The functional and clinical relevance of childhood trauma-related admixture of affective, anxious and psychosis symptoms

Acta Psychiatrica Scandinavica

Volumn 133, Issue 2, 2016, Pages 91-101

  van Nierop, M ^a   Bak, M ^a   de Graaf, R ^b   ten Have, M ^b   van Dorsselaer, S ^b   Bruggeman, Richard ^d   Cahn, Wiepke ^e   de Haan, Lieuwe ^f   Kahn, Rene S ^e   Meijer, Carin J ^f   Myin Germeys, Inez ^a   van Os, Jim ^a,g   Wiersma, Durk ^d   van Winkel, R ^a,c  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NETHERLANDS INSTITUTE OF MENTAL HEALTH AND ADDICTION   (Netherlands)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Admixture of symptoms; Childhood trauma; Functional outcome; Stratified medicine

Indexed keywords

ANXIETY DISORDER; ARTICLE; CHILD ABUSE; CHILDHOOD TRAUMA; CONTROLLED STUDY; HELP SEEKING BEHAVIOR; HUMAN; MOOD DISORDER; PREVALENCE; PRIORITY JOURNAL; PSYCHOSIS; QUALITY OF LIFE; SOCIAL INTERACTION; SUBSTANCE ABUSE;

EID: 84953838208     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/acps.12437     Document Type: Article

References (48)

