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Volumn 265, Issue , 2016, Pages 34-45

Behavioral phenotyping of minipigs transgenic for the Huntington gene

Author keywords

Animal models; Behavioral; Cognitive; Minipig; Motor; Phenotyping; Preclinical research

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; COLOR DISCRIMINATION; COLOR DISCRIMINATION TEST; CONTROLLED STUDY; DOMINANCE BEHAVIOR; DOMINANCE TEST; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; EXPLORATORY BEHAVIOR; FEASIBILITY STUDY; FEMALE; GAIT; GAIT TEST; HUNTINGTON CHOREA; HURDLE TEST; LEARNING; MINIPIG; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; STARTBOX BACK AND FORTH TEST; TONGUE COORDINATION TEST; TRANSGENIC PIG; WILD TYPE; ANIMAL; COLOR VISION; DISEASE MODEL; EQUIPMENT DESIGN; GENETICS; HUMAN; METABOLISM; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PERCEPTIVE DISCRIMINATION; PHENOTYPE; PHYSIOLOGY; PIG; PSYCHOLOGY; TONGUE; TRANSGENIC ANIMAL;

EID: 84954271904     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2015.11.013     Document Type: Article
Times cited : (17)

References (53)
  • 1
    • 84906929865 scopus 로고    scopus 로고
    • Regional atrophy associated with cognitive and motor function in prodromal huntington disease
    • Aylward E.H., Harrington D.L., Mills J.A., Nopoulos P.C., Ross C.A., Long J.D., et al. Regional atrophy associated with cognitive and motor function in prodromal huntington disease. J Huntingt Dis 2013, 2:477-489.
    • (2013) J Huntingt Dis , vol.2 , pp. 477-489
    • Aylward, E.H.1    Harrington, D.L.2    Mills, J.A.3    Nopoulos, P.C.4    Ross, C.A.5    Long, J.D.6
  • 3
    • 78650850960 scopus 로고    scopus 로고
    • Tapping linked to function and structure in premanifest and symptomatic Huntington disease
    • Bechtel N., Scahill R.I., Rosas H.D., Acharya T., van den Bogaard S.J., Jauffret C., et al. Tapping linked to function and structure in premanifest and symptomatic Huntington disease. Neurology 2010, 75:2150-2160.
    • (2010) Neurology , vol.75 , pp. 2150-2160
    • Bechtel, N.1    Scahill, R.I.2    Rosas, H.D.3    Acharya, T.4    van den Bogaard, S.J.5    Jauffret, C.6
  • 6
    • 84929222865 scopus 로고    scopus 로고
    • Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy
    • (eCollection;%2015.: 2179-88)
    • Chang R., Liu X., Li S., Li X.J. Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy. Drug Des Dev Ther 2015, 9:2179-2188. (eCollection;%2015.: 2179-88). 10.2147/DDDT.S58470.
    • (2015) Drug Des Dev Ther , vol.9 , pp. 2179-2188
    • Chang, R.1    Liu, X.2    Li, S.3    Li, X.J.4
  • 8
    • 79952223775 scopus 로고    scopus 로고
    • Huntington's disease: can mice lead the way to treatment?
    • Crook Z.R., Housman D. Huntington's disease: can mice lead the way to treatment?. Neuron 2011, 69:423-435.
    • (2011) Neuron , vol.69 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 9
    • 84912051121 scopus 로고    scopus 로고
    • Pig models of neurodegenerative disorders: utilization in cell replacement-based preclinical safety and efficacy studies
    • Dolezalova D., Hruska-Plochan M., Bjarkam C.R., Sorensen J.C., Cunningham M., Weingarten D., et al. Pig models of neurodegenerative disorders: utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol 2014, 522:2784-2801.
    • (2014) J Comp Neurol , vol.522 , pp. 2784-2801
    • Dolezalova, D.1    Hruska-Plochan, M.2    Bjarkam, C.R.3    Sorensen, J.C.4    Cunningham, M.5    Weingarten, D.6
  • 11
    • 84881549745 scopus 로고    scopus 로고
    • Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study
    • Epping E.A., Mills J.A., Beglinger L.J., Fiedorowicz J.G., Craufurd D., Smith M.M., et al. Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study. J Psychiatr Res 2013, 47:1423-1431.
