Adverse vascular risk is related to cognitive decline in older adults

Journal of Alzheimer's Disease

Volumn 44, Issue 4, 2015, Pages 1361-1373

  Jefferson, Angela L ^a   Hohman, Timothy J ^a   Liu, Dandan ^b   Haj Hassan, Shereen ^a   Gifford, Katherine A ^a   Benson, Elleena M ^a   Skinner, Jeannine S ^c   Lu, Zengqi ^b   Sparling, Jamie ^d,e   Sumner, Emily C ^a   Bell, Susan ^a,b   Ruberg, Frederick L ^d,f  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Vanderbilt Meharry Alliance ^*  (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NEWTON WELLESLEY HOSPITAL   (United States)

^f BOSTON MEDICAL CENTER   (United States)

Author keywords

Blood pressure; diabetes mellitus; Framingham Stroke Risk Profile; smoking; stroke

Indexed keywords

ANTIHYPERTENSIVE AGENT;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DRUG USE; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; FRAMINGHAM RISK SCORE; FRAMINGHAM STROKE RISK PROFILE SCORE; HEART ATRIUM FIBRILLATION; HUMAN; INFORMATION PROCESSING SPEED; LINEAR REGRESSION ANALYSIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MILD COGNITIVE IMPAIRMENT; NERVOUS SYSTEM PARAMETERS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; SMOKING; SYSTOLIC BLOOD PRESSURE; COGNITION DISORDERS; COMPLICATION; MENTAL HEALTH; NEUROPSYCHOLOGICAL TEST; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS;

EID: 84923313636     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141812     Document Type: Article

References (57)

