Interferon-regulatory factor 5-dependent signaling restricts orthobunyavirus dissemination to the central nervous system

Journal of Virology

Volumn 90, Issue 1, 2016, Pages 189-205

  Proenca Modena, Jose Luiz ^a,b   Hyde, Jennifer L ^a   Sesti Costa, Renata ^a,c   Lucas, Tiffany ^a   Pinto, Amelia K ^a   Richner, Justin M ^a   Gorman, Matthew J ^a   Lazear, Helen M ^a,d   Diamond, Michael S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 5; VIRUS RNA; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BRAIN REGION; BUNYAVIRUS INFECTION; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE STORM; DENDRITIC CELL; GENE DELETION; HISTOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LA CROSSE VIRUS; LIVER; LIVER INJURY; MENINGOENCEPHALITIS; MOUSE; NONHUMAN; OROPOUCHE VIRUS; ORTHOBUNYAVIRUS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN; TUNEL ASSAY; VIRUS REPLICATION; WILD TYPE; ANIMAL; APOPTOSIS; BRAIN; C57BL MOUSE; CELL CULTURE; CENTRAL NERVOUS SYSTEM; DISEASE MODEL; GENE INACTIVATION; HOST PATHOGEN INTERACTION; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SURVIVAL ANALYSIS; THEORETICAL MODEL; VIROLOGY;

ANIMALS; APOPTOSIS; BRAIN; BUNYAVIRIDAE INFECTIONS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; GENE KNOCKOUT TECHNIQUES; HOST-PATHOGEN INTERACTIONS; INTERFERON REGULATORY FACTORS; INTERFERON TYPE I; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, THEORETICAL; ORTHOBUNYAVIRUS; SIGNAL TRANSDUCTION; SPLEEN; SURVIVAL ANALYSIS; VIRUS REPLICATION;

EID: 84953873558     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02276-15     Document Type: Article

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