    • (2013) J Psychiatr Res , vol.47 , pp. 1423-1431
    • Epping, E.A.1    Mills, J.A.2    Beglinger, L.J.3    Fiedorowicz, J.G.4    Craufurd, D.5    Smith, M.M.6
  • 12
    • 84928695807 scopus 로고    scopus 로고
    • Aggression in Huntington's disease: a systematic review of rates of aggression and treatment methods
    • Fisher C.A., Sewell K., Brown A., Churchyard A. Aggression in Huntington's disease: a systematic review of rates of aggression and treatment methods. J Huntingt Dis 2014, 3:319-332.
    • (2014) J Huntingt Dis , vol.3 , pp. 319-332
    • Fisher, C.A.1    Sewell, K.2    Brown, A.3    Churchyard, A.4
  • 14
    • 79953661978 scopus 로고    scopus 로고
    • Dysphagia in Huntingtons disease: a review
    • Heemskerk A.W., Roos R.A. Dysphagia in Huntingtons disease: a review. Dysphagia 2011, 26:62-66.
    • (2011) Dysphagia , vol.26 , pp. 62-66
    • Heemskerk, A.W.1    Roos, R.A.2
  • 15
    • 84907939186 scopus 로고    scopus 로고
    • Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease
    • Howland D.S., Munoz-Sanjuan I. Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease. Mov Disord 2014, 29:1397-1403.
    • (2014) Mov Disord , vol.29 , pp. 1397-1403
    • Howland, D.S.1    Munoz-Sanjuan, I.2
  • 16
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's disease rating scale: reliability and consistency
    • Huntington Study Group
    • Unified Huntington's disease rating scale: reliability and consistency. Mov Disord 1996, 11:136-142. Huntington Study Group.
    • (1996) Mov Disord , vol.11 , pp. 136-142
  • 17
    • 80052528377 scopus 로고    scopus 로고
    • Experimental models of HD and reflection on therapeutic strategies
    • Kim J., Bordiuk O.L., Ferrante R.J. Experimental models of HD and reflection on therapeutic strategies. Int Rev Neurobiol 2011, 98:419-481.
    • (2011) Int Rev Neurobiol , vol.98 , pp. 419-481
    • Kim, J.1    Bordiuk, O.L.2    Ferrante, R.J.3
  • 18
    • 0033500593 scopus 로고    scopus 로고
    • Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
    • Lione L.A., Carter R.J., Hunt M.J., Bates G.P., Morton A.J., Dunnett S.B. Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation. J Neurosci 1999, 19:10428-10437.
    • (1999) J Neurosci , vol.19 , pp. 10428-10437
    • Lione, L.A.1    Carter, R.J.2    Hunt, M.J.3    Bates, G.P.4    Morton, A.J.5    Dunnett, S.B.6
  • 19
    • 84907937405 scopus 로고    scopus 로고
    • Animal models of Huntington's disease for translation to the clinic: best practices
    • Menalled L., Brunner D. Animal models of Huntington's disease for translation to the clinic: best practices. Mov Disord 2014, 29:1375-1390.
    • (2014) Mov Disord , vol.29 , pp. 1375-1390
    • Menalled, L.1    Brunner, D.2
  • 20
    • 84902330133 scopus 로고    scopus 로고
    • Large genetic animal models of Huntington's disease
    • Morton A.J., Howland D.S. Large genetic animal models of Huntington's disease. J Huntingt. Dis 2013, 2:3-19.
    • (2013) J Huntingt. Dis , vol.2 , pp. 3-19
    • Morton, A.J.1    Howland, D.S.2
  • 21
    • 79551554590 scopus 로고    scopus 로고
    • The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
    • Munoz-Sanjuan I., Bates G.P. The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease. J Clin Invest 2011, 121:476-483.
    • (2011) J Clin Invest , vol.121 , pp. 476-483
    • Munoz-Sanjuan, I.1    Bates, G.P.2
  • 22
    • 81055156193 scopus 로고    scopus 로고
    • Cognitive impairment in Huntington disease: diagnosis and treatment
    • Paulsen J.S. Cognitive impairment in Huntington disease: diagnosis and treatment. Curr Neurol Neurosci Rep 2011, 11:474-483.
