Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension

Journal of Molecular and Cellular Cardiology

Volumn 91, Issue , 2016, Pages 179-187

  Guo, Dongqing ^a   Gu, Junzhong ^a   Jiang, Hui ^b   Ahmed, Asif ^c   Zhang, Zhiren ^d   Gu, Yuchun ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c ASTON UNIVERSITY   (United Kingdom)

^d HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Activators; PKM2; Pulmonary arterial hypertension; ROS

Indexed keywords

ACETYLCYSTEINE; APOCYNIN; CALCIUM; CALCIUM CHANNEL CAV1.2; FRUCTOSE 1,6 BISPHOSPHATE; MONOCROTALINE; PYRUVATE KINASE; PYRUVATE KINASE M2; REACTIVE OXYGEN METABOLITE; SERINE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; ACETOPHENONE DERIVATIVE; CACNA1C PROTEIN, RAT; CALCIUM CHANNEL L TYPE; MANGANESE(III)-TETRAKIS(4-BENZOIC ACID)PORPHYRIN; METALLOPORPHYRIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOLYSIS; HEART RIGHT VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHOSPHORYLATION; PRIMARY CELL CULTURE; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT;

ACETOPHENONES; ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; METALLOPORPHYRINS; MONOCROTALINE; MYOCYTES, SMOOTH MUSCLE; ORGAN CULTURE TECHNIQUES; PENTOSE PHOSPHATE PATHWAY; PHOSPHORYLATION; PRIMARY CELL CULTURE; PULMONARY ARTERY; PYRUVATE KINASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SERINE;

EID: 84954231983     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.01.009     Document Type: Article

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