Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Winkler, Jeremy W ^a   Orr, Sarah K ^a   Dalli, Jesmond ^a   Cheng, Chien Yee C ^a   Sanger, Julia M ^a   Chiang, Nan ^a   Petasis, Nicos A ^b   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL; APOPTOSIS; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MICROBIOLOGY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOGENICITY; PATHOLOGY; PERITONITIS; SKIN; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; DOCOSAHEXAENOIC ACIDS; FIBROBLASTS; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MICE; NEUTROPHIL INFILTRATION; NEUTROPHILS; PERITONITIS; SKIN; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84953923877     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18972     Document Type: Article

References (25)

1. Serhan, C. N. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92-101 (2014).
2. Samuelsson, B. Role of basic science in the development of new medicines: Examples from the eicosanoid field. J. Biol. Chem. 287, 10070-10080 (2012).
3. Haeggstrom, J. Z. & Funk, C. D. Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease. Chem. Rev. 111, 5866-5898 (2011).
4. Ward, P. A. New approaches to the study of sepsis. EMBO Mol Med 4, 1234-1243 (2012).
5. De Caterina, R. N-3 fatty acids in cardiovascular disease. N. Engl. J. Med. 364, 2439-2450 (2011).
6. Chiang, N. et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 484, 524-528 (2012).
7. Dalli, J. et al. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem. Biol. 20, 188-201 (2013).
8. Serhan, C. N. et al. Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals. J. Exp. Med. 196, 1025-1037 (2002).
9. Hong, S., Gronert, K., Devchand, P., Moussignac, R.-L. & Serhan, C. N. Novel docosatrienes and 17s-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells: Autacoids in anti-inflammation. J. Biol. Chem. 278, 14677-14687 (2003).
10. Duffield, J. S. et al. Resolvin D series and protectin D1 mitigate acute kidney injury. J. Immunol. 177, 5902-5911 (2006).
11. Tabas, I. & Glass, C. K. Anti-inflammatory therapy in chronic disease: Challenges and opportunities. Science 339, 166-172 (2013).
12. Winkler, J. W., Uddin, J., Serhan, C. N. & Petasis, N. A. Stereocontrolled total synthesis of the potent anti-inflammatory and proresolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer. Org Lett 15, 1424-1427 (2013).
13. Colas, R. A., Shinohara, M., Dalli, J., Chiang, N. & Serhan, C. N. Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol 307, C39-54 (2014).
14. Poon, I. K., Lucas, C. D., Rossi, A. G. & Ravichandran, K. S. Apoptotic cell clearance: Basic biology and therapeutic potential. Nat Rev Immunol 14, 166-180 (2014).
15. Oh, S. F., Vickery, T. W. & Serhan, C. N. Chiral lipidomics of e-series resolvins: Aspirin and the biosynthesis of novel mediators. Biochim. Biophys. Acta. 1811, 737-747 (2011).
16. Weiss, G. A. et al. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. Lipids Health Dis 12, 89 (2013).
17. El Kebir, D., Gjorstrup, P. & Filep, J. G. Resolvin e1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proc. Natl. Acad. Sci. USA 109, 14983-14988 (2012).
18. Fredman, G. et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene b4 synthesis by inhibiting a calcium-activated kinase pathway. Proc. Natl. Acad. Sci. USA 111, 14530-14535 (2014).
19. Dinarello, C. A., Simon, A. & van der Meer, J. W. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 11, 633-652 (2012).
20. Edwards, J. C. W., Sedgwick, A. D. & Willoughby, D. A. The formation of a structure with the features of a synovial lining by subcutaneous injection of air: An in vivo tissue culture system. J. Pathol. 134, 147-156 (1981).
21. Qu, X. et al. Resolvins e1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation. J. Pathol. 228, 506-519 (2012).
22. Hsiao, H. M. et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One 8, e58258 (2013).
23. Mustafa, M. et al. Resolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol 305, C673-679 (2013).
24. Hall, S. E., Savill, J. S., Henson, P. M. & Haslett, C. Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. J. Immunol. 153, 3218-3227 (1994).
25. Grinnell, F. Fibroblast spreading and phagocytosis: Similar cell responses to different-sized substrata. J. Cell. Physiol. 119, 58-64 (1984).