    • (2011) Curr Neurol Neurosci Rep , vol.11 , pp. 474-483
    • Paulsen, J.S.1
  • 23
    • 84907927371 scopus 로고    scopus 로고
    • Onset of Huntington's disease: can it be purely cognitive?
    • Paulsen J.S., Long J.D. Onset of Huntington's disease: can it be purely cognitive?. Mov Disord 2014, 29:1342-1350.
    • (2014) Mov Disord , vol.29 , pp. 1342-1350
    • Paulsen, J.S.1    Long, J.D.2
  • 24
    • 84901341459 scopus 로고    scopus 로고
    • Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study
    • (eCollection;%2014.:78)
    • Paulsen J.S., Long J.D., Johnson H.J., Aylward E.H., Ross C.A., Williams J.K., et al. Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD study. Front Aging Neurosci 2014, 6:78. (eCollection;%2014.:78). 10.3389/fnagi.2014.00078.
    • (2014) Front Aging Neurosci , vol.6 , pp. 78
    • Paulsen, J.S.1    Long, J.D.2    Johnson, H.J.3    Aylward, E.H.4    Ross, C.A.5    Williams, J.K.6
  • 25
    • 84907926731 scopus 로고    scopus 로고
    • Preclinical models: needed in translation? A Pro/Con debate
    • Philips T., Rothstein J.D., Pouladi M.A. Preclinical models: needed in translation? A Pro/Con debate. Mov Disord 2014, 29:1391-1396.
    • (2014) Mov Disord , vol.29 , pp. 1391-1396
    • Philips, T.1    Rothstein, J.D.2    Pouladi, M.A.3
  • 26
    • 84884537922 scopus 로고    scopus 로고
    • Choosing an animal model for the study of Huntington's disease
    • Pouladi M.A., Morton A.J., Hayden M.R. Choosing an animal model for the study of Huntington's disease. Nat Rev Neurosci 2013, 14:708-721.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 708-721
    • Pouladi, M.A.1    Morton, A.J.2    Hayden, M.R.3
  • 27
    • 52649182047 scopus 로고    scopus 로고
    • Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease
    • Rao A.K., Muratori L., Louis E.D., Moskowitz C.B., Marder K.S. Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease. Mov Disord 2008, 23:1100-1107.
    • (2008) Mov Disord , vol.23 , pp. 1100-1107
    • Rao, A.K.1    Muratori, L.2    Louis, E.D.3    Moskowitz, C.B.4    Marder, K.S.5
  • 28
    • 84865633470 scopus 로고    scopus 로고
    • Longitudinal change in gait and motor function in pre-manifest Huntington's disease
    • (RRN1268.: RRN1268)
    • Rao A.K., Mazzoni P., Wasserman P., Marder K. Longitudinal change in gait and motor function in pre-manifest Huntington's disease. PLoS Curr 2011, 3. (RRN1268.: RRN1268).
    • (2011) PLoS Curr , vol.3
    • Rao, A.K.1    Mazzoni, P.2    Wasserman, P.3    Marder, K.4
  • 29
    • 84879134175 scopus 로고    scopus 로고
    • Huntington's disease: towards disease modification-gaps and bridges, facts and opinions
    • Reilmann R. Huntington's disease: towards disease modification-gaps and bridges, facts and opinions. Basal Ganglia 2012, 2:241-248.
    • (2012) Basal Ganglia , vol.2 , pp. 241-248
    • Reilmann, R.1
  • 30
    • 78649376549 scopus 로고    scopus 로고
    • Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease
    • Reilmann R., Bohlen S., Klopstock T., Bender A., Weindl A., Saemann P., et al. Tongue force analysis assesses motor phenotype in premanifest and symptomatic Huntington's disease. Mov Disord 2010, 25:2195-2202.
    • (2010) Mov Disord , vol.25 , pp. 2195-2202
    • Reilmann, R.1    Bohlen, S.2    Klopstock, T.3    Bender, A.4    Weindl, A.5    Saemann, P.6
  • 31
    • 84907940340 scopus 로고    scopus 로고
    • Diagnostic criteria for Huntington's disease based on natural history
    • Reilmann R., Leavitt B.R., Ross C.A. Diagnostic criteria for Huntington's disease based on natural history. Mov Disord 2014, 29:1335-1341.