1. Kivipelto M, Laakso MP, Tuomilehto J, Nissinen A, Soininen H (2002) Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: Potential for pharmacological intervention. CNS Drugs 16, 435-444.
2. Arvanitakis Z, Wilson RS, Bienias JL, EvansDA, BennettDA (2004) Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 61, 661-666.
3. Ott A, Slooter AJ, Hofman A, van Harskamp F, Witteman JC, Van Broeckhoven C, van Duijn CM, BretelerMM (1998) Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: The Rotterdam study. Lancet 351, 1840-1843.
4. Bangen KJ, Restom K, Liu TT, Jak AJ, Wierenga CE, Salmon DP, Bondi MW (2009) Differential age effects on cerebral blood flow and bold response to encoding: Associations with cognition and stroke risk. Neurobiol Aging 30, 1276-1287.
5. Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118, 103-113.
6. de Toledo Ferraz Alves TC, Scazufca M, Squarzoni P, de Souza Duran FL, Tamashiro-Duran JH, Vallada HP, Andrei A, Wajngarten M, Menezes PR, Busatto GF (2011) Subtle gray matter changes in temporo-parietal cortex associated with cardiovascular risk factors. J Alzheimers Dis 27, 575-589.
7. Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C (2004) Stroke risk profile predicts white matter hyperintensity volume: The Framingham study. Stroke 35, 1857-1861.
8. Brady CB, Spiro A, 3rd, McGlinchey-Berroth R, Milberg W, Gaziano JM (2001) Stroke risk predicts verbal fluency decline in healthy older men: Evidence from the normative aging study. J Gerontol B Psychol Sci Soc Sci 56, P340-P346.
9. Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA (2004) Framingham stroke risk profile and lowered cognitive performance. Stroke 35, 404-409.
10. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB (1991) Probability of stroke: A risk profile from the Framingham study. Stroke 22, 312-318.
11. Kaffashian S, Dugravot A, Elbaz A, Shipley MJ, Sabia S, Kivimaki M, Singh-Manoux A (2013) Predicting cognitive decline: A dementia risk score vs. The Framingham vascular risk scores. Neurology 80, 1300-1306.
12. Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM (2008) Framingham stroke risk profile and poor cognitive function: A population-based study. BMC Neurol 8, 12.
13. Maineri Nde L, Xavier FM, Berleze MC, Moriguchi EH (2007) Risk factors for cerebrovascular disease and cognitive function in the elderly. Arq Bras Cardiol 89, 142-146, 158-162.
14. Kaffashian S, DugravotA, Brunner EJ, Sabia S, Ankri J, Kivimaki M, Singh-Manoux A (2012) Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study. Alzheimers Dement 9, 572-579.
15. Albert MS, Dekosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH (2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279.
16. de Groot JC, de Leeuw FE, Oudkerk M, van Gijn J, Hofman A, Jolles J, BretelerMM (2000) Cerebral white matter lesions and cognitive function: The Rotterdam scan study. Ann Neurol 47, 145-151.
17. Buckner RL (2004) Memory and executive function in aging and ad: Multiple factors that cause decline and reserve factors that compensate. Neuron 44, 195-208.
18. Qiu C, Cotch MF, Sigurdsson S, Jonsson PV, Jonsdottir MK, Sveinbjrnsdottir S, Eiriksdottir G, Klein R, Harris TB, van Buchem MA, Gudnason V, Launer LJ (2010) Cerebral microbleeds, retinopathy, and dementia: TheAGESReykjavik study. Neurology 75, 2221-2228.
19. Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ (2010) Cardiac index is associated with brain aging: The Framingham heart study. Circulation 122, 690-697.
20. Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA (2007) The National Alzheimer's Coordinating Center (NACC) database: The uniform data set. Alzheimer Dis Assoc Disord 21, 249-258.
21. Morris JC (1993) The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology 43, 2412-2414.
22. Weintraub S, Salmon D, Mercaldo N, Ferris S, Graff-Radford NR, Chui H, Cummings J, DeCarli C, Foster NL, Galasko D, Peskind E, Dietrich W, Beekly DL, Kukull WA, Morris JC (2009) The Alzheimer's disease centers' Uniform Data Set (UDS): The neuropsychologic test battery. Alzheimer Dis Assoc Disord 23, 91-101.
23. PetersenRC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256, 183-194.
24. D'Agostino RB, Wolf PA, Belanger AJ, Kannel WB (1994) Stroke risk profile: Adjustment for antihypertensive medication. The Framingham study. Stroke 25, 40-43.
25. O'Brien RM (2007) A caution regarding rules of thumb for variance inflation factors. Qual Quant 41, 673-690.
26. Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, Yan JC, Zhou HD, Chongqing Ageing Study G (2011) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology 76, 1485-1491.
27. van der Flier WM, van der Vlies AE, Weverling-Rijnsburger AW, de Boer NL, Admiraal-Behloul F, Bollen EL, Westendorp RG, van Buchem MA, MiddelkoopHA (2005) MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic. Int J Geriatr Psychiatry 20, 1060-1066.
28. Rossi R, Geroldi C, Bresciani L, Testa C, Binetti G, Zanetti O, Frisoni GB (2007) Clinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairment. Dement Geriatr Cogn 23, 175-183.
29. Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ (2013) Tracking pathophysiological processes in Alzheimer's disease: An updated hypothetical model of dynamic biomarkers. Lancet Neurol 12, 207-216.
30. Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197-2204.
31. Schneider JA, Bennett D (2010) Where vascular meets neurodegenerative disease. Stroke 41, S144-S146.
32. Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ (2008) Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Ann Neurol 64, 168-176.
33. Delano-Wood L, Bondi MW, Sacco J, Abeles N, Jak AJ, Libon DJ, Bozoki A (2009) Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology. J Int Neuropsychol Soc 15, 906-914.
34. Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA (2009) The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis 18, 691-701.
35. Petersen P, Kastrup J, Videbaek R, Boysen G (1989) Cerebral blood flow before and after cardioversion of atrial fibrillation. J Cereb Blood Flow Metab 9, 422-425.
36. Ezekowitz MD, James KE, Nazarian SM, Davenport J, Broderick JP, Gupta SR, ThadaniV, Meyer ML, Bridgers SL (1995) Silent cerebral infarction in patients with nonrheumatic atrial fibrillation. The veterans affairs stroke prevention in nonrheumatic atrial fibrillation investigators. Circulation 92, 2178-2182.
37. Leys D, Erkinjuntti T, Desmond DW, Schmidt R, Englund E, Pasquier F, Parnetti L, Ghika J, Kalaria RN, Chabriat H, Scheltens P, Bogousslavsky J (1999) Vascular dementia: The role of cerebral infarcts. Alzheimer Dis Assoc Disord 13 Suppl 3, S38-S48.
38. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, BretelerMM (2002) Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 125, 765-772.
39. Hara M, Yakushiji Y, Nannri H, Sasaki S, Noguchi T, Nishiyama M, Hirotsu T, Nakajima J, Hara H (2013) Joint effect of hypertension and lifestyle-related risk factors on the risk of brain microbleeds in healthy individuals. Hypertens Res 36, 789-794.
40. Carmelli D, Swan GE, Reed T, Wolf PA, Miller BL, DeCarli C (1999) Midlife cardiovascular risk factors and brain morphology in identical older male twins. Neurology 52, 1119-1124.
41. Swan GE, DeCarli C, Miller BL, Reed T, Wolf PA, Jack LM, Carmelli D (1998) Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology 51, 986-993.
42. Mensah GA, Mokdad AH, Ford ES, Greenlund KJ, Croft JB (2005) State of disparities in cardiovascular health in the United States. Circulation 111, 1233-1241.
43. Levine DA, Lewis CE, Williams OD, Safford MM, Liu K, Calhoun DA, Kim Y, Jacobs DR, Jr., Kiefe CI (2011) Geographic and demographic variability in 20-year hypertension incidence: The CARDIA study. Hypertension 57, 39-47.
44. Hertz RP, Unger AN, Ferrario CM (2006) Diabetes, hypertension, and dyslipidemia in Mexican Americans and non-Hispanic whites. Am J Prev Med 30, 103-110.
45. Boykin S, Diez-Roux AV, Carnethon M, Shrager S, Ni H, Whitt-Glover M (2011) Racial/ethnic heterogeneity in the socioeconomic patterning of CVD risk factors: In the United States: The multi-ethnic study of atherosclerosis. J Health Care Poor Underserved 22, 111-127.
46. Gifford KA, Badaracco M, Liu D, Tripodis Y, Gentile A, Lu Z, Palmisano J, Jefferson AL (2013) Blood pressure and cognition among older adults: A meta-analysis. Arch Clin Neuropsychol 28, 649-664.
47. Dregan A, Stewart R, Gulliford MC (2013) Cardiovascular risk factors and cognitive decline in adults aged 50 and over: A population-based cohort study. Age Ageing 42, 338-345.
48. Diez-Roux AV, Nieto FJ, Muntaner C, Tyroler HA, ComstockGW, Shahar E, Cooper LS, Watson RL, SzkloM (1997) Neighborhood environments and coronary heart disease: A multilevel analysis. Am J Epidemiol 146, 48-63.
49. Smith GD, Hart C, Watt G, Hole D, Hawthorne V (1998) Individual social class, area-based deprivation, cardiovascular disease risk factors, and mortality: The Renfrew and Paisley study. J Epidemiol Community Health 52, 399-405.
50. Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, AuR, Benjamin EJ (2011) Inflammatory markers and neuropsychological functioning: The Framingham heart study. Neuroepidemiology 37, 21-30.
51. Levy D, AndersonKM, Savage DD, KannelWB, Christiansen JC, Castelli WP (1988) Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors. The Framingham heart study. Ann Intern Med 108, 7-13.
52. Pfeffer RI, Kurosaki TT, Harrah CH Jr, Chance JM, Filos S (1982) Measurement of functional activities in older adults in the community. J Gerontol 37, 323-329.
53. Wechsler D (1987) Wechsler memory scale-revised, Psychological Corporation, San Antonio, Texas.
54. Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Motor Skill 8, 271-276.
55. Kaplan E, Goodglass H, Weintraub S (1983) The Boston naming test, Lea & Febiger, Philadelphia.
56. Goodglass H, Kaplan E (1983) The assessment of aphasia and related disorders, Lea & Febiger, Philadelphia, PA.
57. Troyer AK, Moscovitch M, Winocur G (1997) Clustering and switching as two components of verbal fluency: Evidence from younger and older healthy adults. Neuropsychology 11, 138-146.