Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder

British Journal of Psychiatry

Volumn 204, Issue 1, 2014, Pages 30-35

  Perroud, Nader ^a   Dayer, Alexandre ^a   Piguet, Camille ^b   Nallet, Audrey ^b   Favre, Sophie ^b   Malafosse, Alain ^b   Aubry, Jean Michel ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR;

ADULT; BIPOLAR DISORDER; CHILD SEXUAL ABUSE; CHILDHOOD TRAUMA QUESTIONNAIRE; EARLY LIFE STRESS; EMOTIONAL ABUSE; EMOTIONAL NEGLECT; EXON; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METHYLATION; NEGLECT; PERSONAL EXPERIENCE; PHYSICAL ABUSE; PHYSICAL NEGLECT; PROMOTER REGION; REVIEW;

EID: 84891783936     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.112.120055     Document Type: Review

References (35)

1. Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M. Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord 2008; 10: 867-76.
2. Leverich GS, McElroy SL, Suppes T, Keck PE, Denicoff KD, Nolen WA, et al. Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry 2002; 51: 288-97. (Pubitemid 34214994)
3. Goldberg JF, Garno JL. Development of posttraumatic stress disorder in adult bipolar patients with histories of severe childhood abuse. J Psychiatr Res 2005; 39: 595-601. (Pubitemid 41278626)
4. Leverich GS, Post RM. Course of bipolar illness after history of childhood trauma. Lancet 2006; 367: 1040-2.
5. Conus P, Cotton S, Schimmelmann BG, Berk M, Daglas R, McGorry PD, et al. Pretreatment and outcome correlates of past sexual and physical trauma in 118 bipolar I disorder patients with a first episode of psychotic mania. Bipolar Disord 2010; 12: 244-52.
6. Etain B, Mathieu F, Henry C, Raust A, Roy I, Germain A, et al. Preferential association between childhood emotional abuse and bipolar disorder. J Trauma Stress 2010; 23: 376-83.
7. Garno JL, Goldberg JF, Ramirez PM, Ritzler BA. Impact of childhood abuse on the clinical course of bipolar disorder. Br J Psychiatry 2005; 186: 121-5. (Pubitemid 40193780)
8. Romero S, Birmaher B, Axelson D, Goldstein T, Goldstein BI, Gill MK, et al. Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder. J Affect Disord 2009; 112: 144-50.
9. Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 2009; 10: 434-45.
10. Darnaudery M, Maccari S. Epigenetic programming of the stress response in male and female rats by prenatal restraint stress. Brain Res Rev 2008; 57: 571-85.
11. Frodl T, O'Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis 2013; 52: 24-37.
12. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7: 847-54. (Pubitemid 38989508)
13. Weaver IC, D'Alessio AC, Brown SE, Hellstrom IC, Dymov S, Sharma S, et al. The transcription factor nerve growth factor-inducible protein A mediates epigenetic programming: altering epigenetic marks by immediate-early genes. J Neurosci 2007; 27: 1756-68. (Pubitemid 46280071)
14. Oberlander TF, Weinberg J, Papsdorf M, Grunau R, Misri S, Devlin AM. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 2008; 3: 97-106.
15. Radtke K, Ruf M, Gunter H, Dohrmann K, Schauer M, Meyer A, et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 2011; 1: e21, doi: 10.1038/tp.2011.21.
16. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342-8.
17. Perroud N, Paoloni-Giacobino A, Prada P, Olie E, Salzmann A, Nicastro R, et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry 2011; 1: e59, doi: 10.1038/tp.2011.60.
18. First MB, Spitzer RL, M. G, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). American Psychiatric Press, 1996.
19. Bernstein DP, Fink L. Childhood Trauma Questionnaire. A Retrospective Self- Report. Psychological Corporation, 1998.
20. Finkelhor D, Hotaling G, Lewis IA, Smith C. Sexual abuse in a national survey of adult men and women: prevalence, characteristics, and risk factors. Child Abuse Negl 1990; 14: 19-28. (Pubitemid 20106929)
21. MacMillan HL, Fleming JE, Trocme N, Boyle MH, Wong M, Racine YA, et al. Prevalence of child physical and sexual abuse in the community. Resultsfrom the Ontario Health Supplement. JAMA 1997; 278: 131-5. (Pubitemid 27287670)
22. Watson S, Gallagher P, Ritchie JC, Ferrier IN, Young AH. Hypothalamic-pituitary-drenal axis function in patients with bipolar disorder. Br J Psychiatry 2004; 184: 496-502. (Pubitemid 38725709)
23. Daban C, Vieta E, Mackin P, Young AH. Hypothalamic-pituitary-adrenal axis and bipolar disorder. Psychiatr Clin North Am 2005; 28: 469-80.
24. Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA.The neurobiology of the switch process in bipolar disorder: a review. J Clin Psychiatry 2010; 71: 1488-501.
25. Yates TM. The developmental consequences of child emotional abuse: a neurodevelopmental perspective. J Emotional Abuse 2007; 7: 19-34.
26. De Bellis MD, Keshavan MS, Clark DB, Casey BJ, Giedd JN, Boring AM, et al. A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development. Biol Psychiatry 1999; 45: 1271-84.
27. Coulston CM, Tanious M, Mulder RT, Porter RJ, Malhi GS. Bordering on bipolar: the overlap between borderline personality and bipolarity. Aust NZ J Psychiatry 2012; 46: 506-21.
28. Carballo JJ, Harkavy-Friedman J, Burke AK, Sher L, Baca-Garcia E, Sullivan GM, et al. Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness? J Affect Disord 2008; 109: 57-63.
29. Coulston CM, Tanious M, Mulder RT, Porter RJ, Malhi GS. Bordering on bipolar: the overlap between borderline personality and bipolarity. Aust NZ J Psychiatry; 46: 506-21.
30. Bassett D. Borderline personality disorder and bipolar affective disorder. Spectra or spectre? A review. Aust NZ J Psychiatry; 46: 327-39.
31. Goldstein BI, Strober MA, Birmaher B, Axelson DA, Esposito-Smythers C, Goldstein TR, et al. Substance use disorders among adolescents with bipolar spectrum disorders. Bipolar Disord 2008; 10: 469-78. (Pubitemid 351619163)
32. Angst J, Gamma A, Rossler W, Ajdacic V, Klein DN. Childhood adversity and chronicity of mood disorders. Eur Arch Psychiatry Clin Neurosci 2011; 261: 21-7.
33. Bilinski P, Wojtyla A, Kapka-Skrzypczak L, Chwedorowicz R, Cyranka M, Studzinski T. Epigenetic regulation in drug addiction. Ann Agric Environ Med 2012; 19: 491-6.
34. Labonte B, Suderman M, Maussion G, Navaro L, Yerko V, Mahar I, et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 2012; 69: 722-31.
35. McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, et al. Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One 2011; 6: e14739.