    • (2014) Mov Disord , vol.29 , pp. 1335-1341
    • Reilmann, R.1    Leavitt, B.R.2    Ross, C.A.3
  • 33
    • 84924599725 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease
    • (in press)
    • Reilmann R., Rouzade-Dominguez M.L., Saft C., Suessmuth S., Priller J., Rosser A., et al. A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease. Mov Disord 2015, (in press).
    • (2015) Mov Disord
    • Reilmann, R.1    Rouzade-Dominguez, M.L.2    Saft, C.3    Suessmuth, S.4    Priller, J.5    Rosser, A.6
  • 34
    • 84859422752 scopus 로고    scopus 로고
    • Huntington's disease: objective assessment of posture-a link between motor and functional deficits
    • Reilmann R., Rumpf S., Beckmann H., Koch R., Ringelstein E.B., Lange H.W. Huntington's disease: objective assessment of posture-a link between motor and functional deficits. Mov Disord 2012, 27:555-559.
    • (2012) Mov Disord , vol.27 , pp. 555-559
    • Reilmann, R.1    Rumpf, S.2    Beckmann, H.3    Koch, R.4    Ringelstein, E.B.5    Lange, H.W.6
  • 36
    • 84907941201 scopus 로고    scopus 로고
    • Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction
    • Ross C.A., Pantelyat A., Kogan J., Brandt J. Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction. Mov Disord 2014, 29:1351-1358.
    • (2014) Mov Disord , vol.29 , pp. 1351-1358
    • Ross, C.A.1    Pantelyat, A.2    Kogan, J.3    Brandt, J.4
  • 37
    • 84907923806 scopus 로고    scopus 로고
    • Clinical trials in Huntington's disease: interventions in early clinical development and newer methodological approaches
    • Sampaio C., Borowsky B., Reilmann R. Clinical trials in Huntington's disease: interventions in early clinical development and newer methodological approaches. Mov Disord 2014, 29:1419-1428.
    • (2014) Mov Disord , vol.29 , pp. 1419-1428
    • Sampaio, C.1    Borowsky, B.2    Reilmann, R.3
  • 38
    • 84873455635 scopus 로고    scopus 로고
    • Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy
    • Scahill R.I., Hobbs N.Z., Say M.J., Bechtel N., Henley S.M., Hyare H., et al. Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy. Hum Brain Mapp 2013, 34:519-529.
    • (2013) Hum Brain Mapp , vol.34 , pp. 519-529
    • Scahill, R.I.1    Hobbs, N.Z.2    Say, M.J.3    Bechtel, N.4    Henley, S.M.5    Hyare, H.6
  • 39
    • 85017584130 scopus 로고    scopus 로고
    • The Libechov minipig as a large animal model for preclinical resarch in Huntington's disease-thoughts and perspectives
    • Schramke S., Schubert R., Frank F., Wirsig M., Fels M., Kemper N., et al. The Libechov minipig as a large animal model for preclinical resarch in Huntington's disease-thoughts and perspectives. Cesk Slov Neurol 2015, 78/111(Suppl 2):55-60.
    • (2015) Cesk Slov Neurol , pp. 55-60
    • Schramke, S.1    Schubert, R.2    Frank, F.3    Wirsig, M.4    Fels, M.5    Kemper, N.6
  • 40
    • 84898847132 scopus 로고    scopus 로고
    • Impaired motor speech performance in Huntington's disease
    • Skodda S., Schlegel U., Hoffmann R., Saft C. Impaired motor speech performance in Huntington's disease. J Neural Transm 2014, 121:399-407.
    • (2014) J Neural Transm , vol.121 , pp. 399-407
    • Skodda, S.1    Schlegel, U.2    Hoffmann, R.3    Saft, C.4
  • 41
    • 84861843888 scopus 로고    scopus 로고
    • Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
    • Stout J.C., Jones R., Labuschagne I., O'Regan A.M., Say M.J., Dumas E.M., et al. Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. J Neurol Neurosurg Psychiatry 2012, 83:687-694.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 687-694
    • Stout, J.C.1    Jones, R.2    Labuschagne, I.3    O'Regan, A.M.4    Say, M.J.5    Dumas, E.M.6
  • 42
    • 68249113963 scopus 로고    scopus 로고
    • Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
    • Tabrizi S.J., Langbehn D.R., Leavitt B.R., Roos R.A., Durr A., Craufurd D., et al. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 2009, 8:791-801.