1. Prata D, Mechelli A, Kapur S. Clinically meaningful biomarkers for psychosis: a systematic and quantitative review. Neurosci Biobehav Rev 2014;45:134-141.
2. Graham J, Salimi-Khorshidi G, Hagan C etal. Meta-analytic evidence for neuroimaging models of depression: state or trait? J Affect Disord 2013;151:423-431.
3. Kapur S, Phillips AG, Insel TR. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry 2012;17:1174-1179.
4. Van Os J, Delespaul P, Wigman J, Myin-Germeys I, Wichers M. Beyond DSM and ICD: introducing "precision diagnosis" for psychiatry using momentary assessment technology. World Psychiatry 2013;12:113-117.
5. Van Nierop M, Viechtbauer W, Gunther N etal. Childhood trauma is associated with a specific admixture of affective, anxiety, and psychosis symptoms cutting across traditional diagnostic boundaries. Psychol Med 2015;45:1277-1288.
6. Wigman JTW, Van Nierop M, Vollebergh W etal. Evidence that psychotic symptoms are prevalent in disorders of anxiety and depression, impacting on illness onset, risk, and severity - implications for diagnosis and ultra-high risk research. Schizophr Bull 2012;38:247-257.
7. Nanni V, Uher R, Danese A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 2012;169:141-151.
8. Kuo JR, Goldin PR, Werner K, Heimberg RG, Gross JJ. Childhood trauma and current psychological functioning in adults with social anxiety disorder. J Anxiety Disord 2011;25:467-473.
9. Varese F, Smeets F, Drukker M etal. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 2012;38:661-671.
10. Mueser KT, Rosenberg SD, Xie H etal. A randomized controlled trial of cognitive-behavioral treatment for posttraumatic stress disorder in severe mental illness. J Consult Clin Psychol 2008;76:259-271.
11. Frueh BC, Grubaugh AL, Cusack KJ, Kimble MO, Elhai JD, Knapp RG. Exposure-based cognitive-behavioral treatment of PTSD in adults with schizophrenia or schizoaffective disorder: a pilot study. J Anxiety Disord 2009;23:665-675.
12. De Bont PA, Van Den Berg DP, Van Der Vleugel BM etal. A multi-site single blind clinical study to compare the effects of prolonged exposure, eye movement desensitization and reprocessing and waiting list on patients with a current diagnosis of psychosis and co morbid post traumatic stress disorder: study protocol for the randomized controlled trial Treating Trauma in Psychosis. Trials 2013;14:151.
13. De Bont PA, Van Minnen A, De Jongh A. Treating PTSD in patients with psychosis: a within-group controlled feasibility study examining the efficacy and safety of evidence-based PE and EMDR protocols. Behav Ther 2013;44:717-730.
14. De Graaf R, Ten Have M, Van Dorsselaer S. The Netherlands Mental Health Survey and Incidence study-2 (NEMESIS-2): design and methods. Int J Methods Psychiatr Res 2010;19:125-141.
15. De Graaf R, Ormel J, Ten Have M, Burger H, Buist-Bouwman M. Mental disorders and service use in the Netherlands. Results from the European Study of the Epidemiology of Mental Disorders (ESEMeD). In: Kessler RC, Üstün TB, eds. The WHO world mental health surveys: global perspectives on the epidemiology of mental disorders. New York: Cambridge University Press, 2008:388-405.
16. Van Nierop M, Van Os J, Gunther N etal. Does social defeat mediate the association between childhood trauma and psychosis? Evidence from the Nemesis-2 study. Acta Psychiatr Scand 2014;129:467-476.
17. Heins M, Simons C, Lataster T etal. Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma. Am J Psychiatry 2011;168:1286-1294.
18. Van Dam DS, Van Nierop M, Viechtbauer W etal. Childhood abuse and neglect in relation to the presence and persistence of psychotic and depressive symptomatology. Psychol Med 2015;45:1363-1377.
19. Stewart AL, Hayes RD, Ware JE. The MOS short form general health survey. Med Care 1988;26:724-735.
20. Korver N, Quee PJ, Boos HB, Simons C, De Haan L. Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods. Int J Methods Psychiatr Res 2012;21:205-221.
21. Andreasen NC, Flaum M, Arndt S. The comprehensive assessment of symptoms and history (CASH). An instrument for assessing diagnosis and psychopathology. Arch Gen Psychiatry 1992;49:615-623.
22. Wing JK, Babor T, Brugha T etal. SCAN. Schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 1990;47:589-593.
23. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-276.
24. Bernstein DP, Stein JA, Newcomb MD etal. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 2003;27:169-190.
25. Andrew G, Peters L. The psychometric properties of the Composite International Diagnostic Interview. Soc Psychiatry Psychiatr Epidemiol 1998;33:80-88.
26. The WHOQOL Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med 1998;28:551-558.
27. A.P.A. Diagnostic and statistical manual of mental disorders (DSM-IV-TR), 4th edn. Washington, DC: American Psychiatric Association, 2000.
28. STATACORP. Stata statistical software: release 13. College Station, TX: StataCorp LP, 2013.
29. Conus P, Cotton S, Schimmelmann BG etal. Pretreatment and outcome correlates of past sexual and physical trauma in 118 bipolar I disorder patients with a first episode of psychotic mania. Bipolar Disord 2010;12:244-252.
30. Gil A, Gama CS, De Jesus DR, Lobato MI, Zimmer M, Belmonte-De-Abreu P. The association of child abuse and neglect with adult disability in schizophrenia and the prominent role of physical neglect. Child Abuse Negl 2009;33:618-624.
31. Van Nierop M, Lataster T, Smeets F etal. Psychopathological mechanisms linking childhood traumatic experiences to risk of psychotic symptoms. Analysis of a large, representative population-based sample. Schizophr Bull 2014;40:S123-130.
32. Gustavsson A, Svensson M, Jacobi F etal. Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011;21:718-779.
33. Shonkoff JP, Boyce WT, McEwen BS. Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA 2009;301:2252-2259.
34. Ogino S, Lochhead P, Chan AT etal. Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol 2013;26:465-484.
35. Schumann G, Binder EB, Holte A etal. Stratified medicine for mental disorders. Eur Neuropsychopharmacol 2014;24:5-50.
36. Owen DR, Rupprecht R, Nutt DJ. Stratified medicine in psychiatry: a worrying example or new opportunity in the treatment of anxiety? J Psychopharmacol 2013;27:119-122.
37. Teicher MH, Samson JA. Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am J Psychiatry 2013;170:1114-1133.
38. Van Winkel R. Etiological stratification as a conceptual framework for gene-by-environment interaction research in psychiatry. Epidemiol Psychiatr Sci 2015;24:6-11.
39. Szyf M. The genome- and system-wide response of DNA methylation to early life adversity and its implication on mental health. Can J Psychiatry 2013;58:697-704.
40. Perroud N, Dayer A, Piguet C etal. Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder. Br J Psychiatry 2014;204:30-35.
41. Mehta D, Klengel T, Conneely KN etal. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci USA 2013;110:8302-8307.
42. McGowan PO, Sasaki A, D'Alessio AC etal. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009;12:342-348.
43. Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C. Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults. Cochrane Database Syst Rev 2013;12:CD003388.
44. Van Winkel R, Van Nierop M, Myin-Germeys I, Van Os J. Childhood trauma as a cause of psychosis: linking genes, psychology, and biology. Can J Psychiatry 2013;58:44-51.
45. Kelleher I, Keeley H, Corcoran P etal. Childhood trauma and psychosis in a prospective cohort study: cause, effect, and directionality. Am J Psychiatry 2013;170:734-741.
46. Myin-Germeys I, Oorschot M, Collip D, Lataster J, Delespaul P, Van Os J. Experience sampling research in psychopathology: opening the black box of daily life. Psychol Med 2009;39:1533-1547.
47. Bringmann LF, Vissers N, Wichers M etal. A network approach to psychopathology: new insights into clinical longitudinal data. PLoS ONE 2013;8:e60188.
48. Frewen PA, Schmittmann VD, Bringmann LF, Borsboom D. Perceived causal relations between anxiety, posttraumatic stress and depression: extension to moderation, mediation, and network analysis. Eur J Psychotraumatol 2013;4, doi: 10.3402/ejpt.v4i0.20656.