Detection times of carboxylic acid metabolites of the synthetic cannabinoids JWH-018 and JWH-073 in human urine

Journal of Analytical Toxicology

Volumn 39, Issue 4, 2015, Pages 280-286

  Hegstad, Solfrid ^a   Westin, Andreas A ^a   Spigset, Olav ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

1 BUTYL 3 (1 NAPHTHOYL)INDOLE; 3 (1 NAPHTHOYL) 1 PENTYLINDOLE; BUTYRIC ACID; CARBOXYLIC ACID; CREATININE; VALERIC ACID; 1-PENTYL-3-(1-NAPHTHOYL)INDOLE; INDOLE DERIVATIVE; JWH-073; NAPHTHALENE DERIVATIVE; STREET DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG URINE LEVEL; FEMALE; FOLLOW UP; HUMAN; KIDNEY CONCENTRATING CAPACITY; LIMIT OF QUANTITATION; MALE; NORMAL HUMAN; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; URINE; CHEMISTRY; LABORATORY DIAGNOSIS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; REPRODUCIBILITY; SUBSTANCE ABUSE; TIME; YOUNG ADULT;

ADULT; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; INDOLES; LIMIT OF DETECTION; MALE; NAPHTHALENES; REPRODUCIBILITY OF RESULTS; SPECIMEN HANDLING; STREET DRUGS; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY; TIME FACTORS; YOUNG ADULT;

EID: 84929666137     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkv013     Document Type: Article

References (26)

1. Lennesta°l, R., Lakso, H.A., Nilsson, M., Mjörndal, T. (2008) Urine monitoring of diazepam abuse-new intake or not? Journal of Analytical Toxicology, 32, 402-407.
2. Schwilke, E.W., Gullberg, R.G., Darwin, W.D., Chiang, C.N., Cadet, J.L., Gorelick, D.A. et al. (2011) Differentiating new cannabis use from residual urinary cannabinoid excretion in chronic, daily cannabis users. Addiction, 106, 499-506.
3. Gunderson, E.W. (2013) Synthetic cannabinoids: a new frontier of designer drugs. Annals of Internal Medicine, 159, 563-564.
4. Brents, L.K., Prather, P.L. (2014) The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products. Drug Metabolism Reviews, 46, 72-85.
5. Fattore, L., Fratta, W. (2011) Beyond THC: The new generation of cannabinoid designer drugs. Frontiers in Behavioral Neuroscience, 5, 60.
6. Tuv, S.S., Krabseth, H., Karinen, R., Olsen, K.M., Øiestad, E.L., Vindenes, V. (2014) Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period. Accident Analysis and Prevention, 62, 26-31.
7. Jang, M., Yang, W., Shin, I., Choi, H., Chang, H., Kim, E. (2014) Determination of AM-2201 metabolites in urine and comparison with JWH-018 abuse. International Journal of Legal Medicine, 128, 285-294.
8. Moran, C.L., Le, V.H., Chimalakonda, K.C., Smedley, A.L., Lackey, F.D., Owen, S.N. et al. (2011) Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Analytical Chemistry, 83, 4228-4236.
9. Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., Endres, G.W., Uzieblo, A., Dobrowolski, P.J. et al. (2011) Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine. Analytical Chemistry, 83, 6381-6388.
10. ElSohly, M.A., Gul, W., Elsohly, K.M., Murphy, T.P., Madgula, V.L., Khan, S.I. (2011) Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites. Journal of Analytical Toxicology, 35, 487-495.
11. Hutter, M., Broecker, S., Kneisel, S., Auwarter, V. (2012) Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in 'herbal mixtures' using LC-MS/MS techniques. Journal of Mass Spectrometry, 47, 54-65.
12. Sobolevsky, T., Prasolov, I., Rodchenkov, G. (2010) Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Science International, 200, 141-147.
13. Wohlfarth, A., Scheidweiler, K.B., Chen, X., Liu, H.F., Huestis, M.A. (2013) Qualitative confirmation of 9 synthetic cannabinoids and 20 metabolites in human urine using LC-MS/MS and library search. Analytical Chemistry, 85, 3730-3738.
14. Scheidweiler, K.B., Huestis, M.A. (2014) Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semiquantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1327, 105-117.
15. Jang, M., Yang, W., Choi, H., Chang, H., Lee, S., Kim, E. et al. (2013) Monitoring of urinary metabolites of JWH-018 and JWH-073 in legal cases. Forensic Science International, 231, 13-19.
16. Yanes, E.G., Lovett, D.P. (2012) High-throughput bioanalytical method for analysis of synthetic cannabinoid metabolites in urine using salting-out sample preparation and LC-MS/MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 909, 42-50.
17. Simoes, S.S., Silva, I., Ajenjo, A.C., Dias, M.J. (2014) Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market. Forensic Science International, 243, 117-125.
18. de Jager, A.D., Warner, J.V., Henman, M., Ferguson, W., Hall, A. (2012) LC-MS/MS method for the quantitation of metabolites of eight commonly-used synthetic cannabinoids in human urine--an Australian perspective. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 897, 22-31.
19. Matuszewski, B.K., Constanzer, M.L., Chavez-Eng, C.M. (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Analytical Chemistry, 75, 3019-3030.
20. Hegstad, S., Hermansson, S., Betner, I., Spigset, O., Falch, B.M. (2014) Screening and quantitative determination of drugs of abuse in diluted urine by UPLC-MS/MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 947-948, 83-95.
21. Poklis, J.L., Amira, D., Wise, L.E., Wiebelhaus, J.M., Haggerty, B.J., Poklis, A. (2012) Detection and disposition of JWH-018 and JWH-073 in mice after exposure to "Magic Gold" smoke. Forensic Science International, 220, 91-96.
22. Huestis, M.A. (2005) Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol. Handbook of Experimental Pharmacology, 168, 657-690.
23. Westin, A.A., Mjønes, G., Burchardt, O., Fuskeva°g, O.M., Slørdal, L. (2014) Can physical exercise or food deprivation cause release of fatstored cannabinoids? Basic & Clinical Pharmacology & Toxicology, 115, 467-471.
24. Huestis, M.A., Cone, E.J. (1998) Differentiating new marijuana use from residual drug excretion in occasional marijuana users. Journal of Analytical Toxicology, 22, 445-454.
25. Smith, M.L., Barnes, A.J., Huestis, M.A. (2009) Identifying new cannabis use with urine creatinine-normalized THCCOOH concentrations and time intervals between specimen collections. Journal of Analytical Toxicology, 33, 185-189.
26. Westin, A.A., Huestis, M.A., Aarstad, K., Spigset, O. (2009) Short communication:Urinary excretion of 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol in a pregnant woman following heavy, chronic cannabis use. Journal of Analytical Toxicology, 33, 610-614.