Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-β and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer's Disease

Journal of Alzheimer's Disease

Volumn 50, Issue 1, 2016, Pages 127-131

  Santos, Cláudia Yang ^a   Lim, Yen Ying ^b,c   Wu, Wen Chih ^b   Machan, Jason Timothy ^d   Polynice, Shahena ^e   Schindler, Rachel ^f   Maruff, Paul ^c,g   Snyder, Peter Jeffrey ^a,b  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b BROWN UNIVERSITY   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Lifespan   (United States)

^e BROWN UNIVERSITY   (United States)

^f PFIZER INC   (United States)

^g Cogstate Ltd ^*  (Australia)

Author keywords

Alzheimer's disease; amyloid beta peptides; blood pressure; cardiovascular diseases; cerebrovascular disorders; comorbidity; memory; mild cognitive impairment; risk factors; short term; workload

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; COGNITIVE DEFECT; DISEASE ASSOCIATION; FEMALE; HEART MUSCLE OXYGEN CONSUMPTION; HEART WORK; HIGH RISK POPULATION; HUMAN; MALE; MEMORY DISORDER; NEUROIMAGING; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; RESTING STATE NETWORK; WORKING MEMORY; BLOOD PRESSURE; DIAGNOSTIC IMAGING; DISEASE COURSE; HEART RATE; MAZE TEST; METABOLISM; MIDDLE AGED; NEOCORTEX; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PROTEIN AGGREGATION, PATHOLOGICAL; WORKLOAD;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BLOOD PRESSURE; DISEASE PROGRESSION; FEMALE; HEART RATE; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MIDDLE AGED; NEOCORTEX; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN AGGREGATION, PATHOLOGICAL; WORKLOAD;

EID: 84954134552     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150576     Document Type: Article

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