    • (2009) Lancet Neurol , vol.8 , pp. 791-801
    • Tabrizi, S.J.1    Langbehn, D.R.2    Leavitt, B.R.3    Roos, R.A.4    Durr, A.5    Craufurd, D.6
  • 43
    • 83555173501 scopus 로고    scopus 로고
    • Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
    • Tabrizi S.J., Reilmann R., Roos R.A., Durr A., Leavitt B., Owen G., et al. Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurol 2012, 11:42-53.
    • (2012) Lancet Neurol , vol.11 , pp. 42-53
    • Tabrizi, S.J.1    Reilmann, R.2    Roos, R.A.3    Durr, A.4    Leavitt, B.5    Owen, G.6
  • 44
    • 78650026297 scopus 로고    scopus 로고
    • Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
    • Tabrizi S.J., Scahill R.I., Durr A., Roos R.A., Leavitt B.R., Jones R., et al. Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 2011, 10:31-42.
    • (2011) Lancet Neurol , vol.10 , pp. 31-42
    • Tabrizi, S.J.1    Scahill, R.I.2    Durr, A.3    Roos, R.A.4    Leavitt, B.R.5    Jones, R.6
  • 45
    • 84879032355 scopus 로고    scopus 로고
    • Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data
    • Tabrizi S.J., Scahill R.I., Owen G., Durr A., Leavitt B.R., Roos R.A., et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol 2013, 12:637-649.
    • (2013) Lancet Neurol , vol.12 , pp. 637-649
    • Tabrizi, S.J.1    Scahill, R.I.2    Owen, G.3    Durr, A.4    Leavitt, B.R.5    Roos, R.A.6
  • 46
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group, (see comments)
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983. The Huntington's Disease Collaborative Research Group, (see comments).
    • (1993) Cell , vol.72 , pp. 971-983
  • 47
    • 84855922033 scopus 로고    scopus 로고
    • Pharmacologic approaches to the treatment of Huntington's disease
    • Venuto C.S., McGarry A., Ma Q., Kieburtz K. Pharmacologic approaches to the treatment of Huntington's disease. Mov Disord 2012, 27:31-41.
    • (2012) Mov Disord , vol.27 , pp. 31-41
    • Venuto, C.S.1    McGarry, A.2    Ma, Q.3    Kieburtz, K.4
  • 49
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • (%20)
    • Walker F.O. Huntington's disease. Lancet 2007, 369:218-228. (%20).
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 51
    • 84907924586 scopus 로고    scopus 로고
    • Targets for future clinical trials in Huntington's disease: what's in the pipeline?
    • Wild E.J., Tabrizi S.J. Targets for future clinical trials in Huntington's disease: what's in the pipeline?. Mov Disord 2014, 29:1434-1445.
    • (2014) Mov Disord , vol.29 , pp. 1434-1445
    • Wild, E.J.1    Tabrizi, S.J.2
  • 52
    • 84867428032 scopus 로고    scopus 로고
    • Mouse models for validating preclinical candidates for Huntington's disease
    • CRC Press, Boca Raton, D.C. Lo, R.E. Hughes (Eds.)
    • William Y., Gray X.M. Mouse models for validating preclinical candidates for Huntington's disease. Neurobiology of Huntington's disease: applications to drug discovery 2011, CRC Press, Boca Raton. D.C. Lo, R.E. Hughes (Eds.).
    • (2011) Neurobiology of Huntington's disease: applications to drug discovery
    • William, Y.1    Gray, X.M.2
  • 53
    • 84860624792 scopus 로고    scopus 로고
    • Transgenic animal models of Huntington's disease
    • Yang S.H., Chan A.W. Transgenic animal models of Huntington's disease. Curr Top Behav Neurosci 2011, 7:61-85.
    • (2011) Curr Top Behav Neurosci , vol.7 , pp. 61-85
    • Yang, S.H.1    Chan, A.W.2


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