Am. Coll. Med. Toxicol. 2015, DOI: 10.1007/s13181-014-0460-x.
28. E. M. Rock, D. Bolognini, C. L. Limebeer, M. G. Cascio, S. Anavi-Goffer, P. J. Fletcher, R. Mechoulam, R. G. Pertwee, L. A. Parker. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. Br. J. Pharmacol. 2012, 165, 2620.
29. S. Hegstad, A. A. Westin, O. Spigset. Detection Times of Carboxylic Acid Metabolites of the Synthetic Cannabinoids JWH-018 and JWH-073 in Human Urine. J. Anal. Toxicol. 2015, 39, 280.
30. U. S. Zimmermann, P. R. Winkelmann, M. Pilhatsch, J. A. Nees, R. Spanagel, K. Schulz. Withdrawal phenomena and dependence syndrome after the consumption of “spice gold.” Dtsch. Arztebl. Int. 2009, 106, 464.
31. N. Nacca, D. Vatti, R. Sullivan, P. Sud, M. Su, J. Marraffa. The synthetic cannabinoid withdrawal syndrome. J. Addict. Med. 2013, 7, 296.
32. D. Hurst, G. Loeffler, R. McLay. Psychosis associated with synthetic cannabinoid agonists: a case series. Am. J. Psychiatry. 2011, 168, 1119.
33. J. Simmons, L. Cookman, C. Kang, C. Skinner. Three cases of ‘spice’ exposure. Clin. Toxicol. Phila. Pa. 2011, 49, 431.
34. J. Lapoint, L. P. James, C. L. Moran, L. S. Nelson, R. S. Hoffman, J. H. Moran. Severe toxicity following synthetic cannabinoid ingestion. Clin. Toxicol. Phila. Pa. 2011, 49, 760.
35. S. Pant, A. Deshmukh, B. Dholaria, V. Kaur, S. Ramavaram, M. Ukor, G. A. Teran. Spicy seizure. Am. J. Med. Sci. 2012, 344, 67.