A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment

Annals of the Rheumatic Diseases

Volumn 75, Issue 2, 2016, Pages 459-465

  Spreafico, Roberto ^a,b   Rossetti, Maura ^a,b   Van Loosdregt, Jorg ^a   Wallace, Carol A ^c   Massa, Margherita ^d   Magni Manzoni, Silvia ^e   Gattorno, Marco ^f   Martini, Alberto ^f   Lovell, Daniel J ^g,h   Albani, Salvatore ^a,b  

^a BURNHAM INSTITUTE   (United States)

^b Singapore Health Services   (Singapore)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^e BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

^g CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^h UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD45RA ANTIGEN; CD69 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; KI 67 ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; FLOW CYTOMETRY; HEREDITY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; JUVENILE RHEUMATOID ARTHRITIS; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MICROENVIRONMENT; NEXT GENERATION SEQUENCING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; BLOOD; IMMUNOLOGY; IMMUNOPHENOTYPING; PATHOLOGY; T LYMPHOCYTE RECEPTOR GENE;

ARTHRITIS, JUVENILE; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; GENES, T-CELL RECEPTOR BETA; HUMANS; IMMUNOPHENOTYPING; SYNOVIAL MEMBRANE;

EID: 84954156587     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206226     Document Type: Article

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